PT84496B - Processo para a preparacao da forma o anidra cristalina do cloridrato de 2-{4-(2-furoil)-(2-piperazino)-1-il}-4-amino-6,7-dimetoxiquinazolina e de composicoes farmacauticas que a contem - Google Patents
Processo para a preparacao da forma o anidra cristalina do cloridrato de 2-{4-(2-furoil)-(2-piperazino)-1-il}-4-amino-6,7-dimetoxiquinazolina e de composicoes farmacauticas que a contemInfo
- Publication number
- PT84496B PT84496B PT84496A PT8449687A PT84496B PT 84496 B PT84496 B PT 84496B PT 84496 A PT84496 A PT 84496A PT 8449687 A PT8449687 A PT 8449687A PT 84496 B PT84496 B PT 84496B
- Authority
- PT
- Portugal
- Prior art keywords
- pharmacotic
- dimetoxyquinazoline
- piperazino
- amino
- compositions containing
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP86103925A EP0237608B1 (de) | 1986-03-21 | 1986-03-21 | Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT84496A PT84496A (de) | 1987-04-01 |
| PT84496B true PT84496B (pt) | 1989-11-10 |
Family
ID=8194990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT84496A PT84496B (pt) | 1986-03-21 | 1987-03-17 | Processo para a preparacao da forma o anidra cristalina do cloridrato de 2-{4-(2-furoil)-(2-piperazino)-1-il}-4-amino-6,7-dimetoxiquinazolina e de composicoes farmacauticas que a contem |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4816455B1 (pt) |
| EP (1) | EP0237608B1 (pt) |
| JP (1) | JPH0662615B2 (pt) |
| KR (1) | KR870008875A (pt) |
| AR (1) | AR242384A1 (pt) |
| AT (1) | ATE72244T1 (pt) |
| AU (1) | AU586318B2 (pt) |
| CA (1) | CA1240999A (pt) |
| DE (1) | DE3683760D1 (pt) |
| DK (1) | DK173283B1 (pt) |
| ES (1) | ES2009486A6 (pt) |
| GR (1) | GR870429B (pt) |
| HU (1) | HU200176B (pt) |
| ID (1) | ID810B (pt) |
| IE (1) | IE59913B1 (pt) |
| IL (1) | IL81841A (pt) |
| NZ (1) | NZ219644A (pt) |
| PT (1) | PT84496B (pt) |
| ZA (1) | ZA87966B (pt) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5412095A (en) * | 1993-04-29 | 1995-05-02 | Abbott Laboratories | Terazosin monohydrochloride and processes and intermediate for its production |
| US5504207A (en) * | 1994-10-18 | 1996-04-02 | Abbott Laboratories | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
| WO1996016946A1 (en) * | 1994-11-25 | 1996-06-06 | Nippon Chemiphar Co., Ltd. | Quinazoline derivative |
| US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
| EP0849265A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| EP0849266B8 (de) * | 1996-12-20 | 2007-10-03 | Heumann PCS GmbH | Neue polymorphe Form von Doxazosinmesylat (Form III) |
| EP0849264A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von doxazosinmesylat (Form I) |
| IL134594A (en) | 1998-06-19 | 2004-12-15 | Teijin Ltd | Polymorphs of 2- (3-cyano-4-isobutyl-oxyphenyl) -4-methyl-5-thiazolecarboxylic acid and processes for their preparation |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| CL2004001034A1 (es) | 2003-05-14 | 2005-03-28 | Teijin Pharma Ltd | Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| EP1826207A4 (en) * | 2004-11-12 | 2009-05-20 | Teijin Pharma Ltd | ACID SALT OF A BENZIMIDAZOLE DERIVATIVE AND CRYSTAL THEREOF |
| DE102005035891A1 (de) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| SG174054A1 (en) | 2006-05-04 | 2011-09-29 | Boehringer Ingelheim Int | Polymorphs |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| WO2009024542A2 (en) * | 2007-08-17 | 2009-02-26 | Boehringer Ingelheim International Gmbh | Purin derivatives for use in the treatment of fab-related diseases |
| AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| CN102123704B (zh) * | 2008-08-15 | 2014-02-12 | 勃林格殷格翰国际有限公司 | 用于治疗fab-相关疾病的嘌呤衍生物 |
| KR20110067096A (ko) | 2008-09-10 | 2011-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 및 관련 상태를 치료하기 위한 병용 요법 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| EA022310B1 (ru) | 2008-12-23 | 2015-12-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Солевые формы органического соединения |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| BR112012012641A2 (pt) | 2009-11-27 | 2020-08-11 | Boehringer Ingelheim International Gmbh | TRATAMENTO DE PACIENTES DIABÉTICOS GENOTIPADOS COM INIBIDORES DE DPP-lVTAL COMO LINAGLIPTINA |
| KR101927068B1 (ko) | 2010-05-05 | 2018-12-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법 |
| CA2803504C (en) | 2010-06-24 | 2022-08-30 | Boehringer Ingelheim International Gmbh | A combination for diabetes therapy comprising linagliptin and a long-acting insulin |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| EP3517539B1 (en) | 2011-07-15 | 2022-12-14 | Boehringer Ingelheim International GmbH | Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| JP6224084B2 (ja) | 2012-05-14 | 2017-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| EP4151218A1 (en) | 2012-05-14 | 2023-03-22 | Boehringer Ingelheim International GmbH | Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| JP6615109B2 (ja) | 2014-02-28 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｄｐｐ−４阻害薬の医学的使用 |
| WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3511836A (en) | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| US4092315A (en) * | 1976-03-01 | 1978-05-30 | Pfizer Inc. | Novel crystalline forms of prazosin hydrochloride |
| GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
| EP0146642B1 (de) * | 1983-11-22 | 1988-01-20 | LUDWIG HEUMANN & CO GMBH | Verfahren zur Herstellung von 4-Amino-6,7-dimethoxy-2-(4-(furo-2-yl)-piperazin-1-yl)-chinazolin und dessen physiologisch annehmbarer Salze |
| FI79107C (fi) * | 1984-06-25 | 1989-11-10 | Orion Yhtymae Oy | Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid. |
-
1986
- 1986-03-21 AT AT86103925T patent/ATE72244T1/de not_active IP Right Cessation
- 1986-03-21 EP EP86103925A patent/EP0237608B1/de not_active Expired - Lifetime
- 1986-03-21 DE DE8686103925T patent/DE3683760D1/de not_active Expired - Lifetime
-
1987
- 1987-02-11 ZA ZA870966A patent/ZA87966B/xx unknown
- 1987-02-12 AU AU68707/87A patent/AU586318B2/en not_active Expired
- 1987-02-13 CA CA000529737A patent/CA1240999A/en not_active Expired
- 1987-02-19 ID IDP16787A patent/ID810B/id unknown
- 1987-02-25 ES ES8700500A patent/ES2009486A6/es not_active Expired
- 1987-03-03 KR KR870001878A patent/KR870008875A/ko not_active Ceased
- 1987-03-03 US US07021161 patent/US4816455B1/en not_active Expired - Fee Related
- 1987-03-10 IL IL81841A patent/IL81841A/xx not_active IP Right Cessation
- 1987-03-16 AR AR87307027A patent/AR242384A1/es active
- 1987-03-16 GR GR870429A patent/GR870429B/el unknown
- 1987-03-16 JP JP62062343A patent/JPH0662615B2/ja not_active Expired - Fee Related
- 1987-03-17 PT PT84496A patent/PT84496B/pt unknown
- 1987-03-17 NZ NZ219644A patent/NZ219644A/xx unknown
- 1987-03-17 HU HU871155A patent/HU200176B/hu unknown
- 1987-03-18 DK DK198701398A patent/DK173283B1/da not_active IP Right Cessation
- 1987-03-18 IE IE70587A patent/IE59913B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AR242384A1 (es) | 1993-03-31 |
| IE870705L (en) | 1987-09-21 |
| JPH0662615B2 (ja) | 1994-08-17 |
| ZA87966B (en) | 1987-08-04 |
| HU200176B (en) | 1990-04-28 |
| GR870429B (en) | 1987-07-13 |
| IL81841A (en) | 1991-06-10 |
| EP0237608B1 (de) | 1992-01-29 |
| ID810B (id) | 1996-07-15 |
| IL81841A0 (en) | 1987-10-20 |
| CA1240999A (en) | 1988-08-23 |
| IE59913B1 (en) | 1994-04-20 |
| PT84496A (de) | 1987-04-01 |
| AU6870787A (en) | 1987-09-24 |
| DK139887A (da) | 1987-09-22 |
| ATE72244T1 (de) | 1992-02-15 |
| DK173283B1 (da) | 2000-06-13 |
| US4816455B1 (en) | 1992-11-24 |
| JPS62226980A (ja) | 1987-10-05 |
| KR870008875A (ko) | 1987-10-21 |
| US4816455A (en) | 1989-03-28 |
| DK139887D0 (da) | 1987-03-18 |
| ES2009486A6 (es) | 1989-10-01 |
| NZ219644A (en) | 1989-04-26 |
| EP0237608A1 (de) | 1987-09-23 |
| DE3683760D1 (de) | 1992-03-12 |
| AU586318B2 (en) | 1989-07-06 |
| HUT47101A (en) | 1989-01-30 |
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