CS224469B1 - Method of l-/-amino-6,7-dimethoxy-2-quinazolinyl/-4-/2-furoyl/-piperazine in crystallic alpha form-l - Google Patents
Method of l-/-amino-6,7-dimethoxy-2-quinazolinyl/-4-/2-furoyl/-piperazine in crystallic alpha form-l Download PDFInfo
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- CS224469B1 CS224469B1 CS137480A CS137480A CS224469B1 CS 224469 B1 CS224469 B1 CS 224469B1 CS 137480 A CS137480 A CS 137480A CS 137480 A CS137480 A CS 137480A CS 224469 B1 CS224469 B1 CS 224469B1
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- furoyl
- quinazolinyl
- dimethoxy
- amino
- piperazine
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-1- 224 469-1- 224 469
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OnpeflejieHHe MOMOHTa, b κοτορϊώ npaKTHqecira hojihoctliooópa3OBajiaci> KpHGTajunneoKaH cZ* -$opMa rHspoxjiopimaI- (4-aMZHO-6,7-ftHMeTOKCH-2-xHHa3Ojrairaji) -4- (2-^ypomi) -nsnepasEHa b ρθθκιχηοηηοκ ομθοη, upobojbitcb η3βθοτηημηB XHMHH MeTO#aMH, ΗΗΠρίϊΜθρ ΟΠΘΚΤρΟΟΚΟΪΕΓΙΘΟΚΗΜ SCCJiejXOBa-ΗΗβΜ Πρθ0.OnpeflejieHHe MOMOHTa b κοτορϊώ npaKTHqecira hojihoctliooópa3OBajiaci> KpHGTajunneoKaH cz * - $ opMa rHspoxjiopimaI- (4-aMZHO ftHMeTOKCH-6,7-2-xHHa3Ojrairaji) -4- (2- ^ ypomi) -nsnepasEHa b ρθθκιχηοηηοκ ομθοη, upobojbitcb η3βθοτηημηB XHMHH meto #aMH, ΗΗΠρίϊΜθρ ΟΠΘΚΤρΟΟΚΟΪΕΓΙΘΟΚΗΜ SCCJiejXOBa-ΗΗβΜ Πρθ0.
ΠΡΗΜΘΡΗ OOymeCTBJíeHHB H30dp6T6HZH B nocjie;íyw[x npHMepax Bcer.ua nojiyqajiacL KpacTajunraecKaaH^opMa na^poxjiopHsa Ι-(4-ημηηο-6,7-.ζβίμθτοκοη-2- xraa3OJiHHHJi)-4-(2-$ypoiui)-iBinepa3iiHa /4/. OnpeflejieiraeCTpyKTypa KpucTajuioB bo Bcex cjiy^aax npoBojpuiocB οπθκτρο-οκοπηήοοκημ HccjiesoBairae npod, eme Bnaaorax ot pacTBopz-tojih, b HH$paKpacHOH odjiacTH. Cyunca/4/npoBojíHJiacL npnTeMEepaTypax οτ 110 flo 120 °G. ípyrae KpHCTajLmnecKHeφορΜΗ rB^pOXJIOpUHa I-(4-aMHH0-6,7-flHMeT0KCI[-2-XHHa30JIH-mui)-4-)2^pypoKJi)-niniepa3ZHa, cjiysamne b npHMepax hcxojí- - 6 - 224 469 hum BemecTBOM, τΒκκβ 3apanee onpeftejuumcB μθτο^ομ HHcppa-KpacHofi cneKTpociconHH. ITpuMep I: Β3βθοβ H3 10 r rnflpoxjiopima I-(4-ar.!HHO-6,7-AHivieTOKCH--2-xHHa3OJDíHHJi)-4-(2-$ypoiui)-iiiinepa3HHá ( o -<popMa) b50 mji flHMeTOcyjiBfóoKCHEa HarpeBajOT jxo 60 °G β τθ^θηηθ7 ^acoB. Hocjie οχλθςήθηκη OTcacuBaiOT, ocaflOK npoMtmaioTaneTOHOM h cyinaT.ΠΡΗΜΘΡΗ OOymeCTBJíeHHB H30dp6T6HZH B nocjie; 4 /. OnpeflejieiraeCTpyKTypa KpucTajuioB bo Bcex cjiy ^ aax npoBojpuiocB οπθκτρο-οκοπηήοοκημ HccjiesoBairae npod, em Bnaaorax ot pacTBopz-tojih, b HH $ paKpacHOH odjiacTH. Cyunca / 4 / npoBojHJiacL npnTeMEepaTypax οτ 110 flo 120 ° G. pyprae e aj aj m m φ ^ ^ ^ ^ ^ OX OX OX OX OX-------nin 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 3apanee onpeftejuumcB μθτο ^ ομ HHcppa-KpacHofi cneKTpociconHH. ITpuMep I: β3βθοβ H3 10 rnflpoxjiopima I- (4-ar.! HHO-6,7-AHivieTOKCH - 2-xHHα3OJDiHHJi) -4- (2- $ ypoiui) -iiiinepa3HHa (o - <popMa) b50 mji flHMeTOcyji jxo 60 ° G β τθ ^ θηηθ7 ^ acoB. Hocjie οχλθςήθηκη OTcacuBaiOT, ocaflOK npoMtmaioTaneTOHOM h cyinaT.
Bhxojí: 9 r/1/(90 % TeopeTiraecKoro Buxofla).Bhxoj: 9 r / 1 / (90% TeopeTiraecKoro Buxofla).
HpHMep 2: Αηθλογβήηο npiíMepy I πρόβολητ npeBpameime nmpoxjiopujiaI- (4-θμηηο-6,7-jweTOKCH-2-xifflaBOJiiíHXJi) -4- (2-mypoiUi) -mniepa3HHa (nojniTHApaTHaa $opMa) b flHMeTiuicyjiB$OKcimeb c4 -4>opMy.HpHMep 2: Αηθλογβήηο npiíMepy I πρόβολητ npeBpameime nmpoxjiopujiaI- (4-θμηηο-6,7-jweTOKCH-2-xifflaBOJiiiHXJi) -4- (2-mypoiUi) -mniepa3HHa (nojniTHApaTHaa $ opMa) b flHMeTiuicyjiB $ OKcimeb c4 -4> opMy.
HpHMep 3: ÁHajiora^HO npzMepy I HarpeBaraeM MeTaojiaTa rnjipoxjiopHflaI— (4—aMHHO—6,7-jweTOKCH-2-XHHa3OJiHHíUi) -4- (2-$ypozji) -nrniepasHHa b AHMeTiuicyjiLťpoKGHfle #o 90 °C β τθηθηηθ 3 na-cob nojiynaioT -$opMy.HpHMep 3: ajajiora HO HOpppepepep ((((((((((((((((((((((((((4 — aMHHO — 6,7-jweTOKCH-2-XHHα3OJiHHiUi) -4- (2- $ ypozji) -nrniepasHHa b AHMeTiuicyjiLťpoKGHfle #o 90 ° C β τθηθηηθ 3 na- cob nojiynaioT - $ opMy.
HpHMep 4: Βθβθοβ 10 r raspoxjiopima Ι-(4-3μηηο-6,7-αημθτοκοη-2—XHHa3ojmHHJi)-4-(2-4ypoiDi)-iimiepa3iiHa (aurz^paTHaH φορ-Ma) b 50 mji jweTHJi$opMaMHaa HarpeBajoT rq 60 °C b Tene-ηξθ 7 HacoB, nocjie oxjiajKseHHa oTcacaBajoT, ocajiOK npoM&-BaioT aupTOHOM h cymaT. Βηχολ: 9 r/1/ (90 % TeopeTiraecKoro BHXOfía). - 7 - 224 469 ΠρΗΜθρ 5: AHajiorumio irpHMepy 4 ppohcxoaht npeBpameHHe rimpoxjio-pufla I- (4-aMKHO-6,7-AHMeTOKGH-2-XHHa3OJiHHHJi) -4- (2-$yponji)-nmiepasHHa (-4>opMa) b jwewi$0MaMH#e b ds -$opMy. Πρημθρ 6:HpHMep 4: βθβθοβ 10 r raspoxjiopima Ι- (4-3μηηο-6,7-απετοκοη-2-XHHα3ojmHHJi) -4- (2-4ypoiDi) -iimiepa3iiHa (aurz ^ paTHaH φορ-Ma) b 50 mji jweTHJi $ opMaMHaa HarpeBajoT rq 60 ° C b Tene-ηξθ 7 HacoB, nocjie oxjiajKseHHa oTcacaBajoT, ocajiOK npoM & -BaioT aupTOHOM h cymaT. :Ηχολ: 9 r / 1 / (90% of TeopeTiraecKoro BHXOfia). - 7 - 224 469 5: AHajiorumio irpHMepy 4 ppohcxoaht npeBpameHHe rimpoxjio-buffer I- (4-aMKHO-6,7-AHMeTOKGH-2-XHHa3OJiHHHJi) -4- (2- $ yponji) -nmiepasHHa (-4> opMa) b jwewi $ 0MaMH # eb ds - $ opMy. Πρημθρ 6:
HarpeBaiOT B3BecB 5 r rnjipoxjiopimá I-(4-aMHHO-6,7-flHMe-TOKCH-2-xzHa30jniHiM)-4-(2-$ypoHJi)-iiiínepa3HHa ( p -čoopMa)b cmsch H3 12,5 mji Tojiyojia flo 70 °G b Tenenze 8 zacoB.PeaKiíKOHHym cmgcl οοτηβίηιοτ ctoztb na hozl, 3aTeM ocajiozοτΑθΛΗΏΤ, npoMHBaiOT TOJiyojioM z apeioHOM z cymaT.HarpeBaiOT B3BecB 5 rnjipoxjiopime I- (4-aMHHO-6,7-flHMe-TOKCH-2-xzHa30jniHiM) -4- (2-ypoHJi) -iiinepa3HHa (p-coopMa) b cmsch H3 12.5 mji Tojiyojia flo 70 ° G b Tenens 8 zacoB.PeaKieKOHHym cmgcl οοτηβίηιοτ ctoztb to hozl, 3aTeM ocajiozοτΑθΛΗΏΤ, npoMHBaiOT TOJiyojioM from apeioHOM from cymaT.
Buxofl: 4,7 r/l/(94$ TeopeTZHecKoro BHX0.ua). ΠρζΜβρ 7; AHajiorzzHO npzwepy 6 H3 5 r rzjipoxjiopzAa I-(4-aMHH0-6,7-jíHMeT0KCH-2-xHHa30JizHZJi) -4- (2-φγροιυι) -nznepa3ZHa(aHnpupaTHaH góopMa) b ομθοη Z3 2,5 mji jiHMeTHJicyjiB^KCHsaz22,5 mji TOJiyojia HarpeBaHneM jfo 70 °C b τθζθηζθ 15 zacosnoJiysaiOT 4,7 r/1/(94$ TeopeTzzecKoro Bnxo.ua). ΠρΗΜβρ 8: . nojiyqaeTca Taxon &e pe3yjiLTaT, xax b npzMepax I so 7,eCJIH HCnOJIB3yiOT CMeCL flZMeTZJIGyJII^OKGHJía C MeTZJI$OMaMH-AOZ HJIH CMGCH flHMeTHJICyJLb$OKCHfla ZJIZ flZMeTZJI$OpMaL-IHSa 0apoMaTzzecKHMH yrjieBOflopoflaMH xax deH30Ji hjih TOJiyoji, ra-jioreHZ3HpoBaHHHMS amzroaTZzecKHMH yrmeBOflopoflarxK xax xxo-ροφορΜ ra zeTHpexxjiopzcTuft yrjiepofí, κθτοηβμη khk ape-TOH, npOGTHMS θφζρθΜΖ K3K JpiOKCaH HJIH ΟΠΖρΤθΜΗ, ΟΟΑθρΧθΠξΖμη οτ 2 λο 4 aTOMOB yrmepojia. $OpMyjia Η300ρθΤΘΗΗΗ 224 469Buxofl: 4.7 r / l / ($ 94 TeopeTZHecKoro BHX0.ua). ΠρζΜβρ 7; AHajiorzzHO npzwepy 6 H3 5 r rjjipoxjiopzAa I- (4-aMHH0-6,7-iHMeT0KCH-2-xHH30nZHZJi) -4- (2-phenylene) -nznepa3ZHa (aHnpupaTHaH góopMa) b ομθοη Z3 2,5 mji jiHMeTHJicyjiB ^ KCHsaz22,5 mji TOJiyojia HarpeBaHneM jfo 70 ° C b τθζθηζθ 15 zacosnoJiysaiOT 4,7 r / 1 / (94 $ TeopeTzzecKoro Bnxo.ua). ΠρΗΜβρ 8:. nojiyqaeTca Taxon & e pe3yjiLTaT, XAX b npzMepax I with 7 eCJIH HCnOJIB3yiOT CMeCL flZMeTZJIGyJII ^ OKGHJía C Metz $ OMaMH-AOZ HJIH CMGCH flHMeTHJICyJLb $ OKCHfla ZJIZ flZMeTZJI $ OpMaL-IHSA 0apoMaTzzecKHMH yrjieBOflopoflaMH XAX deH30Ji hjih TOJiyoji, trans-jioreHZ3HpoBaHHHMS amzroaTZzecKHMH yrmeBOflopoflarxK XAX xxo-ροφορΜ ra zeTHpexxjiopzcTuft yrjiepofi, khk ape-TOH, npOGTHMS K3K JpiOKCaH HJIH ΟΠΖρΤθΜΗ, θΑθρΧθΠξΖμη. $ OpMyjia Η300ρθΤΘΗΗΗ 224,469
Cnocod nojiynenmi KpHCTajunnecKOM có πφορΜΕί rmiporniopn^aI-/4-aMHHO-6,7-KffivieT0KGH-2-XHHa30JiHHHJi/4-/ 2-/pypoiui/-ic-me-pa3HHa HarpesaHneM raj]poxjiopi5^a-I-/4-aMHHO-6,7~jweTOKCH--2-XHHa3Ojmmui/-4~/2-4)ypoiui/-inniepa3HHa mni ero ira^paTa,mru cojiLBaTa %o dojiee bucokux TewmepaTyp b npucyTCTBHspacTBopHTejm flo iipaKTiraecKH nojmoro odpasoBaHmi KpucTaji-jnnecKOH ού -φορκω, oTjranaioiiíEracH τθμ, ητο yse nweioimrifcH bspyroii KpncTajunnecKo0 φορΜθ, κεκ HanpuMep, β - mra'V -$opMa rmipoxjiopíma I-/4-arraH0-6,7-flHMeT0Kcn-2-xHHa30-jiHHmi/-4-/2^)ypomi/-iranepa3iiH mra nx nmpaT, araraupaT mraccwr&BaT nepeMennroaioT npn TeMnepaTypax ot 40 ao 95 °C bflHMeTmicyjiL$0KCH1ne, jweTmižoMarBW mra CMecnx hx Apyr c.npyroM mra c apOMaTHnecKHMX yrjieBOftopoftaMH khk demoji mraTojiyoji, rajioreHH3npoBaHHuira ajm^aTmiecKHMu ynneBojiopoflaMHKas χποροφορΜ mra neTupexxjiopHCTHS: yrjiepoA, κθτοηθμη khkaijeTOH, npocTHira θφκρεΜΗ Kaic jraokcaH, mra cimpTaira, co-flepsamuMH ot 2βο 4 aTOMOB yrjiepo^a, n, řípu cnynae nociieoxaawHHfí, ~ ’ οταθληιοτ nojiyneimyio KpHCTamranec-Kyro -$opMy rajpoxjiopHfla Ι-/4-3μηηο-6,7-λεμθτοκοη-2-:...-xHHa30jraHmi/-4~/ 2-$ypomi/-iranepa3HHa. * 224 469 AHHOTaiwCnocod nojiynenmi KpHCTajunnecKOM có προμηνική μεταφοράς ^ aI- / 4-aMHHO-6,7-KffivieT0KGH-2-XHHa30JiHHHJi / 4- / 2- / pypoiui / -ic-me-pa3HHa HarpesaHneM raj] poxjiopi5 ^ aI- / 4-aMHHO- 6.7 ~ jweTOKCH - 2-XHHa3Ojmmui / -4 ~ / 2-4) ypoiui / -inniepa3HHa mni ero ira ^ paTa, mru cojiLBaTa% o milking bucokux TewmepaB npucyTCTBHspacTBopHTejm flo iipaKTiraecKH τθμ, ητο yse nweioimrifcH bspyroii KpncTajunnecKo0 φορΜθ, κεκ HanpuMep, β - mra'V - $ opMa rmipoxjiopim I- / 4-arraH0-6,7-flHMeT0Kcn-2-xHHa30-jiHHmi / -4- / 2 ^) ypomi / - iranepa3iiH MRA nx nmpaT, araraupaT mraccwr & BaT nepeMennroaioT npn TeMnepaTypax OT 40 and 95 ° C bflHMeTmicyjiL $ 0KCH1ne, jweTmižoMarBW MRA CMecnx hx pyr c.npyroM MRA c apOMaTHnecKHMX yrjieBOftopoftaMH KHK demo mraTojiyoji, rajioreHH3npoBaHHuira AJM-aTmiecKHMu ynneBojiopoflaMHKas χποροφορΜ MRA neTupexxjiopHCTHS: yrjiepoA, κθτοηθμη khkaijeTOH, npocTHira θφκρεΜΗ Kaic jraokcaH, mra cimpTaira, co-flepsamuMH ot 2βο 4 aTOMOB yrjiepo ^ a, n, rpu cnynae nocieoxaawHHfi, ~ 'οταθληιοτ nojiyneimyio KpHCTamranec-Kyro - $ opMy rajpoxjiopHfla Ι- / 4-3μηηο-6,7-λεμθτοκοη-2 -: ...- xHHa30jraHmi / -4- (2-ylamino) -iranepa3HHa. * 224 469 AHHOTaiw
KpHCTajunniecKaji -$opMa rHApoxjiopo;a I-/4-aMHH0-6,7-jmr^e-TopKCH-2-XHHa30jiHHo/~4-/2-$ypoo/-iiHnepa3HHa ΜΟίχθτ ólítbnojiyneHa npn noMoiiíH nepeMemHBajDiH, npn TeMnepaTypax ot 40£0 95 °G pce HMeíoineroca b .npyroií κρποταοοθοκοΗ φορΜβ,KpHCTajunniecKaji - $ opMa rHApoxjiopo; and I- / 4-aMHH0-6,7-jmr ^ e-TopKCH-2-XHHa30jiHHo / ~ 4- / 2- $ ypoo / -iiHnepa3HHa 0 95 ° G pce HMeíoineroca b .npyroii κρποταοοθοκοΗ φορΜβ
KaK HaiipHMep, β - hjihT -epopea rnspooopíma I-/4-aMHH0--6,7-jweTOKCH-2-zHHa3(wiHZJi/-4-/2^ypoo/-nHnepa3HHa rahx ropaT, aaropaT mm cojiBBaT b ňHMeTocyjiL$oKcoe, jm-ΜΘΤκπφοΜθΜΗβθ mra CMecBX hx flpyr C ΛΡΥΓΟΜ OH c apoMaTH—ηθοκημη yivieBOftopojiaMH xaK óeH30Ji ra Tojiyoji, rajioreHH3H-pOBaHHHMH aJDK^aTHHeCKHMH yTJieBOAOpO^aMH KHK XJIOpO$OpM OHΗΘΤΈΐρθΧΧΗΟρΗΟΤίώ yTJiepO#, ΚΘΤ0Η3ΜΗ K3IC aneTOH, npOCTBMHθφπρβΜΞ KaK flHOKCaH, HJIH CHHpTaMH, COftepzaHíHMH OT 2 SO 4aTOMOB yrjiepo.ua 5 h, npw cjiynae nocne oxjiasaeHHH, OT#ejunoT HOjiyHeHHyio KpHCTajuiHHecKyio cb -ajfopMy ropo-xjiopoa I-/4-aMHHO-6,7-AHMeTOKCH-2-XHHa30jiHHo/-4-/2-^)ypo-o/-HHnepa3HHa.KaK HaiipHMep, β - hjihT -epopea rnspooopim I- / 4-aMHH0--6,7-jweTOKCH-2-zHHa3 (wiHZJi / -4- / 2 ^ ypoo / -nHnepa3HHa rahx ropaT, aaropaT mm cBiBB btHMeTocyji $ oKcoe, JM-ΜΘΤκπφοΜθΜΗβθ MRA CMecBX hx flpyr C ΛΡΥΓΟΜ OH C apoMaTH-ηθοκημη yivieBOftopojiaMH xaK óeH30Ji ra Tojiyoji, rajioreHH3H-pOBaHHHMH aJDK ^ aTHHeCKHMH yTJieBOAOpO ^ AMH KHK XJIOpO $ OPM OHΗΘΤΈΐρθΧΧΗΟρΗΟΤίώ yTJiepO #, ΚΘΤ0Η3ΜΗ K3IC aneTOH, npOCTBMHθφπρβΜΞ KaK flHOKCaH, HJIH CHHpTaMH, COftepzaHíHMH OT 5 h, npw cjiynae nocne oxjiasaeHHH, OT # ejunoT HOjiyHeHHyio KpHCTajuiHHecKyio cb -ajfopMy ropo-xjiopoa I- / 4-aMHHO-6,7-AHMeTOKCH-2-XHHa30jiHHo / -4- / 2- ^) ypo-o / -HHnepa3HHa.
WggWK···" »· 7UWggWK ··· "7U
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DD21188479A DD141674B1 (en) | 1979-03-29 | 1979-03-29 | PROCESS FOR PREPARING THE CRYSTALLINE ALPHA FORM OF 1- (4-AMINO-6,7-DIMETHOXY-2-CHINAZOLINYL) -4- (2-FUROYL) -PIPERAZINE HYDROCHLORIDE |
Publications (1)
Publication Number | Publication Date |
---|---|
CS224469B1 true CS224469B1 (en) | 1984-01-16 |
Family
ID=5517404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS137480A CS224469B1 (en) | 1979-03-29 | 1980-02-27 | Method of l-/-amino-6,7-dimethoxy-2-quinazolinyl/-4-/2-furoyl/-piperazine in crystallic alpha form-l |
Country Status (7)
Country | Link |
---|---|
CS (1) | CS224469B1 (en) |
DD (1) | DD141674B1 (en) |
HU (1) | HU182796B (en) |
PL (3) | PL128496B1 (en) |
RO (3) | RO83455B (en) |
SU (1) | SU1206277A1 (en) |
YU (3) | YU41908B (en) |
-
1979
- 1979-03-29 DD DD21188479A patent/DD141674B1/en unknown
-
1980
- 1980-02-12 YU YU36180A patent/YU41908B/en unknown
- 1980-02-27 CS CS137480A patent/CS224469B1/en unknown
- 1980-02-28 SU SU807771089A patent/SU1206277A1/en active
- 1980-03-26 RO RO105233A patent/RO83455B/en unknown
- 1980-03-26 RO RO80100627A patent/RO79381A/en unknown
- 1980-03-26 RO RO105234A patent/RO83442B/en unknown
- 1980-03-27 PL PL22305180A patent/PL128496B1/en unknown
- 1980-03-27 PL PL24061180A patent/PL129719B1/en unknown
- 1980-03-27 PL PL24061080A patent/PL129723B1/en unknown
- 1980-03-28 HU HU74180A patent/HU182796B/en unknown
-
1983
- 1983-02-07 YU YU26883A patent/YU42069B/en unknown
- 1983-02-07 YU YU26783A patent/YU42068B/en unknown
Also Published As
Publication number | Publication date |
---|---|
YU41908B (en) | 1988-02-29 |
PL129723B1 (en) | 1984-06-30 |
RO83455B (en) | 1984-02-28 |
YU26883A (en) | 1983-10-31 |
RO83455A (en) | 1984-02-21 |
YU26783A (en) | 1984-04-30 |
HU182796B (en) | 1984-03-28 |
PL129719B1 (en) | 1984-06-30 |
DD141674A1 (en) | 1980-05-14 |
SU1206277A1 (en) | 1986-01-23 |
DD141674B1 (en) | 1982-06-30 |
YU36180A (en) | 1983-06-30 |
YU42069B (en) | 1988-04-30 |
YU42068B (en) | 1988-04-30 |
PL128496B1 (en) | 1984-01-31 |
RO79381A (en) | 1982-06-25 |
PL223051A1 (en) | 1980-12-15 |
RO83442B (en) | 1984-02-28 |
RO83442A (en) | 1984-02-21 |
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