PT82702B - Processo para a preparacao de estimulantes cardiacos de tetrahidroimidazoquinazolinonas - Google Patents
Processo para a preparacao de estimulantes cardiacos de tetrahidroimidazoquinazolinonasInfo
- Publication number
- PT82702B PT82702B PT82702A PT8270286A PT82702B PT 82702 B PT82702 B PT 82702B PT 82702 A PT82702 A PT 82702A PT 8270286 A PT8270286 A PT 8270286A PT 82702 B PT82702 B PT 82702B
- Authority
- PT
- Portugal
- Prior art keywords
- tetrahydroimidazoquinazolinones
- preparation
- cardiac stimulants
- stimulants
- cardiac
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858514207A GB8514207D0 (en) | 1985-06-05 | 1985-06-05 | Cardiac stimulants |
| GB858527208A GB8527208D0 (en) | 1985-11-05 | 1985-11-05 | Cardiac stimulants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT82702A PT82702A (en) | 1986-07-01 |
| PT82702B true PT82702B (pt) | 1988-12-15 |
Family
ID=26289332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT82702A PT82702B (pt) | 1985-06-05 | 1986-06-03 | Processo para a preparacao de estimulantes cardiacos de tetrahidroimidazoquinazolinonas |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4783467A (pt) |
| EP (1) | EP0205280A3 (pt) |
| KR (1) | KR870001362B1 (pt) |
| CN (1) | CN86103833A (pt) |
| AU (1) | AU562773B2 (pt) |
| CA (1) | CA1270486A (pt) |
| DK (1) | DK262486A (pt) |
| ES (2) | ES8708139A1 (pt) |
| FI (1) | FI862375A (pt) |
| GR (1) | GR861425B (pt) |
| HU (1) | HU196408B (pt) |
| IL (1) | IL79003A0 (pt) |
| NO (1) | NO862233L (pt) |
| NZ (1) | NZ216386A (pt) |
| PT (1) | PT82702B (pt) |
| YU (1) | YU95186A (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783467A (en) * | 1985-06-05 | 1988-11-08 | Pfizer Inc. | Tetrahydroimidazoquinazolinone inotropic agents |
| CA2113115A1 (en) * | 1991-07-29 | 1993-02-18 | Vlad E. Gregor | Quinazoline derivatives as acetylcholinesterase inhibitors |
| US7700608B2 (en) | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
| US8436006B2 (en) * | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US8426429B2 (en) * | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US8383637B2 (en) * | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US7910597B2 (en) | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
| US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
| WO2022199627A1 (en) * | 2021-03-23 | 2022-09-29 | National Institute Of Biological Sciences, Beijing | Polycyclic compounds and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932407A (en) * | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
| US3983120A (en) * | 1974-11-06 | 1976-09-28 | Bristol-Myers Company | Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones |
| US3983119A (en) * | 1974-11-06 | 1976-09-28 | Bristol-Myers Company | Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones |
| NL7807507A (nl) * | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
| US4208521A (en) * | 1978-07-31 | 1980-06-17 | Bristol-Myers Company | Process for the preparation of imidazo[2,1-b]quinazolinones |
| CA1131631A (en) * | 1979-06-20 | 1982-09-14 | Madhukar S. Chodnekar | Quinazoline derivatives and pharmaceutical preparations |
| EP0054180A3 (de) * | 1980-12-16 | 1982-12-01 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung eines Imidazochinazolinonderivates |
| JPS604186A (ja) * | 1983-06-21 | 1985-01-10 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン化合物 |
| JPS6028979A (ja) * | 1983-07-14 | 1985-02-14 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン類化合物 |
| US4593029A (en) * | 1984-02-15 | 1986-06-03 | Syntex (U.S.A.) Inc. | Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones |
| US4783467A (en) * | 1985-06-05 | 1988-11-08 | Pfizer Inc. | Tetrahydroimidazoquinazolinone inotropic agents |
-
1986
- 1986-05-22 US US06/865,693 patent/US4783467A/en not_active Expired - Lifetime
- 1986-05-28 EP EP86304040A patent/EP0205280A3/en not_active Withdrawn
- 1986-06-02 IL IL79003A patent/IL79003A0/xx unknown
- 1986-06-02 GR GR861425A patent/GR861425B/el unknown
- 1986-06-03 PT PT82702A patent/PT82702B/pt not_active IP Right Cessation
- 1986-06-03 CA CA000510658A patent/CA1270486A/en not_active Expired - Fee Related
- 1986-06-03 YU YU00951/86A patent/YU95186A/xx unknown
- 1986-06-03 NZ NZ216386A patent/NZ216386A/xx unknown
- 1986-06-04 DK DK262486A patent/DK262486A/da not_active Application Discontinuation
- 1986-06-04 AU AU58427/86A patent/AU562773B2/en not_active Ceased
- 1986-06-04 FI FI862375A patent/FI862375A/fi not_active Application Discontinuation
- 1986-06-04 ES ES555723A patent/ES8708139A1/es not_active Expired
- 1986-06-04 HU HU862365A patent/HU196408B/hu unknown
- 1986-06-04 NO NO862233A patent/NO862233L/no unknown
- 1986-06-04 KR KR1019860004434A patent/KR870001362B1/ko not_active IP Right Cessation
- 1986-06-05 CN CN198686103833A patent/CN86103833A/zh active Pending
-
1987
- 1987-02-26 ES ES557427A patent/ES8800224A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI862375A (fi) | 1986-12-06 |
| NO862233D0 (no) | 1986-06-04 |
| ES8800224A1 (es) | 1987-10-16 |
| ES557427A0 (es) | 1987-10-16 |
| IL79003A0 (en) | 1986-09-30 |
| DK262486A (da) | 1987-02-16 |
| HUT41793A (en) | 1987-05-28 |
| KR870000338A (ko) | 1987-02-17 |
| EP0205280A3 (en) | 1988-11-30 |
| PT82702A (en) | 1986-07-01 |
| FI862375A0 (fi) | 1986-06-04 |
| NO862233L (no) | 1986-12-08 |
| ES8708139A1 (es) | 1987-09-16 |
| AU5842786A (en) | 1986-12-11 |
| DK262486D0 (da) | 1986-06-04 |
| CA1270486A (en) | 1990-06-19 |
| YU95186A (en) | 1988-04-30 |
| ES555723A0 (es) | 1987-09-16 |
| CN86103833A (zh) | 1986-12-31 |
| KR870001362B1 (ko) | 1987-07-20 |
| US4783467A (en) | 1988-11-08 |
| NZ216386A (en) | 1988-08-30 |
| HU196408B (en) | 1988-11-28 |
| EP0205280A2 (en) | 1986-12-17 |
| AU562773B2 (en) | 1987-06-18 |
| GR861425B (en) | 1986-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19911103 |