AU2011340037B2 - Multifunctional nitroxide derivatives and uses thereof - Google Patents

Multifunctional nitroxide derivatives and uses thereof Download PDF

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Publication number
AU2011340037B2
AU2011340037B2 AU2011340037A AU2011340037A AU2011340037B2 AU 2011340037 B2 AU2011340037 B2 AU 2011340037B2 AU 2011340037 A AU2011340037 A AU 2011340037A AU 2011340037 A AU2011340037 A AU 2011340037A AU 2011340037 B2 AU2011340037 B2 AU 2011340037B2
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AU2011340037A1 (en
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Prakash Jagtap
Andrew Lurie Salzman
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Tisbury Pharmaceuticals Inc
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
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    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

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  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
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  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
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  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
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  • Psychiatry (AREA)
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AU2011340037A 2010-12-09 2011-12-08 Multifunctional nitroxide derivatives and uses thereof Ceased AU2011340037B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42138210P 2010-12-09 2010-12-09
US61/421,382 2010-12-09
PCT/IL2011/000931 WO2012077108A1 (en) 2010-12-09 2011-12-08 Multifunctional nitroxide derivatives and uses thereof

Publications (2)

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AU2011340037A1 AU2011340037A1 (en) 2013-07-04
AU2011340037B2 true AU2011340037B2 (en) 2016-03-17

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AU (1) AU2011340037B2 (enExample)
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Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
PT2964218T (pt) * 2013-03-05 2018-03-26 Radikal Therapeutics Inc Pró-fármacos de derivados de nitróxido multifuncional e utilizações dos mesmos
JP6557977B2 (ja) * 2015-01-15 2019-08-14 Jnc株式会社 含窒素環化合物を含有する液晶組成物および液晶表示素子
WO2017208129A1 (en) 2016-05-31 2017-12-07 Tisbury Pharmaceuticals, Inc. Pharmaceutical composition and method for reducing intraocular pressure
CN111630048B (zh) * 2018-03-19 2023-09-29 四川科伦博泰生物医药股份有限公司 脒类和胍类衍生物、其制备方法及其在医药上的应用
EP4025300A1 (en) * 2019-09-03 2022-07-13 Salzman Group Ltd. Atp-regulated potassium channel openers comprising guanidine and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060025446A1 (en) * 2004-07-27 2006-02-02 Jeffrey Sterling Propargyl nitroxides and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2A (en) * 1826-12-15 1836-07-29 John Goulding Mode of manufacturing wool or other fibrous materials
GB1489879A (en) * 1974-12-20 1977-10-26 Leo Pharm Prod Ltd N'-cyano-n'-3-pyridylguanidines
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
US5132311A (en) * 1990-06-27 1992-07-21 G. D. Searle & Co. Cyanoquanidine type III antiarrhythmic agents and use
US5374643A (en) * 1992-09-11 1994-12-20 E. R. Squibb & Sons, Inc. Aryl urea (thiourea) and cyanoguanidine derivatives
RU2180852C2 (ru) * 1994-12-12 2002-03-27 Омерос Медикл Системс, Инк. Ингибирующий раствор и способ подавления боли, воспаления или спазма
WO2000047207A1 (en) * 1999-02-09 2000-08-17 Bristol-Myers Squibb Company LACTAM INHIBITORS OF FXa AND METHOD
US7304066B2 (en) * 2001-05-24 2007-12-04 Bjoerkling Fredrik Pyridyl cyanoguanidine compounds
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US20060264408A1 (en) * 2003-03-06 2006-11-23 Haj-Yehia Abdullah I Sod minic multifunctional compounds for treating inflammatory bowel disease
CN1854135B (zh) * 2005-04-18 2013-06-12 李伟章 由氰基胍连接组成的杂环化合物及其医药应用
US20070275944A1 (en) * 2006-04-05 2007-11-29 The Board Of Trustees Operating Michigan State University Antioxidants and methods of their use
US7683043B2 (en) * 2006-06-06 2010-03-23 Xenoport, Inc. Creatine phosphate analog prodrugs, compositions and uses thereof
CA2707158A1 (en) * 2007-11-28 2009-06-04 Revision Therapeutics, Inc. Modulators of ocular oxidative stress

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060025446A1 (en) * 2004-07-27 2006-02-02 Jeffrey Sterling Propargyl nitroxides and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders

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RS54889B1 (sr) 2016-10-31
CA2820763A1 (en) 2012-06-14
RU2597265C2 (ru) 2016-09-10
WO2012077108A1 (en) 2012-06-14
US9102659B2 (en) 2015-08-11
SI2649048T1 (sl) 2016-10-28
BR112013014190A2 (pt) 2016-09-13
ES2580104T3 (es) 2016-08-19
PL2649048T3 (pl) 2016-10-31
AU2011340037A1 (en) 2013-07-04
US9522903B2 (en) 2016-12-20
JP5853030B2 (ja) 2016-02-09
PT2649048T (pt) 2016-07-13
DK2649048T3 (en) 2016-07-25
US20130338146A1 (en) 2013-12-19
HUE029466T2 (en) 2017-02-28
CN103347856A (zh) 2013-10-09
JP2013544880A (ja) 2013-12-19
RU2013126219A (ru) 2015-01-20
HRP20160747T1 (hr) 2016-09-23
CN103347856B (zh) 2016-03-09
EP2649048A1 (en) 2013-10-16
US20170107198A1 (en) 2017-04-20
US20150336932A1 (en) 2015-11-26

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