RS20080002A - N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof - Google Patents

N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof

Info

Publication number
RS20080002A
RS20080002A RSP-2008/0002A RSP20080002A RS20080002A RS 20080002 A RS20080002 A RS 20080002A RS P20080002 A RSP20080002 A RS P20080002A RS 20080002 A RS20080002 A RS 20080002A
Authority
RS
Serbia
Prior art keywords
cancer
pyrimidine
phenyl
compound
relates
Prior art date
Application number
RSP-2008/0002A
Other languages
English (en)
Inventor
Dong-Yeon Kim
Dae-Jin Cho
Gong-Yeal Lee
Hong-Youb Kim
Seok-Hun Woo
Yong-Seok Kim
Sun-Ahe Lee
Byoung-Cheol Han
Original Assignee
Il-Yang Pharm. Co.Ltd.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Il-Yang Pharm. Co.Ltd., filed Critical Il-Yang Pharm. Co.Ltd.,
Publication of RS20080002A publication Critical patent/RS20080002A/sr
Publication of RS53379B publication Critical patent/RS53379B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Pyridine Compounds (AREA)

Abstract

Predstavljeni pronalazak se odnosi na novi derivat N-fenil-2-pirimidin-amina predstavljen prethodnom formulom (1) i njegovu so koji pokazuju bolji efekat na kancer kod tolpokrvnih životinja, kao što su rak pluća, rak želudca, rak debelog creva, rak pankreasa, hepatom, rak prostate, rak dojke, hronična ili akutna leukemija, hematološki malignitet, encefalofima, rak bešike, rak rektuma, rak grlića materice, limfom, itd. Predstavljeni pronalazak se takođe odnosi na postupak za pripremu jedinjenja, i na farmaceutsku kompoziciju za tretman prethodno navedenih različitih bolesti, koja sadrži efikasnu količinu jedinjenja kao aktivni sastojak zajedno sa farmaceutski prihvatljivim inertnim nosačima: gde su Rl do R8 kao što je određeno u prethodnom tekstu.
RS20080002A 2005-08-05 2005-09-07 Derivati n-fenil-2-pirimidin-amina i postupak za njihovo pripremanje RS53379B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020050071656A KR100674813B1 (ko) 2005-08-05 2005-08-05 Ｎ-페닐-2-피리미딘-아민 유도체 및 그의 제조방법
PCT/KR2005/002962 WO2007018325A1 (en) 2005-08-05 2005-09-07 N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof

Publications (2)

Publication Number Publication Date
RS20080002A true RS20080002A (en) 2009-07-15
RS53379B RS53379B (sr) 2014-10-31

Family

ID=37727490

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20080002A RS53379B (sr) 2005-08-05 2005-09-07 Derivati n-fenil-2-pirimidin-amina i postupak za njihovo pripremanje

Country Status (16)

Country Link
US (1) US7501424B2 (sr)
EP (1) EP1922309B1 (sr)
JP (1) JP5094721B2 (sr)
KR (1) KR100674813B1 (sr)
CN (1) CN101155786B (sr)
AU (1) AU2005335298C1 (sr)
CA (1) CA2617991C (sr)
DK (1) DK1922309T3 (sr)
EA (1) EA015103B1 (sr)
ES (1) ES2493627T3 (sr)
MX (1) MX2008001221A (sr)
NZ (1) NZ564908A (sr)
PL (1) PL1922309T3 (sr)
PT (1) PT1922309E (sr)
RS (1) RS53379B (sr)
WO (1) WO2007018325A1 (sr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100654039B1 (ko) 2005-11-14 2006-12-05 에스케이 텔레콤주식회사 무선 인터넷에서 서비스 서버의 인증방법 및 이를 이용한결제방법
ES2633318T3 (es) 2006-10-23 2017-09-20 Cephalon, Inc. Derivados bicíclicos fusionados de 2,4-diaminopirimidina como inhibidores de ALK y c-Met
KR20120049397A (ko) * 2006-11-03 2012-05-16 노파르티스 아게 단백질 키나제 억제제로서의 화합물 및 조성물
CN101687853A (zh) 2007-05-04 2010-03-31 Irm责任有限公司 作为c-kit和pdgfr激酶抑制剂的嘧啶衍生物和组合物
CA2686382C (en) * 2007-05-04 2013-09-17 Irm Llc Phenylaminopyrimidine derivatives and compositions thereof as c-kit and pdgfr kinase inhibitors
WO2008151183A1 (en) 2007-06-04 2008-12-11 Avila Therapeutics, Inc. Heterocyclic compounds and uses thereof
EA017392B1 (ru) 2007-08-22 2012-12-28 Айрм Ллк Производные 2-гетероариламинопиримидина в качестве ингибиторов киназ
US20100016590A1 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
KR20100021321A (ko) * 2008-08-14 2010-02-24 일양약품주식회사 Ν-페닐-2-피리미딘-아민 유도체의 제조방법
KR101251726B1 (ko) 2008-11-05 2013-04-05 테바 파마슈티컬 인더스트리즈 리미티드 닐로티닙 ＨＣｌ 결정형
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
CN103003264B (zh) 2010-05-21 2014-08-06 切米利亚股份公司 嘧啶衍生物
EP2688883B1 (en) 2011-03-24 2016-05-18 Noviga Research AB Pyrimidine derivatives
KR101369584B1 (ko) 2011-04-19 2014-03-06 일양약품주식회사 페닐-이속사졸 유도체 및 그의 제조방법
RU2486180C1 (ru) * 2011-11-02 2013-06-27 Общество с ограниченной ответственностью "ТехноХим" (ООО "ТехноХим") Способ получения 2-ариламино-4-гетарилпиримидинов
KR101956586B1 (ko) * 2012-03-27 2019-03-11 일양약품주식회사 약제학적 조성물 및 이의 제조방법
JP5910311B2 (ja) * 2012-05-23 2016-04-27 ニプロ株式会社 医薬錠剤およびその製造方法
CN104940748A (zh) * 2015-06-09 2015-09-30 林正兴 一种治疗胃癌的药物组合物
EP3609882B1 (en) 2017-03-17 2022-07-13 Cardio Therapeutics Pty Ltd Heterocyclic inhibitors of pcsk9
CN107056713A (zh) * 2017-05-18 2017-08-18 厦门大学 4‑((4‑取代芳基‑2‑嘧啶基)氨基)苯甲酰肼衍生物及其制备方法和应用
CN111039932B (zh) * 2019-12-13 2023-09-12 安徽峆一药业股份有限公司 一种拉多替尼的高收率合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
AU5127800A (en) * 1999-05-13 2000-12-05 Nutrasweet Company, The Use of additives to modify the taste characteristics of n-neohexyl-alpha-aspartyl-l-phenylalanine methyl ester
BR0014454A (pt) * 1999-10-04 2002-08-20 Composição edulcorante com um alto grau de edulcoração, edulcorante, alimento e bebida, ou um outro produto edulcorado, processos para conferir um sabor doce, e para corrigir um sabor, modificador de sabor, e, alimento e bebida, um medicamento etc. com sabor amargo aperfeiçoado
GB0021726D0 (en) * 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
WO2002024681A2 (en) * 2000-09-20 2002-03-28 Ortho-Mcneil Pharmaceutical, Inc. Pyrazine derivatives as modulators of tyrosine kinases
US7129242B2 (en) * 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
ATE339418T1 (de) * 2001-06-01 2006-10-15 Vertex Pharma Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen
US6958340B2 (en) 2001-08-01 2005-10-25 Merck & Co., Inc. Tyrosine kinase inhibitors
US7494997B2 (en) * 2002-06-28 2009-02-24 Nippon Shinyaku Co., Ltd. Amide derivative
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
JP2006522125A (ja) * 2003-03-25 2006-09-28 バーテックス　ファーマシューティカルズ　インコーポレイテッド プロテインキナーゼのインヒビターとして有用なチアゾール
WO2004087698A2 (en) * 2003-03-25 2004-10-14 Vertex Pharmaceuticals Incorporated Thiazoles useful as inhibitors of protein kinases
AU2003232650A1 (en) 2003-05-06 2004-11-26 Il Yang Pharm Co., Ltd. N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
JP2006527230A (ja) * 2003-06-13 2006-11-30 ノバルティス アクチエンゲゼルシャフト Ｒａｆキナーゼ阻害剤としての２−アミノピリミジン誘導体
PT1702917T (pt) * 2003-12-25 2017-11-14 Nippon Shinyaku Co Ltd Derivado de amida e medicamento
WO2005063720A1 (ja) * 2003-12-25 2005-07-14 Nippon Shinyaku Co., Ltd. アミド誘導体及び医薬
JPWO2005113550A1 (ja) * 2004-05-20 2008-03-27 三菱ウェルファーマ株式会社 アミノピリミジン誘導体及びその医薬としての用途

Also Published As

Publication number Publication date
KR100674813B1 (ko) 2007-01-29
AU2005335298B2 (en) 2010-05-27
US7501424B2 (en) 2009-03-10
EA015103B1 (ru) 2011-06-30
AU2005335298A1 (en) 2007-02-15
AU2005335298C1 (en) 2010-11-25
DK1922309T3 (da) 2014-08-25
EP1922309A1 (en) 2008-05-21
CA2617991A1 (en) 2007-02-15
ES2493627T3 (es) 2014-09-12
JP5094721B2 (ja) 2012-12-12
CA2617991C (en) 2011-08-09
CN101155786A (zh) 2008-04-02
JP2009503060A (ja) 2009-01-29
CN101155786B (zh) 2012-08-29
MX2008001221A (es) 2009-02-24
EA200800516A1 (ru) 2008-08-29
PL1922309T3 (pl) 2014-11-28
EP1922309B1 (en) 2014-05-21
PT1922309E (pt) 2014-09-02
WO2007018325A1 (en) 2007-02-15
EP1922309A4 (en) 2009-10-14
NZ564908A (en) 2011-02-25
RS53379B (sr) 2014-10-31
US20080096899A1 (en) 2008-04-24

Similar Documents

Publication Publication Date Title
RS20080002A (en) N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
JP2008535902A5 (sr)
MX2009006742A (es) Inhibidores acilaminopirazoles como fgfr.
TW200728307A (en) Novel spirochromanone derivatives
WO2007064345A3 (en) Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
MXPA06009475A (es) Derivados de quinazolina y usos terapeuticos de los mismos.
IL184872A0 (en) Pyrazole derivatives, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for treatment and prevention of cancers
IL185063A0 (en) Pyrazole derivatives, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for treatment and prevention of cancers
MX2007004183A (es) Derivados de benzoimidazol utiles como agentes antiproliferacion.
EA200701930A1 (ru) Производные пиримидина для лечения гиперпролиферативных нарушений
WO2005115470A3 (fr) COMPOSITIONS PHARMACEUTIQUES CONTENANT DES DERIVES DE β-­CARBOLINE, ET LEUR UTILISATION POUR LE TRAITEMENT DES CANCERS
GB0112348D0 (en) Compounds
CA2575720A1 (en) Pyrimidine derivatives
MX2007007027A (es) Derivados piperazinilpiridina como agentes anti-obesidad.
WO2005105753A8 (en) Naphthalimide derivatives, methods for their production and pharmaceutical compositions therefrom
SI1727817T1 (sl) Azabiciklooktan-3-onski derivati in njihova uporaba
CA2706832A1 (en) Mevalonic acid derivatives
DK1056704T3 (da) Antitumormidler
UA92009C2 (ru) Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
SG145570A1 (en) 4-æ7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents
TW200635592A (en) Pyridyl-substituted spiro-hydantoin compounds and use thereof
PT1718651E (pt) Derivados 7h-pirrolopirimidina
ATE489399T1 (de) Antitumor wirksame 2-substituierte estra-1,3, 5(10)-trien-3-yl sulfamate
MX2009005242A (es) Derivados de 3-(hetero)arilisoquinolinamida sustituida en posición 5, 6 o 7 y uso terapeutico del mismo.
WO2004044174A3 (en) Topoisomerase-targeting agents