IL89354A0 - 3-alkenyl-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents
3-alkenyl-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the sameInfo
- Publication number
- IL89354A0 IL89354A0 IL89354A IL8935489A IL89354A0 IL 89354 A0 IL89354 A0 IL 89354A0 IL 89354 A IL89354 A IL 89354A IL 8935489 A IL8935489 A IL 8935489A IL 89354 A0 IL89354 A0 IL 89354A0
- Authority
- IL
- Israel
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- azabicyclo
- hept
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888804058A GB8804058D0 (en) | 1988-02-22 | 1988-02-22 | 3-alkenyl-1-azabicyclo(3 2 0)hept-2-ene-2-carboxylic acid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL89354A0 true IL89354A0 (en) | 1989-09-10 |
Family
ID=10632122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL89354A IL89354A0 (en) | 1988-02-22 | 1989-02-21 | 3-alkenyl-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4923857A (xx) |
| EP (1) | EP0330108B1 (xx) |
| JP (1) | JP2748500B2 (xx) |
| KR (1) | KR890013020A (xx) |
| CN (1) | CN1037149A (xx) |
| AT (1) | ATE132150T1 (xx) |
| AU (1) | AU2983889A (xx) |
| DE (1) | DE68925223T2 (xx) |
| DK (1) | DK66789A (xx) |
| FI (1) | FI890689A (xx) |
| GB (1) | GB8804058D0 (xx) |
| HU (1) | HUT49612A (xx) |
| IE (1) | IE890500L (xx) |
| IL (1) | IL89354A0 (xx) |
| NO (1) | NO890723L (xx) |
| OA (1) | OA09039A (xx) |
| PT (1) | PT89769B (xx) |
| ZA (1) | ZA89986B (xx) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2937911A1 (de) * | 1978-09-19 | 1980-03-27 | Daikin Ind Ltd | Fluor enthaltende phenylbenzoatverbindungen, verfahren zu ihrer herstellung und ihre verwendung |
| US5102877A (en) * | 1989-04-28 | 1992-04-07 | Fujisawa Pharmaceutical Co., Ltd. | 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds |
| EP0430037A3 (en) * | 1989-11-21 | 1992-05-27 | Banyu Pharmaceutical Co., Ltd. | Process for producing 2-carbon-substituted carbapenem derivatives |
| US5258509A (en) * | 1989-11-21 | 1993-11-02 | Banyu Pharmaceutical Co., Ltd. | Process for producing 2-carbon-substituted carbapenem derivatives |
| CA2045847A1 (en) * | 1990-06-29 | 1991-12-30 | Frank P. Dininno | Carbapenem antibacterial agents |
| JPH06503803A (ja) * | 1990-07-27 | 1994-04-28 | 藤沢薬品工業株式会社 | １―アザビシクロ［３．２．０］ヘプト―２―エン―２―カルボン酸化合物 |
| US5371215A (en) * | 1991-03-20 | 1994-12-06 | American Cyanamid Company | 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them |
| US5189158A (en) * | 1991-03-20 | 1993-02-23 | American Cyanamid Company | 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them |
| US6005138A (en) * | 1991-09-23 | 1999-12-21 | Florida State University | Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them |
| US6395894B2 (en) | 1998-04-16 | 2002-05-28 | Philip J. Pye | Process for the synthesis of carbapenem intermidiates, and compounds produced |
| AU745980B2 (en) * | 1998-04-16 | 2002-04-11 | Merck & Co., Inc. | Titanium catalyzed preparation of carbapenem intermediates |
| JP2002518402A (ja) | 1998-06-17 | 2002-06-25 | メルク エンド カムパニー インコーポレーテッド | カルバペネム中間体の合成方法、及び製造された化合物 |
| US6194568B1 (en) | 1998-07-13 | 2001-02-27 | Merck & Co., Inc. | Process for synthesizing carbapenem intermediates |
| KR100351660B1 (ko) * | 2000-07-14 | 2002-09-05 | 한국화학연구원 | 2-아릴에테닐 카바페넴 유도체 및 그의 제조방법 |
| US7361785B2 (en) * | 2002-11-05 | 2008-04-22 | Lead Chemical Co., Ltd. | Compound protecting against ultraviolet rays |
| EP1909788A2 (en) | 2005-07-29 | 2008-04-16 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| DK2118074T3 (en) | 2007-02-01 | 2014-03-10 | Resverlogix Corp | Compounds for the prevention and treatment of cardiovascular diseases |
| RU2520098C2 (ru) | 2008-06-26 | 2014-06-20 | Ресверлоджикс Корп. | Способы получения производных хиназолинона |
| JP5635535B2 (ja) | 2009-01-08 | 2014-12-03 | レスバーロジックス コーポレイション | 心血管疾患の予防および治療のための化合物 |
| CA2992231C (en) | 2009-03-18 | 2022-03-29 | Resverlogix Corp. | Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents |
| KR20190091564A (ko) | 2009-04-22 | 2019-08-06 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| MX352760B (es) | 2011-09-09 | 2017-12-07 | Merck Sharp & Dohme Corp Star | Metodos para tratar infecciones intrapulmonares. |
| CN103945848B (zh) | 2011-11-01 | 2016-09-07 | 雷斯韦洛吉克斯公司 | 被取代的喹唑啉酮的口服即释制剂 |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| CA2895905A1 (en) | 2012-12-21 | 2014-06-26 | Zenith Epigenetics Corp. | Novel heterocyclic compounds as bromodomain inhibitors |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| MX2020004205A (es) | 2013-03-15 | 2021-11-16 | Merck Sharp & Dohme Llc | Composiciones antibioticas de ceftolozano. |
| US20140275000A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane pharmaceutical compositions |
| WO2015035376A2 (en) | 2013-09-09 | 2015-03-12 | Calixa Therapeutics, Inc. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| KR102662814B1 (ko) | 2015-03-13 | 2024-05-03 | 리스버로직스 코퍼레이션 | 보체 관련 질환을 치료하기 위한 조성물 및 치료 방법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4543257A (en) * | 1977-10-19 | 1985-09-24 | Merck & Co., Inc. | 1-Carba-2-penem-3-carboxylic acid |
| US4348320A (en) * | 1976-11-19 | 1982-09-07 | Merck & Co., Inc. | Substituted azetidiones |
| US4260627A (en) * | 1978-10-24 | 1981-04-07 | Merck & Co., Inc. | 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids |
| US4465632A (en) * | 1978-10-24 | 1984-08-14 | Merck & Co., Inc. | Process for preparing 1-6-and 2-substituted-1-carba-2-penem-3-carboxylic acids |
| EP0010317B1 (en) * | 1978-10-24 | 1983-12-21 | Merck & Co. Inc. | 6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds |
| US4267188A (en) * | 1979-08-09 | 1981-05-12 | Merck & Co., Inc. | 5-Substituted-1-carba-pen-2-em-3-carboxylic acid |
| US4552873A (en) * | 1981-08-19 | 1985-11-12 | Sankyo Company Limited | Carbapenem compounds, and compositions containing them |
| US4729993A (en) * | 1984-12-13 | 1988-03-08 | Merck & Co., Inc. | Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent |
| CA1282415C (en) * | 1985-08-31 | 1991-04-02 | Yasuhiro Kuramoto | Azetidin-2-on derivatives and process for production thereof |
-
1988
- 1988-02-22 GB GB888804058A patent/GB8804058D0/en active Pending
-
1989
- 1989-02-08 ZA ZA89986A patent/ZA89986B/xx unknown
- 1989-02-10 AU AU29838/89A patent/AU2983889A/en not_active Abandoned
- 1989-02-13 DK DK066789A patent/DK66789A/da not_active Application Discontinuation
- 1989-02-14 FI FI890689A patent/FI890689A/fi not_active Application Discontinuation
- 1989-02-16 IE IE890500A patent/IE890500L/xx unknown
- 1989-02-17 US US07/312,061 patent/US4923857A/en not_active Expired - Fee Related
- 1989-02-18 DE DE68925223T patent/DE68925223T2/de not_active Expired - Fee Related
- 1989-02-18 EP EP89102859A patent/EP0330108B1/en not_active Expired - Lifetime
- 1989-02-18 AT AT89102859T patent/ATE132150T1/de not_active IP Right Cessation
- 1989-02-21 PT PT89769A patent/PT89769B/pt not_active IP Right Cessation
- 1989-02-21 HU HU89839A patent/HUT49612A/hu unknown
- 1989-02-21 NO NO89890723A patent/NO890723L/no unknown
- 1989-02-21 KR KR1019890002054A patent/KR890013020A/ko not_active Application Discontinuation
- 1989-02-21 IL IL89354A patent/IL89354A0/xx unknown
- 1989-02-21 CN CN89100880A patent/CN1037149A/zh active Pending
- 1989-02-22 JP JP1042769A patent/JP2748500B2/ja not_active Expired - Lifetime
- 1989-02-22 OA OA59530A patent/OA09039A/xx unknown
-
1990
- 1990-01-30 US US07/472,270 patent/US5081237A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1037149A (zh) | 1989-11-15 |
| US5081237A (en) | 1992-01-14 |
| DK66789A (da) | 1989-08-23 |
| FI890689A0 (fi) | 1989-02-14 |
| OA09039A (fr) | 1991-03-31 |
| JP2748500B2 (ja) | 1998-05-06 |
| PT89769A (pt) | 1989-10-04 |
| EP0330108B1 (en) | 1995-12-27 |
| EP0330108A1 (en) | 1989-08-30 |
| NO890723D0 (no) | 1989-02-21 |
| ATE132150T1 (de) | 1996-01-15 |
| FI890689A (fi) | 1989-08-23 |
| IE890500L (en) | 1989-08-22 |
| DE68925223T2 (de) | 1996-06-13 |
| KR890013020A (ko) | 1989-09-20 |
| NO890723L (no) | 1989-08-23 |
| PT89769B (pt) | 1994-03-31 |
| JPH021490A (ja) | 1990-01-05 |
| GB8804058D0 (en) | 1988-03-23 |
| HUT49612A (en) | 1989-10-30 |
| DE68925223D1 (de) | 1996-02-08 |
| AU2983889A (en) | 1989-08-24 |
| ZA89986B (en) | 1989-10-25 |
| DK66789D0 (da) | 1989-02-13 |
| US4923857A (en) | 1990-05-08 |
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