PT96994A - Metodo para purificacao de hiv gp12o, de forma a proporcionar um glicopeptido - Google Patents
Metodo para purificacao de hiv gp12o, de forma a proporcionar um glicopeptidoInfo
- Publication number
- PT96994A PT96994A PT96994A PT9699491A PT96994A PT 96994 A PT96994 A PT 96994A PT 96994 A PT96994 A PT 96994A PT 9699491 A PT9699491 A PT 9699491A PT 96994 A PT96994 A PT 96994A
- Authority
- PT
- Portugal
- Prior art keywords
- protein
- hiv
- binding affinity
- glycopeptide
- substantially identical
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title abstract 2
- 108010015899 Glycopeptides Proteins 0.000 title abstract 2
- 102000002068 Glycopeptides Human genes 0.000 title abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 230000027455 binding Effects 0.000 abstract 3
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 238000001261 affinity purification Methods 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000006916 protein interaction Effects 0.000 abstract 1
- 238000004007 reversed phase HPLC Methods 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Table Devices Or Equipment (AREA)
- Cookers (AREA)
- Gloves (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49085890A | 1990-03-09 | 1990-03-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT96994A true PT96994A (pt) | 1991-10-31 |
PT96994B PT96994B (pt) | 1998-07-31 |
Family
ID=23949786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT96994A PT96994B (pt) | 1990-03-09 | 1991-03-08 | Metodo para purificacao da gp12o de hiv, de forma a proporcionar um glicopeptido |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0519001B2 (pt) |
JP (2) | JP2624894B2 (pt) |
AT (1) | ATE207930T1 (pt) |
CA (1) | CA2077753C (pt) |
DE (1) | DE69132795T3 (pt) |
IE (1) | IE910779A1 (pt) |
PT (1) | PT96994B (pt) |
WO (1) | WO1991013906A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE207930T1 (de) * | 1990-03-09 | 2001-11-15 | Chiron Corp | Gereinigtes gp120, in dem seine natürliche konformation erhalten bleibt |
EP0527760B1 (en) * | 1990-04-03 | 1995-07-19 | Genentech, Inc. | Methods and compositions for vaccination against hiv |
US7041293B1 (en) | 1990-04-03 | 2006-05-09 | Genentech, Inc. | HIV env antibodies |
DK0679187T4 (da) † | 1993-01-16 | 2001-09-17 | Manfred Schawaller | Fremgangsmåde til udvinding af native, oligomere, glycosylerede ektodomæner fra virale membranproteiner, og deres anvendelse, især som vaccine mod HIV |
EP0708659A4 (en) | 1993-06-07 | 2000-08-23 | Genentech Inc | HIV ENVELOPE POLYPEPTIDE |
JP3313117B2 (ja) * | 1994-03-22 | 2002-08-12 | ザ イミューン リスポンス コーポレイション | ウイルス粒子の効率の高い生産および単離 |
KR100374308B1 (ko) * | 1995-07-27 | 2003-12-18 | 주식회사 엘지생명과학 | 재조합차이니스햄스터오바리세포로부터발현된수두바이러스의지피i당단백질의정제방법 |
US6585979B1 (en) | 1996-07-08 | 2003-07-01 | Genentech, Inc. | HIV envelope polypeptides and immunogenic composition |
ES2299276T3 (es) | 1998-12-31 | 2008-05-16 | Novartis Vaccines And Diagnostics, Inc. | Polipeptidos env del vih modificados. |
AU2487300A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
CA2634992C (en) | 2001-07-05 | 2012-10-16 | Novartis Vaccines And Diagnostics, Inc. | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
US20030170614A1 (en) | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
US7786288B2 (en) * | 2003-10-23 | 2010-08-31 | Karp Nelson M | Immunizing compositions encoding an epitope obtained from the HIV-1 capsid protein cyclophilin A binding site |
JPWO2006011580A1 (ja) * | 2004-07-27 | 2008-05-01 | ジェノミディア株式会社 | ウイルスエンベロープの精製方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01120284A (ja) * | 1987-11-05 | 1989-05-12 | Shiro Kato | Hiv不完全粒子および該製造方法 |
ATE207930T1 (de) * | 1990-03-09 | 2001-11-15 | Chiron Corp | Gereinigtes gp120, in dem seine natürliche konformation erhalten bleibt |
-
1991
- 1991-03-08 AT AT91906615T patent/ATE207930T1/de not_active IP Right Cessation
- 1991-03-08 IE IE077991A patent/IE910779A1/en not_active IP Right Cessation
- 1991-03-08 CA CA002077753A patent/CA2077753C/en not_active Expired - Lifetime
- 1991-03-08 WO PCT/US1991/001484 patent/WO1991013906A1/en active IP Right Grant
- 1991-03-08 DE DE69132795T patent/DE69132795T3/de not_active Expired - Lifetime
- 1991-03-08 EP EP91906615A patent/EP0519001B2/en not_active Expired - Lifetime
- 1991-03-08 PT PT96994A patent/PT96994B/pt not_active IP Right Cessation
- 1991-03-08 JP JP3507168A patent/JP2624894B2/ja not_active Expired - Lifetime
-
1996
- 1996-07-22 JP JP8192595A patent/JPH09227588A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2624894B2 (ja) | 1997-06-25 |
EP0519001B2 (en) | 2007-12-19 |
CA2077753A1 (en) | 1991-09-10 |
EP0519001A1 (en) | 1992-12-23 |
WO1991013906A1 (en) | 1991-09-19 |
DE69132795D1 (de) | 2001-12-13 |
DE69132795T2 (de) | 2002-06-20 |
EP0519001B1 (en) | 2001-10-31 |
CA2077753C (en) | 2000-02-29 |
PT96994B (pt) | 1998-07-31 |
IE910779A1 (en) | 1991-09-11 |
JPH09227588A (ja) | 1997-09-02 |
DE69132795T3 (de) | 2008-07-10 |
JPH05505616A (ja) | 1993-08-19 |
ATE207930T1 (de) | 2001-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT96994A (pt) | Metodo para purificacao de hiv gp12o, de forma a proporcionar um glicopeptido | |
Furthmayr et al. | Fractionation of the major sialoglycopeptides of the human red blood cell membrane | |
DK0458841T3 (da) | Fremgangsmåde til anvendelse og fremstilling af peptider | |
MX9603637A (es) | Purificacion de anticuerpo. | |
ES2146600T3 (es) | Condroitinasa, procedimiento para su preparacion y composicion farmaceutica. | |
ES2188665T3 (es) | Procedimiento para la preparacion de fragmentos de cardiodilatina, fragmentos de cardiodilatina muy purificados y productos intermedios para su preparacion. | |
PL374311A1 (en) | Methods for purifying protein | |
DK0731812T3 (da) | Fremgangsmåde til isolering af Poly-beta-1-4-N-Acetylglucosamin | |
SE8402861D0 (sv) | Rening av biologiskt material | |
CA1133898A (en) | Purification of interferon | |
ES2058538T3 (es) | Compuestos de proteina a purificados y procedimiento para su preparacion. | |
PT98669A (pt) | Processo para a preparacao da estrutura proteica da toxina de gelonina vegetal | |
JP2004512539A (ja) | 複合分離法 | |
Zlotkin et al. | A protein toxic to crustacea from the venom of the scorpion Androctonus australis | |
DK0402205T3 (da) | Fremgangsmåde til fremstilling af oprensede albuminopløsninger | |
EP0239311A3 (en) | Mutual separation of proteins | |
EP0252064A3 (en) | Preparations active against pseudomonas aeruginosa infections, and process for their preparation | |
CA2369827A1 (en) | Separation of plasma components | |
EP0117470B1 (en) | Process for producing interferon (ifn-gamma) subtypes 26k and 21k | |
Kobayashi et al. | Improved procedure for the isolation of J-chain from human polymeric immunoglobulins | |
CA1270597A (en) | Thf compositions | |
Polo et al. | HPLC purification of the main allergen of Parietaria judaica pollen | |
DE3686961D1 (de) | Polydisperse native pseudomonas-flagella(h)-antigene (fag) und verfahren zu ihrer gewinnung. | |
Ishaq et al. | Purification and identification of antigenic polypeptides of Sm and RNP antigens of goat liver | |
TH17361A (th) | โปรตีนจากรีคอมบิแนนท์ มิวแทนท์ ของpasteurella multocida กรรมวิธีสำหรับเตรียมลำดับดีเอนเอที่มีประมวลรหัสของโปรตีนเรพลิคอนที่มีลำดับดีเอนเอและเซลล์ที่ทรานสฟอร์มด้วยเรพลิคอนดังกล่าวชนิดเดียวกัน |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB1A | Laying open of patent application |
Effective date: 19910710 |
|
FG3A | Patent granted, date of granting |
Effective date: 19980414 |
|
PD4A | Change of proprietorship |
Owner name: NOVARTIS VACCINES AND DIAGNOSTICS, INC., US Effective date: 20080215 |
|
MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20130415 |