PT80435B - Process for the preparation of 1,n-di-arylpyrazol-3-amines - Google Patents

Process for the preparation of 1,n-di-arylpyrazol-3-amines

Info

Publication number
PT80435B
PT80435B PT80435A PT8043585A PT80435B PT 80435 B PT80435 B PT 80435B PT 80435 A PT80435 A PT 80435A PT 8043585 A PT8043585 A PT 8043585A PT 80435 B PT80435 B PT 80435B
Authority
PT
Portugal
Prior art keywords
alkyl
substd
nr7r8
opt
cor6
Prior art date
Application number
PT80435A
Other languages
English (en)
Other versions
PT80435A (en
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848412181A external-priority patent/GB8412181D0/en
Priority claimed from GB848429128A external-priority patent/GB8429128D0/en
Application filed by Fisons Plc filed Critical Fisons Plc
Publication of PT80435A publication Critical patent/PT80435A/pt
Publication of PT80435B publication Critical patent/PT80435B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
  • Jib Cranes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
PT80435A 1984-05-12 1985-05-10 Process for the preparation of 1,n-di-arylpyrazol-3-amines PT80435B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848412181A GB8412181D0 (en) 1984-05-12 1984-05-12 Heterocyclic compounds
GB848429128A GB8429128D0 (en) 1984-11-17 1984-11-17 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
PT80435A PT80435A (en) 1985-06-01
PT80435B true PT80435B (en) 1987-04-13

Family

ID=26287734

Family Applications (1)

Application Number Title Priority Date Filing Date
PT80435A PT80435B (en) 1984-05-12 1985-05-10 Process for the preparation of 1,n-di-arylpyrazol-3-amines

Country Status (15)

Country Link
US (1) US4810719A (pt)
EP (1) EP0178035B1 (pt)
JP (1) JPH0625134B2 (pt)
AT (1) ATE49198T1 (pt)
AU (1) AU586166B2 (pt)
CA (1) CA1246567A (pt)
DE (1) DE3575130D1 (pt)
DK (1) DK204085A (pt)
ES (2) ES8609267A1 (pt)
FI (1) FI851836L (pt)
GR (1) GR851132B (pt)
IL (1) IL75146A (pt)
NO (1) NO169283C (pt)
NZ (1) NZ212025A (pt)
PT (1) PT80435B (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824859A (en) * 1983-05-21 1989-04-25 Fisons Plc. Pyrazoline compounds compositions and use
IL73418A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 5-cyano-1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
DE3773746D1 (en) * 1986-05-07 1991-11-21 Fisons Plc Pyrazole.
EP0254259A3 (en) * 1986-07-21 1989-11-23 Otsuka Pharmaceutical Factory, Inc. P-aminophenol derivatives
US4970210A (en) * 1987-07-17 1990-11-13 Abbott Laboratories Triazinone lipoxygenase compounds
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
US5550147A (en) * 1992-02-05 1996-08-27 Fujisawa Pharmaceutical Co., Ltd. Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
ATE247655T1 (de) * 1994-12-13 2003-09-15 Euro Celtique Sa Dreifachsubstituierte thioxanthine
AU4527896A (en) * 1994-12-13 1996-07-03 Euro-Celtique S.A. Aryl thioxanthines
ES2247604T3 (es) * 1995-06-12 2006-03-01 G.D. SEARLE & CO. Composiciones que comprenden un inhibidor de ciclooxigenasa-2 y un inhibidor de 5-lipoxigenasa.
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
JP2002528499A (ja) * 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー Ｉｍｐｄｈ酵素のインヒビターであるアミノ核誘導化合物
AU2972701A (en) * 2000-02-07 2001-08-14 Bristol Myers Squibb Co 3-aminopyrazole inhibitors of cyclin dependent kinases
BR0108908A (pt) * 2000-03-03 2002-12-24 Pfizer Prod Inc Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos
JP4759207B2 (ja) * 2000-05-15 2011-08-31 あすか製薬株式会社 １−（ベンゾチアゾール−２−イル）ピラゾール誘導体およびそれを含有するｃｏｘ−２阻害剤
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
WO2003037352A1 (en) * 2001-11-02 2003-05-08 Pfizer Products Inc. 1-phenyl-5-n-heterocyclyl-pyrazoles as cyclooxygenase inhibitors for the treatment of inflammation associated disorders
US7329288B2 (en) 2004-02-27 2008-02-12 L'oreal S.A. N-heteroaryl secondary para-phenylenediamine, a dye composition comprising such a para-phenylenediamine, a process for preparing this composition and use thereof
FR2866887A1 (fr) * 2004-02-27 2005-09-02 Oreal Para-phenylenediamine secondaire n-heteroaryle, compositon tinctoriale comprenant une telle para-phenylenediamine, procede mettant en oeuvre cette composition et utilisation
CN103739595A (zh) * 2006-10-02 2014-04-23 Irm责任有限公司 作为蛋白激酶抑制剂的化合物和组合物
PL2195312T3 (pl) * 2007-10-09 2013-04-30 Merck Patent Gmbh Pochodne pirydynowe użyteczne jako aktywatory glukokinazowe
KR20110074583A (ko) * 2008-10-15 2011-06-30 닛토덴코 가부시키가이샤 폴리글루타메이트 접합체의 제조 방법
US9675774B2 (en) 2009-04-02 2017-06-13 Breathe Technologies, Inc. Methods, systems and devices for non-invasive open ventilation with gas delivery nozzles in free space
CA2782410A1 (en) * 2009-12-16 2011-06-23 Nitto Denko Corporation Controlled synthesis of polyglutamic acid
EP2680846A4 (en) 2011-03-01 2014-08-06 Npharmakon Llc USE OF N- (4-METHOXYPHENYL) -1-PHENYL-1H-PYRAZOL-3-AMINE AND COMPOUNDS ASSOCIATED THEREWITH
JP2016535010A (ja) 2013-10-17 2016-11-10 ダウ アグロサイエンシィズ エルエルシー 有害生物防除性化合物の製造方法
EP3057430A4 (en) 2013-10-17 2017-09-13 Dow AgroSciences LLC Processes for the preparation of pesticidal compounds
MX2016004940A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Proceso para la preparacion de compuestos plaguicidas.
MX2016004945A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de compuestos plaguicidas.
CN105636446B (zh) 2013-10-17 2018-07-13 美国陶氏益农公司 制备杀虫化合物的方法
KR20160074540A (ko) 2013-10-17 2016-06-28 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
CA2936111C (en) * 2014-01-06 2023-03-14 Algomedix, Inc. Trpa1 modulators
JP6615876B2 (ja) * 2014-06-26 2019-12-04 モナシュ ユニヴァーシティ 酵素相互作用薬剤
CA2954631A1 (en) * 2014-07-31 2016-02-04 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
CN106488909A (zh) 2014-07-31 2017-03-08 美国陶氏益农公司 制备3‑(3‑氯‑1h‑吡唑‑1‑基)吡啶的方法
CA2958058A1 (en) 2014-08-19 2016-02-25 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
CA2960985A1 (en) 2014-09-12 2016-03-17 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
US10233155B2 (en) 2016-12-29 2019-03-19 Dow Agrosciences Llc Processes for the preparation of pesticide compounds
US10100033B2 (en) 2016-12-29 2018-10-16 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB743505A (en) * 1953-05-29 1956-01-18 Ilford Ltd Improvements in or relating to pyrazole derivatives
US3398158A (en) * 1964-02-19 1968-08-20 Warner Lambert Pharmaceutical 1-phenyl-4-alkylamino-pyrazoles
IT1061812B (it) * 1976-06-25 1983-04-30 Montedison Spa Processo per la preparazione di i fenil 3 ammino pirazoli
JPS6039269B2 (ja) * 1977-05-24 1985-09-05 三共株式会社 アシルケテン−ｓ・ｎ−アセタ−ル化合物、およびその製法
DE2747531A1 (de) * 1977-10-22 1979-04-26 Basf Ag Substituierte 3-aminopyrazole
JPS5632416A (en) * 1979-07-13 1981-04-01 Wellcome Found Heterocyclic compound
DD149231A1 (de) * 1980-02-20 1981-07-01 Manfred Schulz Stabilisatoren fuer hochpolymere,niedermolekulare organische verbindungen und oele
DD151366A1 (de) * 1980-06-06 1981-10-14 Regina Werndl Diazotypiematerial mit verbesserter lichtstabilitaet der bildfarbstoffe
DE3035395A1 (de) * 1980-09-19 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von pyrazol
NL8105652A (nl) * 1980-12-16 1982-07-16 Wellcome Found Heterocyclische verbindingen.
BE891489A (fr) * 1980-12-16 1982-06-15 Wellcome Found Composes heterocycliques
EP0070376A1 (en) * 1981-07-13 1983-01-26 American Cyanamid Company Heterocyclic substituted-amino-pyrazolines
MA19539A1 (fr) * 1981-07-17 1983-04-01 May & Baker Ltd N Acylaminophenylpyrazoles
GB8303782D0 (en) * 1983-02-11 1983-03-16 Wellcome Found Heterocyclic compounds
DK60684A (da) * 1983-02-11 1984-08-12 Wellcome Found Fremgangsmaade til fremstilling af 3-(n-substitueret amino)-2-pyrazoliner og mellemprodukter anvendelige ved udoevelse af fremgangsmaaden

Also Published As

Publication number Publication date
NZ212025A (en) 1989-03-29
IL75146A (en) 1989-07-31
AU4227585A (en) 1985-11-14
US4810719A (en) 1989-03-07
JPH0625134B2 (ja) 1994-04-06
JPS60246371A (ja) 1985-12-06
FI851836L (fi) 1985-11-13
ATE49198T1 (de) 1990-01-15
DK204085D0 (da) 1985-05-08
NO169283C (no) 1992-06-10
NO851876L (no) 1985-11-13
AU586166B2 (en) 1989-07-06
ES8609267A1 (es) 1986-07-16
DE3575130D1 (de) 1990-02-08
ES8705393A1 (es) 1987-05-01
DK204085A (da) 1985-11-13
FI851836A0 (fi) 1985-05-09
ES551362A0 (es) 1987-05-01
GR851132B (pt) 1985-11-25
PT80435A (en) 1985-06-01
IL75146A0 (en) 1985-09-29
EP0178035A1 (en) 1986-04-16
EP0178035B1 (en) 1990-01-03
NO169283B (no) 1992-02-24
ES543046A0 (es) 1986-07-16
CA1246567A (en) 1988-12-13

Similar Documents

Publication Publication Date Title
PT80435A (en) Process for the preparation of 1,n-di-arylpyrazol-3-amines
SE9401728D0 (sv) New compounds II
UA26403A (uk) Похідhі n-заміщеhого 4-феhіл-4-піперидиhкарбоксаміду та їх фармацевтичhо прийhятhі солі, що проявляють аhестезувальhу та аhальгезувальhу дію, спосіб їх одержаhhя та фармацевтичhа композиція
MX9603092A (es) Nuevos compuestos con efecto analgesico y anestesico local.
DE3479728D1 (en) Derivatives of thiophenesulfonamide, their preparation and pharmaceutical composition for the topical treatment of elevated intraocular pressure
ZA845931B (en) 1-(4'-alkylsulphonylphenyl)-2-amino-1,3-propanediol n-substituted derivatives
EP0370300A3 (de) Cyclopropyl-Substituierte Azolylmethylcarbinole, Verfarhren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
IT8420213A0 (it) Procedimento per la preparazione di 1,8-diidrossi-10-acil-9-antroni, in particolare per l'uso nel trattamento di psoriasi.
ES8105711A1 (es) Un metodo de preparar derivados de piperidina
ATE22531T1 (de) Pharmazeutische zusammenstellung fuer induktion von cytoprotektion.
FI972389A (fi) Uusi menetelmä ranitidiinin valmistamiseksi
PT75339B (en) Process for the preparation of n1-acyl-3-amino-1,2,3,4-tetrahydroquinoline compounds
ES8307711A1 (es) "procedimiento para la preparacion de un nuevo derivado de alquilenodiamina".
ES8403898A1 (es) Procedimiento para preparar derivados de ergolina.
RU95120677A (ru) Способ лечения злокачественных опухолей
JO1652B1 (en) New compounds for local anesthesia and a way to prepare them
DE3469358D1 (en) Novel 3-(4'-aminobutylamino)-propylamino-bleomycin derivatives, a process for their preparation and their use as medicaments

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19941031