KR890003369A - 약제학적 제제 - Google Patents
약제학적 제제 Download PDFInfo
- Publication number
- KR890003369A KR890003369A KR1019880010430A KR880010430A KR890003369A KR 890003369 A KR890003369 A KR 890003369A KR 1019880010430 A KR1019880010430 A KR 1019880010430A KR 880010430 A KR880010430 A KR 880010430A KR 890003369 A KR890003369 A KR 890003369A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- alkyl
- formula
- phenylsulfone
- propenyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (17)
- 광 손상된 피부와 관련된 질환의 국소 치료를 위한 약제의 제조에 사용되는 일반식 (Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염.상긱식에서, n은 1 또는 2이고 ; Z 는 -S(O)mR 이며 ; m 은 0,1 또는 2이고 ; R 은 저급-알킬, 저급-알케닐, 저급-알키닐, 저급-알콕시-저급-알킬, 저급-알카노일-저급-알킬, 히드록시-저급-알킬, 할로-저급-알킬 또는 저급-카브알콕시-저급-알킬이거나, m이 1 또는 2인 경우, R 이 또한 저급-알콕시, 히드록시, 모노-저급-알킬 아미노 또는 디-저급-알킬 아미노이다.
- 제 1 항에 있어서, 제 1 항에 따른 용도를 위한, 화합물 에틸 p-[2-(5,6,7,8-테트라히드로-5,5,8,8-테트라메틸-2-나프틸)-프로페닐] 페닐술폰을 제외한 화합물.
- 제 1 항에 있어서, 제 1 항에 따른 용도를 위한 n 이 2 이고, m 이 2이며, R이 에틸을 제외한 저급알킬인 화합물.
- 제 1 항에 따른 용도를 위한 메틸 p-[2-(5,6,7,8- 테트라히드로-5,5,8,8-테트라메틸-2-나프틸)프로페닐]페닐술폰.
- 제 1 항에 있어서, 상기 언급된 국소용 조성물이 일반식 (Ⅰ)의 화합물을 조성물의 약 0,00001 내지 약 1.0중량%의 양으로 함유하는 제 1 항에 따른 용도를 위한 화합물.
- 제 1 항에 있어서, 상기 언급된 국소용 조성물이 일반식 (Ⅰ)의 화합물을 조성물의 약 0,0001 내지 약 0.1중량%의 양으로 함유하는 제 1 항에 따른 용도를 위한 화합물.
- 광손상된 피부와 관련된 질환의 국소 치료에 사용하기 위한 제 1 항에 따르는 일반식 (Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염.
- 제7항에 따른용도를 위한, 화합물에틸 p-[2-(5,6,7,8-테트라히드로-5,5,8,8-테트라메틸-2-나프틸)프로페닐]페닐술폰을 제외한 제 1 항에 따른 일반식 (Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염.
- 제 7 항에 따른 용도를 위한 n 이 2이고, m 이 2이며 R이 에틸 이외의 저급 알킬인 제 1 항에 따른 일반식(Ⅰ)의 화합물.
- 제 7 항에 따른 용도를 위한 메틸 p-[2-5,6,7,8-테트라히드로-5,5,8,8-테트라메틸-2-나프틸)프로페닐]페닐술폰.
- 특히 실시예와 관련하여 전술한 바와 같은 발명.
- 광 손상된 피부와 관련된 질환을 치료할 필요가 있는 환자의 피부 영역에 일반식 (Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염을 상기 피부 영역의 광 손상의 결과를 역전시키는데 유효한 양으로 국소적으로 투여함을 특징으로 하여, 광 손상된 피부와 관련된 질환을 치료하는 방법.상기식에서, n 은 1 또는 2 이고 ; Z 는 -S(O)mR이며 ; m 은 0,1 또는 2이고 ; R은 저급-알킬, 저급-알케닐, 저급-알키닐, 저급-알콕시-저급-알킬, 저급-알카노일-저급-알킬, 히드록시-저급-알킬, 할로-저급-알킬 또는 저급-카브알콕시-저급-알킬이거나, m이 1 또는 2인 경우, R은 또한 저급-알콕시, 히드록시, 모노-저급-알킬 아미노 또는 디-저급-알킬 아미노이다.
- 제 12 항에 있어서, 일반식 (Ⅰ)의 화합물에서 n 이 2이고, m이 2이며 R이 에틸 이외의 저급 알킬인 방법.
- 제 12 항에 있어서, 일반식 (Ⅰ)의 화합물이 메틸 p-[2-(5,6,7,8-테트라히드로-5,5,7,8-테트라메틸-2-니프틸)프로페닐]페닐술폰인 방법.
- 제 12 항에 있어서, 일반식 (Ⅰ)의 화합물을, 적어도 0.0001중량%의 상기 일반식(Ⅰ)의 화합물 및 피부학적으로 허용되는 불활성 담체를 함유하는 국소용 조성물로 투여하는 방법.
- 제 12 항에 있어서, 상기 국소용 조성물이 일반식 (Ⅰ)의 화합물을 조성물의 약 0.00001 내지 약 1.0중량%의 양으로 함유하는 방법.
- 제 12 항에 있어서, 상기 국소용 조성물이 일반식 (Ⅰ)의 화합물을 조성물의 약 0.0001 내지 약 0.1중량%의 양으로 함유하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8699287A | 1987-08-19 | 1987-08-19 | |
US086,992 | 1987-08-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890003369A true KR890003369A (ko) | 1989-04-14 |
Family
ID=22202176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880010430A KR890003369A (ko) | 1987-08-19 | 1988-08-17 | 약제학적 제제 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0303915B1 (ko) |
JP (1) | JPH0627063B2 (ko) |
KR (1) | KR890003369A (ko) |
AT (1) | ATE89723T1 (ko) |
AU (1) | AU610632B2 (ko) |
CA (1) | CA1329553C (ko) |
DE (1) | DE3881299D1 (ko) |
HU (1) | HU203195B (ko) |
IE (1) | IE62691B1 (ko) |
IL (1) | IL87488A0 (ko) |
PH (1) | PH24867A (ko) |
ZA (1) | ZA885192B (ko) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264578A (en) | 1987-03-20 | 1993-11-23 | Allergan, Inc. | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity |
US5602130A (en) * | 1987-03-20 | 1997-02-11 | Allergan | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
US5272156A (en) * | 1989-09-19 | 1993-12-21 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
US5183827A (en) * | 1989-09-19 | 1993-02-02 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
US5264456A (en) * | 1989-12-29 | 1993-11-23 | Allergan, Inc. | Acetylenes disubstituted with a furyl group and a substituted phenyl group having retinoid like activity |
US5324840A (en) * | 1992-06-11 | 1994-06-28 | Allergan, Inc. | Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects |
CH686285A5 (fr) * | 1992-08-06 | 1996-02-29 | Beiersdorf Ag | Preparation cosmetique ou pharmaceutique servant a retarder le vieillissement de la peau humaine. |
US6172115B1 (en) | 1993-02-11 | 2001-01-09 | Allergan Sales, Inc. | Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid |
US5455265A (en) | 1993-02-11 | 1995-10-03 | Allergan, Inc. | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors |
US5475022A (en) * | 1993-10-18 | 1995-12-12 | Allergan, Inc. | Phenyl or heteroaryl and tetrahydronaphthyl substituted diene compounds having retinoid like biological activity |
US5426118A (en) * | 1993-12-30 | 1995-06-20 | Allergan, Inc. | [4-(1,2-epoxycyclohexanyl)but-3-en-1-ynyl]aromatic and heteroaromatic acids and derivatives having retinoid-like biological activity |
US5498755A (en) * | 1994-08-23 | 1996-03-12 | Chandraratna; Roshantha A. | Disubstituted aryl and heteroaryl imines having retinoid-like biological activity |
US5648514A (en) | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
US5618931A (en) * | 1994-12-29 | 1997-04-08 | Allergan | Acetylenes disubstituted with a 5 substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
US5543534A (en) * | 1994-12-29 | 1996-08-06 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity |
US5489584A (en) * | 1994-12-29 | 1996-02-06 | Allergan, Inc. | Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
US5599967A (en) * | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
US5556996A (en) * | 1994-12-29 | 1996-09-17 | Allergan | Oxiranyls disubstituted with a phenyl group and a substituted chromanyl or tetrahydroquinolinyl group having retinoid like activity |
US5618943A (en) * | 1994-12-29 | 1997-04-08 | Allergan | Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
US5514825A (en) * | 1994-12-29 | 1996-05-07 | Allergan, Inc. | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
US5534641A (en) * | 1994-12-29 | 1996-07-09 | Allergan | Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
US5534261A (en) * | 1995-01-17 | 1996-07-09 | University Of Southern California | Retinoid-based compositions and method for preventing adhesion formation using the same |
US6025388A (en) * | 1995-04-26 | 2000-02-15 | Allergan Sales, Inc. | Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids |
US5616712A (en) * | 1995-05-16 | 1997-04-01 | Allergan | Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-thio-1,2,3,4-tetrahdroquinolinyl, 2-alkylthio-3,4-dihydroquinolinyl or 2-alkoxy-3,4-dihydroquinolinyl group having retinoid-like biological activity |
US5675033A (en) * | 1995-06-06 | 1997-10-07 | Allergan | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
US5917082A (en) | 1995-06-06 | 1999-06-29 | Allergan Sales, Inc. | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
US5958954A (en) | 1995-09-01 | 1999-09-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US6218128B1 (en) | 1997-09-12 | 2001-04-17 | Allergan Sales, Inc. | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities |
US6008204A (en) | 1995-09-01 | 1999-12-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US5952345A (en) | 1995-09-01 | 1999-09-14 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
AU7598596A (en) * | 1995-11-01 | 1997-05-22 | Allergan, Inc. | Sulfides, sulfoxides and sulfones disubstituted with a tetrahydronaphthalenyl, chromanyl, thiochromanyl or tetrahydroquinolinyl and substituted phenyl or heteroaryl group, having retinoid-like biological activity |
US5675024A (en) | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
US5663357A (en) | 1995-11-22 | 1997-09-02 | Allergan | Substituted heteroarylamides having retinoid-like biological activity |
US5965606A (en) | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
US5688957A (en) * | 1995-12-29 | 1997-11-18 | Allergan | (3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!aryl and (3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!heteroaryl carboxylic acids and esters having retinoid-like biological activity |
US5808124A (en) * | 1996-06-21 | 1998-09-15 | Allergan | O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5773594A (en) | 1996-06-21 | 1998-06-30 | Allergan | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5763635A (en) | 1996-06-21 | 1998-06-09 | Allergan | Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity |
US5747542A (en) * | 1996-06-21 | 1998-05-05 | Allergan | Oxo-substituted tetrahydronaphthalene derivatives having retinold and/or retinoid antagonist-like biological activity |
US5723666A (en) * | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US6555690B2 (en) | 1996-06-21 | 2003-04-29 | Allergan, Inc. | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5741896A (en) | 1996-06-21 | 1998-04-21 | Allergan | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5739338A (en) * | 1996-11-05 | 1998-04-14 | Allergan | N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity |
US5728846A (en) | 1996-12-12 | 1998-03-17 | Allergan | Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives |
US5760276A (en) * | 1997-03-06 | 1998-06-02 | Allergan | Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity |
US6037488A (en) | 1997-04-19 | 2000-03-14 | Allergan Sales, Inc. | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity |
US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
DE19926779A1 (de) * | 1999-06-11 | 2000-12-14 | Basf Ag | Verwendung von substituierten Vinyl-tetrahydronaphthalinen und Vinyl-benzotetrahydropyranen als Lichtschutzmittel |
US6369225B1 (en) | 2000-08-29 | 2002-04-09 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
US6380256B1 (en) | 2000-08-29 | 2002-04-30 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
US6313107B1 (en) | 2000-08-29 | 2001-11-06 | Allergan Sales, Inc. | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS235526B2 (en) * | 1981-02-13 | 1985-05-15 | Hoffmann La Roche | Method of tetrahydronaphtalene and indane new derivatives production |
CA1162200A (en) * | 1981-02-13 | 1984-02-14 | Michael Klaus | Process for the manufacture of indanyl (or tetrahydronaphthyl)propenyl phenyl derivatives |
US4603146A (en) * | 1984-05-16 | 1986-07-29 | Kligman Albert M | Methods for retarding the effects of aging of the skin |
WO1988000466A1 (en) * | 1986-07-16 | 1988-01-28 | Kligman Albert M | Methods for treatment of sundamaged human skin with retinoids |
US4889847A (en) * | 1986-11-03 | 1989-12-26 | Ortho Pharmaceutical Corporation | Prevention of glucocorticoid-induced skin atrophy |
-
1988
- 1988-07-18 ZA ZA885192A patent/ZA885192B/xx unknown
- 1988-08-05 AT AT88112801T patent/ATE89723T1/de not_active IP Right Cessation
- 1988-08-05 EP EP88112801A patent/EP0303915B1/de not_active Expired - Lifetime
- 1988-08-05 DE DE8888112801T patent/DE3881299D1/de not_active Expired - Fee Related
- 1988-08-17 HU HU884372A patent/HU203195B/hu not_active IP Right Cessation
- 1988-08-17 KR KR1019880010430A patent/KR890003369A/ko not_active Application Discontinuation
- 1988-08-17 CA CA000574958A patent/CA1329553C/en not_active Expired - Fee Related
- 1988-08-18 JP JP63203952A patent/JPH0627063B2/ja not_active Expired - Lifetime
- 1988-08-18 PH PH37425A patent/PH24867A/en unknown
- 1988-08-18 IL IL87488A patent/IL87488A0/xx not_active IP Right Cessation
- 1988-08-18 IE IE252388A patent/IE62691B1/en not_active IP Right Cessation
- 1988-08-19 AU AU21184/88A patent/AU610632B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0303915B1 (de) | 1993-05-26 |
IE882523L (en) | 1989-02-19 |
AU610632B2 (en) | 1991-05-23 |
ATE89723T1 (de) | 1993-06-15 |
IE62691B1 (en) | 1995-02-22 |
PH24867A (en) | 1990-12-26 |
IL87488A0 (en) | 1989-01-31 |
ZA885192B (en) | 1989-04-26 |
DE3881299D1 (de) | 1993-07-01 |
JPH0627063B2 (ja) | 1994-04-13 |
HUT48116A (en) | 1989-05-29 |
HU203195B (en) | 1991-06-28 |
EP0303915A3 (en) | 1990-08-08 |
CA1329553C (en) | 1994-05-17 |
EP0303915A2 (de) | 1989-02-22 |
JPS6470457A (en) | 1989-03-15 |
AU2118488A (en) | 1989-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR890003369A (ko) | 약제학적 제제 | |
KR900701282A (ko) | 심장 또는 뇌의 허혈성 질환의 치료, 예방제 | |
KR920002144A (ko) | 아연 l-카르노신 염 또는 이의 착화합물을 유효성분으로 함유하는 염증성 장질환 예방 및 치료제 | |
KR960705573A (ko) | 에스트로겐 조성물 및 신경 보호 방법(Estrogen Compositions and Method for Neuroprotection) | |
KR900017590A (ko) | 좌창(Acne)치료방법 및 그 약제 조성물 | |
KR890011592A (ko) | 기관내 허혈병의 치료용 조성물 | |
ATE16191T1 (de) | Stabile salze von s-adenosinylmethionin, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen welche als aktive substanz diese derivate enthalten. | |
KR940005274A (ko) | 쇼그렌(Sjoegren)증후군 치료제 | |
KR950007848A (ko) | (S)-(-)-α-에틸-2-옥소-1-피롤리딘아세트아미드를 사용한 불안치료방법 | |
PT99690A (pt) | Metodo para o tratamento de doencas utilizando derivados de 2'-o-alquil-adenosina e para a preparacao de composicoes que os contem e de um hidrato de 6-ciclo- -hexil-2'-ometil-adenosina | |
US5188817A (en) | Method of treatment for periodontitis | |
KR950000663A (ko) | 트리테르펜 유도체 및 이를 함유하는 엔도텔린-수용체 길항물질 | |
KR900016135A (ko) | 피부 및 점막-상피의 질환 치료용 4-퀴놀린 카복실산 유도체 | |
KR950016727A (ko) | 트롬보모듈린 발현을 증가시키는 방법 | |
KR950016760A (ko) | 치질 치료제 | |
KR950703527A (ko) | 프로스타글란딘 유도체 | |
DE69501359D1 (de) | Verwendung von Phosphatdiestern zur Behandlung von Erkrankungen der Retina | |
KR950031085A (ko) | 표피증식 질환 치료용 의약 조성물 | |
KR890012942A (ko) | 5-치환된 오르니틴 유도체 | |
KR950701638A (ko) | 푸린 동족체의 항비루스성 포스폰산 유도체(Antiviral phosphonic acid derivatives of purine analogues) | |
KR880007068A (ko) | 13-시스 레티노산의 용도 | |
US5006510A (en) | Method for relieving chronic pain with a somatostatin analog composition | |
KR910002442A (ko) | 안구질환을 치료하는 방법 및 제약학적 조성물 | |
KR880002518A (ko) | 소염제 조성물 | |
KR890008136A (ko) | 항균성 9-데옥소-9a-알릴 및 프로파길-9a-아자-9a-호모에리트로 마이신 A 유도체 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |