ES2036518T3 - Un procedimiento para preparar una oxazolona heterociclica. - Google Patents

Un procedimiento para preparar una oxazolona heterociclica.

Info

Publication number
ES2036518T3
ES2036518T3 ES198686115560T ES86115560T ES2036518T3 ES 2036518 T3 ES2036518 T3 ES 2036518T3 ES 198686115560 T ES198686115560 T ES 198686115560T ES 86115560 T ES86115560 T ES 86115560T ES 2036518 T3 ES2036518 T3 ES 2036518T3
Authority
ES
Spain
Prior art keywords
oxazolone
preparing
procedure
hetero cyclic
hetero
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686115560T
Other languages
English (en)
Inventor
Richard A. Schnettler
George P. Claxton
Winton D. Jones, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2036518T3 publication Critical patent/ES2036518T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LAS OXAZOLONAS HETEROCICLICAS MEJORAN LA FUERZA DE CONTRACCION DEL MIOCARDIO Y LA FUNCION CARDIACA Y SE EMPLEAN COMO CARDIOTONICOS EN EL TRATAMIENTO DEL FALLO CARDIACO.
ES198686115560T 1985-11-13 1986-11-10 Un procedimiento para preparar una oxazolona heterociclica. Expired - Lifetime ES2036518T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/797,580 US4698353A (en) 1985-11-13 1985-11-13 Cardiotonic heterocyclic oxazolones

Publications (1)

Publication Number Publication Date
ES2036518T3 true ES2036518T3 (es) 1993-06-01

Family

ID=25171234

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686115560T Expired - Lifetime ES2036518T3 (es) 1985-11-13 1986-11-10 Un procedimiento para preparar una oxazolona heterociclica.

Country Status (21)

Country Link
US (1) US4698353A (es)
EP (1) EP0222358B1 (es)
JP (1) JPS62114975A (es)
KR (1) KR900000369B1 (es)
CN (1) CN1017150B (es)
AR (1) AR242207A1 (es)
AT (1) ATE62685T1 (es)
AU (1) AU586295B2 (es)
CA (1) CA1280754C (es)
DE (1) DE3678795D1 (es)
DK (1) DK540686A (es)
ES (1) ES2036518T3 (es)
FI (1) FI864596A (es)
GR (1) GR3001806T3 (es)
HU (1) HU197898B (es)
IL (1) IL80583A0 (es)
NO (1) NO168105C (es)
NZ (1) NZ218237A (es)
PH (1) PH23218A (es)
PT (1) PT83734B (es)
ZA (1) ZA868503B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670450A (en) * 1985-11-13 1987-06-02 Merrell Dow Pharmaceuticals Inc. Cardiotonic thiazolones
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
US4990519A (en) * 1988-10-24 1991-02-05 Merrell Dow Pharmaceuticals Method of using quinolyloxazole-2-ones as proteinkinase C inhibitors
US4999431A (en) * 1988-10-24 1991-03-12 Merrell Dow Pharmaceuticals Process for preparing quinoline aldehyde and ketone derivatives
US4886811A (en) * 1988-10-24 1989-12-12 Merrell Dow Pharmaceuticals Qunolyloxazole-2-ones useful as proteinkinase C inhibitors
ZA908934B (en) * 1989-11-13 1991-08-28 Merrell Dow Pharma Novel pyridyloxazole-2-ones useful as proteinkinase c inhibitors
ZA908852B (en) * 1989-11-13 1991-09-25 Merrell Dow Pharma Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones
ZA908935B (en) * 1989-11-13 1991-08-28 Merrell Dow Pharma Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones
US5182293A (en) * 1989-11-13 1993-01-26 Merrell Dow Pharmaceuticals Inc. Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones
US5063238A (en) * 1989-11-13 1991-11-05 Merrell Dow Pharmaceuticals Inc. Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones
ATE155686T1 (de) * 1991-05-14 1997-08-15 Merrell Pharma Inc Hemmung von metastasen bei krebspatienten mit pyridyloxazol-2-onen
CN1064080C (zh) * 1997-06-26 2001-04-04 梁国坚 鹿茸细胞的工业化生产方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3538104A (en) * 1969-02-28 1970-11-03 Geigy Chem Corp Pyridyl-2-imidazolones
US3879410A (en) * 1971-02-08 1975-04-22 Messrs Lab Guidotti & C S P A 4-Aryl-4-oxazolin-2-ones exhibiting myotonic and myorelaxing activity
SU427015A1 (ru) * 1972-04-21 1974-05-05 В. М. Дзиомко , А. В. Иващенко Способ получения замещенных 4-оксазолин-2-онов
JPS5111763A (en) * 1974-07-16 1976-01-30 Sankyo Co 55 chikan 44 okisazorin 22 onno seizoho
JPS5811867B2 (ja) * 1974-11-06 1983-03-04 東京田辺製薬株式会社 ５，５−ジメチル−４−フエニルオキサゾリジン−２−オン誘導体の製造方法
IT1109002B (it) * 1977-09-22 1985-12-16 Menarini Sas Derivati del 2 oxazolidone e loro metodi di preparazione
DE2935902A1 (de) * 1979-09-05 1981-04-02 A. Nattermann & Cie GmbH, 5000 Köln Oxazolinalkansaeuren, deren salze und ester, verfahren zu deren herstellung und diese enthaltende arzneimittel
US4532250A (en) * 1983-11-23 1985-07-30 American Hospital Supply Corporation 5-Heteroarylimidazol-2-ones having cardiotonic activity

Also Published As

Publication number Publication date
FI864596A0 (fi) 1986-11-12
IL80583A0 (en) 1987-02-27
PT83734A (en) 1986-12-01
KR900000369B1 (ko) 1990-01-25
KR870004980A (ko) 1987-06-02
EP0222358A1 (en) 1987-05-20
AR242207A1 (es) 1993-03-31
NO168105C (no) 1992-01-15
ZA868503B (en) 1987-06-24
AU6493286A (en) 1987-05-21
CA1280754C (en) 1991-02-26
NO168105B (no) 1991-10-07
FI864596A (fi) 1987-05-14
DK540686D0 (da) 1986-11-12
PT83734B (pt) 1988-08-17
NZ218237A (en) 1989-08-29
NO864515D0 (no) 1986-11-12
HU197898B (en) 1989-06-28
CN1017150B (zh) 1992-06-24
DE3678795D1 (de) 1991-05-23
HUT45032A (en) 1988-05-30
ATE62685T1 (de) 1991-05-15
PH23218A (en) 1989-06-06
NO864515L (no) 1987-05-14
DK540686A (da) 1987-05-14
JPS62114975A (ja) 1987-05-26
GR3001806T3 (en) 1992-11-23
AU586295B2 (en) 1989-07-06
CN86107813A (zh) 1987-07-29
EP0222358B1 (en) 1991-04-17
US4698353A (en) 1987-10-06

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