PT84496B - Processo para a preparacao da forma o anidra cristalina do cloridrato de 2-{4-(2-furoil)-(2-piperazino)-1-il}-4-amino-6,7-dimetoxiquinazolina e de composicoes farmacauticas que a contem - Google Patents

Processo para a preparacao da forma o anidra cristalina do cloridrato de 2-{4-(2-furoil)-(2-piperazino)-1-il}-4-amino-6,7-dimetoxiquinazolina e de composicoes farmacauticas que a contem

Info

Publication number
PT84496B
PT84496B PT84496A PT8449687A PT84496B PT 84496 B PT84496 B PT 84496B PT 84496 A PT84496 A PT 84496A PT 8449687 A PT8449687 A PT 8449687A PT 84496 B PT84496 B PT 84496B
Authority
PT
Portugal
Prior art keywords
pharmacotic
dimetoxyquinazoline
piperazino
amino
compositions containing
Prior art date
Application number
PT84496A
Other languages
English (en)
Other versions
PT84496A (de
Inventor
Helmut Schickaneder
Ingomar Grafe
Kurt Henning Ahrens
Original Assignee
Heumann Pharma Gmbh & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma Gmbh & Co filed Critical Heumann Pharma Gmbh & Co
Publication of PT84496A publication Critical patent/PT84496A/pt
Publication of PT84496B publication Critical patent/PT84496B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT84496A 1986-03-21 1987-03-17 Processo para a preparacao da forma o anidra cristalina do cloridrato de 2-{4-(2-furoil)-(2-piperazino)-1-il}-4-amino-6,7-dimetoxiquinazolina e de composicoes farmacauticas que a contem PT84496B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP86103925A EP0237608B1 (de) 1986-03-21 1986-03-21 Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung

Publications (2)

Publication Number Publication Date
PT84496A PT84496A (de) 1987-04-01
PT84496B true PT84496B (pt) 1989-11-10

Family

ID=8194990

Family Applications (1)

Application Number Title Priority Date Filing Date
PT84496A PT84496B (pt) 1986-03-21 1987-03-17 Processo para a preparacao da forma o anidra cristalina do cloridrato de 2-{4-(2-furoil)-(2-piperazino)-1-il}-4-amino-6,7-dimetoxiquinazolina e de composicoes farmacauticas que a contem

Country Status (19)

Country Link
US (1) US4816455B1 (pt)
EP (1) EP0237608B1 (pt)
JP (1) JPH0662615B2 (pt)
KR (1) KR870008875A (pt)
AR (1) AR242384A1 (pt)
AT (1) ATE72244T1 (pt)
AU (1) AU586318B2 (pt)
CA (1) CA1240999A (pt)
DE (1) DE3683760D1 (pt)
DK (1) DK173283B1 (pt)
ES (1) ES2009486A6 (pt)
GR (1) GR870429B (pt)
HU (1) HU200176B (pt)
ID (1) ID810B (pt)
IE (1) IE59913B1 (pt)
IL (1) IL81841A (pt)
NZ (1) NZ219644A (pt)
PT (1) PT84496B (pt)
ZA (1) ZA87966B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5412095A (en) * 1993-04-29 1995-05-02 Abbott Laboratories Terazosin monohydrochloride and processes and intermediate for its production
US5504207A (en) * 1994-10-18 1996-04-02 Abbott Laboratories Process and intermediate for the preparation of terazosin hydrochloride dihydrate
EP0794178A4 (en) * 1994-11-25 1998-02-25 Nippon Chemiphar Co CHINAZOLIN DERIVATIVES
US5587377A (en) * 1995-10-24 1996-12-24 Invamed, Inc. Terazosin crystalline polymorph and pharmaceutical compositions thereof
ATE353892T1 (de) * 1996-12-20 2007-03-15 Heumann Pharma Gmbh & Co Neue polymorphe form von doxazosinmesylat (form iii)
EP0849264A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von doxazosinmesylat (Form I)
EP0849265A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von Doxazosin-Mesylat (Form II)
CA2301863C (en) 1998-06-19 2009-01-27 Teijin Limited Polymorphs modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and method of producing the same
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
CL2004001034A1 (es) 2003-05-14 2005-03-28 Teijin Pharma Ltd Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
US20080015240A1 (en) * 2004-11-12 2008-01-17 Mitsuru Teramoto Acid Salt of Benzimidazole Derivative and Crystal Thereof
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
CN103951667A (zh) 2006-05-04 2014-07-30 勃林格殷格翰国际有限公司 多晶型
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
EP3542801A1 (en) * 2007-08-17 2019-09-25 Boehringer Ingelheim International GmbH Purin derivatives for use in the treatment of fap-related diseases
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
PE20110297A1 (es) * 2008-08-15 2011-05-26 Boehringer Ingelheim Int Inhibidores de dpp-4 para la cicatrizacion de heridas
AU2009290911A1 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
US8865729B2 (en) 2008-12-23 2014-10-21 Boehringer Ingelheim International Gmbh Salt forms of a xanthine compound
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
AU2010323068B2 (en) 2009-11-27 2015-09-03 Boehringer Ingelheim International Gmbh Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin
EA033415B1 (ru) 2010-05-05 2019-10-31 Boehringer Ingelheim Int Способы лечения ожирения, применение ингибитора dpp-4 в этих способах и способ лечения пациентов, страдающих диабетом типа 2
BR112012032579B1 (pt) 2010-06-24 2021-05-11 Boehringer Ingelheim International Gmbh uso de linagliptina e composição farmacêutica compreendendo linagliptina e insulina basal de longa duração
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
NZ618698A (en) 2011-07-15 2015-08-28 Boehringer Ingelheim Int Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
WO2015128453A1 (en) 2014-02-28 2015-09-03 Boehringer Ingelheim International Gmbh Medical use of a dpp-4 inhibitor
MX2018015089A (es) 2016-06-10 2019-05-13 Boehringer Ingelheim Int Combinacion de linagliptina y metformina.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4092315A (en) * 1976-03-01 1978-05-30 Pfizer Inc. Novel crystalline forms of prazosin hydrochloride
GB1591490A (en) * 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
EP0146642B1 (de) * 1983-11-22 1988-01-20 LUDWIG HEUMANN & CO GMBH Verfahren zur Herstellung von 4-Amino-6,7-dimethoxy-2-(4-(furo-2-yl)-piperazin-1-yl)-chinazolin und dessen physiologisch annehmbarer Salze
FI79107C (fi) * 1984-06-25 1989-11-10 Orion Yhtymae Oy Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.

Also Published As

Publication number Publication date
ES2009486A6 (es) 1989-10-01
US4816455B1 (en) 1992-11-24
IL81841A0 (en) 1987-10-20
IL81841A (en) 1991-06-10
PT84496A (de) 1987-04-01
JPS62226980A (ja) 1987-10-05
AU586318B2 (en) 1989-07-06
NZ219644A (en) 1989-04-26
DK139887D0 (da) 1987-03-18
CA1240999A (en) 1988-08-23
IE59913B1 (en) 1994-04-20
HU200176B (en) 1990-04-28
IE870705L (en) 1987-09-21
DE3683760D1 (de) 1992-03-12
ZA87966B (en) 1987-08-04
AR242384A1 (es) 1993-03-31
EP0237608A1 (de) 1987-09-23
DK139887A (da) 1987-09-22
KR870008875A (ko) 1987-10-21
JPH0662615B2 (ja) 1994-08-17
DK173283B1 (da) 2000-06-13
US4816455A (en) 1989-03-28
EP0237608B1 (de) 1992-01-29
ATE72244T1 (de) 1992-02-15
HUT47101A (en) 1989-01-30
ID810B (id) 1996-07-15
AU6870787A (en) 1987-09-24
GR870429B (en) 1987-07-13

Similar Documents

Publication Publication Date Title
PT84496B (pt) Processo para a preparacao da forma o anidra cristalina do cloridrato de 2-{4-(2-furoil)-(2-piperazino)-1-il}-4-amino-6,7-dimetoxiquinazolina e de composicoes farmacauticas que a contem
PT84824B (pt) Processo para a preparacao de 5-aril-alquil-4-alcoxi-2-(5h)-furanonas, dos seus intermediarios e de composicoes farmaceuticas que as contem
PT81746B (pt) Processo para a preparacao de peptido-aldeidos e de composicoes farmaceuticas que os contem
PT81362B (pt) Processo para a preparacao de 9-amino-1,2,3,4-tetra-hidroacridin-1-ol e compostos relacionados e de composicoes farmaceuticas que os contem
PT81969B (pt) Processo para preparacao de 11 beta-fenil-esteroides e de composicoes farmaceuticas que os contem
PT83013B (pt) Processo para a preparacao de hidroxialquilxantinas terciarias, e de composicoes farmaceuticas que as contem
PT82226B (pt) Processo para a preparacao de 3-ariluracilos e de composicoes herbicidas que os contem
PT84569B (pt) Processo para a preparacao de tiazepinas e de composicoes farmaceuticas que os contem
PT83143B (pt) Processo para a preparacao de 1,4-dihidro-piridinas 2-substituidas com tiometilo e de composicoes farmaceuticas que as contem
PT80892B (pt) Processo para a preparacao de derivados da quoinona e de composicoes farmaceuticas que os contem
PT99671A (pt) Processo para a preparacao de heparosanos-n,o-sulfatados e de composicoes farmaceuticas que os contem
PT81749B (pt) Processo para a preparacao de 1,2,4-triazoles e de composicoes pesticidas que os contem
PT87968A (pt) Processo para a preparacao de 5,6-dimetoxi-1,2-benzimidazolo-3-propanaminas substituidas em n e de compostos relacionados e de composicoes farmaceuticas que os contem
PT83397B (pt) Processo para a preparacao de aril-piridinas e de composicoes insecticidas que as contem
PT81041B (pt) Processo para a preparacao de derivados de etilenodiamina-monoamida e de composicoes farmaceuticas que os contem
PT80363B (pt) Processo para a preparacao de derivados de fenol e de composicoes farmaceuticas que os contem
PT90142A (pt) Processo para a preparacao de novos imidazois substituidos em 2,3 e 4 e de 1,2,4-triazois substituido4 em 3,4 e 5 bem como de composicoes farmaceuticas que os contem
PT84828B (pt) Processo para a preparacao de compostos heterociclicos triciclicos fundidos e de composicoes farmaceuticas que os contem
PT80246B (pt) Processo para a preparacao de novos derivados de cefalosporina e de composicoes farmaceuticas que os contem
PT81659B (pt) Processo para a preparacao de aminoacil-labdanos e de composicoes farmaceuticas que os contem
PT84358B (pt) Processo para a preparacao de naftotiazepinonas e de composicoes farmaceuticas que as contem
PT93227A (pt) Processo para a preparacao de tetra-hidro-imidazo-{1,4}-benzodiazepin-2-tionas e de composicoes antivirais que as contem
PT84023B (pt) Processo para a preparacao de novos derivados da 1-benzeno-sulfonil-2-oxo-alcoxi-pirrolidina e de composicoes farmaceuticas que os contem
PT87942A (pt) Processo para a preparacao de benzimidazois substituidos e de composicoes farmaceuticas que os contem
PT89614A (pt) Processo para a preparacao de derivados dos acidos quinolonoe naftiridono-carboxilicos e de composicoes antibacterianas que os contem