PT91046A - Processo para a preparacao de derivados alquilaminocarbonil-aminodiol de amino--acidos, uteis como agentes anti-hipertensivos - Google Patents

Processo para a preparacao de derivados alquilaminocarbonil-aminodiol de amino--acidos, uteis como agentes anti-hipertensivos

Info

Publication number
PT91046A
PT91046A PT91046A PT9104689A PT91046A PT 91046 A PT91046 A PT 91046A PT 91046 A PT91046 A PT 91046A PT 9104689 A PT9104689 A PT 9104689A PT 91046 A PT91046 A PT 91046A
Authority
PT
Portugal
Prior art keywords
aminodyol
alkylaminocarbonyl
derivatives
preparation
amino acids
Prior art date
Application number
PT91046A
Other languages
English (en)
Other versions
PT91046B (pt
Inventor
Gunnar J Hanson
John S Baran
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT91046A publication Critical patent/PT91046A/pt
Publication of PT91046B publication Critical patent/PT91046B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT91046A 1988-07-01 1989-07-03 Processo para a preparacao de derivados alquilaminocarbonil-aminodiol de amino--acidos, uteis como agentes anti-hipertensivos PT91046B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/214,234 US4902706A (en) 1988-07-01 1988-07-01 Aminoalkylaminocarbonyl aminodiol amino acid derivatives as antihypertensive agents

Publications (2)

Publication Number Publication Date
PT91046A true PT91046A (pt) 1990-02-08
PT91046B PT91046B (pt) 1994-12-30

Family

ID=22798300

Family Applications (2)

Application Number Title Priority Date Filing Date
PT91021A PT91021A (pt) 1988-07-01 1989-06-29 Processo para a preparacao de derivados alquilaminocarbonil-aminodiol de amino--acidos, uteis como agentes anti-hipertensivos
PT91046A PT91046B (pt) 1988-07-01 1989-07-03 Processo para a preparacao de derivados alquilaminocarbonil-aminodiol de amino--acidos, uteis como agentes anti-hipertensivos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT91021A PT91021A (pt) 1988-07-01 1989-06-29 Processo para a preparacao de derivados alquilaminocarbonil-aminodiol de amino--acidos, uteis como agentes anti-hipertensivos

Country Status (6)

Country Link
US (1) US4902706A (pt)
KR (1) KR900001718A (pt)
DK (1) DK326989A (pt)
NO (1) NO892745D0 (pt)
PT (2) PT91021A (pt)
ZA (1) ZA895001B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
EP0326364B1 (en) * 1988-01-26 1994-06-22 Sankyo Company Limited Renin inhibitory oligopeptides, their preparation and use
US5229420A (en) * 1988-07-01 1993-07-20 G. D. Searle & Co. Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents
US5229369A (en) * 1988-07-01 1993-07-20 G. D. Searle & Co. Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
US5178877A (en) * 1991-01-04 1993-01-12 Abbott Laboratories Encapsulated renin inhibitor composition
TW198712B (pt) * 1991-04-17 1993-01-21 Hoffmann La Roche
US5227401A (en) * 1991-10-29 1993-07-13 G. D. Searle & Co. Ethynyl alanine amino diol compounds for treatment of hypertension
US5223535A (en) * 1991-10-29 1993-06-29 G. D. Searle & Co. Propargyl glycine amino propargyl diol compounds for treatment of hypertension
US5330996A (en) * 1991-10-29 1994-07-19 G. D. Searle & Co. Amino acyl amino propargyl diol compounds for treatment of hypertension
US5317039A (en) * 1992-07-20 1994-05-31 G. D. Searle & Co. Cyclopropyl-alanine aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension
US5246969A (en) * 1992-07-20 1993-09-21 G. D. Searle & Co. Di-propargyl-containing aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension
US5314920A (en) * 1992-07-20 1994-05-24 G. D. Searle & Co. Ethynyl-alanine aryl/alkylsulfonyl-terminated amino-diol compounds for treatment of hypertension
US5268391A (en) * 1992-07-20 1993-12-07 C. D. Searle & Co. Propargyl-terminated cycloalkylalkyl-P2-site substituted aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension
US5252591A (en) 1992-08-14 1993-10-12 G. D. Searle & Company Pyridinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5212185A (en) * 1992-08-14 1993-05-18 G. D. Searle & Co. Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5373017A (en) * 1992-08-14 1994-12-13 G. D. Searle & Co. Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5298505A (en) * 1992-08-14 1994-03-29 G. D. Searle & Co. Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension
US5422349A (en) * 1992-08-14 1995-06-06 G. D. Seale & Co. Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5312838A (en) * 1992-09-21 1994-05-17 G. D. Searle & Co. β-alanineamide aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension
US5414018A (en) * 1993-09-24 1995-05-09 G. D. Searle & Co. Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension
US5416119A (en) * 1993-10-25 1995-05-16 G. D. Searle & Co. Alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkyl-alanine amino-diol compounds for treatment of hypertension
US5432201A (en) * 1993-11-22 1995-07-11 G. D. Searle & Co. Alkylaminoalkyl-sulfonyl-terminated β-alanineamide amino-diol compounds for treatment of hypertension
US5780494A (en) * 1994-11-14 1998-07-14 G. D. Searle & Co. Piperidinyl-terminated alkylamino ethynl alanine amino diol compounds for treatment of hypertension
KR20000014745A (ko) * 1998-08-21 2000-03-15 이재성 버섯균 고체배양물을 이용한 밥의 제조방법
CA2467476A1 (en) * 2001-11-19 2003-05-30 Pharmacia & Upjohn Company Amino diols useful in the treatment of alzheimer's disease

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227851A (ja) * 1983-06-09 1984-12-21 Sankyo Co Ltd レニン阻害作用を有するペプチド類
US4652551A (en) * 1984-06-22 1987-03-24 Abbott Laboratories Renin inhibiting compounds
US4645759A (en) * 1984-06-22 1987-02-24 Abbott Laboratories Renin inhibiting compounds
EP0181110A3 (en) * 1984-10-22 1988-05-11 Kissei Pharmaceutical Co. Ltd. Histidine derivatives as renin inhibitors
DK34086A (da) * 1985-01-23 1986-07-24 Abbott Lab Peptidylaminodioler
JPS61236770A (ja) * 1985-04-15 1986-10-22 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
JPS6256458A (ja) * 1985-09-04 1987-03-12 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
IL81234A (en) * 1986-01-16 1992-09-06 Abbott Lab Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
JPS63503380A (ja) * 1986-01-16 1988-12-08 アボット・ラボラトリーズ ペプチド類似体
US4921855A (en) * 1987-06-22 1990-05-01 Fujisawa Pharmaceutical Co., Ltd. New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same
IL87614A0 (en) * 1987-09-16 1989-01-31 Abbott Lab Peptidylheterocycles

Also Published As

Publication number Publication date
US4902706A (en) 1990-02-20
DK326989D0 (da) 1989-06-30
PT91046B (pt) 1994-12-30
DK326989A (da) 1990-01-02
ZA895001B (en) 1990-09-26
KR900001718A (ko) 1990-02-27
PT91021A (pt) 1990-02-08
NO892745D0 (no) 1989-07-03

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940617

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19951231