RS54889B1 - Multifunkcionalni derivati nitroksida i njihove upotrebe - Google Patents

Multifunkcionalni derivati nitroksida i njihove upotrebe

Info

Publication number
RS54889B1
RS54889B1 RS20160494A RSP20160494A RS54889B1 RS 54889 B1 RS54889 B1 RS 54889B1 RS 20160494 A RS20160494 A RS 20160494A RS P20160494 A RSP20160494 A RS P20160494A RS 54889 B1 RS54889 B1 RS 54889B1
Authority
RS
Serbia
Prior art keywords
alkyl
attached
compound
methyl
alkylene
Prior art date
Application number
RS20160494A
Other languages
English (en)
Serbian (sr)
Inventor
Prakash Jagtap
Andrew Lurie Salzman
Original Assignee
Radikal Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radikal Therapeutics Inc filed Critical Radikal Therapeutics Inc
Publication of RS54889B1 publication Critical patent/RS54889B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
RS20160494A 2010-12-09 2011-12-08 Multifunkcionalni derivati nitroksida i njihove upotrebe RS54889B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42138210P 2010-12-09 2010-12-09
PCT/IL2011/000931 WO2012077108A1 (en) 2010-12-09 2011-12-08 Multifunctional nitroxide derivatives and uses thereof
EP11808945.7A EP2649048B1 (en) 2010-12-09 2011-12-08 Multifunctional nitroxide derivatives and uses thereof

Publications (1)

Publication Number Publication Date
RS54889B1 true RS54889B1 (sr) 2016-10-31

Family

ID=45496220

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20160494A RS54889B1 (sr) 2010-12-09 2011-12-08 Multifunkcionalni derivati nitroksida i njihove upotrebe

Country Status (17)

Country Link
US (3) US9102659B2 (enExample)
EP (1) EP2649048B1 (enExample)
JP (1) JP5853030B2 (enExample)
CN (1) CN103347856B (enExample)
AU (1) AU2011340037B2 (enExample)
BR (1) BR112013014190A2 (enExample)
CA (1) CA2820763A1 (enExample)
DK (1) DK2649048T3 (enExample)
ES (1) ES2580104T3 (enExample)
HR (1) HRP20160747T1 (enExample)
HU (1) HUE029466T2 (enExample)
PL (1) PL2649048T3 (enExample)
PT (1) PT2649048T (enExample)
RS (1) RS54889B1 (enExample)
RU (1) RU2597265C2 (enExample)
SI (1) SI2649048T1 (enExample)
WO (1) WO2012077108A1 (enExample)

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Publication number Priority date Publication date Assignee Title
PT2964218T (pt) * 2013-03-05 2018-03-26 Radikal Therapeutics Inc Pró-fármacos de derivados de nitróxido multifuncional e utilizações dos mesmos
JP6557977B2 (ja) * 2015-01-15 2019-08-14 Jnc株式会社 含窒素環化合物を含有する液晶組成物および液晶表示素子
WO2017208129A1 (en) 2016-05-31 2017-12-07 Tisbury Pharmaceuticals, Inc. Pharmaceutical composition and method for reducing intraocular pressure
CN111630048B (zh) * 2018-03-19 2023-09-29 四川科伦博泰生物医药股份有限公司 脒类和胍类衍生物、其制备方法及其在医药上的应用
EP4025300A1 (en) * 2019-09-03 2022-07-13 Salzman Group Ltd. Atp-regulated potassium channel openers comprising guanidine and uses thereof

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US2A (en) * 1826-12-15 1836-07-29 John Goulding Mode of manufacturing wool or other fibrous materials
GB1489879A (en) * 1974-12-20 1977-10-26 Leo Pharm Prod Ltd N'-cyano-n'-3-pyridylguanidines
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
US5132311A (en) * 1990-06-27 1992-07-21 G. D. Searle & Co. Cyanoquanidine type III antiarrhythmic agents and use
US5374643A (en) * 1992-09-11 1994-12-20 E. R. Squibb & Sons, Inc. Aryl urea (thiourea) and cyanoguanidine derivatives
RU2180852C2 (ru) * 1994-12-12 2002-03-27 Омерос Медикл Системс, Инк. Ингибирующий раствор и способ подавления боли, воспаления или спазма
WO2000047207A1 (en) * 1999-02-09 2000-08-17 Bristol-Myers Squibb Company LACTAM INHIBITORS OF FXa AND METHOD
US7304066B2 (en) * 2001-05-24 2007-12-04 Bjoerkling Fredrik Pyridyl cyanoguanidine compounds
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US20060264408A1 (en) * 2003-03-06 2006-11-23 Haj-Yehia Abdullah I Sod minic multifunctional compounds for treating inflammatory bowel disease
US20060025446A1 (en) 2004-07-27 2006-02-02 Jeffrey Sterling Propargyl nitroxides and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders
CN1854135B (zh) * 2005-04-18 2013-06-12 李伟章 由氰基胍连接组成的杂环化合物及其医药应用
US20070275944A1 (en) * 2006-04-05 2007-11-29 The Board Of Trustees Operating Michigan State University Antioxidants and methods of their use
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CA2707158A1 (en) * 2007-11-28 2009-06-04 Revision Therapeutics, Inc. Modulators of ocular oxidative stress

Also Published As

Publication number Publication date
EP2649048B1 (en) 2016-03-30
CA2820763A1 (en) 2012-06-14
RU2597265C2 (ru) 2016-09-10
WO2012077108A1 (en) 2012-06-14
US9102659B2 (en) 2015-08-11
SI2649048T1 (sl) 2016-10-28
BR112013014190A2 (pt) 2016-09-13
ES2580104T3 (es) 2016-08-19
PL2649048T3 (pl) 2016-10-31
AU2011340037A1 (en) 2013-07-04
US9522903B2 (en) 2016-12-20
JP5853030B2 (ja) 2016-02-09
PT2649048T (pt) 2016-07-13
DK2649048T3 (en) 2016-07-25
US20130338146A1 (en) 2013-12-19
AU2011340037B2 (en) 2016-03-17
HUE029466T2 (en) 2017-02-28
CN103347856A (zh) 2013-10-09
JP2013544880A (ja) 2013-12-19
RU2013126219A (ru) 2015-01-20
HRP20160747T1 (hr) 2016-09-23
CN103347856B (zh) 2016-03-09
EP2649048A1 (en) 2013-10-16
US20170107198A1 (en) 2017-04-20
US20150336932A1 (en) 2015-11-26

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