CN103347856B - 多官能氮氧衍生物及其用途 - Google Patents

多官能氮氧衍生物及其用途 Download PDF

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Publication number
CN103347856B
CN103347856B CN201180067011.6A CN201180067011A CN103347856B CN 103347856 B CN103347856 B CN 103347856B CN 201180067011 A CN201180067011 A CN 201180067011A CN 103347856 B CN103347856 B CN 103347856B
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disease
exist
guanidine
compound
methyl
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CN103347856A (zh
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普拉卡什·贾格塔
安德鲁·劳瑞·萨尔兹曼
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Tisbury Pharmaceutical Co Ltd
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Rotikal Therapy Ltd
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
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  • Otolaryngology (AREA)
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CN201180067011.6A 2010-12-09 2011-12-08 多官能氮氧衍生物及其用途 Expired - Fee Related CN103347856B (zh)

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Application Number Priority Date Filing Date Title
US42138210P 2010-12-09 2010-12-09
US61/421,382 2010-12-09
PCT/IL2011/000931 WO2012077108A1 (en) 2010-12-09 2011-12-08 Multifunctional nitroxide derivatives and uses thereof

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CN103347856A CN103347856A (zh) 2013-10-09
CN103347856B true CN103347856B (zh) 2016-03-09

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JP (1) JP5853030B2 (enExample)
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AU (1) AU2011340037B2 (enExample)
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AU2014224249B2 (en) * 2013-03-05 2017-10-05 Salzman Group Pty. Ltd Prodrugs of multifunctional nitroxide derivatives and uses thereof
JP6557977B2 (ja) * 2015-01-15 2019-08-14 Jnc株式会社 含窒素環化合物を含有する液晶組成物および液晶表示素子
WO2017208129A1 (en) 2016-05-31 2017-12-07 Tisbury Pharmaceuticals, Inc. Pharmaceutical composition and method for reducing intraocular pressure
CN111630048B (zh) * 2018-03-19 2023-09-29 四川科伦博泰生物医药股份有限公司 脒类和胍类衍生物、其制备方法及其在医药上的应用
WO2021044413A1 (en) * 2019-09-03 2021-03-11 Salzman Group Ltd. Atp-regulated potassium channel openers comprising guanidine and uses thereof

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US20060025446A1 (en) * 2004-07-27 2006-02-02 Jeffrey Sterling Propargyl nitroxides and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders
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