PT99690A - Metodo para o tratamento de doencas utilizando derivados de 2'-o-alquil-adenosina e para a preparacao de composicoes que os contem e de um hidrato de 6-ciclo- -hexil-2'-ometil-adenosina - Google Patents

Metodo para o tratamento de doencas utilizando derivados de 2'-o-alquil-adenosina e para a preparacao de composicoes que os contem e de um hidrato de 6-ciclo- -hexil-2'-ometil-adenosina

Info

Publication number
PT99690A
PT99690A PT99690A PT9969091A PT99690A PT 99690 A PT99690 A PT 99690A PT 99690 A PT99690 A PT 99690A PT 9969091 A PT9969091 A PT 9969091A PT 99690 A PT99690 A PT 99690A
Authority
PT
Portugal
Prior art keywords
adenosine
alkyl
treatment
ometel
cyclohexyl
Prior art date
Application number
PT99690A
Other languages
English (en)
Other versions
PT99690B (pt
Inventor
Fulvio Gadient
Else Mueller
Maria Milavec
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4039060A external-priority patent/DE4039060A1/de
Priority claimed from GB919116212A external-priority patent/GB9116212D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of PT99690A publication Critical patent/PT99690A/pt
Publication of PT99690B publication Critical patent/PT99690B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT99690A 1990-12-07 1991-12-05 Metodo para o tratamento de doencas utilizando derivados de 2'-o-alquil-adenosina e para a preparacao de composicoes que os contem e de um hidrato de 6-ciclo- -hexil-2'-ometil-adenosina PT99690B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4039060A DE4039060A1 (de) 1990-12-07 1990-12-07 Neue kristallform
GB919116212A GB9116212D0 (en) 1991-07-26 1991-07-26 New use of organic compounds

Publications (2)

Publication Number Publication Date
PT99690A true PT99690A (pt) 1992-10-30
PT99690B PT99690B (pt) 1999-05-31

Family

ID=25899101

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99690A PT99690B (pt) 1990-12-07 1991-12-05 Metodo para o tratamento de doencas utilizando derivados de 2'-o-alquil-adenosina e para a preparacao de composicoes que os contem e de um hidrato de 6-ciclo- -hexil-2'-ometil-adenosina

Country Status (9)

Country Link
EP (2) EP0774259A1 (pt)
JP (2) JPH04290895A (pt)
AT (1) ATE157007T1 (pt)
AU (1) AU647216B2 (pt)
CA (1) CA2056967A1 (pt)
DE (1) DE69127350D1 (pt)
HU (1) HUT61567A (pt)
IE (1) IE914248A1 (pt)
PT (1) PT99690B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
DK0667898T3 (da) * 1991-08-09 2002-02-04 Massachusetts Inst Technology Anvendelser af TAU/neurofilamentproteinkinasen PK40
DK62692D0 (pt) * 1992-05-14 1992-05-14 Novo Nordisk As
DK62592D0 (pt) * 1992-05-14 1992-05-14 Novo Nordisk As
EP0601322A3 (en) * 1992-10-27 1994-10-12 Nippon Zoki Pharmaceutical Co Adenosine deaminase inhibitor.
DK155292D0 (da) * 1992-12-23 1992-12-23 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
PL316985A1 (en) * 1994-05-10 1997-03-03 Sandoz Ltd Derivatives of adenosine
AU2022597A (en) * 1996-03-13 1997-10-01 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
WO1997033590A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
WO1998016539A1 (en) * 1996-10-14 1998-04-23 Novo Nordisk A/S Novel therapeutically active adenosine derivatives
WO1999006059A2 (en) * 1997-07-30 1999-02-11 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
US5998386A (en) * 1997-09-19 1999-12-07 Feldman; Arthur M. Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue
US6252061B1 (en) 1998-03-23 2001-06-26 Reliable Biopharmaceutical, Inc. Process for the production of 2-halo-6-aminopurine derivatives
JP3619017B2 (ja) 1998-06-24 2005-02-09 日本臓器製薬株式会社 新規アラビノシルアデニン誘導体
WO2002020055A1 (fr) 2000-09-08 2002-03-14 Daiichi Suntory Pharma Co., Ltd. Médicaments contre les défaillances cardiaques
EP1258247A1 (en) * 2001-05-14 2002-11-20 Aventis Pharma Deutschland GmbH Adenosine analogues for the treatment of insulin resistance syndrome and diabetes
JP5145563B2 (ja) * 2005-11-24 2013-02-20 国立大学法人北海道大学 神経変性疾患治療薬
CA2654371A1 (en) * 2006-06-27 2008-01-03 Biovitrum Ab (Publ) Therapeutic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230160A1 (de) * 1972-06-21 1974-01-31 Merck Patent Gmbh Adenosinderivat
AU579412B2 (en) * 1984-10-26 1988-11-24 Warner-Lambert Company N` - substituted adenosines
WO1988003148A2 (en) * 1986-10-31 1988-05-05 Warner-Lambert Company Heteroaromatic derivatives of adenoside
WO1988003147A1 (en) * 1986-10-31 1988-05-05 Warner-Lambert Company Selected n6-substituted adenosines having selective a2 binding activity
JPH0723394B2 (ja) 1986-11-27 1995-03-15 日本臓器製薬株式会社 新規アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
US4962194A (en) * 1987-04-02 1990-10-09 Warner-Lambert Company Method of preparing 51,N6-disubstituted adenosines from inosines
GB2226027B (en) * 1988-12-13 1992-05-20 Sandoz Ltd Adenosine derivatives,their production and use
JPH0725785B2 (ja) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物

Also Published As

Publication number Publication date
IE914248A1 (en) 1992-06-17
EP0490818A1 (en) 1992-06-17
AU647216B2 (en) 1994-03-17
AU8888791A (en) 1992-06-11
EP0490818B1 (en) 1997-08-20
HUT61567A (en) 1993-01-28
DE69127350D1 (de) 1997-09-25
CA2056967A1 (en) 1992-06-08
EP0774259A1 (en) 1997-05-21
HU913662D0 (en) 1992-02-28
JPH09110700A (ja) 1997-04-28
PT99690B (pt) 1999-05-31
JPH04290895A (ja) 1992-10-15
ATE157007T1 (de) 1997-09-15

Similar Documents

Publication Publication Date Title
PT99690A (pt) Metodo para o tratamento de doencas utilizando derivados de 2'-o-alquil-adenosina e para a preparacao de composicoes que os contem e de um hidrato de 6-ciclo- -hexil-2'-ometil-adenosina
KR890003369A (ko) 약제학적 제제
ATE94877T1 (de) Piperazinylderivate von purinen und deren isostere als hypoglykaemische wirkstoffe.
DE69034043D1 (de) Pcp-rezeptor-liganden und deren verwendung
KR930702022A (ko) 인슐린의 경구 투여에 의한 타잎 1 당뇨병의 치료 또는 예방법
SE8102193L (sv) Terapeutiskt aktiv organisk forening och dess anvendning
BR9910921A (pt) Composto, processo para preparar o mesmo, formulação farmacêutica, uso de um composto, e, processo para a profilaxia e/ou tratamento de condições clìnicas associadas com a resistência à insulina
NO178914C (no) Fremgangsmåte for fremstilling av et farmasöytisk preparat for behandling av Diabetes mellitus
BR9306841A (pt) Composição farmacêutica processo para proporcionar um tratamento anti-histamínico o qual não induz qualquer arritmia cardíaca significativa em um paciente ser humano e uso de uma composição para a mnaufactura de um medicamento para uso em um tratamento anti-histamínico
DE69634556D1 (de) L-Carnitin oder ihre Derivate und Resveratrol oder ihre Derivate zur Vorbeugung und Behandlung von kardiovaskulären Erkrankungen, peripheren Gefässkrankheit, peripheren diabetischen Neuropathie und diese enthaltende pharmazeutische Zusammensetzungen
ATE131173T1 (de) Fluorierte gallensäure-derivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen daraus.
ATE16183T1 (de) Thiazolidin-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ES2128309T3 (es) Utilizacion de taurina para la fabricacion de un medicamento para estimular actividad de mieloperoxidasa.
DE4394931T1 (de) Verwendung von Norastemizol zur Behandlung von allergischen Erkrankungen
BR9913746C1 (pt) Derivado de piridìnio, processo para a preparação do mesmo, uso do mesmo, composição farmacêutica, processo para preparação de uma formulação parenteral,e, métodos de tratamento de um paciente diabético e de prevenção ou de tratamento de doenças causadas por diabetes e por complicações relacionadas com o envelhecimento
ATE174221T1 (de) Behandlung von pankreaskrankheit mit 15-keto- prostaglandin e-derivaten
DK199789D0 (da) Anvendelse af et phenylquinolincarboxylsyrederivat eller et farmaceutisk egnet salt deraf til fremstilling af et topisk farmaceutisk praeparat til behandling af hud- og/eller slimepithelsygdomme
HK1058190A1 (en) Novel heterocyclic analogs of diphenylethylene compounds
BR0215090A (pt) Composto, enanciÈmero (r) ou enanciÈmero (s) de um composto, formulação farmacêutica, método para tratar ou prevenir distúrbios lipìdicos (dislipidemia) associados ou não com resistência à insulina, uso de um composto, método para tratar ou prevenir diabetes de tipo 2, processo para preparar um composto, e, composição farmacêutica
NO920855D0 (no) Medikamentinneholdende matrise
KR880004810A (ko) 소화성 궤양 치료제
FR2357536A1 (fr) Nouveaux derives d'acides phenoxy-phenoxy-alcanecarboxyliques substitues dans les noyaux, a activite herbicide et leur application a la lutte contre les mauvaises herbes
PT92189A (pt) Processo para a preparacao de derivados de difenilacetamidas e de composicoes farmaceuticas que os contem
DE69018099D1 (de) Polyamin-Derivate als antineoplastische Mittel.
ATE2746T1 (de) Piperidinderivate von 4,5-dialkyl-3-hydroxypyrrol-2-carbons[ureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920612

FG3A Patent granted, date of granting

Effective date: 19990212

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000831