ID810B - KRISTAL BENTUK ε DARI 2-(4-(2-FUROIL)-(2-PIPERAZIN)-1-IL)-4-AMINO-6,7-DIMETOKSIQUINAZOLIN HIDROKLORIDA ANHIDRAT DAN PROSES UNTUK PEMBUATANNYA - Google Patents
KRISTAL BENTUK ε DARI 2-(4-(2-FUROIL)-(2-PIPERAZIN)-1-IL)-4-AMINO-6,7-DIMETOKSIQUINAZOLIN HIDROKLORIDA ANHIDRAT DAN PROSES UNTUK PEMBUATANNYAInfo
- Publication number
- ID810B ID810B IDP16787A ID870167A ID810B ID 810 B ID810 B ID 810B ID P16787 A IDP16787 A ID P16787A ID 870167 A ID870167 A ID 870167A ID 810 B ID810 B ID 810B
- Authority
- ID
- Indonesia
- Prior art keywords
- hydroxloride
- dimetocysiquinazoline
- furoil
- anhydrates
- piperazin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP86103925A EP0237608B1 (de) | 1986-03-21 | 1986-03-21 | Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID810B true ID810B (id) | 1996-07-15 |
Family
ID=8194990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDP16787A ID810B (id) | 1986-03-21 | 1987-02-19 | KRISTAL BENTUK ε DARI 2-(4-(2-FUROIL)-(2-PIPERAZIN)-1-IL)-4-AMINO-6,7-DIMETOKSIQUINAZOLIN HIDROKLORIDA ANHIDRAT DAN PROSES UNTUK PEMBUATANNYA |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4816455B1 (id) |
| EP (1) | EP0237608B1 (id) |
| JP (1) | JPH0662615B2 (id) |
| KR (1) | KR870008875A (id) |
| AR (1) | AR242384A1 (id) |
| AT (1) | ATE72244T1 (id) |
| AU (1) | AU586318B2 (id) |
| CA (1) | CA1240999A (id) |
| DE (1) | DE3683760D1 (id) |
| DK (1) | DK173283B1 (id) |
| ES (1) | ES2009486A6 (id) |
| GR (1) | GR870429B (id) |
| HU (1) | HU200176B (id) |
| ID (1) | ID810B (id) |
| IE (1) | IE59913B1 (id) |
| IL (1) | IL81841A (id) |
| NZ (1) | NZ219644A (id) |
| PT (1) | PT84496B (id) |
| ZA (1) | ZA87966B (id) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5412095A (en) * | 1993-04-29 | 1995-05-02 | Abbott Laboratories | Terazosin monohydrochloride and processes and intermediate for its production |
| US5504207A (en) * | 1994-10-18 | 1996-04-02 | Abbott Laboratories | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
| EP0794178A4 (en) * | 1994-11-25 | 1998-02-25 | Nippon Chemiphar Co | CHINAZOLIN DERIVATIVES |
| US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
| ATE353892T1 (de) * | 1996-12-20 | 2007-03-15 | Heumann Pharma Gmbh & Co | Neue polymorphe form von doxazosinmesylat (form iii) |
| EP0849264A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von doxazosinmesylat (Form I) |
| EP0849265A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| CA2301863C (en) | 1998-06-19 | 2009-01-27 | Teijin Limited | Polymorphs modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and method of producing the same |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| CL2004001034A1 (es) | 2003-05-14 | 2005-03-28 | Teijin Pharma Ltd | Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| US20080015240A1 (en) * | 2004-11-12 | 2008-01-17 | Mitsuru Teramoto | Acid Salt of Benzimidazole Derivative and Crystal Thereof |
| DE102005035891A1 (de) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| CN103951667A (zh) | 2006-05-04 | 2014-07-30 | 勃林格殷格翰国际有限公司 | 多晶型 |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| EP3542801A1 (en) * | 2007-08-17 | 2019-09-25 | Boehringer Ingelheim International GmbH | Purin derivatives for use in the treatment of fap-related diseases |
| AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| PE20110297A1 (es) * | 2008-08-15 | 2011-05-26 | Boehringer Ingelheim Int | Inhibidores de dpp-4 para la cicatrizacion de heridas |
| AU2009290911A1 (en) | 2008-09-10 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| US8865729B2 (en) | 2008-12-23 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Salt forms of a xanthine compound |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| AU2010323068B2 (en) | 2009-11-27 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin |
| EA033415B1 (ru) | 2010-05-05 | 2019-10-31 | Boehringer Ingelheim Int | Способы лечения ожирения, применение ингибитора dpp-4 в этих способах и способ лечения пациентов, страдающих диабетом типа 2 |
| BR112012032579B1 (pt) | 2010-06-24 | 2021-05-11 | Boehringer Ingelheim International Gmbh | uso de linagliptina e composição farmacêutica compreendendo linagliptina e insulina basal de longa duração |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| NZ618698A (en) | 2011-07-15 | 2015-08-28 | Boehringer Ingelheim Int | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| JP6224084B2 (ja) | 2012-05-14 | 2017-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| WO2015128453A1 (en) | 2014-02-28 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Medical use of a dpp-4 inhibitor |
| MX2018015089A (es) | 2016-06-10 | 2019-05-13 | Boehringer Ingelheim Int | Combinacion de linagliptina y metformina. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| US4092315A (en) * | 1976-03-01 | 1978-05-30 | Pfizer Inc. | Novel crystalline forms of prazosin hydrochloride |
| GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
| EP0146642B1 (de) * | 1983-11-22 | 1988-01-20 | LUDWIG HEUMANN & CO GMBH | Verfahren zur Herstellung von 4-Amino-6,7-dimethoxy-2-(4-(furo-2-yl)-piperazin-1-yl)-chinazolin und dessen physiologisch annehmbarer Salze |
| FI79107C (fi) * | 1984-06-25 | 1989-11-10 | Orion Yhtymae Oy | Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid. |
-
1986
- 1986-03-21 AT AT86103925T patent/ATE72244T1/de not_active IP Right Cessation
- 1986-03-21 DE DE8686103925T patent/DE3683760D1/de not_active Expired - Lifetime
- 1986-03-21 EP EP86103925A patent/EP0237608B1/de not_active Expired - Lifetime
-
1987
- 1987-02-11 ZA ZA870966A patent/ZA87966B/xx unknown
- 1987-02-12 AU AU68707/87A patent/AU586318B2/en not_active Expired
- 1987-02-13 CA CA000529737A patent/CA1240999A/en not_active Expired
- 1987-02-19 ID IDP16787A patent/ID810B/id unknown
- 1987-02-25 ES ES8700500A patent/ES2009486A6/es not_active Expired
- 1987-03-03 US US07021161 patent/US4816455B1/en not_active Expired - Fee Related
- 1987-03-03 KR KR870001878A patent/KR870008875A/ko not_active Application Discontinuation
- 1987-03-10 IL IL81841A patent/IL81841A/xx not_active IP Right Cessation
- 1987-03-16 GR GR870429A patent/GR870429B/el unknown
- 1987-03-16 JP JP62062343A patent/JPH0662615B2/ja not_active Expired - Fee Related
- 1987-03-16 AR AR87307027A patent/AR242384A1/es active
- 1987-03-17 NZ NZ219644A patent/NZ219644A/xx unknown
- 1987-03-17 HU HU871155A patent/HU200176B/hu unknown
- 1987-03-17 PT PT84496A patent/PT84496B/pt unknown
- 1987-03-18 DK DK198701398A patent/DK173283B1/da not_active IP Right Cessation
- 1987-03-18 IE IE70587A patent/IE59913B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2009486A6 (es) | 1989-10-01 |
| US4816455B1 (en) | 1992-11-24 |
| IL81841A0 (en) | 1987-10-20 |
| IL81841A (en) | 1991-06-10 |
| PT84496A (de) | 1987-04-01 |
| JPS62226980A (ja) | 1987-10-05 |
| AU586318B2 (en) | 1989-07-06 |
| NZ219644A (en) | 1989-04-26 |
| DK139887D0 (da) | 1987-03-18 |
| CA1240999A (en) | 1988-08-23 |
| IE59913B1 (en) | 1994-04-20 |
| HU200176B (en) | 1990-04-28 |
| IE870705L (en) | 1987-09-21 |
| DE3683760D1 (de) | 1992-03-12 |
| ZA87966B (en) | 1987-08-04 |
| AR242384A1 (es) | 1993-03-31 |
| EP0237608A1 (de) | 1987-09-23 |
| DK139887A (da) | 1987-09-22 |
| KR870008875A (ko) | 1987-10-21 |
| JPH0662615B2 (ja) | 1994-08-17 |
| DK173283B1 (da) | 2000-06-13 |
| US4816455A (en) | 1989-03-28 |
| EP0237608B1 (de) | 1992-01-29 |
| PT84496B (pt) | 1989-11-10 |
| ATE72244T1 (de) | 1992-02-15 |
| HUT47101A (en) | 1989-01-30 |
| AU6870787A (en) | 1987-09-24 |
| GR870429B (en) | 1987-07-13 |
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