PT85582A - Process for the preparation of novel 9-deazaguanines and of pharmaceutical compositions containing them - Google Patents
Process for the preparation of novel 9-deazaguanines and of pharmaceutical compositions containing themInfo
- Publication number
- PT85582A PT85582A PT85582A PT8558287A PT85582A PT 85582 A PT85582 A PT 85582A PT 85582 A PT85582 A PT 85582A PT 8558287 A PT8558287 A PT 8558287A PT 85582 A PT85582 A PT 85582A
- Authority
- PT
- Portugal
- Prior art keywords
- pharmaceutical compositions
- novel
- deazaguanines
- preparation
- compositions containing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- YKBGVTZYEHREMT-KVQBGUIXSA-N 2'-deoxyguanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 YKBGVTZYEHREMT-KVQBGUIXSA-N 0.000 abstract 1
- YKBGVTZYEHREMT-UHFFFAOYSA-N 2'-deoxyguanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1CC(O)C(CO)O1 YKBGVTZYEHREMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000005569 Gout Diseases 0.000 abstract 1
- KCTZOTUQSGYWLV-UHFFFAOYSA-N N1C=NC=C2N=CC=C21 Chemical class N1C=NC=C2N=CC=C21 KCTZOTUQSGYWLV-UHFFFAOYSA-N 0.000 abstract 1
- 101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- VGONTNSXDCQUGY-UHFFFAOYSA-N desoxyinosine Natural products C1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 VGONTNSXDCQUGY-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90048686A | 1986-08-26 | 1986-08-26 | |
| US5941987A | 1987-06-18 | 1987-06-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT85582A true PT85582A (en) | 1987-09-01 |
| PT85582B PT85582B (pt) | 1990-05-31 |
Family
ID=26738724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT85582A PT85582B (pt) | 1986-08-26 | 1987-08-25 | Processo para a preparacao de novas 9-deazaguaninas e de composicoes farmaceuticas que as contem |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0260491B1 (pt) |
| JP (2) | JP2595254B2 (pt) |
| KR (2) | KR940008421B1 (pt) |
| AT (1) | ATE67203T1 (pt) |
| AU (1) | AU619724B2 (pt) |
| CA (2) | CA1293727C (pt) |
| DE (1) | DE3772913D1 (pt) |
| DK (1) | DK169705B1 (pt) |
| ES (1) | ES2038635T3 (pt) |
| FI (1) | FI85856C (pt) |
| GR (1) | GR3002697T3 (pt) |
| IE (1) | IE60433B1 (pt) |
| NO (1) | NO166485C (pt) |
| NZ (1) | NZ221463A (pt) |
| PH (1) | PH24669A (pt) |
| PT (1) | PT85582B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1294960C (en) * | 1986-10-24 | 1992-01-28 | Thomas C. Malone | 7-deazaguanines as immunomodulators |
| DE69031337T2 (de) * | 1989-02-27 | 1998-03-05 | Biocryst | 9-substituierte-8-unsubstituierte-9-deazaguanine |
| WO1991006548A1 (en) * | 1989-10-31 | 1991-05-16 | Biocryst, Inc. | Inhibitors of purine nucleoside phosphorylase |
| US5726311A (en) * | 1989-11-29 | 1998-03-10 | Biocryst Pharmaceuticals, Inc. | 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same |
| WO1995001355A1 (en) * | 1993-06-30 | 1995-01-12 | Biocryst Pharmaceuticals, Inc. | 9-deazahypoxanthines as pnp inhibitors |
| US5386031A (en) * | 1993-12-15 | 1995-01-31 | Warner-Lambert Company | Process for the synthesis of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo[3,]pyrimidin-4-ones |
| HUT77436A (hu) * | 1994-10-05 | 1998-04-28 | Darwin Discovery Limited | Purin- és guaninszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására |
| FR2728181B1 (fr) * | 1994-12-16 | 1997-01-31 | Appryl Snc | Composante catalytique pour la polymerisation des olefines, son procede de fabrication, et procede de polymerisation des olefines en presence de ladite composante catalytique |
| PT831829E (pt) * | 1995-06-07 | 2003-12-31 | Pfizer | Derivados de pirimidina heterociclicos de aneis fundidos |
| US6395733B1 (en) | 1995-06-07 | 2002-05-28 | Pfizer Inc | Heterocyclic ring-fused pyrimidine derivatives |
| NZ523970A (en) * | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
| NZ546274A (en) * | 2003-10-03 | 2009-12-24 | 3M Innovative Properties Co | Pyrazolopyridines and analags thereof |
| NZ540160A (en) * | 2005-05-20 | 2008-03-28 | Einstein Coll Med | Inhibitors of nucleoside phosphorylases |
| GB201417163D0 (en) | 2014-09-29 | 2014-11-12 | Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin | Substituted pyrimidine derivatives useful in the treatment of autoimmune diseases |
| GB201417165D0 (en) * | 2014-09-29 | 2014-11-12 | Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin | Treatments for Autoimmune Disease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN164556B (pt) * | 1986-03-06 | 1989-04-08 | Takeda Chemical Industries Ltd | |
| CA1294960C (en) * | 1986-10-24 | 1992-01-28 | Thomas C. Malone | 7-deazaguanines as immunomodulators |
| DE3739366A1 (de) * | 1987-04-10 | 1988-10-27 | Boehringer Mannheim Gmbh | Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel |
-
1987
- 1987-07-30 IE IE207087A patent/IE60433B1/en not_active IP Right Cessation
- 1987-07-30 CA CA000543431A patent/CA1293727C/en not_active Expired - Fee Related
- 1987-08-17 NZ NZ221463A patent/NZ221463A/xx unknown
- 1987-08-24 FI FI873648A patent/FI85856C/fi not_active IP Right Cessation
- 1987-08-24 DK DK440287A patent/DK169705B1/da not_active IP Right Cessation
- 1987-08-24 PH PH35723A patent/PH24669A/en unknown
- 1987-08-25 DE DE8787112339T patent/DE3772913D1/de not_active Expired - Fee Related
- 1987-08-25 ES ES87112339T patent/ES2038635T3/es not_active Expired - Lifetime
- 1987-08-25 EP EP87112339A patent/EP0260491B1/en not_active Expired - Lifetime
- 1987-08-25 JP JP62209423A patent/JP2595254B2/ja not_active Expired - Fee Related
- 1987-08-25 PT PT85582A patent/PT85582B/pt not_active IP Right Cessation
- 1987-08-25 AU AU77416/87A patent/AU619724B2/en not_active Ceased
- 1987-08-25 NO NO87873584A patent/NO166485C/no unknown
- 1987-08-25 AT AT87112339T patent/ATE67203T1/de not_active IP Right Cessation
- 1987-08-26 KR KR1019870009320A patent/KR940008421B1/ko not_active Expired - Fee Related
-
1991
- 1991-03-07 CA CA000616019A patent/CA1320203C/en not_active Expired - Fee Related
- 1991-09-12 GR GR91401215T patent/GR3002697T3/el unknown
-
1994
- 1994-06-08 KR KR1019940012787A patent/KR940008848B1/ko not_active Expired - Fee Related
-
1996
- 1996-06-05 JP JP8142606A patent/JP2650644B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU619724B2 (en) | 1992-02-06 |
| FI873648A0 (fi) | 1987-08-24 |
| NO873584L (no) | 1988-02-29 |
| IE872070L (en) | 1988-02-26 |
| KR940008421B1 (ko) | 1994-09-14 |
| CA1320203C (en) | 1993-07-13 |
| IE60433B1 (en) | 1994-07-13 |
| FI873648A7 (fi) | 1988-02-27 |
| EP0260491A1 (en) | 1988-03-23 |
| JP2650644B2 (ja) | 1997-09-03 |
| ES2038635T3 (es) | 1993-08-01 |
| NO166485C (no) | 1991-07-31 |
| NZ221463A (en) | 1990-07-26 |
| AU7741687A (en) | 1988-03-03 |
| KR880002873A (ko) | 1988-05-12 |
| JPH08311040A (ja) | 1996-11-26 |
| ATE67203T1 (de) | 1991-09-15 |
| DK169705B1 (da) | 1995-01-16 |
| FI85856B (fi) | 1992-02-28 |
| DE3772913D1 (de) | 1991-10-17 |
| GR3002697T3 (en) | 1993-01-25 |
| DK440287A (da) | 1988-02-27 |
| CA1293727C (en) | 1991-12-31 |
| JPS6388185A (ja) | 1988-04-19 |
| PT85582B (pt) | 1990-05-31 |
| EP0260491B1 (en) | 1991-09-11 |
| KR940008848B1 (ko) | 1994-09-28 |
| JP2595254B2 (ja) | 1997-04-02 |
| NO873584D0 (no) | 1987-08-25 |
| PH24669A (en) | 1990-09-07 |
| FI85856C (fi) | 1992-06-10 |
| DK440287D0 (da) | 1987-08-24 |
| NO166485B (no) | 1991-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20040531 |