RO83455B - Procedeu pentru prepararea formei cristaline alfa a clorhidratului de1-(4-amino-6, 7-dimetoxi-2-chinazolinil)-4-(2-furoil)-piperazina - Google Patents

Procedeu pentru prepararea formei cristaline alfa a clorhidratului de1-(4-amino-6, 7-dimetoxi-2-chinazolinil)-4-(2-furoil)-piperazina

Info

Publication number
RO83455B
RO83455B RO105233A RO10523380A RO83455B RO 83455 B RO83455 B RO 83455B RO 105233 A RO105233 A RO 105233A RO 10523380 A RO10523380 A RO 10523380A RO 83455 B RO83455 B RO 83455B
Authority
RO
Romania
Prior art keywords
furoyl
quinazolinyl
dimethoxy
amino
piperazine
Prior art date
Application number
RO105233A
Other languages
English (en)
Other versions
RO83455A (ro
Inventor
Dieter Lehmann
Gottfried Faust
Werner Popel
Werner Fiedler
Gunter Dietz
Original Assignee
Veb Arzneimittelwerk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Veb Arzneimittelwerk filed Critical Veb Arzneimittelwerk
Publication of RO83455A publication Critical patent/RO83455A/ro
Publication of RO83455B publication Critical patent/RO83455B/ro

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea formei cristaline alfa-a clorhidratului de 1-(4-amino-6,7-dimetoxi-2-chinazolinil)-4-(2.furoil)-piperazina consta în aceea ca se amesteca sub agitare, la temperaturi cuprinse între 40 tsi 95 degree C un clorhidrat de 1(4-amino-6,7-dimetoxi-2-chinazolinil)-4-(2-furoil)-piperazina sub forma beta sau gama sau un hidrat anhidrat sau solvent al acestuia în dimezilsulfoxid dimetilformamida sau amestecuri ale acestora între ele sau cu solventi alesi dintre benzen toluen cloroform sau tetraclorura de carbon acetona dioxan sau alcooli cu 2....4 atomi de carbon iar forma cristalina alfa a clorhidratatului de 1-(4-amino-6,7-dimetoxi-2-chinazolinil)-4-(2-furoil)-piperazina obtinut se separa, eventual dupa racire.
RO105233A 1979-03-29 1980-03-26 Procedeu pentru prepararea formei cristaline alfa a clorhidratului de1-(4-amino-6, 7-dimetoxi-2-chinazolinil)-4-(2-furoil)-piperazina RO83455B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD21188479A DD141674B1 (de) 1979-03-29 1979-03-29 Verfahren zur herstellung der kristallinen alpha-form von 1-(4-amino-6,7-dimethoxy-2-chinazolinyl)-4-(2-furoyl)-piperazin-hydrochlorid

Publications (2)

Publication Number Publication Date
RO83455A RO83455A (ro) 1984-02-21
RO83455B true RO83455B (ro) 1984-02-28

Family

ID=5517404

Family Applications (3)

Application Number Title Priority Date Filing Date
RO80100627A RO79381A (ro) 1979-03-29 1980-03-26 Procedeu de preparare a fotmei cristaline alfa a clorhidratului de 1(4-amino-6,7-dimetoxi-2-chinazolinil)-4-(2-furol)-piperazina
RO105234A RO83442B (ro) 1979-03-29 1980-03-26 Procedeu pentru prepararea formei alfa a clorhidratului de 1-(4-amino-6, 7-dimetoxi-2-chinazolinil)-4-(2-furoil)-piperazina
RO105233A RO83455B (ro) 1979-03-29 1980-03-26 Procedeu pentru prepararea formei cristaline alfa a clorhidratului de1-(4-amino-6, 7-dimetoxi-2-chinazolinil)-4-(2-furoil)-piperazina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
RO80100627A RO79381A (ro) 1979-03-29 1980-03-26 Procedeu de preparare a fotmei cristaline alfa a clorhidratului de 1(4-amino-6,7-dimetoxi-2-chinazolinil)-4-(2-furol)-piperazina
RO105234A RO83442B (ro) 1979-03-29 1980-03-26 Procedeu pentru prepararea formei alfa a clorhidratului de 1-(4-amino-6, 7-dimetoxi-2-chinazolinil)-4-(2-furoil)-piperazina

Country Status (7)

Country Link
CS (1) CS224469B1 (ro)
DD (1) DD141674B1 (ro)
HU (1) HU182796B (ro)
PL (3) PL128496B1 (ro)
RO (3) RO79381A (ro)
SU (1) SU1206277A1 (ro)
YU (3) YU41908B (ro)

Also Published As

Publication number Publication date
SU1206277A1 (ru) 1986-01-23
PL129719B1 (en) 1984-06-30
DD141674B1 (de) 1982-06-30
PL223051A1 (ro) 1980-12-15
RO83442B (ro) 1984-02-28
RO83442A (ro) 1984-02-21
PL128496B1 (en) 1984-01-31
YU26783A (en) 1984-04-30
CS224469B1 (en) 1984-01-16
YU42069B (en) 1988-04-30
YU36180A (en) 1983-06-30
RO83455A (ro) 1984-02-21
YU41908B (en) 1988-02-29
HU182796B (en) 1984-03-28
PL129723B1 (en) 1984-06-30
YU26883A (en) 1983-10-31
YU42068B (en) 1988-04-30
RO79381A (ro) 1982-06-25
DD141674A1 (de) 1980-05-14

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