PT99690A - Metodo para o tratamento de doencas utilizando derivados de 2'-o-alquil-adenosina e para a preparacao de composicoes que os contem e de um hidrato de 6-ciclo- -hexil-2'-ometil-adenosina - Google Patents

Metodo para o tratamento de doencas utilizando derivados de 2'-o-alquil-adenosina e para a preparacao de composicoes que os contem e de um hidrato de 6-ciclo- -hexil-2'-ometil-adenosina

Info

Publication number
PT99690A
PT99690A PT99690A PT9969091A PT99690A PT 99690 A PT99690 A PT 99690A PT 99690 A PT99690 A PT 99690A PT 9969091 A PT9969091 A PT 9969091A PT 99690 A PT99690 A PT 99690A
Authority
PT
Portugal
Prior art keywords
adenosine
alkyl
treatment
ometel
cyclohexyl
Prior art date
Application number
PT99690A
Other languages
English (en)
Other versions
PT99690B (pt
Inventor
Fulvio Gadient
Else Mueller
Maria Milavec
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4039060A external-priority patent/DE4039060A1/de
Priority claimed from GB919116212A external-priority patent/GB9116212D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of PT99690A publication Critical patent/PT99690A/pt
Publication of PT99690B publication Critical patent/PT99690B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT99690A 1990-12-07 1991-12-05 Metodo para o tratamento de doencas utilizando derivados de 2'-o-alquil-adenosina e para a preparacao de composicoes que os contem e de um hidrato de 6-ciclo- -hexil-2'-ometil-adenosina PT99690B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4039060A DE4039060A1 (de) 1990-12-07 1990-12-07 Neue kristallform
GB919116212A GB9116212D0 (en) 1991-07-26 1991-07-26 New use of organic compounds

Publications (2)

Publication Number Publication Date
PT99690A true PT99690A (pt) 1992-10-30
PT99690B PT99690B (pt) 1999-05-31

Family

ID=25899101

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99690A PT99690B (pt) 1990-12-07 1991-12-05 Metodo para o tratamento de doencas utilizando derivados de 2'-o-alquil-adenosina e para a preparacao de composicoes que os contem e de um hidrato de 6-ciclo- -hexil-2'-ometil-adenosina

Country Status (9)

Country Link
EP (2) EP0490818B1 (pt)
JP (2) JPH04290895A (pt)
AT (1) ATE157007T1 (pt)
AU (1) AU647216B2 (pt)
CA (1) CA2056967A1 (pt)
DE (1) DE69127350D1 (pt)
HU (1) HUT61567A (pt)
IE (1) IE914248A1 (pt)
PT (1) PT99690B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
JPH06510427A (ja) * 1991-08-09 1994-11-24 マサチユセツツ・インスチチユート・オブ・テクノロジー Ｔａｕ／ニューロフィラメント蛋白質キナーゼｐｋ４０及びｐｋ３６
DK62592D0 (pt) * 1992-05-14 1992-05-14 Novo Nordisk As
DK62692D0 (pt) * 1992-05-14 1992-05-14 Novo Nordisk As
EP0601322A3 (en) * 1992-10-27 1994-10-12 Nippon Zoki Pharmaceutical Co Adenosine deaminase inhibitor.
DK155292D0 (da) * 1992-12-23 1992-12-23 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
WO1995030683A1 (en) * 1994-05-10 1995-11-16 Sandoz Ltd. Adenosine derivatives
WO1997033590A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
WO1997033591A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
AU4377397A (en) * 1996-10-14 1998-05-11 Novo Nordisk A/S Novel therapeutically active adenosine derivatives
WO1999006059A2 (en) * 1997-07-30 1999-02-11 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
US5998386A (en) * 1997-09-19 1999-12-07 Feldman; Arthur M. Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue
US6252061B1 (en) 1998-03-23 2001-06-26 Reliable Biopharmaceutical, Inc. Process for the production of 2-halo-6-aminopurine derivatives
JP3619017B2 (ja) 1998-06-24 2005-02-09 日本臓器製薬株式会社 新規アラビノシルアデニン誘導体
ATE475432T1 (de) 2000-09-08 2010-08-15 Daiichi Sankyo Co Ltd Arzneimittel für herzversagen
EP1258247A1 (en) * 2001-05-14 2002-11-20 Aventis Pharma Deutschland GmbH Adenosine analogues for the treatment of insulin resistance syndrome and diabetes
JP5145563B2 (ja) * 2005-11-24 2013-02-20 国立大学法人北海道大学 神経変性疾患治療薬
BRPI0713902A2 (pt) 2006-06-27 2012-11-27 Biovitrum Ab compostos terapêuticos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230160A1 (de) * 1972-06-21 1974-01-31 Merck Patent Gmbh Adenosinderivat
AU579412B2 (en) * 1984-10-26 1988-11-24 Warner-Lambert Company N` - substituted adenosines
WO1988003147A1 (en) * 1986-10-31 1988-05-05 Warner-Lambert Company Selected n6-substituted adenosines having selective a2 binding activity
AU8274187A (en) * 1986-10-31 1988-05-25 Warner-Lambert Company Heteroaromatic derivatives of adenosine
JPH0723394B2 (ja) 1986-11-27 1995-03-15 日本臓器製薬株式会社 新規アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
US4962194A (en) * 1987-04-02 1990-10-09 Warner-Lambert Company Method of preparing 51,N6-disubstituted adenosines from inosines
GB2226027B (en) * 1988-12-13 1992-05-20 Sandoz Ltd Adenosine derivatives,their production and use
JPH0725785B2 (ja) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物

Also Published As

Publication number Publication date
HUT61567A (en) 1993-01-28
ATE157007T1 (de) 1997-09-15
HU913662D0 (en) 1992-02-28
IE914248A1 (en) 1992-06-17
JPH04290895A (ja) 1992-10-15
AU647216B2 (en) 1994-03-17
JPH09110700A (ja) 1997-04-28
CA2056967A1 (en) 1992-06-08
DE69127350D1 (de) 1997-09-25
AU8888791A (en) 1992-06-11
PT99690B (pt) 1999-05-31
EP0774259A1 (en) 1997-05-21
EP0490818B1 (en) 1997-08-20
EP0490818A1 (en) 1992-06-17

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Effective date: 19920612

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Effective date: 20000831