RO82759B - Procedeu de preparare a unei glicoproteine cu actiune antitumorala - Google Patents

Procedeu de preparare a unei glicoproteine cu actiune antitumorala

Info

Publication number
RO82759B
RO82759B RO106582A RO10658282A RO82759B RO 82759 B RO82759 B RO 82759B RO 106582 A RO106582 A RO 106582A RO 10658282 A RO10658282 A RO 10658282A RO 82759 B RO82759 B RO 82759B
Authority
RO
Romania
Prior art keywords
coriolus
verzicolor
atcc
solution
preparation
Prior art date
Application number
RO106582A
Other languages
English (en)
Other versions
RO82759A (ro
Inventor
Chiakao Yoshikumi
Takayoshi Fujii
Takao Furusho
Kenichi Matsunaga
Ohara Minoru
Kobayashi Akira
Original Assignee
Kureha Kagaku Kogyo Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kureha Kagaku Kogyo Kabushiki Kaisha filed Critical Kureha Kagaku Kogyo Kabushiki Kaisha
Publication of RO82759A publication Critical patent/RO82759A/ro
Publication of RO82759B publication Critical patent/RO82759B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/375—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Basidiomycetes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Inventia se refera la un procedeu de preparare a unei glicoproteine cu actiune antitumorala constînd în aceea ca, cuprinde extragerea corpurilor de fruct, micelii sau micelii cultivate ale unei ciuperci bazidomicete, apartinînd grupului Coriolus cu apa fierbinte sau cu solutii alcaline apoase de concentratie 0,1...2,0 N, la o temepratura cuprinsa între 80 si 100 degree C, timp de 1 - 8h, neutralizînd extractul astfel obtinut cu un acid, extractul neutralizat astfel obtinut se supune la dializa si/sau la ultrafiltrare pentru a se îndeparta substantele cu greutate moleculara inferioara sub 5000, substanta rezultata se trateaza printr-o metoda de precipitare fractionata la punctul izoelectric, la un pH cuprins între 2,5 si 5,0 în conditii de pH al solutiei cuprins între 2,5 si 5,0 intensitate ionica a solutiei fiind de 0,1...3,1 niu la o temperatura cuprinsa între 5 si 25 degree C, timp de peste 0,5 h, precipitatul astfel obtinut dezvoltîndu-se în apa, dupa care urmeaza desalinarea si uscarea solutiei astfel tratate. Ciperca bazidomicetica este aleasa între Coroiolus verzicolor ATTC 20547, Coriolus verzicolor ATCC 20548, Coriolus verzicolor ATCC 20549, Coriolus verzicolor ATCC 20549, Coriolus verzicolor ATCC 20550, Coriolus..................
RO106582A 1981-02-10 1982-02-09 Procedeu de preparare a unei glicoproteine cu actiune antitumorala RO82759B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56018655A JPS5932480B2 (ja) 1981-02-10 1981-02-10 新規な糖蛋白複合体

Publications (2)

Publication Number Publication Date
RO82759A RO82759A (ro) 1984-01-14
RO82759B true RO82759B (ro) 1984-01-30

Family

ID=11977627

Family Applications (1)

Application Number Title Priority Date Filing Date
RO106582A RO82759B (ro) 1981-02-10 1982-02-09 Procedeu de preparare a unei glicoproteine cu actiune antitumorala

Country Status (11)

Country Link
US (1) US4663438A (ro)
EP (1) EP0058093B1 (ro)
JP (1) JPS5932480B2 (ro)
AU (1) AU551672B2 (ro)
CA (1) CA1184899A (ro)
DD (1) DD202168A5 (ro)
DE (1) DE3261014D1 (ro)
PH (2) PH18378A (ro)
RO (1) RO82759B (ro)
SU (1) SU1291027A3 (ro)
ZA (1) ZA82511B (ro)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3429551A1 (de) * 1983-08-11 1985-02-21 Kureha Kagaku Kogyo K.K., Nihonbashi, Tokio/Tokyo Pharmazeutische zubereitung, die ein glycoprotein enthaelt
NL8401225A (nl) * 1984-04-16 1985-11-18 Univ Utrecht Farmaceutisch produkt met anti-tumor werking; gebruik van een farmaceutisch produkt of van farmaceutische samenstellingen in een antitumor therapie.
JPS61130235A (ja) * 1984-11-28 1986-06-18 Sunstar Inc 感染症治療薬
US4828821A (en) * 1986-08-22 1989-05-09 Collaborative Research, Inc. Method of inhibiting calculus formulation and improving dental hygiene
JPH0825896B2 (ja) * 1987-06-18 1996-03-13 呉羽化学工業株式会社 抗レトロウィルス剤
AU599241B2 (en) * 1987-06-18 1990-07-12 Kureha Kagaku Kogyo Kabushiki Kaisha Polysaccharides and antiviral drugs containing the same as active ingredient
JPS6466127A (en) * 1987-09-07 1989-03-13 Nichirei Kk Antitumor agent
JPH0816119B2 (ja) * 1987-09-24 1996-02-21 呉羽化学工業株式会社 蛋白多糖体ｋｖ−０７１及びそれを有効成分とするヒトロタウイルス感染症予防剤
JPH0816118B2 (ja) * 1988-02-03 1996-02-21 呉羽化学工業株式会社 抗ウイルス剤
JPH08208704A (ja) * 1995-02-06 1996-08-13 Kureha Chem Ind Co Ltd 新規な糖タンパク質複合体、その製造方法、並びに抗腫瘍剤、免疫調節剤及び増殖因子阻害剤
US7048932B2 (en) * 2002-05-22 2006-05-23 The Chinese University Of Hong Kong Preparation and standardization of immunomodulatory peptide-linked glucans with verifiable oral absorbability from coriolus versicolor
RU2007145748A (ru) * 2007-12-11 2009-06-20 ОАО Завод экологической техники и экопитания "ДИОД" (RU) Штамм гриба hypsizygus ulmarius (bull.) redhead s-ulm1, используемый для получения средства, обладающего противоопухолевой активностью и антиоксидантным действием и способ получения средства, обладающего противоопухолевой активностью и антиоксидантным действием, на основе этого штамма
CN116879481B (zh) * 2023-09-06 2023-12-01 北京豪思生物科技股份有限公司 一种血清中芳香族氨基酸的检测方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE757248A (fr) * 1969-10-15 1971-04-08 Kureha Chemical Ind Co Ltd Substance a propriete anticancereuse et procedes pour sa preparation
JPS5290614A (en) * 1975-12-18 1977-07-30 Kureha Chem Ind Co Ltd Preparation of anti-tumor substance
PH14773A (en) * 1976-01-01 1981-12-09 Kureha Chemical Ind Co Ltd Protein-bound polysaccharides
JPS536413A (en) * 1976-07-07 1978-01-20 Kureha Chem Ind Co Ltd Preparation of n-containing polysaccharides
JPS536412A (en) * 1976-07-07 1978-01-20 Kureha Chem Ind Co Ltd Preparation of n-containing polysaccharides
JPS5315495A (en) * 1976-07-22 1978-02-13 Kureha Chem Ind Co Ltd Preparation of polysaccharides
JPS5446830A (en) * 1977-09-16 1979-04-13 Kureha Chem Ind Co Ltd Pesticide for plant viral disease

Also Published As

Publication number Publication date
US4663438A (en) 1987-05-05
DE3261014D1 (en) 1984-11-29
DD202168A5 (de) 1983-08-31
PH18757A (en) 1985-09-19
JPS5932480B2 (ja) 1984-08-09
AU551672B2 (en) 1986-05-08
RO82759A (ro) 1984-01-14
SU1291027A3 (ru) 1987-02-15
CA1184899A (en) 1985-04-02
AU8016682A (en) 1982-08-19
EP0058093A1 (en) 1982-08-18
EP0058093B1 (en) 1984-10-24
ZA82511B (en) 1982-12-29
JPS57134496A (en) 1982-08-19
PH18378A (en) 1985-06-19

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