PT89769B - Processo para a preparacao de derivados do acido 3-alcenil-1-azabiciclo-{3,2,0}hept-2-eno-2-carboxilico - Google Patents

Processo para a preparacao de derivados do acido 3-alcenil-1-azabiciclo-{3,2,0}hept-2-eno-2-carboxilico

Info

Publication number
PT89769B
PT89769B PT89769A PT8976989A PT89769B PT 89769 B PT89769 B PT 89769B PT 89769 A PT89769 A PT 89769A PT 8976989 A PT8976989 A PT 8976989A PT 89769 B PT89769 B PT 89769B
Authority
PT
Portugal
Prior art keywords
preparation
alcenyl
eno
azabicyclo
hept
Prior art date
Application number
PT89769A
Other languages
English (en)
Other versions
PT89769A (pt
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of PT89769A publication Critical patent/PT89769A/pt
Publication of PT89769B publication Critical patent/PT89769B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
PT89769A 1988-02-22 1989-02-21 Processo para a preparacao de derivados do acido 3-alcenil-1-azabiciclo-{3,2,0}hept-2-eno-2-carboxilico PT89769B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888804058A GB8804058D0 (en) 1988-02-22 1988-02-22 3-alkenyl-1-azabicyclo(3 2 0)hept-2-ene-2-carboxylic acid compounds

Publications (2)

Publication Number Publication Date
PT89769A PT89769A (pt) 1989-10-04
PT89769B true PT89769B (pt) 1994-03-31

Family

ID=10632122

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89769A PT89769B (pt) 1988-02-22 1989-02-21 Processo para a preparacao de derivados do acido 3-alcenil-1-azabiciclo-{3,2,0}hept-2-eno-2-carboxilico

Country Status (18)

Country Link
US (2) US4923857A (pt)
EP (1) EP0330108B1 (pt)
JP (1) JP2748500B2 (pt)
KR (1) KR890013020A (pt)
CN (1) CN1037149A (pt)
AT (1) ATE132150T1 (pt)
AU (1) AU2983889A (pt)
DE (1) DE68925223T2 (pt)
DK (1) DK66789A (pt)
FI (1) FI890689A (pt)
GB (1) GB8804058D0 (pt)
HU (1) HUT49612A (pt)
IE (1) IE890500L (pt)
IL (1) IL89354A0 (pt)
NO (1) NO890723L (pt)
OA (1) OA09039A (pt)
PT (1) PT89769B (pt)
ZA (1) ZA89986B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2937911A1 (de) * 1978-09-19 1980-03-27 Daikin Ind Ltd Fluor enthaltende phenylbenzoatverbindungen, verfahren zu ihrer herstellung und ihre verwendung
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
US5258509A (en) * 1989-11-21 1993-11-02 Banyu Pharmaceutical Co., Ltd. Process for producing 2-carbon-substituted carbapenem derivatives
EP0430037A3 (en) * 1989-11-21 1992-05-27 Banyu Pharmaceutical Co., Ltd. Process for producing 2-carbon-substituted carbapenem derivatives
EP0465126A3 (en) * 1990-06-29 1992-03-11 Merck & Co. Inc. Carbapenem antibacterial agents
JPH06503803A (ja) * 1990-07-27 1994-04-28 藤沢薬品工業株式会社 １―アザビシクロ［３．２．０］ヘプト―２―エン―２―カルボン酸化合物
US5189158A (en) * 1991-03-20 1993-02-23 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
US5371215A (en) * 1991-03-20 1994-12-06 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6395894B2 (en) 1998-04-16 2002-05-28 Philip J. Pye Process for the synthesis of carbapenem intermidiates, and compounds produced
CA2328219A1 (en) * 1998-04-16 1999-10-21 Merck & Co., Inc. Titanium catalyzed preparation of carbapenem intermediates
ATE263766T1 (de) 1998-06-17 2004-04-15 Merck & Co Inc Verfahren zur synthese von carbapenem- zwischenprodukten
US6194568B1 (en) 1998-07-13 2001-02-27 Merck & Co., Inc. Process for synthesizing carbapenem intermediates
KR100351660B1 (ko) * 2000-07-14 2002-09-05 한국화학연구원 2-아릴에테닐 카바페넴 유도체 및 그의 제조방법
CN100334061C (zh) * 2002-11-05 2007-08-29 立德化学株式会社 紫外线防御化合物
AU2006275514B2 (en) 2005-07-29 2012-04-05 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
CN101641339B (zh) 2007-02-01 2013-07-17 雷斯韦洛吉克斯公司 用于预防和治疗心血管疾病的化合物
KR101629356B1 (ko) 2008-06-26 2016-06-13 리스버로직스 코퍼레이션 퀴나졸리논 유도체의 제조방법
AU2010204106B2 (en) 2009-01-08 2014-05-08 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
MX2021012876A (es) 2009-03-18 2022-06-23 Resverlogix Corp Nuevos agentes anti-inflamatorios.
ES2821018T3 (es) 2009-04-22 2021-04-23 Resverlogix Corp Nuevos agentes antiinflamatorios
EA028342B1 (ru) 2011-09-09 2017-11-30 Мерк Шарп И Доум Корп. Способы лечения пневмонии
PT2773354T (pt) 2011-11-01 2019-07-17 Resverlogix Corp Formulações orais de libertação imediata para quinazolinonas substituídas
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
AU2013365926B9 (en) 2012-12-21 2019-01-17 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
AU2014227660B2 (en) 2013-03-15 2014-11-06 Merck Sharp & Dohme Llc Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543257A (en) * 1977-10-19 1985-09-24 Merck & Co., Inc. 1-Carba-2-penem-3-carboxylic acid
US4348320A (en) * 1976-11-19 1982-09-07 Merck & Co., Inc. Substituted azetidiones
DK446179A (da) * 1978-10-24 1980-05-29 Merck & Co Inc Fremgangsmaade til fremstilling af substituerede 1-carbadethiapen-2-em-3-carboxylsyrer
US4465632A (en) * 1978-10-24 1984-08-14 Merck & Co., Inc. Process for preparing 1-6-and 2-substituted-1-carba-2-penem-3-carboxylic acids
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
US4267188A (en) * 1979-08-09 1981-05-12 Merck & Co., Inc. 5-Substituted-1-carba-pen-2-em-3-carboxylic acid
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4729993A (en) * 1984-12-13 1988-03-08 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
EP0213610A1 (en) * 1985-08-31 1987-03-11 Lederle (Japan) Ltd. Azetidin-2-one derivatives and process for production thereof

Also Published As

Publication number Publication date
JP2748500B2 (ja) 1998-05-06
US5081237A (en) 1992-01-14
IE890500L (en) 1989-08-22
KR890013020A (ko) 1989-09-20
NO890723L (no) 1989-08-23
HUT49612A (en) 1989-10-30
EP0330108B1 (en) 1995-12-27
NO890723D0 (no) 1989-02-21
AU2983889A (en) 1989-08-24
PT89769A (pt) 1989-10-04
GB8804058D0 (en) 1988-03-23
DE68925223T2 (de) 1996-06-13
ZA89986B (en) 1989-10-25
IL89354A0 (en) 1989-09-10
EP0330108A1 (en) 1989-08-30
US4923857A (en) 1990-05-08
FI890689A (fi) 1989-08-23
DE68925223D1 (de) 1996-02-08
FI890689A0 (fi) 1989-02-14
CN1037149A (zh) 1989-11-15
ATE132150T1 (de) 1996-01-15
DK66789A (da) 1989-08-23
DK66789D0 (da) 1989-02-13
JPH021490A (ja) 1990-01-05
OA09039A (fr) 1991-03-31

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Legal Events

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FG3A Patent granted, date of granting

Effective date: 19930913

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19950331