PT99647A - Processo para a preparacao de somatotropinas com alteracoes na regiao de alfa- helice 3 na regiao de alfa-helice 2 suas combinacoes e combinacoes com outras mutacoes - Google Patents
Processo para a preparacao de somatotropinas com alteracoes na regiao de alfa- helice 3 na regiao de alfa-helice 2 suas combinacoes e combinacoes com outras mutacoes Download PDFInfo
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- PT99647A PT99647A PT99647A PT9964791A PT99647A PT 99647 A PT99647 A PT 99647A PT 99647 A PT99647 A PT 99647A PT 9964791 A PT9964791 A PT 9964791A PT 99647 A PT99647 A PT 99647A
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- 150000007523 nucleic acids Chemical class 0.000 description 1
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- 229960005190 phenylalanine Drugs 0.000 description 1
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- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
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- 238000012868 site-directed mutagenesis technique Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- 238000010998 test method Methods 0.000 description 1
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- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/621,197 US5310882A (en) | 1990-11-30 | 1990-11-30 | Somatotropins with alterations in the α-helix 3 region |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT99647A true PT99647A (pt) | 1992-10-30 |
Family
ID=24489157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99647A PT99647A (pt) | 1990-11-30 | 1991-11-29 | Processo para a preparacao de somatotropinas com alteracoes na regiao de alfa- helice 3 na regiao de alfa-helice 2 suas combinacoes e combinacoes com outras mutacoes |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5310882A (fi) |
| EP (1) | EP0488279A3 (fi) |
| JP (1) | JPH0570497A (fi) |
| KR (1) | KR920009414A (fi) |
| AU (1) | AU662492B2 (fi) |
| CA (1) | CA2056564A1 (fi) |
| FI (1) | FI915655A (fi) |
| HU (1) | HUT62328A (fi) |
| IE (1) | IE914154A1 (fi) |
| IL (1) | IL100170A0 (fi) |
| NO (1) | NO914720L (fi) |
| NZ (1) | NZ240720A (fi) |
| PT (1) | PT99647A (fi) |
| TW (1) | TW205045B (fi) |
| ZA (1) | ZA919452B (fi) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4805393A (en) * | 1992-08-07 | 1994-03-03 | Pitman-Moore, Inc. | Improving the body composition of fish via the administration of porcine somatotropin (pst) |
| ZA936811B (en) * | 1992-10-28 | 1995-03-15 | Upjohn Co | Somatotropin modifications |
| WO2002026967A2 (en) * | 2000-09-25 | 2002-04-04 | Thomas Jefferson University | Targeted gene correction by single-stranded oligodeoxynucleotides |
| WO2004022593A2 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| US7772162B2 (en) * | 2006-03-27 | 2010-08-10 | Board Of Regents, The University Of Texas System | Use of fluorocarbon surfactants to improve the productivity of gas and gas condensate wells |
| US20070225176A1 (en) * | 2006-03-27 | 2007-09-27 | Pope Gary A | Use of fluorocarbon surfactants to improve the productivity of gas and gas condensate wells |
| US20080047706A1 (en) * | 2006-08-23 | 2008-02-28 | Pope Gary A | Method of obtaining a treatment composition for improving the productivity of hydrocarbon producing wells |
| EP2137280A4 (en) * | 2007-03-23 | 2010-09-08 | Univ Texas | METHOD FOR TREATING A FRACTURED FORMATION |
| EP2132240A4 (en) * | 2007-03-23 | 2010-03-10 | Univ Texas | COMPOSITIONS AND METHOD FOR TREATING A WATER BLOCKED DRILL OXIDE |
| MX2009010142A (es) * | 2007-03-23 | 2010-03-22 | Univ Texas | Composiciones y metodos para tratar un pozo de agua bloqueado. |
| RU2009136515A (ru) * | 2007-03-23 | 2011-04-27 | Борд Оф Риджентс, Зе Юниверсити Оф Техас Систем (Us) | Способ и система для обработки углеводородных формаций |
| CN107056929A (zh) * | 2009-12-21 | 2017-08-18 | Ambrx 公司 | 经过修饰的猪促生长素多肽和其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68929273T2 (de) * | 1988-08-24 | 2001-07-05 | American Cyanamid Co., Wayne | Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung |
| WO1990004788A1 (en) * | 1988-10-28 | 1990-05-03 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
| EP0482124B1 (en) * | 1989-07-10 | 1993-12-22 | The Upjohn Company | Somatotropin analogs |
| WO1991005853A1 (en) * | 1989-10-12 | 1991-05-02 | Ohio University | Growth hormone antagonists |
-
1990
- 1990-11-30 US US07/621,197 patent/US5310882A/en not_active Expired - Fee Related
-
1991
- 1991-11-25 NZ NZ240720A patent/NZ240720A/en unknown
- 1991-11-27 IL IL100170A patent/IL100170A0/xx unknown
- 1991-11-28 EP EP19910120390 patent/EP0488279A3/en not_active Withdrawn
- 1991-11-28 CA CA002056564A patent/CA2056564A1/en not_active Abandoned
- 1991-11-29 FI FI915655A patent/FI915655A/fi not_active Application Discontinuation
- 1991-11-29 HU HU913724A patent/HUT62328A/hu unknown
- 1991-11-29 AU AU88293/91A patent/AU662492B2/en not_active Expired - Fee Related
- 1991-11-29 IE IE415491A patent/IE914154A1/en not_active Application Discontinuation
- 1991-11-29 NO NO91914720A patent/NO914720L/no unknown
- 1991-11-29 PT PT99647A patent/PT99647A/pt not_active Application Discontinuation
- 1991-11-29 JP JP3339492A patent/JPH0570497A/ja active Pending
- 1991-11-29 ZA ZA919452A patent/ZA919452B/xx unknown
- 1991-11-29 TW TW080109400A patent/TW205045B/zh active
- 1991-11-30 KR KR1019910021902A patent/KR920009414A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US5310882A (en) | 1994-05-10 |
| NO914720L (no) | 1992-06-01 |
| HUT62328A (en) | 1993-04-28 |
| ZA919452B (en) | 1992-08-26 |
| EP0488279A2 (en) | 1992-06-03 |
| TW205045B (fi) | 1993-05-01 |
| FI915655A (fi) | 1992-05-31 |
| IE914154A1 (en) | 1992-06-03 |
| EP0488279A3 (en) | 1993-02-24 |
| IL100170A0 (en) | 1992-08-18 |
| NO914720D0 (no) | 1991-11-29 |
| NZ240720A (en) | 1995-07-26 |
| JPH0570497A (ja) | 1993-03-23 |
| FI915655A0 (fi) | 1991-11-29 |
| CA2056564A1 (en) | 1992-05-31 |
| HU913724D0 (en) | 1992-02-28 |
| AU8829391A (en) | 1992-06-04 |
| AU662492B2 (en) | 1995-09-07 |
| KR920009414A (ko) | 1992-06-25 |
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