ID810B - CRYSTAL FORM ε FROM 2- (4- (2-FUROIL) - (2-PIPERAZIN) -1-IL) -4-AMINO-6,7-DIMETOCYSIQUINAZOLINE HYDROXLORIDE ANHYDRATES AND PROCESSES FOR THE PRODUCTION - Google Patents
CRYSTAL FORM ε FROM 2- (4- (2-FUROIL) - (2-PIPERAZIN) -1-IL) -4-AMINO-6,7-DIMETOCYSIQUINAZOLINE HYDROXLORIDE ANHYDRATES AND PROCESSES FOR THE PRODUCTIONInfo
- Publication number
- ID810B ID810B IDP16787A ID870167A ID810B ID 810 B ID810 B ID 810B ID P16787 A IDP16787 A ID P16787A ID 870167 A ID870167 A ID 870167A ID 810 B ID810 B ID 810B
- Authority
- ID
- Indonesia
- Prior art keywords
- hydroxloride
- dimetocysiquinazoline
- furoil
- anhydrates
- piperazin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP86103925A EP0237608B1 (en) | 1986-03-21 | 1986-03-21 | Crystalline anhydrous sigma-form of 2-[4-(2-furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxyquinazoline hydrochloride, and process for its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID810B true ID810B (en) | 1996-07-15 |
Family
ID=8194990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDP16787A ID810B (en) | 1986-03-21 | 1987-02-19 | CRYSTAL FORM ε FROM 2- (4- (2-FUROIL) - (2-PIPERAZIN) -1-IL) -4-AMINO-6,7-DIMETOCYSIQUINAZOLINE HYDROXLORIDE ANHYDRATES AND PROCESSES FOR THE PRODUCTION |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4816455B1 (en) |
| EP (1) | EP0237608B1 (en) |
| JP (1) | JPH0662615B2 (en) |
| KR (1) | KR870008875A (en) |
| AR (1) | AR242384A1 (en) |
| AT (1) | ATE72244T1 (en) |
| AU (1) | AU586318B2 (en) |
| CA (1) | CA1240999A (en) |
| DE (1) | DE3683760D1 (en) |
| DK (1) | DK173283B1 (en) |
| ES (1) | ES2009486A6 (en) |
| GR (1) | GR870429B (en) |
| HU (1) | HU200176B (en) |
| ID (1) | ID810B (en) |
| IE (1) | IE59913B1 (en) |
| IL (1) | IL81841A (en) |
| NZ (1) | NZ219644A (en) |
| PT (1) | PT84496B (en) |
| ZA (1) | ZA87966B (en) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5412095A (en) * | 1993-04-29 | 1995-05-02 | Abbott Laboratories | Terazosin monohydrochloride and processes and intermediate for its production |
| US5504207A (en) * | 1994-10-18 | 1996-04-02 | Abbott Laboratories | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
| US6706705B1 (en) * | 1994-11-25 | 2004-03-16 | Nippon Chemiphar Co., Ltd. | Quinazoline derivatives |
| US5587377A (en) * | 1995-10-24 | 1996-12-24 | Invamed, Inc. | Terazosin crystalline polymorph and pharmaceutical compositions thereof |
| EP0849264A1 (en) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Novel polymorphic form of doxazosin mesylate (form I) |
| EP0849265A1 (en) * | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Novel polymorphic form of doxazosin mesylate (form II) |
| PT849266E (en) * | 1996-12-20 | 2007-03-30 | Heumann Pcs Gmbh | Novel polymorphic form of doxazosin mesylate (form iii) |
| SK287928B6 (en) | 1998-06-19 | 2012-04-03 | Teijin Pharma Limited | Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)-4- methyl-5-thiazole-carboxylic acid and processes for the preparation thereof |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| CL2004001034A1 (en) | 2003-05-14 | 2005-03-28 | Teijin Pharma Ltd | CRYSTALLINE FORMS OF ACID 4- (1 - ((, ETILBENZOTIOFEN-3-IL) ME TIL) BENZIMIDAZOL-2-ILTIO) BUTANOIC; PROCEDURE FOR THE PREPARATION OF CRYSTAL FORMS; PHARMACEUTICAL COMPOSITION; AND ITS USE FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC DISEASES, R |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (en) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for preparing chiral 8- (3-amino-piperidin-1-yl) -xanthines |
| US20080015240A1 (en) * | 2004-11-12 | 2008-01-17 | Mitsuru Teramoto | Acid Salt of Benzimidazole Derivative and Crystal Thereof |
| DE102005035891A1 (en) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8- (3-amino-piperidin-1-yl) -xanthines, their preparation and their use as pharmaceuticals |
| PE20080251A1 (en) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | USES OF DPP IV INHIBITORS |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| CN102838599A (en) | 2006-05-04 | 2012-12-26 | 贝林格尔.英格海姆国际有限公司 | Polymorphs |
| AU2008290582B2 (en) * | 2007-08-17 | 2014-08-14 | Boehringer Ingelheim International Gmbh | Purin derivatives for use in the treatment of fab-related diseases |
| PE20091730A1 (en) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | FORMULATIONS INVOLVING A DPP4 INHIBITOR |
| PE20100156A1 (en) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | NAFLD TREATMENT |
| KR20200118243A (en) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | Treatment for diabetes in patients inappropriate for metformin therapy |
| UY32030A (en) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "TREATMENT FOR DIABETES IN INAPPROPRIATE PATIENTS FOR THERAPY WITH METFORMIN" |
| MX370599B (en) * | 2008-08-15 | 2019-12-18 | Boehringer Ingelheim Int | Purin derivatives for use in the treatment of fab-related diseases. |
| BRPI0919288A2 (en) | 2008-09-10 | 2015-12-15 | Boehring Ingelheim Internat Gmbh | combination therapy for treatment of diabetes and related conditions. |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| EA022310B1 (en) | 2008-12-23 | 2015-12-30 | Бёрингер Ингельхайм Интернациональ Гмбх | SALT FORMS OF ORGANIC COMPOUND |
| AR074990A1 (en) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | TREATMENT OF DIABETES IN PATIENTS WITH AN INAPPROPRIATE GLUCEMIC CONTROL THROUGH METFORMIN THERAPY |
| NZ599298A (en) | 2009-11-27 | 2014-11-28 | Boehringer Ingelheim Int | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
| WO2011138421A1 (en) | 2010-05-05 | 2011-11-10 | Boehringer Ingelheim International Gmbh | Combination therapy |
| NZ603319A (en) | 2010-06-24 | 2015-04-24 | Boehringer Ingelheim Int | Diabetes therapy |
| AR083878A1 (en) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | VASOPROTECTORA AND CARDIOPROTECTORA ANTIDIABETIC THERAPY, LINAGLIPTINA, TREATMENT METHOD |
| CA2841552C (en) | 2011-07-15 | 2020-06-23 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| US20130303554A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in sirs and/or sepsis |
| EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| ES2950384T3 (en) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Medical use of a DPP-4 inhibitor |
| WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3511836A (en) | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
| US4092315A (en) * | 1976-03-01 | 1978-05-30 | Pfizer Inc. | Novel crystalline forms of prazosin hydrochloride |
| GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
| EP0146642B1 (en) * | 1983-11-22 | 1988-01-20 | LUDWIG HEUMANN & CO GMBH | Process for the preparation of 4-amino-6,7-dimethoxy-2-(4-(furoyl-2)-piperazin-1-yl)-quinazoline and its physiologically acceptable salt |
| FI79107C (en) * | 1984-06-25 | 1989-11-10 | Orion Yhtymae Oy | Process for the preparation of stable form of prazosin hydrochloride. |
-
1986
- 1986-03-21 EP EP86103925A patent/EP0237608B1/en not_active Expired - Lifetime
- 1986-03-21 AT AT86103925T patent/ATE72244T1/en not_active IP Right Cessation
- 1986-03-21 DE DE8686103925T patent/DE3683760D1/en not_active Expired - Lifetime
-
1987
- 1987-02-11 ZA ZA870966A patent/ZA87966B/en unknown
- 1987-02-12 AU AU68707/87A patent/AU586318B2/en not_active Expired
- 1987-02-13 CA CA000529737A patent/CA1240999A/en not_active Expired
- 1987-02-19 ID IDP16787A patent/ID810B/en unknown
- 1987-02-25 ES ES8700500A patent/ES2009486A6/en not_active Expired
- 1987-03-03 KR KR870001878A patent/KR870008875A/en not_active Ceased
- 1987-03-03 US US07021161 patent/US4816455B1/en not_active Expired - Fee Related
- 1987-03-10 IL IL81841A patent/IL81841A/en not_active IP Right Cessation
- 1987-03-16 JP JP62062343A patent/JPH0662615B2/en not_active Expired - Fee Related
- 1987-03-16 AR AR87307027A patent/AR242384A1/en active
- 1987-03-16 GR GR870429A patent/GR870429B/en unknown
- 1987-03-17 HU HU871155A patent/HU200176B/en unknown
- 1987-03-17 PT PT84496A patent/PT84496B/en unknown
- 1987-03-17 NZ NZ219644A patent/NZ219644A/en unknown
- 1987-03-18 DK DK198701398A patent/DK173283B1/en not_active IP Right Cessation
- 1987-03-18 IE IE70587A patent/IE59913B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62226980A (en) | 1987-10-05 |
| HUT47101A (en) | 1989-01-30 |
| IL81841A (en) | 1991-06-10 |
| JPH0662615B2 (en) | 1994-08-17 |
| EP0237608A1 (en) | 1987-09-23 |
| CA1240999A (en) | 1988-08-23 |
| HU200176B (en) | 1990-04-28 |
| IL81841A0 (en) | 1987-10-20 |
| US4816455B1 (en) | 1992-11-24 |
| DK139887A (en) | 1987-09-22 |
| US4816455A (en) | 1989-03-28 |
| GR870429B (en) | 1987-07-13 |
| AU6870787A (en) | 1987-09-24 |
| KR870008875A (en) | 1987-10-21 |
| PT84496B (en) | 1989-11-10 |
| IE59913B1 (en) | 1994-04-20 |
| DK173283B1 (en) | 2000-06-13 |
| DE3683760D1 (en) | 1992-03-12 |
| AU586318B2 (en) | 1989-07-06 |
| IE870705L (en) | 1987-09-21 |
| ATE72244T1 (en) | 1992-02-15 |
| EP0237608B1 (en) | 1992-01-29 |
| AR242384A1 (en) | 1993-03-31 |
| DK139887D0 (en) | 1987-03-18 |
| ZA87966B (en) | 1987-08-04 |
| ES2009486A6 (en) | 1989-10-01 |
| PT84496A (en) | 1987-04-01 |
| NZ219644A (en) | 1989-04-26 |
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