DE68910523T2 - Trizyklische 3-oxo-propannitril-derivate und verfahren zu deren herstellung. - Google Patents

Trizyklische 3-oxo-propannitril-derivate und verfahren zu deren herstellung.

Info

Publication number
DE68910523T2
DE68910523T2 DE89906767T DE68910523T DE68910523T2 DE 68910523 T2 DE68910523 T2 DE 68910523T2 DE 89906767 T DE89906767 T DE 89906767T DE 68910523 T DE68910523 T DE 68910523T DE 68910523 T2 DE68910523 T2 DE 68910523T2
Authority
DE
Germany
Prior art keywords
propannitrile
tricyclic
oxo
derivatives
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89906767T
Other languages
English (en)
Other versions
DE68910523D1 (de
Inventor
Gianfederico Doria
Anna Isetta
Mario Ferrari
Domenico Trizio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of DE68910523D1 publication Critical patent/DE68910523D1/de
Application granted granted Critical
Publication of DE68910523T2 publication Critical patent/DE68910523T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE89906767T 1988-06-20 1989-06-16 Trizyklische 3-oxo-propannitril-derivate und verfahren zu deren herstellung. Expired - Fee Related DE68910523T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888814586A GB8814586D0 (en) 1988-06-20 1988-06-20 Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation
PCT/EP1989/000683 WO1989012638A1 (en) 1988-06-20 1989-06-16 Tricyclic 3-oxo-propanenitrile derivatives and process for their preparation

Publications (2)

Publication Number Publication Date
DE68910523D1 DE68910523D1 (de) 1993-12-09
DE68910523T2 true DE68910523T2 (de) 1994-04-07

Family

ID=10638991

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89906767T Expired - Fee Related DE68910523T2 (de) 1988-06-20 1989-06-16 Trizyklische 3-oxo-propannitril-derivate und verfahren zu deren herstellung.

Country Status (19)

Country Link
US (1) US5166152A (de)
EP (1) EP0420883B1 (de)
JP (1) JPH03505204A (de)
KR (1) KR900701790A (de)
CN (1) CN1039026A (de)
AU (1) AU3758089A (de)
CA (1) CA1337937C (de)
DE (1) DE68910523T2 (de)
DK (1) DK300990A (de)
ES (1) ES2012736A6 (de)
GB (1) GB8814586D0 (de)
GR (1) GR1000467B (de)
HU (1) HUT58739A (de)
IL (1) IL90389A (de)
NZ (1) NZ229586A (de)
PT (1) PT90904B (de)
WO (1) WO1989012638A1 (de)
YU (1) YU125389A (de)
ZA (1) ZA894679B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814587D0 (en) * 1988-06-20 1988-07-27 Erba Carlo Spa Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation
GB8907799D0 (en) * 1989-04-06 1989-05-17 Erba Carlo Spa Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases
US5260328A (en) * 1989-04-06 1993-11-09 Farmitalia Carlo Erba Srl Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis
GB8916290D0 (en) * 1989-07-17 1989-08-31 Erba Carlo Spa Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis
AU6668896A (en) * 1995-08-31 1997-03-19 Idemitsu Kosan Co. Ltd Process for producing thiochroman derivatives
EP0970956A4 (de) * 1995-10-04 2000-01-12 Idemitsu Kosan Co Pyrazol-derivate
GB9720899D0 (en) * 1997-10-01 1997-12-03 Pharmacia & Upjohn Spa Condensed heterocyclic compounds
GB9720901D0 (en) * 1997-10-01 1997-12-03 Pharmacia & Upjohn Spa Condensed benzothiopyranic compounds
EP2499146B1 (de) * 2009-11-13 2016-09-21 Merck Serono S.A. Trizyklische pyrazolamin-derivate
CA2912921C (en) * 2013-06-24 2021-05-18 Merck Patent Gmbh Pyrazole compounds as modulators of fshr and uses thereof
CN103626787B (zh) * 2013-12-10 2016-06-15 沈阳药科大学 噻吩并硫杂类化合物及其应用
WO2015196335A1 (en) 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2009079A1 (de) * 1968-05-22 1970-01-30 Sandoz Sa
US4268516A (en) * 1978-10-11 1981-05-19 Pfizer Inc. [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents
US4816467A (en) * 1987-01-09 1989-03-28 Farmitalia Carlo Erba S.R.L Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use
JPH02502906A (ja) * 1987-04-09 1990-09-13 イー・アイ・デユポン・デ・ニモアス・アンド・カンパニー 殺虫性置換インダゾール類
GB2227741B (en) * 1989-02-06 1992-08-05 Erba Carlo Spa Condensed 3-oxo-propanenitrile derivatives and process for their preparation

Also Published As

Publication number Publication date
DK300990A (da) 1991-02-20
KR900701790A (ko) 1990-12-04
PT90904B (pt) 1994-12-30
EP0420883B1 (de) 1993-11-03
YU125389A (en) 1991-02-28
GR890100371A (en) 1990-05-11
WO1989012638A1 (en) 1989-12-28
HUT58739A (en) 1992-03-30
AU3758089A (en) 1990-01-12
CA1337937C (en) 1996-01-16
HU893875D0 (en) 1991-07-29
DE68910523D1 (de) 1993-12-09
CN1039026A (zh) 1990-01-24
US5166152A (en) 1992-11-24
PT90904A (pt) 1989-12-29
GB8814586D0 (en) 1988-07-27
ZA894679B (en) 1991-02-27
NZ229586A (en) 1991-07-26
ES2012736A6 (es) 1990-04-01
GR1000467B (el) 1992-07-30
IL90389A (en) 1992-12-01
IL90389A0 (en) 1990-01-18
JPH03505204A (ja) 1991-11-14
DK300990D0 (da) 1990-12-19
EP0420883A1 (de) 1991-04-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee