ES8603379A1 - Procedimiento para preparar cloruro de carnitino-nitrilo op-ticamente activo - Google Patents

Procedimiento para preparar cloruro de carnitino-nitrilo op-ticamente activo

Info

Publication number
ES8603379A1
ES8603379A1 ES541848A ES541848A ES8603379A1 ES 8603379 A1 ES8603379 A1 ES 8603379A1 ES 541848 A ES541848 A ES 541848A ES 541848 A ES541848 A ES 541848A ES 8603379 A1 ES8603379 A1 ES 8603379A1
Authority
ES
Spain
Prior art keywords
tartrate
optically active
ammonium
tartaric acid
oxypropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541848A
Other languages
English (en)
Other versions
ES541848A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of ES541848A0 publication Critical patent/ES541848A0/es
Publication of ES8603379A1 publication Critical patent/ES8603379A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARACION DE CLORURO DE CARNITINO-NITRILO OPTICAMENTE ACTIVO. COMPRENDE LA TRANSFORMACION DE CLORURO DE 3-CLORO-2-OXI-PROPILTRIMETILAMONIO RACEMICO CON ACIDO TARTARICO OPTICAMENTE ACTIVO EN EL TARTRATO DE DI-(3-CLORO-2-OXI-PROPILTRIMETILAMONIO) OPTICAMENTE ACTIVO; SEGUIDA DEL DESDOBLAMIENTO DE ESTE COMPUESTO EN ACIDO TARTARICO Y CLORURO DE 3-CLORO-2-OXI-PROPILTRIMETILAMONIO OPTICAMENTE ACTIVO, QUE SE HACE REACCIONAR CON CIANUROS INORGANICOS; Y, POR ULTIMO, SE SEPARA EL PRODUCTO FORMADO SIGUIENDO METODOS CONVENCIONALES. EL DESDOBLAMIENTO DEL RACEMATO SE LLEVA A CABO POR TRATAMIENTO CON ACIDO L-(B)-TARTARICO, EN PRESENCIA DE TRIALQUILAMINA, O CON AYUDA DE LA SAL DE PLATA DEL ACIDO L-(B)-TARTARICO.
ES541848A 1984-04-04 1985-04-02 Procedimiento para preparar cloruro de carnitino-nitrilo op-ticamente activo Expired ES8603379A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1704/84A CH658857A5 (de) 1984-04-04 1984-04-04 Optisch aktives di-(3-chlor-2-oxy-propyltrimethylammonium)-tartrat.

Publications (2)

Publication Number Publication Date
ES541848A0 ES541848A0 (es) 1985-12-16
ES8603379A1 true ES8603379A1 (es) 1985-12-16

Family

ID=4216650

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541848A Expired ES8603379A1 (es) 1984-04-04 1985-04-02 Procedimiento para preparar cloruro de carnitino-nitrilo op-ticamente activo

Country Status (28)

Country Link
US (4) US4692543A (es)
EP (1) EP0157315B1 (es)
JP (1) JPS60231632A (es)
CN (1) CN85101426A (es)
AR (1) AR240309A1 (es)
AT (1) ATE34738T1 (es)
AU (1) AU570780B2 (es)
BG (2) BG44373A3 (es)
BR (1) BR8501627A (es)
CA (1) CA1238923A (es)
CH (1) CH658857A5 (es)
CS (1) CS266568B2 (es)
DD (2) DD232036A5 (es)
DE (1) DE3563044D1 (es)
DK (1) DK153185A (es)
ES (1) ES8603379A1 (es)
FI (1) FI850682L (es)
HU (1) HU195764B (es)
IL (1) IL74553A (es)
IN (1) IN164370B (es)
MX (1) MX160765A (es)
NO (1) NO162717C (es)
PL (1) PL148361B1 (es)
RO (1) RO92320B (es)
SU (2) SU1329616A3 (es)
TR (1) TR22235A (es)
YU (2) YU53485A (es)
ZA (1) ZA851960B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1289973C (en) * 1986-08-26 1991-10-01 Kazuhiko Katayama Process for preparing 3-halogeno-2- hydroxypropyltrimethylammonium halide
CH668964A5 (de) * 1987-02-04 1989-02-15 Lonza Ag Verfahren zur herstellung von optisch aktivem beta-methylcholin.
DE3735757A1 (de) * 1987-10-22 1989-05-03 Degussa Optisch aktive salze aus einem substituierten thiazolidin-4-carboxylat und 3-chlor-2-hydroxypropyltrimethylammonium, deren herstellung und verwendung
DE4015573A1 (de) * 1990-05-15 1991-11-21 Degussa Optisch aktive salze aus einem substituierten thiazolidin-4-carboxylat und 3-cyano-2-hydroxypropyltrimethylammonium, deren herstellung und verwendung
DE4111913A1 (de) * 1991-04-12 1992-10-15 Degussa Verfahren zur herstellung von l-carnitin aus d,l-carnitinnitrilsalzen
US5576459A (en) * 1994-02-02 1996-11-19 Sachem, Inc. Quaternary nitrogen or phosphorus chirates
KR100255039B1 (ko) 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
EP2325164A1 (en) * 2009-11-18 2011-05-25 Lonza Ltd. Methods for the production of l-carnitine
CN102329243B (zh) * 2011-10-12 2013-11-20 浙江工业大学 L-(-)-3-氯-2-羟基丙基三甲铵氯化物的管式反应方法
CN113214093B (zh) * 2021-05-21 2022-11-29 济南亚西亚药业有限公司 酒石酸氢胆碱废母液中回收氯化胆碱和酒石酸盐的方法
CN115850113A (zh) * 2022-12-16 2023-03-28 山东阳谷华泰化工股份有限公司 一种l-卡内腈的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD23217A (es) *
US2303602A (en) * 1940-08-03 1942-12-01 Standard Brands Inc Calcium tartrate production
US2692285A (en) * 1951-05-07 1954-10-19 Searle & Co Di-sec-alkyl-dialkylammonium salts and processes for preparing the same
GB717476A (en) * 1951-12-12 1954-10-27 Ciba Ltd Manufacture of new quaternary ammonium salts
GB752681A (en) * 1953-04-25 1956-07-11 Recip Ab Quaternary ammonium compounds
US3151149A (en) * 1959-01-31 1964-09-29 Berlin Chemie Veb Production of pure d-and l-carnitinenitrile-chloride
US3135788A (en) * 1959-09-28 1964-06-02 Nihon Zoki Seiyaku Kabushikika Preparation of dl-carnitine hydrochloride from trimethylamine hydrochloride and epihalogenohydrin
BE660039A (es) * 1965-02-22 1965-08-23
ES332080A1 (es) * 1965-10-15 1967-10-01 Otsuka Pharma Co Ltd Procedimiento para obtencion de complejos de sales opticamente activas de hidroxido de nitrilo,carnitina y acidos glutamicos n-acilos.
NL6801823A (es) * 1968-02-08 1969-08-12
US3808254A (en) * 1971-06-10 1974-04-30 Syntex Corp Resolution-racemization of alpha-amino-alpha-phenylacetonitrile
JPS5212688B2 (es) * 1973-08-23 1977-04-08
US4070394A (en) * 1976-01-23 1978-01-24 Ethyl Corporation Carnitine nitrile halide preparation
US4062698A (en) * 1976-11-03 1977-12-13 International Business Machines Corporation Photoelectrical converter
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
NL7804880A (nl) * 1978-05-05 1979-11-07 Zaltbommel Chem Fab Werkwijze voor het bereiden van 3-halogeen-2- -hydroxyalkyltrialkylammoniumchloriden.
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni

Also Published As

Publication number Publication date
DD236922A5 (de) 1986-06-25
PL148361B1 (en) 1989-10-31
SU1491332A3 (ru) 1989-06-30
US4732999A (en) 1988-03-22
ES541848A0 (es) 1985-12-16
RO92320B (ro) 1987-10-02
DK153185D0 (da) 1985-04-03
NO162717C (no) 1990-02-07
CS248785A2 (en) 1989-04-14
YU53485A (en) 1988-02-29
US4732709A (en) 1988-03-22
DK153185A (da) 1985-10-05
EP0157315B1 (de) 1988-06-01
NO162717B (no) 1989-10-30
US4692543A (en) 1987-09-08
CA1238923A (en) 1988-07-05
JPS60231632A (ja) 1985-11-18
DE3563044D1 (en) 1988-07-07
PL252722A1 (en) 1985-12-03
IN164370B (es) 1989-03-04
BG43863A3 (en) 1988-08-15
BG44373A3 (en) 1988-11-15
SU1329616A3 (ru) 1987-08-07
HU195764B (en) 1988-07-28
AU4019185A (en) 1985-10-10
TR22235A (tr) 1986-10-10
MX160765A (es) 1990-05-09
HUT39412A (en) 1986-09-29
BR8501627A (pt) 1985-12-03
AR240309A1 (es) 1990-03-30
ATE34738T1 (de) 1988-06-15
CS266568B2 (en) 1990-01-12
YU142287A (en) 1988-04-30
US4670192A (en) 1987-06-02
IL74553A (en) 1990-06-10
EP0157315A2 (de) 1985-10-09
ZA851960B (en) 1985-11-27
RO92320A (ro) 1987-09-30
CN85101426A (zh) 1986-09-24
IL74553A0 (en) 1985-06-30
FI850682A0 (fi) 1985-02-19
FI850682L (fi) 1985-10-05
AU570780B2 (en) 1988-03-24
DD232036A5 (de) 1986-01-15
CH658857A5 (de) 1986-12-15
EP0157315A3 (en) 1986-07-02
NO851388L (no) 1985-10-07

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