RS54888B1 - Derivati biciklo(3.1.0)heksan-2,6-dikarboksilne kiseline kao agonisti mglu2 receptora - Google Patents
Derivati biciklo(3.1.0)heksan-2,6-dikarboksilne kiseline kao agonisti mglu2 receptoraInfo
- Publication number
- RS54888B1 RS54888B1 RS20160491A RSP20160491A RS54888B1 RS 54888 B1 RS54888 B1 RS 54888B1 RS 20160491 A RS20160491 A RS 20160491A RS P20160491 A RSP20160491 A RS P20160491A RS 54888 B1 RS54888 B1 RS 54888B1
- Authority
- RS
- Serbia
- Prior art keywords
- hydrogen
- optionally substituted
- fluorine atoms
- pharmaceutically acceptable
- benzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11382208 | 2011-06-17 | ||
| US201161522791P | 2011-08-12 | 2011-08-12 | |
| EP12729769.5A EP2721012B1 (en) | 2011-06-17 | 2012-06-07 | Bicyclo(3.1.0)hexane-2,6-dicarboxylic acid derivatives as mglu2 receptor agonist |
| PCT/US2012/041229 WO2012173850A1 (en) | 2011-06-17 | 2012-06-07 | Bicyclo (3.1.0) hexane- 2, 6 -dicarboxylic acid derivatives as mglu2 receptor agonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS54888B1 true RS54888B1 (sr) | 2016-10-31 |
Family
ID=47357416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20160491A RS54888B1 (sr) | 2011-06-17 | 2012-06-07 | Derivati biciklo(3.1.0)heksan-2,6-dikarboksilne kiseline kao agonisti mglu2 receptora |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9296710B2 (enExample) |
| EP (1) | EP2721012B1 (enExample) |
| JP (1) | JP5945592B2 (enExample) |
| KR (1) | KR101598679B1 (enExample) |
| CN (1) | CN103596933B (enExample) |
| AU (1) | AU2012271024B2 (enExample) |
| BR (1) | BR112013031928B1 (enExample) |
| CA (1) | CA2836485C (enExample) |
| CY (1) | CY1117682T1 (enExample) |
| DK (1) | DK2721012T3 (enExample) |
| EA (1) | EA023553B1 (enExample) |
| ES (1) | ES2587204T3 (enExample) |
| HR (1) | HRP20160676T1 (enExample) |
| HU (1) | HUE030171T2 (enExample) |
| MX (1) | MX2013014802A (enExample) |
| PL (1) | PL2721012T3 (enExample) |
| PT (1) | PT2721012T (enExample) |
| RS (1) | RS54888B1 (enExample) |
| SI (1) | SI2721012T1 (enExample) |
| WO (1) | WO2012173850A1 (enExample) |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993006127A1 (en) | 1991-09-17 | 1993-04-01 | Warner-Lambert Company | Novel amino acid prodrug renin inhibitors |
| US5576323A (en) | 1993-12-03 | 1996-11-19 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5849525A (en) | 1994-03-09 | 1998-12-15 | Brigham And Women's Hospital, Inc. | Compositions corresponding to a proton-coupled peptide transporter and methods of making and using same |
| US5688826A (en) | 1995-11-16 | 1997-11-18 | Eli Lilly And Company | Excitatory amino acid derivatives |
| EA001617B1 (ru) | 1995-11-16 | 2001-06-25 | Эли Лилли Энд Компани | Антагонисты рецепторов возбудительной аминокислоты |
| GB9605429D0 (en) * | 1995-11-16 | 1996-05-15 | Lilly Co Eli | Excitatory amino acid receptor antagonists |
| US5952294A (en) | 1996-07-31 | 1999-09-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peptidyl prodrugs and methods of making and using the same |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| CN1182105C (zh) | 1998-01-28 | 2004-12-29 | 大正制药株式会社 | 含氟氨基酸衍生物 |
| DE69918136T2 (de) | 1998-08-31 | 2005-07-07 | Taisho Pharmaceutical Co., Ltd. | 6-Fluorobicyclo[3.1.0]Hexan-Derivate |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| CN1216038C (zh) | 2000-06-28 | 2005-08-24 | 大正制药株式会社 | 新型二羧酸衍生物 |
| US7256217B2 (en) | 2001-01-11 | 2007-08-14 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| WO2002055485A1 (en) | 2001-01-11 | 2002-07-18 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| WO2002068380A1 (en) * | 2001-02-22 | 2002-09-06 | Eli Lilly And Company | Synthetic excitatory amino acids |
| EP1395257A1 (en) | 2001-06-12 | 2004-03-10 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| PL208123B1 (pl) | 2001-12-27 | 2011-03-31 | Taisho Pharmaceutical Co Ltd | Pochodna kwasu 2-amino-3-alkoksy-6-fluorobicyklo [3.1.0] heksano-2, 6-dikarboksylowego, zawierająca ją kompozycja farmaceutyczna i lek, oraz jej zastosowanie |
| US20050192273A1 (en) | 2002-04-03 | 2005-09-01 | Johnson Bryan G. | Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist |
| WO2003084610A1 (en) | 2002-04-03 | 2003-10-16 | Eli Lilly And Company | Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist |
| HRP20041179B1 (hr) * | 2002-06-11 | 2012-11-30 | Eli Lilly And Company | Prekursorski oblici lijekova za aminokiseline s pobuđivačkom aktivnosti |
| CN101362793A (zh) * | 2002-06-11 | 2009-02-11 | 伊莱利利公司 | 兴奋性氨基酸前药 |
| CN100582087C (zh) * | 2003-06-26 | 2010-01-20 | 大正制药株式会社 | 2-氨基-双环[3.1.0]己烷-2,6-二甲酸酯衍生物 |
| US7381746B2 (en) * | 2003-06-26 | 2008-06-03 | Taisho Pharmaceutical Co., Ltd. | 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative |
| JP5536227B2 (ja) * | 2009-11-18 | 2014-07-02 | スヴェン・ライフ・サイエンシズ・リミテッド | α４β２ニコチン性アセチルコリン受容体リガンドとしての二環式化合物 |
| JO2978B1 (en) * | 2009-12-21 | 2016-03-15 | ايلي ليلي اند كومباني | MGLU2 aids |
-
2012
- 2012-06-07 KR KR1020137033028A patent/KR101598679B1/ko active Active
- 2012-06-07 CA CA2836485A patent/CA2836485C/en active Active
- 2012-06-07 EP EP12729769.5A patent/EP2721012B1/en active Active
- 2012-06-07 BR BR112013031928-3A patent/BR112013031928B1/pt active IP Right Grant
- 2012-06-07 JP JP2014515878A patent/JP5945592B2/ja active Active
- 2012-06-07 HU HUE12729769A patent/HUE030171T2/en unknown
- 2012-06-07 MX MX2013014802A patent/MX2013014802A/es active IP Right Grant
- 2012-06-07 SI SI201230569A patent/SI2721012T1/sl unknown
- 2012-06-07 DK DK12729769.5T patent/DK2721012T3/en active
- 2012-06-07 PT PT127297695T patent/PT2721012T/pt unknown
- 2012-06-07 HR HRP20160676TT patent/HRP20160676T1/hr unknown
- 2012-06-07 US US14/123,768 patent/US9296710B2/en active Active
- 2012-06-07 ES ES12729769.5T patent/ES2587204T3/es active Active
- 2012-06-07 RS RS20160491A patent/RS54888B1/sr unknown
- 2012-06-07 PL PL12729769T patent/PL2721012T3/pl unknown
- 2012-06-07 WO PCT/US2012/041229 patent/WO2012173850A1/en not_active Ceased
- 2012-06-07 AU AU2012271024A patent/AU2012271024B2/en active Active
- 2012-06-07 EA EA201391700A patent/EA023553B1/ru not_active IP Right Cessation
- 2012-06-07 CN CN201280029080.2A patent/CN103596933B/zh active Active
-
2016
- 2016-06-24 CY CY20161100570T patent/CY1117682T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2013014802A (es) | 2014-01-24 |
| WO2012173850A1 (en) | 2012-12-20 |
| CY1117682T1 (el) | 2017-05-17 |
| JP5945592B2 (ja) | 2016-07-05 |
| KR101598679B1 (ko) | 2016-02-29 |
| EP2721012A1 (en) | 2014-04-23 |
| CA2836485C (en) | 2016-12-13 |
| CA2836485A1 (en) | 2012-12-20 |
| ES2587204T3 (es) | 2016-10-21 |
| SI2721012T1 (sl) | 2016-08-31 |
| CN103596933B (zh) | 2016-03-23 |
| JP2014517035A (ja) | 2014-07-17 |
| DK2721012T3 (en) | 2016-08-15 |
| BR112013031928A2 (pt) | 2016-12-13 |
| AU2012271024A1 (en) | 2013-11-21 |
| EA201391700A1 (ru) | 2014-04-30 |
| US20140113944A1 (en) | 2014-04-24 |
| HUE030171T2 (en) | 2017-05-29 |
| BR112013031928B1 (pt) | 2022-05-24 |
| AU2012271024B2 (en) | 2015-07-09 |
| US9296710B2 (en) | 2016-03-29 |
| PT2721012T (pt) | 2016-07-27 |
| KR20140009568A (ko) | 2014-01-22 |
| HRP20160676T1 (hr) | 2016-07-15 |
| EA023553B1 (ru) | 2016-06-30 |
| EP2721012B1 (en) | 2016-05-25 |
| CN103596933A (zh) | 2014-02-19 |
| PL2721012T3 (pl) | 2017-05-31 |
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