PT788481E - Processo para preparacao de levobupivacaina e seus analogos - Google Patents
Processo para preparacao de levobupivacaina e seus analogosInfo
- Publication number
- PT788481E PT788481E PT95934739T PT95934739T PT788481E PT 788481 E PT788481 E PT 788481E PT 95934739 T PT95934739 T PT 95934739T PT 95934739 T PT95934739 T PT 95934739T PT 788481 E PT788481 E PT 788481E
- Authority
- PT
- Portugal
- Prior art keywords
- pct
- levobupivacaine
- amidation
- alkylation
- resultant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9421478A GB9421478D0 (en) | 1994-10-25 | 1994-10-25 | Process and compounds |
GBGB9504925.0A GB9504925D0 (en) | 1995-03-10 | 1995-03-10 | Process for preparing analgesic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
PT788481E true PT788481E (pt) | 2004-01-30 |
Family
ID=26305864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95934739T PT788481E (pt) | 1994-10-25 | 1995-10-23 | Processo para preparacao de levobupivacaina e seus analogos |
Country Status (12)
Country | Link |
---|---|
US (1) | US5777124A (pt) |
EP (1) | EP0788481B1 (pt) |
JP (1) | JP4118946B2 (pt) |
AT (1) | ATE248148T1 (pt) |
AU (1) | AU694569B2 (pt) |
CA (1) | CA2200356C (pt) |
DE (1) | DE69531624T2 (pt) |
DK (1) | DK0788481T3 (pt) |
ES (1) | ES2203645T3 (pt) |
MX (1) | MX9703025A (pt) |
PT (1) | PT788481E (pt) |
WO (1) | WO1996012700A1 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003024930A1 (fr) * | 2001-09-10 | 2003-03-27 | Mercian Corporation | Procede de fabrication d'un derive de pipecolamide |
BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
EP2959893A1 (en) | 2002-12-13 | 2015-12-30 | DURECT Corporation | Oral drug delivery system comprising high viscosity liquid carrier materials |
SI2767292T1 (sl) | 2004-09-17 | 2017-01-31 | Durect Corporation | Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem |
US20060270708A1 (en) * | 2005-05-25 | 2006-11-30 | Navinta Llc | Novel process for preparation of isotonic aqueous injection of ropivacaine |
US7683175B2 (en) * | 2005-06-06 | 2010-03-23 | Navinta, Llc | Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom |
US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
EP2010491A1 (en) * | 2006-04-25 | 2009-01-07 | Disham Pharmaceuticals and Chemicals Ltd. | Ropivacaine hydrochloride anhydrate and the preparation thereof |
US8337883B2 (en) | 2006-11-03 | 2012-12-25 | Durect Corporation | Transdermal delivery systems |
KR100844336B1 (ko) | 2007-01-16 | 2008-07-07 | 하나제약 주식회사 | 레보부피바카인 및 이의 염산염의 신규한 제조방법 |
JP2011506318A (ja) * | 2007-12-06 | 2011-03-03 | デュレクト コーポレーション | 経口医薬製剤 |
ES2383715T3 (es) * | 2008-01-15 | 2012-06-25 | Pharmathen S.A. | Proceso para producir ácido 2-pipecólico-2',6'-xilidida útil como un producto intermedio para la preparación de anestésicos locales |
US20100260844A1 (en) * | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
CN102558030A (zh) * | 2010-12-11 | 2012-07-11 | 山东方明药业股份有限公司 | 1-n-(2,6-二甲基苯基)-2-哌啶甲酰胺的合成 |
CN103086954A (zh) * | 2013-02-04 | 2013-05-08 | 山东省医药工业研究所 | 一种制备罗哌卡因的方法 |
JP2016515523A (ja) | 2013-03-15 | 2016-05-30 | デュレクト コーポレーション | 溶解変動性を低減させるためのレオロジー改質剤を有する組成物 |
CN103664744B (zh) * | 2013-11-30 | 2015-07-15 | 山东永泰化工有限公司 | 一种左布比卡因的制备方法 |
CN104003930B (zh) * | 2014-06-13 | 2016-06-08 | 山东金诃药物研究开发有限公司 | 一种盐酸罗哌卡因的制备方法 |
CN105418489A (zh) * | 2016-01-22 | 2016-03-23 | 江苏宝众宝达药业有限公司 | 一种布比卡因的合成方法 |
CN106187864B (zh) * | 2016-07-11 | 2018-11-23 | 江苏天和制药有限公司 | 一种由盐酸布比卡因制备高纯度布比卡因碱的方法 |
CN109438331A (zh) * | 2018-09-20 | 2019-03-08 | 山东科源制药股份有限公司 | 一种制备罗哌卡因中间体的方法 |
JP2023515918A (ja) | 2020-01-13 | 2023-04-17 | デュレクト コーポレーション | 不純物が低減された徐放性薬物送達システム及び関連の方法 |
CN111548303A (zh) * | 2020-06-28 | 2020-08-18 | 山东美泰医药有限公司 | 一种盐酸左布比卡因的杂质及其制备和分析方法 |
CN112939848B (zh) * | 2021-02-25 | 2022-07-01 | 浙江工业大学 | 一种布比卡因及其中间体(s)-2-哌啶甲酸的制备方法 |
US11890422B2 (en) | 2022-05-05 | 2024-02-06 | Pfof Llc | Anesthetic nerve block and method |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6803337A (pt) * | 1967-03-20 | 1968-09-23 | ||
AU560367B2 (en) * | 1983-08-01 | 1987-04-02 | Astra Lakemedel Aktiebolag | L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same |
US4695576A (en) * | 1984-07-09 | 1987-09-22 | Astra Lake Medel Aktiebolag | L-N-n-propylpipecolic acid-2,6-xylidide |
-
1995
- 1995-10-23 DE DE69531624T patent/DE69531624T2/de not_active Expired - Lifetime
- 1995-10-23 JP JP51373996A patent/JP4118946B2/ja not_active Expired - Fee Related
- 1995-10-23 DK DK95934739T patent/DK0788481T3/da active
- 1995-10-23 MX MX9703025A patent/MX9703025A/es unknown
- 1995-10-23 WO PCT/GB1995/002514 patent/WO1996012700A1/en active IP Right Grant
- 1995-10-23 AT AT95934739T patent/ATE248148T1/de not_active IP Right Cessation
- 1995-10-23 EP EP95934739A patent/EP0788481B1/en not_active Expired - Lifetime
- 1995-10-23 PT PT95934739T patent/PT788481E/pt unknown
- 1995-10-23 CA CA002200356A patent/CA2200356C/en not_active Expired - Fee Related
- 1995-10-23 US US08/836,449 patent/US5777124A/en not_active Expired - Lifetime
- 1995-10-23 AU AU37049/95A patent/AU694569B2/en not_active Ceased
- 1995-10-23 ES ES95934739T patent/ES2203645T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2203645T3 (es) | 2004-04-16 |
ATE248148T1 (de) | 2003-09-15 |
CA2200356C (en) | 2007-07-31 |
EP0788481A1 (en) | 1997-08-13 |
JPH10507748A (ja) | 1998-07-28 |
DE69531624T2 (de) | 2004-06-17 |
US5777124A (en) | 1998-07-07 |
EP0788481B1 (en) | 2003-08-27 |
CA2200356A1 (en) | 1996-05-02 |
AU694569B2 (en) | 1998-07-23 |
AU3704995A (en) | 1996-05-15 |
WO1996012700A1 (en) | 1996-05-02 |
JP4118946B2 (ja) | 2008-07-16 |
MX9703025A (es) | 1997-10-31 |
DE69531624D1 (de) | 2003-10-02 |
DK0788481T3 (da) | 2003-12-01 |
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