RO79525B - Procedeu de preparare a unui vaccin contra influentei - Google Patents
Procedeu de preparare a unui vaccin contra influenteiInfo
- Publication number
- RO79525B RO79525B RO101109A RO10110980A RO79525B RO 79525 B RO79525 B RO 79525B RO 101109 A RO101109 A RO 101109A RO 10110980 A RO10110980 A RO 10110980A RO 79525 B RO79525 B RO 79525B
- Authority
- RO
- Romania
- Prior art keywords
- virus
- cells
- liquid medium
- temperature
- incubating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Procedeu de preparare a unui vaccin contra influentei ecvine A1 si A2 precum si al influentei umane ales dintre tulpinile de virus B/Hong Kong A texas si A/URSS caracterizat prin aceea ca consta în infectarea unei parti din celulele unei culturi celulare în mediu lichid cuprinzînd un monostrat de celule în mediu lichid cu un diluant continînd virusul influentei incubarea monostraturilor infectate la temperatura de 34....37 degree C timp de 1 pîna la 72h în prezenta enzimei proteolitice tripsina într-o concentratie optima cuprinsa între 8 si 15 miu g/ml din nou incubarea la temperatura de 34....37 degree C pana la observarea efectelor citopatice maxime apoi recoltarea fluidului ce contine virusul si prelucrarea la vaccin viu atenuat sau omorît prin procedee curente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3923679A | 1979-05-15 | 1979-05-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
RO79525A RO79525A (ro) | 1984-07-17 |
RO79525B true RO79525B (ro) | 1984-09-30 |
Family
ID=21904398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO101109A RO79525B (ro) | 1979-05-15 | 1980-05-13 | Procedeu de preparare a unui vaccin contra influentei |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0019218B2 (ro) |
JP (1) | JPS55153723A (ro) |
AR (1) | AR220838A1 (ro) |
AT (1) | ATE16454T1 (ro) |
AU (1) | AU535804B2 (ro) |
CA (1) | CA1122527A (ro) |
DE (1) | DE3071225D1 (ro) |
DK (1) | DK154749C (ro) |
ES (1) | ES491517A0 (ro) |
IL (1) | IL60063A0 (ro) |
NO (1) | NO801443L (ro) |
RO (1) | RO79525B (ro) |
YU (1) | YU41923B (ro) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6146873A (en) * | 1994-11-10 | 2000-11-14 | Baxter Aktiengesellschaft | Production of orthomyxoviruses in monkey kidney cells using protein-free media |
US5753489A (en) * | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
WO1996015231A2 (en) * | 1994-11-10 | 1996-05-23 | Immuno Aktiengesellschaft | Method for producing biologicals in protein-free culture |
US5698433A (en) * | 1994-11-10 | 1997-12-16 | Immuno Ag | Method for producing influenza virus and vaccine |
EP0808361A4 (en) * | 1994-11-16 | 2001-07-18 | St Jude Childrens Res Hospital | NEW REPLICATION PROCESS |
DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
DE19612967A1 (de) * | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
DE10144906B4 (de) | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
US6830917B2 (en) * | 2001-12-10 | 2004-12-14 | Baxter Healthcare S.A. | Method of isolation and purification of trypsin from pronase protease and use thereof |
WO2006062637A2 (en) | 2004-11-03 | 2006-06-15 | Novartis Vaccines And Diagnostics Inc. | Influenza vaccination |
WO2007132763A1 (ja) * | 2006-05-11 | 2007-11-22 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | インフルエンザウイルスの増殖方法 |
US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
TW201012930A (en) * | 2008-06-16 | 2010-04-01 | Intervet Int Bv | Method of replicating viruses in suspension |
DK2396032T3 (en) | 2009-02-10 | 2016-12-19 | Seqirus Uk Ltd | Influenza vaccines with reduced amounts of squalene |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2262962B1 (ro) * | 1974-03-05 | 1977-11-04 | Science Union & Cie |
-
1980
- 1980-04-22 CA CA350,366A patent/CA1122527A/en not_active Expired
- 1980-04-30 AR AR280860A patent/AR220838A1/es active
- 1980-05-08 EP EP80102525A patent/EP0019218B2/de not_active Expired - Lifetime
- 1980-05-08 AT AT80102525T patent/ATE16454T1/de not_active IP Right Cessation
- 1980-05-08 DE DE8080102525T patent/DE3071225D1/de not_active Expired
- 1980-05-09 AU AU58244/80A patent/AU535804B2/en not_active Expired
- 1980-05-13 RO RO101109A patent/RO79525B/ro unknown
- 1980-05-13 YU YU1265/80A patent/YU41923B/xx unknown
- 1980-05-13 JP JP6235780A patent/JPS55153723A/ja active Granted
- 1980-05-13 IL IL60063A patent/IL60063A0/xx unknown
- 1980-05-14 NO NO801443A patent/NO801443L/no unknown
- 1980-05-14 ES ES491517A patent/ES491517A0/es active Granted
- 1980-05-14 DK DK212580A patent/DK154749C/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0019218B1 (de) | 1985-11-13 |
ATE16454T1 (de) | 1985-11-15 |
DK154749C (da) | 1989-05-16 |
DK154749B (da) | 1988-12-19 |
EP0019218A3 (en) | 1981-03-25 |
AU535804B2 (en) | 1984-04-05 |
IL60063A0 (en) | 1980-07-31 |
EP0019218A2 (de) | 1980-11-26 |
ES8104405A1 (es) | 1981-04-01 |
NO801443L (no) | 1980-11-17 |
YU126580A (en) | 1983-12-31 |
DK212580A (da) | 1980-11-16 |
RO79525A (ro) | 1984-07-17 |
EP0019218B2 (de) | 1995-03-01 |
CA1122527A (en) | 1982-04-27 |
JPH0124769B2 (ro) | 1989-05-15 |
AU5824480A (en) | 1980-11-20 |
ES491517A0 (es) | 1981-04-01 |
AR220838A1 (es) | 1980-11-28 |
YU41923B (en) | 1988-02-29 |
DE3071225D1 (en) | 1985-12-19 |
JPS55153723A (en) | 1980-11-29 |
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