RO92320B - Procedeu pentru prepararea clorurii de carnitinnitril optic activ - Google Patents

Procedeu pentru prepararea clorurii de carnitinnitril optic activ

Info

Publication number
RO92320B
RO92320B RO118253A RO11825385A RO92320B RO 92320 B RO92320 B RO 92320B RO 118253 A RO118253 A RO 118253A RO 11825385 A RO11825385 A RO 11825385A RO 92320 B RO92320 B RO 92320B
Authority
RO
Romania
Prior art keywords
optically active
chloride
preparing optically
carnitine nitrile
nitrile chloride
Prior art date
Application number
RO118253A
Other languages
English (en)
Other versions
RO92320A (ro
Inventor
Tenud Leander
Gosteli Jacques
Original Assignee
Lonza A.G.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza A.G. filed Critical Lonza A.G.
Publication of RO92320A publication Critical patent/RO92320A/ro
Publication of RO92320B publication Critical patent/RO92320B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedeul pentru prepararea clorurii de carnitinnitril optic activa consta în aceea ca se pleaca de la clorura de 3-clor-2-oxi-propiltrimetilamoniu racemica, aceasta prin scindare de randament cu acid tartric optic activ fiind transformata în di-(3-clor-2-oxipropiltrimetilamoniu)-tratatul optoc activ dorit; acesta din urma se scindeaza în acid tartric si clorura de 3-clor-2-oxi-propiltrimetilamoniu optic activa si ultima reactioneaza cu cianuri anorganice.
RO118253A 1984-04-04 1985-04-03 Procedeu pentru prepararea clorurii de carnitinnitril optic activ RO92320B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1704/84A CH658857A5 (de) 1984-04-04 1984-04-04 Optisch aktives di-(3-chlor-2-oxy-propyltrimethylammonium)-tartrat.

Publications (2)

Publication Number Publication Date
RO92320A RO92320A (ro) 1987-09-30
RO92320B true RO92320B (ro) 1987-10-02

Family

ID=4216650

Family Applications (1)

Application Number Title Priority Date Filing Date
RO118253A RO92320B (ro) 1984-04-04 1985-04-03 Procedeu pentru prepararea clorurii de carnitinnitril optic activ

Country Status (28)

Country Link
US (4) US4692543A (ro)
EP (1) EP0157315B1 (ro)
JP (1) JPS60231632A (ro)
CN (1) CN85101426A (ro)
AR (1) AR240309A1 (ro)
AT (1) ATE34738T1 (ro)
AU (1) AU570780B2 (ro)
BG (2) BG43863A3 (ro)
BR (1) BR8501627A (ro)
CA (1) CA1238923A (ro)
CH (1) CH658857A5 (ro)
CS (1) CS266568B2 (ro)
DD (2) DD236922A5 (ro)
DE (1) DE3563044D1 (ro)
DK (1) DK153185A (ro)
ES (1) ES8603379A1 (ro)
FI (1) FI850682L (ro)
HU (1) HU195764B (ro)
IL (1) IL74553A (ro)
IN (1) IN164370B (ro)
MX (1) MX160765A (ro)
NO (1) NO162717C (ro)
PL (1) PL148361B1 (ro)
RO (1) RO92320B (ro)
SU (2) SU1329616A3 (ro)
TR (1) TR22235A (ro)
YU (2) YU53485A (ro)
ZA (1) ZA851960B (ro)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1289973C (en) * 1986-08-26 1991-10-01 Kazuhiko Katayama Process for preparing 3-halogeno-2- hydroxypropyltrimethylammonium halide
CH668964A5 (de) * 1987-02-04 1989-02-15 Lonza Ag Verfahren zur herstellung von optisch aktivem beta-methylcholin.
DE3735757A1 (de) * 1987-10-22 1989-05-03 Degussa Optisch aktive salze aus einem substituierten thiazolidin-4-carboxylat und 3-chlor-2-hydroxypropyltrimethylammonium, deren herstellung und verwendung
DE4015573A1 (de) * 1990-05-15 1991-11-21 Degussa Optisch aktive salze aus einem substituierten thiazolidin-4-carboxylat und 3-cyano-2-hydroxypropyltrimethylammonium, deren herstellung und verwendung
DE4111913A1 (de) * 1991-04-12 1992-10-15 Degussa Verfahren zur herstellung von l-carnitin aus d,l-carnitinnitrilsalzen
US5576459A (en) * 1994-02-02 1996-11-19 Sachem, Inc. Quaternary nitrogen or phosphorus chirates
KR100255039B1 (ko) 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
EP2325164A1 (en) * 2009-11-18 2011-05-25 Lonza Ltd. Methods for the production of l-carnitine
CN102329243B (zh) * 2011-10-12 2013-11-20 浙江工业大学 L-(-)-3-氯-2-羟基丙基三甲铵氯化物的管式反应方法
CN113214093B (zh) * 2021-05-21 2022-11-29 济南亚西亚药业有限公司 酒石酸氢胆碱废母液中回收氯化胆碱和酒石酸盐的方法
CN115850113A (zh) * 2022-12-16 2023-03-28 山东阳谷华泰化工股份有限公司 一种l-卡内腈的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD23217A (ro) *
US2303602A (en) * 1940-08-03 1942-12-01 Standard Brands Inc Calcium tartrate production
US2692285A (en) * 1951-05-07 1954-10-19 Searle & Co Di-sec-alkyl-dialkylammonium salts and processes for preparing the same
GB717476A (en) * 1951-12-12 1954-10-27 Ciba Ltd Manufacture of new quaternary ammonium salts
GB752681A (en) * 1953-04-25 1956-07-11 Recip Ab Quaternary ammonium compounds
US3151149A (en) * 1959-01-31 1964-09-29 Berlin Chemie Veb Production of pure d-and l-carnitinenitrile-chloride
US3135788A (en) * 1959-09-28 1964-06-02 Nihon Zoki Seiyaku Kabushikika Preparation of dl-carnitine hydrochloride from trimethylamine hydrochloride and epihalogenohydrin
BE660039A (ro) * 1965-02-22 1965-08-23
ES332080A1 (es) * 1965-10-15 1967-10-01 Otsuka Pharma Co Ltd Procedimiento para obtencion de complejos de sales opticamente activas de hidroxido de nitrilo,carnitina y acidos glutamicos n-acilos.
NL6801823A (ro) * 1968-02-08 1969-08-12
US3808254A (en) * 1971-06-10 1974-04-30 Syntex Corp Resolution-racemization of alpha-amino-alpha-phenylacetonitrile
JPS5212688B2 (ro) * 1973-08-23 1977-04-08
US4070394A (en) * 1976-01-23 1978-01-24 Ethyl Corporation Carnitine nitrile halide preparation
US4062698A (en) * 1976-11-03 1977-12-13 International Business Machines Corporation Photoelectrical converter
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
NL7804880A (nl) * 1978-05-05 1979-11-07 Zaltbommel Chem Fab Werkwijze voor het bereiden van 3-halogeen-2- -hydroxyalkyltrialkylammoniumchloriden.
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni

Also Published As

Publication number Publication date
ATE34738T1 (de) 1988-06-15
HU195764B (en) 1988-07-28
YU53485A (en) 1988-02-29
EP0157315B1 (de) 1988-06-01
IL74553A (en) 1990-06-10
JPS60231632A (ja) 1985-11-18
US4692543A (en) 1987-09-08
IN164370B (ro) 1989-03-04
AU4019185A (en) 1985-10-10
ZA851960B (en) 1985-11-27
TR22235A (tr) 1986-10-10
DD236922A5 (de) 1986-06-25
IL74553A0 (en) 1985-06-30
BG43863A3 (en) 1988-08-15
NO162717B (no) 1989-10-30
AU570780B2 (en) 1988-03-24
BG44373A3 (en) 1988-11-15
CS248785A2 (en) 1989-04-14
FI850682L (fi) 1985-10-05
EP0157315A2 (de) 1985-10-09
EP0157315A3 (en) 1986-07-02
NO162717C (no) 1990-02-07
HUT39412A (en) 1986-09-29
YU142287A (en) 1988-04-30
US4732999A (en) 1988-03-22
SU1491332A3 (ru) 1989-06-30
MX160765A (es) 1990-05-09
DK153185D0 (da) 1985-04-03
PL148361B1 (en) 1989-10-31
AR240309A1 (es) 1990-03-30
CN85101426A (zh) 1986-09-24
DE3563044D1 (en) 1988-07-07
US4732709A (en) 1988-03-22
DK153185A (da) 1985-10-05
NO851388L (no) 1985-10-07
CS266568B2 (en) 1990-01-12
FI850682A0 (fi) 1985-02-19
DD232036A5 (de) 1986-01-15
CH658857A5 (de) 1986-12-15
CA1238923A (en) 1988-07-05
ES541848A0 (es) 1985-12-16
SU1329616A3 (ru) 1987-08-07
PL252722A1 (en) 1985-12-03
US4670192A (en) 1987-06-02
RO92320A (ro) 1987-09-30
BR8501627A (pt) 1985-12-03
ES8603379A1 (es) 1985-12-16

Similar Documents

Publication Publication Date Title
ES8704490A1 (es) Procedimiento para la obtencion de derivados del acido benzoico
BE859100A (fr) Procede de preparation de xylose par hydrolyse enzymatique de xylanes.
RO92320B (ro) Procedeu pentru prepararea clorurii de carnitinnitril optic activ
ES2130079B1 (es) Resolucion de aminas
IT8121232A0 (it) Procedimento per produrre acido l-glutammico mediante fermentazione.
UA7088A1 (uk) Спосіб одержання солі 2-(2-гідроксіетоксі)етіламіна та 3,6-діхлор-2-метоксібензойної кислоти
ES2038282T3 (es) Metodo para producir un derivado de benzoilurea.
UA8357A1 (uk) Спосіб оптичного поділу піранобензоксадіазольної сполуки
ES8206541A1 (es) Procedimiento para la obtencion de fosfonohidroxiacetonitri-lo
GB1459807A (en) Process for the production of 7-d-a-amino-phenyl-acetamido-3- desacetoxy-cephalosporanic acid
UA8032A1 (uk) Спосіб одержання 2-(4-метоксіфенілпропіоніл)аміно-6-н-пропіламіно-4,5,6,7-тетрагідробензотіазола у вигляді рацемата або (-)-енантіомера або його кислотно-аддітивної солі
IT1196984B (it) Procedimento per la preparazione di nitrato di potassio
PT89282A (pt) Processo para a hidrolise enzimatica de monoaminocompostos de alfa-aminoadipinilo
JPS52131522A (en) Purification of amino acid
HUT36124A (en) Process for preparing sorbinyl by means of the resolution of 6-fluoro-4-ureido-chromane-4-carboxylic acid
IT7827076A0 (it) Processo per la produzione di acido 2-ammino-2-fenilacetico eventualmente sostituito, otticamente attivo.
FR2359133A1 (fr) Procede de preparation de (vinyl 2,2-disubstitue)-g-butyrolactones
ATE14874T1 (de) Herstellungsverfahren der sorbinsaeure unter kristallisation.
FI854450A (fi) Framstaellning av legerat staol under anvaendning av kemiskt framstaelld v2o3 som vanadintillsatsmedel.
ES469645A1 (es) Procedimiento para la preparacion de 3-bromoftalida.
DK159432C (da) Fremgangsmaade til fremstilling af 4-amino-5-dialkoxymethylpyrimidinderivater
IT8121235A0 (it) Processo per la produzione di acido l-aspartico usando microorganismi immobilizzati.
ES2004876A6 (es) Un nuevo procedimiento para la preparacion de 4-(6' -metoxi-2' -naftil)butan-2-ona".
SU1133853A1 (ru) Полиимид, обладающий способностью перерабатываться прессованием
RO83459B1 (ro) Procedeu pentru obtinerea clorurii acidului cianacetic