PT83734B - Processo para a preparacao de oxazolonas heterociclicas com actividade cardiotonica - Google Patents
Processo para a preparacao de oxazolonas heterociclicas com actividade cardiotonicaInfo
- Publication number
- PT83734B PT83734B PT83734A PT8373486A PT83734B PT 83734 B PT83734 B PT 83734B PT 83734 A PT83734 A PT 83734A PT 8373486 A PT8373486 A PT 8373486A PT 83734 B PT83734 B PT 83734B
- Authority
- PT
- Portugal
- Prior art keywords
- oxazolones
- heterocyclic
- preparation
- cardiotonic activity
- cardiotonic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/797,580 US4698353A (en) | 1985-11-13 | 1985-11-13 | Cardiotonic heterocyclic oxazolones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT83734A PT83734A (en) | 1986-12-01 |
| PT83734B true PT83734B (pt) | 1988-08-17 |
Family
ID=25171234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT83734A PT83734B (pt) | 1985-11-13 | 1986-11-12 | Processo para a preparacao de oxazolonas heterociclicas com actividade cardiotonica |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4698353A (pt) |
| EP (1) | EP0222358B1 (pt) |
| JP (1) | JPS62114975A (pt) |
| KR (1) | KR900000369B1 (pt) |
| CN (1) | CN1017150B (pt) |
| AR (1) | AR242207A1 (pt) |
| AT (1) | ATE62685T1 (pt) |
| AU (1) | AU586295B2 (pt) |
| CA (1) | CA1280754C (pt) |
| DE (1) | DE3678795D1 (pt) |
| DK (1) | DK540686A (pt) |
| ES (1) | ES2036518T3 (pt) |
| FI (1) | FI864596A (pt) |
| GR (1) | GR3001806T3 (pt) |
| HU (1) | HU197898B (pt) |
| IL (1) | IL80583A0 (pt) |
| NO (1) | NO168105C (pt) |
| NZ (1) | NZ218237A (pt) |
| PH (1) | PH23218A (pt) |
| PT (1) | PT83734B (pt) |
| ZA (1) | ZA868503B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670450A (en) * | 1985-11-13 | 1987-06-02 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic thiazolones |
| US4876352A (en) * | 1988-09-14 | 1989-10-24 | Schering Corporation | Pressurized fluorination of hydroxy alkyl groups |
| US4990519A (en) * | 1988-10-24 | 1991-02-05 | Merrell Dow Pharmaceuticals | Method of using quinolyloxazole-2-ones as proteinkinase C inhibitors |
| US4999431A (en) * | 1988-10-24 | 1991-03-12 | Merrell Dow Pharmaceuticals | Process for preparing quinoline aldehyde and ketone derivatives |
| US4886811A (en) * | 1988-10-24 | 1989-12-12 | Merrell Dow Pharmaceuticals | Qunolyloxazole-2-ones useful as proteinkinase C inhibitors |
| ZA908934B (en) * | 1989-11-13 | 1991-08-28 | Merrell Dow Pharma | Novel pyridyloxazole-2-ones useful as proteinkinase c inhibitors |
| ZA908852B (en) * | 1989-11-13 | 1991-09-25 | Merrell Dow Pharma | Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones |
| ZA908935B (en) * | 1989-11-13 | 1991-08-28 | Merrell Dow Pharma | Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones |
| US5182293A (en) * | 1989-11-13 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones |
| US5063238A (en) * | 1989-11-13 | 1991-11-05 | Merrell Dow Pharmaceuticals Inc. | Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones |
| ATE155686T1 (de) * | 1991-05-14 | 1997-08-15 | Merrell Pharma Inc | Hemmung von metastasen bei krebspatienten mit pyridyloxazol-2-onen |
| CN1064080C (zh) * | 1997-06-26 | 2001-04-04 | 梁国坚 | 鹿茸细胞的工业化生产方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3538104A (en) * | 1969-02-28 | 1970-11-03 | Geigy Chem Corp | Pyridyl-2-imidazolones |
| US3879410A (en) * | 1971-02-08 | 1975-04-22 | Messrs Lab Guidotti & C S P A | 4-Aryl-4-oxazolin-2-ones exhibiting myotonic and myorelaxing activity |
| SU427015A1 (ru) * | 1972-04-21 | 1974-05-05 | В. М. Дзиомко , А. В. Иващенко | Способ получения замещенных 4-оксазолин-2-онов |
| JPS5111763A (en) * | 1974-07-16 | 1976-01-30 | Sankyo Co | 55 chikan 44 okisazorin 22 onno seizoho |
| JPS5811867B2 (ja) * | 1974-11-06 | 1983-03-04 | 東京田辺製薬株式会社 | ５，５−ジメチル−４−フエニルオキサゾリジン−２−オン誘導体の製造方法 |
| IT1109002B (it) * | 1977-09-22 | 1985-12-16 | Menarini Sas | Derivati del 2 oxazolidone e loro metodi di preparazione |
| DE2935902A1 (de) * | 1979-09-05 | 1981-04-02 | A. Nattermann & Cie GmbH, 5000 Köln | Oxazolinalkansaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| US4532250A (en) * | 1983-11-23 | 1985-07-30 | American Hospital Supply Corporation | 5-Heteroarylimidazol-2-ones having cardiotonic activity |
-
1985
- 1985-11-13 US US06/797,580 patent/US4698353A/en not_active Expired - Lifetime
-
1986
- 1986-11-07 AU AU64932/86A patent/AU586295B2/en not_active Ceased
- 1986-11-07 ZA ZA868503A patent/ZA868503B/xx unknown
- 1986-11-07 CA CA000522445A patent/CA1280754C/en not_active Expired - Lifetime
- 1986-11-10 ES ES198686115560T patent/ES2036518T3/es not_active Expired - Lifetime
- 1986-11-10 AT AT86115560T patent/ATE62685T1/de not_active IP Right Cessation
- 1986-11-10 NZ NZ218237A patent/NZ218237A/xx unknown
- 1986-11-10 DE DE8686115560T patent/DE3678795D1/de not_active Expired - Fee Related
- 1986-11-10 PH PH34457A patent/PH23218A/en unknown
- 1986-11-10 EP EP86115560A patent/EP0222358B1/en not_active Expired - Lifetime
- 1986-11-11 IL IL80583A patent/IL80583A0/xx not_active IP Right Cessation
- 1986-11-11 AR AR86305850A patent/AR242207A1/es active
- 1986-11-11 HU HU864655A patent/HU197898B/hu not_active IP Right Cessation
- 1986-11-12 KR KR1019860009533A patent/KR900000369B1/ko not_active IP Right Cessation
- 1986-11-12 NO NO864515A patent/NO168105C/no unknown
- 1986-11-12 FI FI864596A patent/FI864596A/fi not_active Application Discontinuation
- 1986-11-12 PT PT83734A patent/PT83734B/pt not_active IP Right Cessation
- 1986-11-12 CN CN86107813A patent/CN1017150B/zh not_active Expired
- 1986-11-12 DK DK540686A patent/DK540686A/da not_active Application Discontinuation
- 1986-11-13 JP JP61268802A patent/JPS62114975A/ja active Pending
-
1991
- 1991-04-18 GR GR91400469T patent/GR3001806T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI864596A0 (fi) | 1986-11-12 |
| IL80583A0 (en) | 1987-02-27 |
| PT83734A (en) | 1986-12-01 |
| KR900000369B1 (ko) | 1990-01-25 |
| KR870004980A (ko) | 1987-06-02 |
| EP0222358A1 (en) | 1987-05-20 |
| AR242207A1 (es) | 1993-03-31 |
| NO168105C (no) | 1992-01-15 |
| ZA868503B (en) | 1987-06-24 |
| AU6493286A (en) | 1987-05-21 |
| CA1280754C (en) | 1991-02-26 |
| NO168105B (no) | 1991-10-07 |
| FI864596A (fi) | 1987-05-14 |
| DK540686D0 (da) | 1986-11-12 |
| NZ218237A (en) | 1989-08-29 |
| NO864515D0 (no) | 1986-11-12 |
| HU197898B (en) | 1989-06-28 |
| CN1017150B (zh) | 1992-06-24 |
| DE3678795D1 (de) | 1991-05-23 |
| HUT45032A (en) | 1988-05-30 |
| ATE62685T1 (de) | 1991-05-15 |
| PH23218A (en) | 1989-06-06 |
| NO864515L (no) | 1987-05-14 |
| DK540686A (da) | 1987-05-14 |
| JPS62114975A (ja) | 1987-05-26 |
| GR3001806T3 (en) | 1992-11-23 |
| ES2036518T3 (es) | 1993-06-01 |
| AU586295B2 (en) | 1989-07-06 |
| CN86107813A (zh) | 1987-07-29 |
| EP0222358B1 (en) | 1991-04-17 |
| US4698353A (en) | 1987-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19940831 |