CA2077753C - Purified gp120 composition retaining natural conformation - Google Patents

Purified gp120 composition retaining natural conformation Download PDF

Info

Publication number
CA2077753C
CA2077753C CA002077753A CA2077753A CA2077753C CA 2077753 C CA2077753 C CA 2077753C CA 002077753 A CA002077753 A CA 002077753A CA 2077753 A CA2077753 A CA 2077753A CA 2077753 C CA2077753 C CA 2077753C
Authority
CA
Canada
Prior art keywords
hiv
protein
chromatography
collection
binding affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002077753A
Other languages
English (en)
French (fr)
Other versions
CA2077753A1 (en
Inventor
Nancy L. Haigwood
Carl Scandella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23949786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2077753(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of CA2077753A1 publication Critical patent/CA2077753A1/en
Application granted granted Critical
Publication of CA2077753C publication Critical patent/CA2077753C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cookers (AREA)
  • Gloves (AREA)
  • Table Devices Or Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002077753A 1990-03-09 1991-03-08 Purified gp120 composition retaining natural conformation Expired - Lifetime CA2077753C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49085890A 1990-03-09 1990-03-09
US490,858 1990-03-09
PCT/US1991/001484 WO1991013906A1 (en) 1990-03-09 1991-03-08 PURIFIED gp120 COMPOSITION RETAINING NATURAL CONFORMATION

Publications (2)

Publication Number Publication Date
CA2077753A1 CA2077753A1 (en) 1991-09-10
CA2077753C true CA2077753C (en) 2000-02-29

Family

ID=23949786

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002077753A Expired - Lifetime CA2077753C (en) 1990-03-09 1991-03-08 Purified gp120 composition retaining natural conformation

Country Status (8)

Country Link
EP (1) EP0519001B2 (pt)
JP (2) JP2624894B2 (pt)
AT (1) ATE207930T1 (pt)
CA (1) CA2077753C (pt)
DE (1) DE69132795T3 (pt)
IE (1) IE910779A1 (pt)
PT (1) PT96994B (pt)
WO (1) WO1991013906A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE910779A1 (en) * 1990-03-09 1991-09-11 Chiron Corp PURIFIED gp120 COMPOSITION RETAINING NATURAL CONFORMATION
US7041293B1 (en) 1990-04-03 2006-05-09 Genentech, Inc. HIV env antibodies
ATE125157T1 (de) * 1990-04-03 1995-08-15 Genentech Inc Methoden und zusammensetzungen zur impfung gegen hiv.
DK0679187T4 (da) 1993-01-16 2001-09-17 Manfred Schawaller Fremgangsmåde til udvinding af native, oligomere, glycosylerede ektodomæner fra virale membranproteiner, og deres anvendelse, især som vaccine mod HIV
CA2164505A1 (en) 1993-06-07 1994-12-22 Phillip W. Berman Hiv envelope polypeptides
WO1995025789A1 (en) * 1994-03-22 1995-09-28 The Immune Response Corporation Highly efficient production and isolation of viral particles
KR100374308B1 (ko) * 1995-07-27 2003-12-18 주식회사 엘지생명과학 재조합차이니스햄스터오바리세포로부터발현된수두바이러스의지피i당단백질의정제방법
US6585979B1 (en) 1996-07-08 2003-07-01 Genentech, Inc. HIV envelope polypeptides and immunogenic composition
US6689879B2 (en) 1998-12-31 2004-02-10 Chiron Corporation Modified HIV Env polypeptides
WO2000039304A2 (en) 1998-12-31 2000-07-06 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US7211659B2 (en) 2001-07-05 2007-05-01 Chiron Corporation Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
US20050214318A1 (en) * 2003-10-23 2005-09-29 Nmk Research, Llc Immunogenic composition and method of developing a vaccine based on fusion protein
WO2006011580A1 (ja) * 2004-07-27 2006-02-02 Genomidea, Inc. ウイルスエンベロープの精製方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01120284A (ja) * 1987-11-05 1989-05-12 Shiro Kato Hiv不完全粒子および該製造方法
IE910779A1 (en) * 1990-03-09 1991-09-11 Chiron Corp PURIFIED gp120 COMPOSITION RETAINING NATURAL CONFORMATION

Also Published As

Publication number Publication date
JPH09227588A (ja) 1997-09-02
EP0519001B2 (en) 2007-12-19
ATE207930T1 (de) 2001-11-15
DE69132795T3 (de) 2008-07-10
EP0519001B1 (en) 2001-10-31
IE910779A1 (en) 1991-09-11
DE69132795D1 (de) 2001-12-13
CA2077753A1 (en) 1991-09-10
JP2624894B2 (ja) 1997-06-25
JPH05505616A (ja) 1993-08-19
EP0519001A1 (en) 1992-12-23
DE69132795T2 (de) 2002-06-20
PT96994A (pt) 1991-10-31
PT96994B (pt) 1998-07-31
WO1991013906A1 (en) 1991-09-19

Similar Documents

Publication Publication Date Title
US5614612A (en) Purified gp120 compositions retaining natural conformation
Haigwood et al. Importance of hypervariable regions of HIV-1 gp120 in the generation of virus neutralizing antibodies
US5639854A (en) Tandem synthetic HIV-1 peptides
Girard et al. Vaccine-induced protection of chimpanzees against infection by a heterologous human immunodeficiency virus type 1
McLain et al. Stimulation of neutralizing antibodies to human immunodeficiency virus type 1 in three strains of mice immunized with a 22 amino acid peptide of gp41 expressed on the surface of a plant virus
US5817792A (en) DNA sequences encoding HIV-1 envelope muteins containing hypervariable domain deletions
AU636944B2 (en) Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens
CA2077753C (en) Purified gp120 composition retaining natural conformation
EP0164403B1 (en) Feline leukemia virus vaccine
EP0436634A1 (en) Hiv proteins and peptides useful in the diagnosis, prophylaxis or therapy of aids
Berzofsky Development of artificial vaccines against HIV using defined epitopes
Natuk et al. Adenovirus-human immunodeficiency virus (HIV) envelope recombinant vaccines elicit high-titered HIV-neutralizing antibodies in the dog model.
Ahmad et al. Reduced virus load in rhesus macaques immunized with recombinant gp160 and challenged with simian immunodeficiency virus
IE921875A1 (en) Vaccine and treatment method for human immunodeficiency¹virus
US5696238A (en) Purified GP120 composition retaining natural conformation
IE83584B1 (en) Purified gp120 composition retaining natural conformation
Haffar et al. HIV-specific humoral and cellular immunity in rabbits vaccinated with recombinant human immunodeficiency virus-like gag-env particles
EP0402088A3 (en) Conjugate immunogen for aids
EP0255190A2 (en) Recombinant polypeptides and their uses, inclusing assay for aids virus
WO1998041536A1 (en) Glycosylation deficient siv and hiv envelope glycoproteins
US5142025A (en) Recombinant HTLV-III proteins and uses thereof
US4789702A (en) Feline leukemia virus vaccine
AU604791B2 (en) Viral vector and recombinant DNA coding, in particular, for the p25 protein of the virus that is a causal agent of aids, infected cell culture, protein obtained, vaccine and antibodies obtained
PT95939A (pt) Processo de producao de particulas de hiv, tornadas recombinantes e nao replicativas, e de vacinas
EP0328390B1 (en) Peptide treatment of refractory infectious diseases

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry