RO79525B - Procedeu de preparare a unui vaccin contra influentei - Google Patents

Procedeu de preparare a unui vaccin contra influentei

Info

Publication number
RO79525B
RO79525B RO101109A RO10110980A RO79525B RO 79525 B RO79525 B RO 79525B RO 101109 A RO101109 A RO 101109A RO 10110980 A RO10110980 A RO 10110980A RO 79525 B RO79525 B RO 79525B
Authority
RO
Romania
Prior art keywords
virus
cells
liquid medium
temperature
incubating
Prior art date
Application number
RO101109A
Other languages
English (en)
Other versions
RO79525A (ro
Inventor
Karen Brown
Richard Stewart
Original Assignee
Cutter Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21904398&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO79525(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cutter Laboratories, Inc. filed Critical Cutter Laboratories, Inc.
Publication of RO79525A publication Critical patent/RO79525A/ro
Publication of RO79525B publication Critical patent/RO79525B/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Procedeu de preparare a unui vaccin contra influentei ecvine A1 si A2 precum si al influentei umane ales dintre tulpinile de virus B/Hong Kong A texas si A/URSS caracterizat prin aceea ca consta în infectarea unei parti din celulele unei culturi celulare în mediu lichid cuprinzînd un monostrat de celule în mediu lichid cu un diluant continînd virusul influentei incubarea monostraturilor infectate la temperatura de 34....37 degree C timp de 1 pîna la 72h în prezenta enzimei proteolitice tripsina într-o concentratie optima cuprinsa între 8 si 15 miu g/ml din nou incubarea la temperatura de 34....37 degree C pana la observarea efectelor citopatice maxime apoi recoltarea fluidului ce contine virusul si prelucrarea la vaccin viu atenuat sau omorît prin procedee curente.
RO101109A 1979-05-15 1980-05-13 Procedeu de preparare a unui vaccin contra influentei RO79525B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3923679A 1979-05-15 1979-05-15

Publications (2)

Publication Number Publication Date
RO79525A RO79525A (ro) 1984-07-17
RO79525B true RO79525B (ro) 1984-09-30

Family

ID=21904398

Family Applications (1)

Application Number Title Priority Date Filing Date
RO101109A RO79525B (ro) 1979-05-15 1980-05-13 Procedeu de preparare a unui vaccin contra influentei

Country Status (13)

Country Link
EP (1) EP0019218B2 (ro)
JP (1) JPS55153723A (ro)
AR (1) AR220838A1 (ro)
AT (1) ATE16454T1 (ro)
AU (1) AU535804B2 (ro)
CA (1) CA1122527A (ro)
DE (1) DE3071225D1 (ro)
DK (1) DK154749C (ro)
ES (1) ES491517A0 (ro)
IL (1) IL60063A0 (ro)
NO (1) NO801443L (ro)
RO (1) RO79525B (ro)
YU (1) YU41923B (ro)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698433A (en) * 1994-11-10 1997-12-16 Immuno Ag Method for producing influenza virus and vaccine
US6146873A (en) * 1994-11-10 2000-11-14 Baxter Aktiengesellschaft Production of orthomyxoviruses in monkey kidney cells using protein-free media
US5753489A (en) * 1994-11-10 1998-05-19 Immuno Ag Method for producing viruses and vaccines in serum-free culture
EP1213030B1 (en) * 1994-11-10 2009-04-22 Baxter Healthcare SA Method for producing biologicals in protein-free culture
NZ296861A (en) * 1994-11-16 1998-05-27 St Jude Childrens Res Hospital Replicating human influenza virus in a vero cell culture involving maintaining consistent minimum concentration of trypsin in the culture medium
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
DE19612967A1 (de) * 1996-04-01 1997-10-02 Behringwerke Ag Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren
DE10144906B4 (de) * 2001-09-12 2013-11-28 Novartis Vaccines And Diagnostics Gmbh Verfahren zur großtechnischen Herstellung von Impfstoffen
US6830917B2 (en) 2001-12-10 2004-12-14 Baxter Healthcare S.A. Method of isolation and purification of trypsin from pronase protease and use thereof
WO2006062637A2 (en) 2004-11-03 2006-06-15 Novartis Vaccines And Diagnostics Inc. Influenza vaccination
US7883844B2 (en) 2006-05-11 2011-02-08 Juridical Foundation The Chemosero-Therapeutic Research Institute Method for propagating influenza virus
US8506966B2 (en) 2008-02-22 2013-08-13 Novartis Ag Adjuvanted influenza vaccines for pediatric use
TW201012930A (en) * 2008-06-16 2010-04-01 Intervet Int Bv Method of replicating viruses in suspension
US9278126B2 (en) 2009-02-10 2016-03-08 Seqirus UK Limited Influenza vaccines with reduced amounts of squalene

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2262962B1 (ro) * 1974-03-05 1977-11-04 Science Union & Cie

Also Published As

Publication number Publication date
ATE16454T1 (de) 1985-11-15
YU41923B (en) 1988-02-29
EP0019218B2 (de) 1995-03-01
ES8104405A1 (es) 1981-04-01
CA1122527A (en) 1982-04-27
AU535804B2 (en) 1984-04-05
EP0019218A2 (de) 1980-11-26
DE3071225D1 (en) 1985-12-19
EP0019218A3 (en) 1981-03-25
IL60063A0 (en) 1980-07-31
YU126580A (en) 1983-12-31
DK212580A (da) 1980-11-16
AU5824480A (en) 1980-11-20
DK154749C (da) 1989-05-16
DK154749B (da) 1988-12-19
AR220838A1 (es) 1980-11-28
EP0019218B1 (de) 1985-11-13
ES491517A0 (es) 1981-04-01
RO79525A (ro) 1984-07-17
JPH0124769B2 (ro) 1989-05-15
JPS55153723A (en) 1980-11-29
NO801443L (no) 1980-11-17

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