DE68904330T2 - Hirudin-varianten, deren verwendung und verfahren zu deren herstellung. - Google Patents
Hirudin-varianten, deren verwendung und verfahren zu deren herstellung.Info
- Publication number
- DE68904330T2 DE68904330T2 DE8989400621T DE68904330T DE68904330T2 DE 68904330 T2 DE68904330 T2 DE 68904330T2 DE 8989400621 T DE8989400621 T DE 8989400621T DE 68904330 T DE68904330 T DE 68904330T DE 68904330 T2 DE68904330 T2 DE 68904330T2
- Authority
- DE
- Germany
- Prior art keywords
- production
- hirudin variants
- hirudin
- variants
- improving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000007625 Hirudins Human genes 0.000 title abstract 2
- 108010007267 Hirudins Proteins 0.000 title abstract 2
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title abstract 2
- 229940006607 hirudin Drugs 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Removal Of Specific Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8802925A FR2628429B1 (fr) | 1988-03-08 | 1988-03-08 | Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68904330D1 DE68904330D1 (de) | 1993-02-25 |
| DE68904330T2 true DE68904330T2 (de) | 1993-05-19 |
Family
ID=9364012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8989400621T Expired - Lifetime DE68904330T2 (de) | 1988-03-08 | 1989-03-06 | Hirudin-varianten, deren verwendung und verfahren zu deren herstellung. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5087613A (de) |
| EP (1) | EP0332523B1 (de) |
| JP (1) | JP2961118B2 (de) |
| AT (1) | ATE84571T1 (de) |
| CA (1) | CA1341429C (de) |
| DE (1) | DE68904330T2 (de) |
| ES (1) | ES2036809T3 (de) |
| FR (1) | FR2628429B1 (de) |
| GR (1) | GR3007254T3 (de) |
| PT (1) | PT89923B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8907110D0 (en) * | 1988-05-04 | 1989-05-10 | Ciba Geigy Ag | Improvements in the production of polypeptides |
| US5268296A (en) * | 1988-06-11 | 1993-12-07 | Ciba-Geigy Corporation | DNA vector and recombinant host cell for production of hirullin P6 and P18 |
| DE3835815A1 (de) * | 1988-10-21 | 1990-04-26 | Hoechst Ag | Neue isohirudine |
| FR2646437B1 (fr) * | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| WO1991008229A1 (de) * | 1989-12-01 | 1991-06-13 | Basf Aktiengesellschaft | Hirudinpolyalkylenglykolkonjugate |
| US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5612311A (en) * | 1990-04-06 | 1997-03-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5574012A (en) * | 1990-07-24 | 1996-11-12 | Merrell Pharmaceuticals Inc. | Analogs of hirudin having anti-platelet activity |
| ZA915658B (en) * | 1990-07-24 | 1992-05-27 | Merrell Dow Pharma | Analogs of hirudin having antiplatelet activity |
| EP0540574B1 (de) * | 1990-07-24 | 1996-09-11 | Merrell Pharmaceuticals Inc. | Antigerinnungspeptide |
| GB9023149D0 (en) * | 1990-10-24 | 1990-12-05 | British Bio Technology | Proteins and nucleic acids |
| US5837808A (en) * | 1991-08-20 | 1998-11-17 | Baxter International Inc. | Analogs of hirudin |
| WO1993004082A1 (en) * | 1991-08-20 | 1993-03-04 | Baxter International Inc. | Analogs of hirudin |
| GB9209032D0 (en) * | 1992-04-25 | 1992-06-10 | Ciba Geigy Ag | New peptide derivatives |
| ATE246203T1 (de) * | 1993-06-11 | 2003-08-15 | Merrell Pharma Inc | Trifunktionelle antithrombin-und antiplättchenpeptide |
| DE4404168A1 (de) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudinderivate und Verfahren zu deren Herstellung |
| US8377863B2 (en) | 2007-05-29 | 2013-02-19 | Unigene Laboratories Inc. | Peptide pharmaceutical for oral delivery |
| ES2929218T3 (es) | 2015-01-12 | 2022-11-28 | Enteris Biopharma Inc | Formas farmacéuticas orales sólidas |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341417C (fr) * | 1984-03-27 | 2003-01-21 | Paul Tolstoshev | Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine |
| DE3429430A1 (de) * | 1984-08-10 | 1986-02-20 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens |
| FR2607517B2 (fr) * | 1986-12-01 | 1989-12-22 | Transgene Sa | Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu |
-
1988
- 1988-03-08 FR FR8802925A patent/FR2628429B1/fr not_active Expired - Fee Related
-
1989
- 1989-03-06 EP EP89400621A patent/EP0332523B1/de not_active Expired - Lifetime
- 1989-03-06 DE DE8989400621T patent/DE68904330T2/de not_active Expired - Lifetime
- 1989-03-06 AT AT89400621T patent/ATE84571T1/de not_active IP Right Cessation
- 1989-03-06 ES ES198989400621T patent/ES2036809T3/es not_active Expired - Lifetime
- 1989-03-07 CA CA000592974A patent/CA1341429C/fr not_active Expired - Fee Related
- 1989-03-07 PT PT89923A patent/PT89923B/pt not_active IP Right Cessation
- 1989-03-08 JP JP1057693A patent/JP2961118B2/ja not_active Expired - Fee Related
- 1989-03-08 US US07/320,530 patent/US5087613A/en not_active Expired - Lifetime
-
1993
- 1993-03-05 GR GR930400475T patent/GR3007254T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0332523A1 (de) | 1989-09-13 |
| ES2036809T3 (es) | 1993-06-01 |
| CA1341429C (fr) | 2003-05-27 |
| ATE84571T1 (de) | 1993-01-15 |
| PT89923B (pt) | 1994-05-31 |
| EP0332523B1 (de) | 1993-01-13 |
| JPH029390A (ja) | 1990-01-12 |
| PT89923A (pt) | 1989-11-10 |
| DE68904330D1 (de) | 1993-02-25 |
| FR2628429B1 (fr) | 1990-12-28 |
| GR3007254T3 (de) | 1993-07-30 |
| US5087613A (en) | 1992-02-11 |
| JP2961118B2 (ja) | 1999-10-12 |
| FR2628429A1 (fr) | 1989-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SCHERING AG, 13353 BERLIN, DE |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE |