ID810B - KRISTAL BENTUK ε DARI 2-(4-(2-FUROIL)-(2-PIPERAZIN)-1-IL)-4-AMINO-6,7-DIMETOKSIQUINAZOLIN HIDROKLORIDA ANHIDRAT DAN PROSES UNTUK PEMBUATANNYA - Google Patents
KRISTAL BENTUK ε DARI 2-(4-(2-FUROIL)-(2-PIPERAZIN)-1-IL)-4-AMINO-6,7-DIMETOKSIQUINAZOLIN HIDROKLORIDA ANHIDRAT DAN PROSES UNTUK PEMBUATANNYAInfo
- Publication number
- ID810B ID810B IDP16787A ID870167A ID810B ID 810 B ID810 B ID 810B ID P16787 A IDP16787 A ID P16787A ID 870167 A ID870167 A ID 870167A ID 810 B ID810 B ID 810B
- Authority
- ID
- Indonesia
- Prior art keywords
- hydroxloride
- dimetocysiquinazoline
- furoil
- anhydrates
- piperazin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP86103925A EP0237608B1 (de) | 1986-03-21 | 1986-03-21 | Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID810B true ID810B (id) | 1996-07-15 |
Family
ID=8194990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDP16787A ID810B (id) | 1986-03-21 | 1987-02-19 | KRISTAL BENTUK ε DARI 2-(4-(2-FUROIL)-(2-PIPERAZIN)-1-IL)-4-AMINO-6,7-DIMETOKSIQUINAZOLIN HIDROKLORIDA ANHIDRAT DAN PROSES UNTUK PEMBUATANNYA |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4816455B1 (id) |
| EP (1) | EP0237608B1 (id) |
| JP (1) | JPH0662615B2 (id) |
| KR (1) | KR870008875A (id) |
| AR (1) | AR242384A1 (id) |
| AT (1) | ATE72244T1 (id) |
| AU (1) | AU586318B2 (id) |
| CA (1) | CA1240999A (id) |
| DE (1) | DE3683760D1 (id) |
| DK (1) | DK173283B1 (id) |
| ES (1) | ES2009486A6 (id) |
| GR (1) | GR870429B (id) |
| HU (1) | HU200176B (id) |
| ID (1) | ID810B (id) |
| IE (1) | IE59913B1 (id) |
| IL (1) | IL81841A (id) |
| NZ (1) | NZ219644A (id) |
| PT (1) | PT84496B (id) |
| ZA (1) | ZA87966B (id) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5412095A (en) * | 1993-04-29 | 1995-05-02 | Abbott Laboratories | Terazosin monohydrochloride and processes and intermediate for its production |
| US5504207A (en) * | 1994-10-18 | 1996-04-02 | Abbott Laboratories | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
| US6706705B1 (en) * | 1994-11-25 | 2004-03-16 | Nippon Chemiphar Co., Ltd. | Quinazoline derivatives |
| US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
| EP0849265A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| EP0849264A1 (de) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von doxazosinmesylat (Form I) |
| EP0849266B8 (de) * | 1996-12-20 | 2007-10-03 | Heumann PCS GmbH | Neue polymorphe Form von Doxazosinmesylat (Form III) |
| JP3547707B2 (ja) | 1998-06-19 | 2004-07-28 | 帝人株式会社 | ２−（３−シアノ−４−イソブチルオキシフェニル）−４−メチル−５−チアゾールカルボン酸の結晶多形体およびその製造方法 |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| CL2004001034A1 (es) | 2003-05-14 | 2005-03-28 | Teijin Pharma Ltd | Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| JPWO2006052026A1 (ja) * | 2004-11-12 | 2008-05-29 | 帝人ファーマ株式会社 | ベンズイミダゾール誘導体の酸性塩及びその結晶 |
| DE102005035891A1 (de) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| CN109503584A (zh) | 2006-05-04 | 2019-03-22 | 勃林格殷格翰国际有限公司 | 多晶型 |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| MX2010001821A (es) * | 2007-08-17 | 2010-03-10 | Boehringer Ingelheim Int | Derivados de purina para uso en el tratamiento de enfermedades relacionadas con fap. |
| PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| ES2764251T3 (es) * | 2008-08-15 | 2020-06-02 | Boehringer Ingelheim Int | Inhibidores de DPP-4 para uso en el tratamiento de curación de heridas en pacientes diabéticos |
| WO2010029089A2 (en) | 2008-09-10 | 2010-03-18 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| EP2382216A1 (en) | 2008-12-23 | 2011-11-02 | Boehringer Ingelheim International GmbH | Salt forms of organic compound |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| NZ599298A (en) | 2009-11-27 | 2014-11-28 | Boehringer Ingelheim Int | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
| KR101927068B1 (ko) | 2010-05-05 | 2018-12-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법 |
| CN106975074A (zh) | 2010-06-24 | 2017-07-25 | 勃林格殷格翰国际有限公司 | 糖尿病治疗 |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| ES2713566T3 (es) | 2011-07-15 | 2019-05-22 | Boehringer Ingelheim Int | Derivado de quinazolina dimérico sustituido, su preparación y su uso en composiciones farmacéuticas para el tratamiento de la diabetes de tipo I y II |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| EP4151218A1 (en) | 2012-05-14 | 2023-03-22 | Boehringer Ingelheim International GmbH | Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis |
| EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
| EP4233840A3 (en) | 2016-06-10 | 2023-10-18 | Boehringer Ingelheim International GmbH | Combinations of linagliptin and metformin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3511836A (en) | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| US4092315A (en) * | 1976-03-01 | 1978-05-30 | Pfizer Inc. | Novel crystalline forms of prazosin hydrochloride |
| GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
| DE3375395D1 (en) * | 1983-11-22 | 1988-02-25 | Heumann Ludwig & Co Gmbh | Process for the preparation of 4-amino-6,7-dimethoxy-2-(4-(furoyl-2)-piperazin-1-yl)-quinazoline and its physiologically acceptable salt |
| FI79107C (fi) * | 1984-06-25 | 1989-11-10 | Orion Yhtymae Oy | Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid. |
-
1986
- 1986-03-21 DE DE8686103925T patent/DE3683760D1/de not_active Expired - Lifetime
- 1986-03-21 AT AT86103925T patent/ATE72244T1/de not_active IP Right Cessation
- 1986-03-21 EP EP86103925A patent/EP0237608B1/de not_active Expired - Lifetime
-
1987
- 1987-02-11 ZA ZA870966A patent/ZA87966B/xx unknown
- 1987-02-12 AU AU68707/87A patent/AU586318B2/en not_active Expired
- 1987-02-13 CA CA000529737A patent/CA1240999A/en not_active Expired
- 1987-02-19 ID IDP16787A patent/ID810B/id unknown
- 1987-02-25 ES ES8700500A patent/ES2009486A6/es not_active Expired
- 1987-03-03 US US07021161 patent/US4816455B1/en not_active Expired - Fee Related
- 1987-03-03 KR KR870001878A patent/KR870008875A/ko not_active Ceased
- 1987-03-10 IL IL81841A patent/IL81841A/xx not_active IP Right Cessation
- 1987-03-16 GR GR870429A patent/GR870429B/el unknown
- 1987-03-16 JP JP62062343A patent/JPH0662615B2/ja not_active Expired - Fee Related
- 1987-03-16 AR AR87307027A patent/AR242384A1/es active
- 1987-03-17 HU HU871155A patent/HU200176B/hu unknown
- 1987-03-17 PT PT84496A patent/PT84496B/pt unknown
- 1987-03-17 NZ NZ219644A patent/NZ219644A/xx unknown
- 1987-03-18 IE IE70587A patent/IE59913B1/en not_active IP Right Cessation
- 1987-03-18 DK DK198701398A patent/DK173283B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL81841A0 (en) | 1987-10-20 |
| DK139887A (da) | 1987-09-22 |
| US4816455B1 (en) | 1992-11-24 |
| HU200176B (en) | 1990-04-28 |
| GR870429B (en) | 1987-07-13 |
| HUT47101A (en) | 1989-01-30 |
| AU586318B2 (en) | 1989-07-06 |
| NZ219644A (en) | 1989-04-26 |
| ES2009486A6 (es) | 1989-10-01 |
| JPS62226980A (ja) | 1987-10-05 |
| CA1240999A (en) | 1988-08-23 |
| ZA87966B (en) | 1987-08-04 |
| PT84496A (de) | 1987-04-01 |
| US4816455A (en) | 1989-03-28 |
| IE870705L (en) | 1987-09-21 |
| AU6870787A (en) | 1987-09-24 |
| EP0237608A1 (de) | 1987-09-23 |
| IE59913B1 (en) | 1994-04-20 |
| DK173283B1 (da) | 2000-06-13 |
| ATE72244T1 (de) | 1992-02-15 |
| JPH0662615B2 (ja) | 1994-08-17 |
| IL81841A (en) | 1991-06-10 |
| AR242384A1 (es) | 1993-03-31 |
| PT84496B (pt) | 1989-11-10 |
| KR870008875A (ko) | 1987-10-21 |
| EP0237608B1 (de) | 1992-01-29 |
| DE3683760D1 (de) | 1992-03-12 |
| DK139887D0 (da) | 1987-03-18 |
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