RO82759B - Procedeu de preparare a unei glicoproteine cu actiune antitumorala - Google Patents
Procedeu de preparare a unei glicoproteine cu actiune antitumoralaInfo
- Publication number
- RO82759B RO82759B RO106582A RO10658282A RO82759B RO 82759 B RO82759 B RO 82759B RO 106582 A RO106582 A RO 106582A RO 10658282 A RO10658282 A RO 10658282A RO 82759 B RO82759 B RO 82759B
- Authority
- RO
- Romania
- Prior art keywords
- coriolus
- verzicolor
- atcc
- solution
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 102000003886 Glycoproteins Human genes 0.000 title abstract 2
- 108090000288 Glycoproteins Proteins 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 241000222356 Coriolus Species 0.000 abstract 6
- 239000000243 solution Substances 0.000 abstract 3
- 241000221198 Basidiomycota Species 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/375—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Basidiomycetes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Inventia se refera la un procedeu de preparare a unei glicoproteine cu actiune antitumorala constînd în aceea ca, cuprinde extragerea corpurilor de fruct, micelii sau micelii cultivate ale unei ciuperci bazidomicete, apartinînd grupului Coriolus cu apa fierbinte sau cu solutii alcaline apoase de concentratie 0,1...2,0 N, la o temepratura cuprinsa între 80 si 100 degree C, timp de 1 - 8h, neutralizînd extractul astfel obtinut cu un acid, extractul neutralizat astfel obtinut se supune la dializa si/sau la ultrafiltrare pentru a se îndeparta substantele cu greutate moleculara inferioara sub 5000, substanta rezultata se trateaza printr-o metoda de precipitare fractionata la punctul izoelectric, la un pH cuprins între 2,5 si 5,0 în conditii de pH al solutiei cuprins între 2,5 si 5,0 intensitate ionica a solutiei fiind de 0,1...3,1 niu la o temperatura cuprinsa între 5 si 25 degree C, timp de peste 0,5 h, precipitatul astfel obtinut dezvoltîndu-se în apa, dupa care urmeaza desalinarea si uscarea solutiei astfel tratate. Ciperca bazidomicetica este aleasa între Coroiolus verzicolor ATTC 20547, Coriolus verzicolor ATCC 20548, Coriolus verzicolor ATCC 20549, Coriolus verzicolor ATCC 20549, Coriolus verzicolor ATCC 20550, Coriolus..................
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56018655A JPS5932480B2 (ja) | 1981-02-10 | 1981-02-10 | 新規な糖蛋白複合体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO82759A RO82759A (ro) | 1984-01-14 |
| RO82759B true RO82759B (ro) | 1984-01-30 |
Family
ID=11977627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO106582A RO82759B (ro) | 1981-02-10 | 1982-02-09 | Procedeu de preparare a unei glicoproteine cu actiune antitumorala |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4663438A (ro) |
| EP (1) | EP0058093B1 (ro) |
| JP (1) | JPS5932480B2 (ro) |
| AU (1) | AU551672B2 (ro) |
| CA (1) | CA1184899A (ro) |
| DD (1) | DD202168A5 (ro) |
| DE (1) | DE3261014D1 (ro) |
| PH (2) | PH18378A (ro) |
| RO (1) | RO82759B (ro) |
| SU (1) | SU1291027A3 (ro) |
| ZA (1) | ZA82511B (ro) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3448151C2 (ro) * | 1983-08-11 | 1989-11-02 | Kureha Kagaku Kogyo K.K., Nihonbashi, Tokio/Tokyo, Jp | |
| NL8401225A (nl) * | 1984-04-16 | 1985-11-18 | Univ Utrecht | Farmaceutisch produkt met anti-tumor werking; gebruik van een farmaceutisch produkt of van farmaceutische samenstellingen in een antitumor therapie. |
| JPS61130235A (ja) * | 1984-11-28 | 1986-06-18 | Sunstar Inc | 感染症治療薬 |
| US4828821A (en) * | 1986-08-22 | 1989-05-09 | Collaborative Research, Inc. | Method of inhibiting calculus formulation and improving dental hygiene |
| CA1332650C (en) * | 1987-06-18 | 1994-10-18 | Kunitaka Hirose | Polysaccharides and antiviral drugs containing the same as active ingredient |
| JPH0825896B2 (ja) * | 1987-06-18 | 1996-03-13 | 呉羽化学工業株式会社 | 抗レトロウィルス剤 |
| JPS6466127A (en) * | 1987-09-07 | 1989-03-13 | Nichirei Kk | Antitumor agent |
| JPH0816119B2 (ja) * | 1987-09-24 | 1996-02-21 | 呉羽化学工業株式会社 | 蛋白多糖体ｋｖ−０７１及びそれを有効成分とするヒトロタウイルス感染症予防剤 |
| JPH0816118B2 (ja) * | 1988-02-03 | 1996-02-21 | 呉羽化学工業株式会社 | 抗ウイルス剤 |
| JPH08208704A (ja) * | 1995-02-06 | 1996-08-13 | Kureha Chem Ind Co Ltd | 新規な糖タンパク質複合体、その製造方法、並びに抗腫瘍剤、免疫調節剤及び増殖因子阻害剤 |
| RU2223781C2 (ru) * | 2000-07-13 | 2004-02-20 | Закрытое Акционерное Общество Производственное Предприятие "Эндо-Фарм-А" | Новый класс физиологически активных гликопротеинов |
| US7048932B2 (en) * | 2002-05-22 | 2006-05-23 | The Chinese University Of Hong Kong | Preparation and standardization of immunomodulatory peptide-linked glucans with verifiable oral absorbability from coriolus versicolor |
| RU2007145748A (ru) * | 2007-12-11 | 2009-06-20 | ОАО Завод экологической техники и экопитания "ДИОД" (RU) | Штамм гриба hypsizygus ulmarius (bull.) redhead s-ulm1, используемый для получения средства, обладающего противоопухолевой активностью и антиоксидантным действием и способ получения средства, обладающего противоопухолевой активностью и антиоксидантным действием, на основе этого штамма |
| CN116879481B (zh) * | 2023-09-06 | 2023-12-01 | 北京豪思生物科技股份有限公司 | 一种血清中芳香族氨基酸的检测方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE757248A (fr) * | 1969-10-15 | 1971-04-08 | Kureha Chemical Ind Co Ltd | Substance a propriete anticancereuse et procedes pour sa preparation |
| JPS5290614A (en) * | 1975-12-18 | 1977-07-30 | Kureha Chem Ind Co Ltd | Preparation of anti-tumor substance |
| PH14773A (en) * | 1976-01-01 | 1981-12-09 | Kureha Chemical Ind Co Ltd | Protein-bound polysaccharides |
| JPS536413A (en) * | 1976-07-07 | 1978-01-20 | Kureha Chem Ind Co Ltd | Preparation of n-containing polysaccharides |
| JPS536412A (en) * | 1976-07-07 | 1978-01-20 | Kureha Chem Ind Co Ltd | Preparation of n-containing polysaccharides |
| JPS5315495A (en) * | 1976-07-22 | 1978-02-13 | Kureha Chem Ind Co Ltd | Preparation of polysaccharides |
| JPS5446830A (en) * | 1977-09-16 | 1979-04-13 | Kureha Chem Ind Co Ltd | Pesticide for plant viral disease |
-
1981
- 1981-02-10 JP JP56018655A patent/JPS5932480B2/ja not_active Expired
-
1982
- 1982-01-26 ZA ZA82511A patent/ZA82511B/xx unknown
- 1982-01-29 CA CA000395240A patent/CA1184899A/en not_active Expired
- 1982-02-02 PH PH26815A patent/PH18378A/en unknown
- 1982-02-03 AU AU80166/82A patent/AU551672B2/en not_active Ceased
- 1982-02-09 SU SU823396893A patent/SU1291027A3/ru active
- 1982-02-09 RO RO106582A patent/RO82759B/ro unknown
- 1982-02-09 DD DD82237287A patent/DD202168A5/de not_active IP Right Cessation
- 1982-02-10 DE DE8282300661T patent/DE3261014D1/de not_active Expired
- 1982-02-10 EP EP82300661A patent/EP0058093B1/en not_active Expired
-
1983
- 1983-10-04 PH PH29659A patent/PH18757A/en unknown
-
1985
- 1985-03-25 US US06/715,816 patent/US4663438A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DD202168A5 (de) | 1983-08-31 |
| JPS5932480B2 (ja) | 1984-08-09 |
| US4663438A (en) | 1987-05-05 |
| AU551672B2 (en) | 1986-05-08 |
| RO82759A (ro) | 1984-01-14 |
| JPS57134496A (en) | 1982-08-19 |
| PH18757A (en) | 1985-09-19 |
| EP0058093B1 (en) | 1984-10-24 |
| SU1291027A3 (ru) | 1987-02-15 |
| DE3261014D1 (en) | 1984-11-29 |
| CA1184899A (en) | 1985-04-02 |
| AU8016682A (en) | 1982-08-19 |
| EP0058093A1 (en) | 1982-08-18 |
| ZA82511B (en) | 1982-12-29 |
| PH18378A (en) | 1985-06-19 |
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