RO121409B1 - Utilizarea eritropoietinei sau a derivaţilor de eritropoietină, pentru tratamentul ischemiei cerebrale - Google Patents
Utilizarea eritropoietinei sau a derivaţilor de eritropoietină, pentru tratamentul ischemiei cerebrale Download PDFInfo
- Publication number
- RO121409B1 RO121409B1 ROA200100684A RO200100684A RO121409B1 RO 121409 B1 RO121409 B1 RO 121409B1 RO A200100684 A ROA200100684 A RO A200100684A RO 200100684 A RO200100684 A RO 200100684A RO 121409 B1 RO121409 B1 RO 121409B1
- Authority
- RO
- Romania
- Prior art keywords
- erythropoietin
- treatment
- stroke
- patients
- use according
- Prior art date
Links
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title claims abstract description 69
- 102000003951 Erythropoietin Human genes 0.000 title claims abstract description 59
- 108090000394 Erythropoietin Proteins 0.000 title claims abstract description 59
- 229940105423 erythropoietin Drugs 0.000 title claims abstract description 59
- 206010008120 Cerebral ischaemia Diseases 0.000 title claims abstract description 19
- 238000011282 treatment Methods 0.000 title claims abstract description 13
- 230000002093 peripheral effect Effects 0.000 claims abstract description 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 6
- 229940127557 pharmaceutical product Drugs 0.000 claims abstract description 6
- 208000006011 Stroke Diseases 0.000 claims description 19
- 201000006474 Brain Ischemia Diseases 0.000 claims description 17
- 206010008118 cerebral infarction Diseases 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 241000124008 Mammalia Species 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 2
- 210000005013 brain tissue Anatomy 0.000 description 13
- 230000000302 ischemic effect Effects 0.000 description 12
- 239000003814 drug Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 description 6
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 description 6
- 230000008499 blood brain barrier function Effects 0.000 description 6
- 210000001218 blood-brain barrier Anatomy 0.000 description 6
- 102000044890 human EPO Human genes 0.000 description 6
- 238000001802 infusion Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 108010092408 Eosinophil Peroxidase Proteins 0.000 description 5
- 102100031939 Erythropoietin Human genes 0.000 description 5
- 241000282412 Homo Species 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 208000012902 Nervous system disease Diseases 0.000 description 3
- 208000025966 Neurological disease Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 208000007502 anemia Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 206010061216 Infarction Diseases 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 206010028851 Necrosis Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000007914 intraventricular administration Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 238000012270 DNA recombination Methods 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010060840 Ischaemic cerebral infarction Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 125000003275 alpha amino acid group Chemical class 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 208000037906 ischaemic injury Diseases 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000003140 lateral ventricle Anatomy 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19857609A DE19857609A1 (de) | 1998-12-14 | 1998-12-14 | Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen |
| PCT/EP1999/009864 WO2000035475A2 (de) | 1998-12-14 | 1999-12-13 | Verfahren zur behandlung von cerebralen ischämien sowie verwendung von erythropoietin oder erythropoietin-derivaten zur behandlung von cerebralen ischämien |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO121409B1 true RO121409B1 (ro) | 2007-05-30 |
Family
ID=7891015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ROA200100684A RO121409B1 (ro) | 1998-12-14 | 1999-12-13 | Utilizarea eritropoietinei sau a derivaţilor de eritropoietină, pentru tratamentul ischemiei cerebrale |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7514072B1 (enExample) |
| EP (1) | EP1140139B2 (enExample) |
| JP (2) | JP4750947B2 (enExample) |
| KR (1) | KR100774827B1 (enExample) |
| CN (1) | CN1187085C (enExample) |
| AT (1) | ATE253932T1 (enExample) |
| AU (1) | AU766216C (enExample) |
| BG (1) | BG65417B1 (enExample) |
| BR (1) | BR9916197A (enExample) |
| CA (1) | CA2353553C (enExample) |
| DE (2) | DE19857609A1 (enExample) |
| DK (1) | DK1140139T4 (enExample) |
| ES (1) | ES2211218T5 (enExample) |
| HK (1) | HK1042655B (enExample) |
| HU (1) | HUP0104709A3 (enExample) |
| ID (1) | ID29107A (enExample) |
| IL (2) | IL143579A0 (enExample) |
| MX (1) | MXPA01005971A (enExample) |
| NO (1) | NO330079B1 (enExample) |
| NZ (1) | NZ541591A (enExample) |
| PL (1) | PL202483B1 (enExample) |
| PT (1) | PT1140139E (enExample) |
| RO (1) | RO121409B1 (enExample) |
| RU (1) | RU2242991C2 (enExample) |
| WO (1) | WO2000035475A2 (enExample) |
| ZA (1) | ZA200104626B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19857609A1 (de) | 1998-12-14 | 2000-06-15 | Hannelore Ehrenreich | Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen |
| US7309687B1 (en) | 1999-04-13 | 2007-12-18 | The Kenneth S. Warren Institute, Inc. | Methods for treatment and prevention of neuromuscular and muscular conditions by peripherally administered erythropoietin |
| US7345019B1 (en) | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
| JP2003520194A (ja) * | 1999-04-13 | 2003-07-02 | ザ ケネス エス．ウォーレン インスティテュート，インコーポレーテッド | 末梢投与したエリスロポエチンによる興奮組織機能のモジュレート |
| US7078376B1 (en) | 2000-08-11 | 2006-07-18 | Baxter Healthcare S.A. | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
| DE10043457A1 (de) * | 2000-09-04 | 2002-03-28 | Hannelore Ehrenreich | Verfahren zur Behandlung von Schizophrenie und verwandten Psychosen sowie Verwendung von Erythropoietin oder Erythropoietinderivaten zur Behandlung von Schizophrenien und verwandten Psychosen |
| PA8536201A1 (es) * | 2000-12-29 | 2002-08-29 | Kenneth S Warren Inst Inc | Protección y mejoramiento de células, tejidos y órganos que responden a la eritropoyetina |
| US6531121B2 (en) | 2000-12-29 | 2003-03-11 | The Kenneth S. Warren Institute, Inc. | Protection and enhancement of erythropoietin-responsive cells, tissues and organs |
| US20030072737A1 (en) | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| US7767643B2 (en) | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
| EP1423509A2 (en) * | 2001-08-30 | 2004-06-02 | Stem Cell Therapeutics Inc. | Differentiation of neural stem cells and therapeutic use thereof |
| ATE541921T1 (de) | 2001-09-14 | 2012-02-15 | Stem Cell Therapeutics Inc | Prolaktin-induzierte zunahme an neuronalen stammzellen und dessen therapeutische anwendung |
| DE10219545A1 (de) * | 2002-04-26 | 2003-11-06 | Lang Florian | Regulation der Apoptose |
| JP2005534650A (ja) * | 2002-06-11 | 2005-11-17 | ザ バーナム インスティテュート | エリスロポイエチンおよびインスリン様増殖因子の神経保護的相乗作用 |
| DE10234192B4 (de) | 2002-07-26 | 2009-11-26 | Epoplus Gmbh Co.Kg | Verwendung von Erythropoetin |
| CA2519803A1 (en) * | 2003-03-27 | 2004-10-14 | Janssen Pharmaceutica N.V. | Use of erythropoietin in stroke recovery |
| US7718363B2 (en) | 2003-04-25 | 2010-05-18 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds |
| US20070111932A1 (en) * | 2003-07-31 | 2007-05-17 | Stem Cell Therapeutics Inc. | Method of enhancing and/or inducing neuronal migration using erythropoietin |
| ZA200603396B (en) | 2003-09-29 | 2007-11-28 | Warren Pharmaceuticals Inc | Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions |
| JP4836797B2 (ja) * | 2003-10-23 | 2011-12-14 | 大塚製薬株式会社 | 放出制御性無菌注射アリピプラゾール製剤および方法 |
| US7846898B2 (en) * | 2004-02-13 | 2010-12-07 | Stem Cell Therapeutics Corp. | Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis |
| US9988427B2 (en) | 2005-05-13 | 2018-06-05 | Charite Universitaetsmedizen-Berlin | Erythropoietin variants |
| EP1736481A1 (en) | 2005-05-13 | 2006-12-27 | Charite Universitätsmedizin-Berlin | Erythropoietin variants |
| CA2622758A1 (en) * | 2005-09-15 | 2007-03-29 | Elan Pharma International, Limited | Nanoparticulate aripiprazole formulations |
| JP2009509943A (ja) | 2005-09-27 | 2009-03-12 | ステム セル セラピューティクス コーポレイション | プロラクチンにより制御される乏突起膠細胞前駆体細胞の増殖 |
| AU2007229301B2 (en) * | 2006-03-17 | 2013-08-01 | Stem Cell Therapeutics Corp. | Continuous dosing regimens for neural stem cell proliferating agents and neural stem cell differentiating agents |
| AR061269A1 (es) * | 2006-06-07 | 2008-08-13 | Chugai Pharmaceutical Co Ltd | Composicion y metodo de revascularizacion para el tratamiento de enfermedades isquemicas usando eritropoyetina |
| MX2010001311A (es) | 2007-07-31 | 2010-04-21 | Otsuka Pharma Co Ltd | Metodo para producir una suspensi?n de aripiprazol y formulacion liofilizada. |
| RU2446834C2 (ru) * | 2010-06-15 | 2012-04-10 | Елена Александровна Лебедева | Способ лечения пострадавших с сочетанной черепно-мозговой травмой |
| US9956265B2 (en) | 2011-04-26 | 2018-05-01 | Ajou University Industry-Academic Cooperation Foundation | Composition for aiding surgical procedures for treating ischemic vascular diseases |
| RU2495688C1 (ru) * | 2012-03-28 | 2013-10-20 | Государственное бюджетное учреждение здравоохранения Центр организации специализированной медицинской помощи "Челябинский государственный институт лазерной хирургии" | Способ лечения ишемии головного мозга в эксперименте |
| US9610444B2 (en) | 2013-03-15 | 2017-04-04 | Pacesetter, Inc. | Erythropoeitin production by electrical stimulation |
| KR20190052855A (ko) | 2017-11-09 | 2019-05-17 | 대한제당 주식회사 | 페길레이션된 에리스로포이에틴을 포함하는 허혈성 뇌질환 치료용 조성물 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| JPS6197229A (ja) | 1984-10-18 | 1986-05-15 | Chugai Pharmaceut Co Ltd | 安定なエリトロポエチン製剤 |
| IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin |
| US5013718A (en) * | 1986-11-21 | 1991-05-07 | Amgen, Inc. | Method for treating iron overload using EPO |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| WO1991006667A1 (en) | 1989-11-06 | 1991-05-16 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
| CA2071989C (en) | 1989-12-22 | 1999-07-27 | Scott C. Chappel | Endogenous gene expression modification with regulatory element |
| US5750376A (en) | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| JP3537151B2 (ja) | 1991-12-26 | 2004-06-14 | 中外製薬株式会社 | 脳機能障害による疾患の予防・治療薬 |
| RU2068268C1 (ru) * | 1992-03-19 | 1996-10-27 | Учебно-научный центр Медицинского центра при Правительстве РФ | Способ профилактики церебро-васкулярных заболеваний |
| US5614184A (en) | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
| US5661125A (en) | 1992-08-06 | 1997-08-26 | Amgen, Inc. | Stable and preserved erythropoietin compositions |
| TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| KR960701650A (ko) | 1993-04-29 | 1996-03-28 | 찰스 엠. 브룩 | 에리트로포이에틴 유사체 조성물 및 방법(Eythropoietin analog compositions and methods) |
| IL110669A (en) | 1993-08-17 | 2008-11-26 | Kirin Amgen Inc | Erythropoietin analogs |
| SE520730C2 (sv) | 1995-01-20 | 2003-08-19 | Eskil Elmer | Behandling av hjärnischemi och hjärnskador med ett neuroprotektivt läkemedel |
| US6121246A (en) | 1995-10-20 | 2000-09-19 | St. Elizabeth's Medical Center Of Boston, Inc. | Method for treating ischemic tissue |
| US6165783A (en) | 1997-10-24 | 2000-12-26 | Neuro Spheres Holdings Ltd. | Erythropoietin-mediated neurogenesis |
| DE19857609A1 (de) | 1998-12-14 | 2000-06-15 | Hannelore Ehrenreich | Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen |
| JP2003520194A (ja) | 1999-04-13 | 2003-07-02 | ザ ケネス エス．ウォーレン インスティテュート，インコーポレーテッド | 末梢投与したエリスロポエチンによる興奮組織機能のモジュレート |
| US20030072737A1 (en) | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
-
1998
- 1998-12-14 DE DE19857609A patent/DE19857609A1/de not_active Ceased
-
1999
- 1999-12-13 CA CA2353553A patent/CA2353553C/en not_active Expired - Fee Related
- 1999-12-13 BR BR9916197-4A patent/BR9916197A/pt not_active Application Discontinuation
- 1999-12-13 DK DK99966958T patent/DK1140139T4/da active
- 1999-12-13 IL IL14357999A patent/IL143579A0/xx active IP Right Grant
- 1999-12-13 WO PCT/EP1999/009864 patent/WO2000035475A2/de not_active Ceased
- 1999-12-13 PT PT99966958T patent/PT1140139E/pt unknown
- 1999-12-13 ES ES99966958T patent/ES2211218T5/es not_active Expired - Lifetime
- 1999-12-13 MX MXPA01005971A patent/MXPA01005971A/es active IP Right Grant
- 1999-12-13 EP EP99966958A patent/EP1140139B2/de not_active Expired - Lifetime
- 1999-12-13 US US09/868,089 patent/US7514072B1/en not_active Expired - Fee Related
- 1999-12-13 CN CNB998160474A patent/CN1187085C/zh not_active Expired - Fee Related
- 1999-12-13 PL PL349335A patent/PL202483B1/pl not_active IP Right Cessation
- 1999-12-13 KR KR1020017007421A patent/KR100774827B1/ko not_active Expired - Fee Related
- 1999-12-13 HU HU0104709A patent/HUP0104709A3/hu unknown
- 1999-12-13 DE DE59907752T patent/DE59907752D1/de not_active Expired - Lifetime
- 1999-12-13 HK HK02104485.2A patent/HK1042655B/zh not_active IP Right Cessation
- 1999-12-13 NZ NZ541591A patent/NZ541591A/en not_active IP Right Cessation
- 1999-12-13 ID IDW00200101535A patent/ID29107A/id unknown
- 1999-12-13 RU RU2001116077/14A patent/RU2242991C2/ru not_active IP Right Cessation
- 1999-12-13 AT AT99966958T patent/ATE253932T1/de active
- 1999-12-13 AU AU22831/00A patent/AU766216C/en not_active Ceased
- 1999-12-13 RO ROA200100684A patent/RO121409B1/ro unknown
- 1999-12-13 JP JP2000587794A patent/JP4750947B2/ja not_active Expired - Fee Related
-
2001
- 2001-06-05 IL IL143579A patent/IL143579A/en not_active IP Right Cessation
- 2001-06-06 ZA ZA200104626A patent/ZA200104626B/en unknown
- 2001-06-07 BG BG105575A patent/BG65417B1/bg unknown
- 2001-06-12 NO NO20012896A patent/NO330079B1/no not_active IP Right Cessation
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2010
- 2010-12-20 JP JP2010283105A patent/JP2011079860A/ja not_active Withdrawn
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