PT89923A - Processo para a preparacao de variantes da hiridina - Google Patents

Processo para a preparacao de variantes da hiridina

Info

Publication number
PT89923A
PT89923A PT89923A PT8992389A PT89923A PT 89923 A PT89923 A PT 89923A PT 89923 A PT89923 A PT 89923A PT 8992389 A PT8992389 A PT 8992389A PT 89923 A PT89923 A PT 89923A
Authority
PT
Portugal
Prior art keywords
hydroidine
variants
preparation
improving
pharmacokinetic properties
Prior art date
Application number
PT89923A
Other languages
English (en)
Other versions
PT89923B (pt
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene Sa filed Critical Transgene Sa
Publication of PT89923A publication Critical patent/PT89923A/pt
Publication of PT89923B publication Critical patent/PT89923B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855Proteins from animals other than mammals or birds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Removal Of Specific Substances (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
PT89923A 1988-03-08 1989-03-07 Processo para a preparacao de variantes da hiridina PT89923B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8802925A FR2628429B1 (fr) 1988-03-08 1988-03-08 Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir

Publications (2)

Publication Number Publication Date
PT89923A true PT89923A (pt) 1989-11-10
PT89923B PT89923B (pt) 1994-05-31

Family

ID=9364012

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89923A PT89923B (pt) 1988-03-08 1989-03-07 Processo para a preparacao de variantes da hiridina

Country Status (10)

Country Link
US (1) US5087613A (pt)
EP (1) EP0332523B1 (pt)
JP (1) JP2961118B2 (pt)
AT (1) ATE84571T1 (pt)
CA (1) CA1341429C (pt)
DE (1) DE68904330T2 (pt)
ES (1) ES2036809T3 (pt)
FR (1) FR2628429B1 (pt)
GR (1) GR3007254T3 (pt)
PT (1) PT89923B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8907110D0 (en) * 1988-05-04 1989-05-10 Ciba Geigy Ag Improvements in the production of polypeptides
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
FR2646437B1 (fr) * 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
US5663141A (en) * 1989-12-01 1997-09-02 Basf Aktiengesellschaft Hirudin/polyalkylene glycol conjugates and hirudin muteins
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
ZA915658B (en) * 1990-07-24 1992-05-27 Merrell Dow Pharma Analogs of hirudin having antiplatelet activity
DK0540574T3 (da) * 1990-07-24 1996-09-30 Merrell Pharma Inc Antikoagulationspeptider
US5574012A (en) * 1990-07-24 1996-11-12 Merrell Pharmaceuticals Inc. Analogs of hirudin having anti-platelet activity
GB9023149D0 (en) * 1990-10-24 1990-12-05 British Bio Technology Proteins and nucleic acids
WO1993004082A1 (en) * 1991-08-20 1993-03-04 Baxter International Inc. Analogs of hirudin
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
GB9209032D0 (en) * 1992-04-25 1992-06-10 Ciba Geigy Ag New peptide derivatives
CN1124964A (zh) * 1993-06-11 1996-06-19 默里尔药物公司 三功能抗凝血酶和抗血小板的肽
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
KR102294577B1 (ko) 2015-01-12 2021-08-26 엔터리스 바이오파마, 인크. 고체 경구 제형

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341414C (fr) * 1984-03-27 2002-12-31 Paul Tolstoshev Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
FR2607517B2 (fr) * 1986-12-01 1989-12-22 Transgene Sa Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu

Also Published As

Publication number Publication date
DE68904330D1 (de) 1993-02-25
CA1341429C (fr) 2003-05-27
PT89923B (pt) 1994-05-31
JPH029390A (ja) 1990-01-12
JP2961118B2 (ja) 1999-10-12
FR2628429A1 (fr) 1989-09-15
DE68904330T2 (de) 1993-05-19
ES2036809T3 (es) 1993-06-01
FR2628429B1 (fr) 1990-12-28
GR3007254T3 (pt) 1993-07-30
EP0332523A1 (fr) 1989-09-13
ATE84571T1 (de) 1993-01-15
US5087613A (en) 1992-02-11
EP0332523B1 (fr) 1993-01-13

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19931118

PC3A Transfer or assignment

Free format text: SCHERING AKTIENGESELLSCHAFT DE

Effective date: 20021002

TE3A Change of address (patent)

Free format text: TRANSGENE S.A. FR

Effective date: 20021002

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090307