PT89504A - Processo para a preparacao de conjugados de anticorpos com hidrazidas de vinca - Google Patents
Processo para a preparacao de conjugados de anticorpos com hidrazidas de vincaInfo
- Publication number
- PT89504A PT89504A PT89504A PT8950489A PT89504A PT 89504 A PT89504 A PT 89504A PT 89504 A PT89504 A PT 89504A PT 8950489 A PT8950489 A PT 8950489A PT 89504 A PT89504 A PT 89504A
- Authority
- PT
- Portugal
- Prior art keywords
- hydraulics
- vinca
- conjugates
- antibodies
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14882288A | 1988-01-27 | 1988-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT89504A true PT89504A (pt) | 1989-10-04 |
Family
ID=22527543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT89504A PT89504A (pt) | 1988-01-27 | 1989-01-23 | Processo para a preparacao de conjugados de anticorpos com hidrazidas de vinca |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0326322A1 (pt) |
| JP (1) | JPH02152996A (pt) |
| KR (1) | KR890011896A (pt) |
| CN (1) | CN1034543A (pt) |
| AU (1) | AU2878989A (pt) |
| DK (1) | DK32989A (pt) |
| HU (1) | HU199783B (pt) |
| IE (1) | IE890237L (pt) |
| IL (1) | IL89043A0 (pt) |
| PT (1) | PT89504A (pt) |
| ZA (1) | ZA89524B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5006652A (en) * | 1988-08-08 | 1991-04-09 | Eli Lilly And Company | Intermediates for antibody-vinca drug conjugates |
| US5094849A (en) * | 1988-08-08 | 1992-03-10 | Eli Lilly And Company | Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers |
| ZA902519B (en) * | 1989-04-04 | 1991-12-24 | Lilly Co Eli | Pharmaceutical formulations |
| ES2049656B1 (es) * | 1992-10-08 | 1994-11-16 | Lilly Co Eli | Grupos de conjugados de farmacos con anticuerpos. |
| CA2227326A1 (en) * | 1995-05-15 | 1996-11-21 | Philip Dehazya | Carbohydrate-mediated coupling of peptides to immunoglobulins |
| SE0302324D0 (sv) * | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| CN102898523B (zh) * | 2012-10-19 | 2014-06-25 | 上海师范大学 | N-取代四氢吡啶连吲哚-单克隆抗体cd14结合物及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK167884A (da) * | 1983-03-30 | 1984-10-01 | Lilly Industries Ltd | Immunoglobulinkonjugater |
| US4675400A (en) * | 1985-06-17 | 1987-06-23 | Eli Lilly And Company | Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids |
| IL82579A0 (en) * | 1986-05-27 | 1987-11-30 | Lilly Co Eli | Immunoglobulin conjugates |
| FR2610198B1 (fr) * | 1987-02-03 | 1990-06-15 | Ire Celltarg Sa | Conjugues d'hydrazide d'alcaloide de vinca lie a une immunoglobuline, procede de preparation et compositions pharmaceutiques en comprenant |
-
1989
- 1989-01-23 IL IL89043A patent/IL89043A0/xx unknown
- 1989-01-23 PT PT89504A patent/PT89504A/pt not_active Application Discontinuation
- 1989-01-23 ZA ZA89524A patent/ZA89524B/xx unknown
- 1989-01-24 EP EP89300641A patent/EP0326322A1/en not_active Withdrawn
- 1989-01-25 AU AU28789/89A patent/AU2878989A/en not_active Abandoned
- 1989-01-26 HU HU89339A patent/HU199783B/hu not_active IP Right Cessation
- 1989-01-26 IE IE890237A patent/IE890237L/xx unknown
- 1989-01-26 KR KR1019890000796A patent/KR890011896A/ko not_active Application Discontinuation
- 1989-01-26 DK DK032989A patent/DK32989A/da not_active Application Discontinuation
- 1989-01-27 JP JP1019404A patent/JPH02152996A/ja active Pending
- 1989-01-27 CN CN89100559A patent/CN1034543A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK32989D0 (da) | 1989-01-26 |
| HU199783B (en) | 1990-03-28 |
| DK32989A (da) | 1989-07-28 |
| ZA89524B (en) | 1990-09-26 |
| JPH02152996A (ja) | 1990-06-12 |
| EP0326322A1 (en) | 1989-08-02 |
| IL89043A0 (en) | 1989-08-15 |
| KR890011896A (ko) | 1989-08-23 |
| AU2878989A (en) | 1989-07-27 |
| IE890237L (en) | 1989-07-27 |
| CN1034543A (zh) | 1989-08-09 |
| HUT48909A (en) | 1989-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC3A | Refusal |
Effective date: 19931124 |