PT640065E - Derivados de fenilo trissubstituido como inibidores de fosfodiestereases e processos para a sua preparacao - Google Patents
Derivados de fenilo trissubstituido como inibidores de fosfodiestereases e processos para a sua preparacaoInfo
- Publication number
- PT640065E PT640065E PT94908454T PT94908454T PT640065E PT 640065 E PT640065 E PT 640065E PT 94908454 T PT94908454 T PT 94908454T PT 94908454 T PT94908454 T PT 94908454T PT 640065 E PT640065 E PT 640065E
- Authority
- PT
- Portugal
- Prior art keywords
- group
- hydrogen atom
- alkyl
- optionally substituted
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939304920A GB9304920D0 (en) | 1993-03-10 | 1993-03-10 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PT640065E true PT640065E (pt) | 2002-04-29 |
Family
ID=10731818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT94908454T PT640065E (pt) | 1993-03-10 | 1994-03-09 | Derivados de fenilo trissubstituido como inibidores de fosfodiestereases e processos para a sua preparacao |
Country Status (14)
Country | Link |
---|---|
US (2) | US5739144A (pt) |
EP (1) | EP0640065B1 (pt) |
JP (1) | JPH08505158A (pt) |
AT (1) | ATE207051T1 (pt) |
AU (1) | AU675511B2 (pt) |
CA (1) | CA2135480C (pt) |
DE (1) | DE69428650T2 (pt) |
DK (1) | DK0640065T3 (pt) |
ES (1) | ES2162623T3 (pt) |
GB (1) | GB9304920D0 (pt) |
NZ (1) | NZ262170A (pt) |
PT (1) | PT640065E (pt) |
SI (1) | SI0640065T1 (pt) |
WO (1) | WO1994020446A1 (pt) |
Families Citing this family (99)
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GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
GB9326699D0 (en) * | 1993-12-22 | 1994-03-02 | Celltech Ltd | Chemical compounds |
JP3806144B2 (ja) * | 1993-12-22 | 2006-08-09 | セルテック セラピューティックス リミテッド | 三置換フェニル誘導体、その調製方法とホスホジエステラーゼ(iv型)阻害剤としてのその使用 |
US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
GB9412571D0 (en) * | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
GB9412573D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
GB9412672D0 (en) * | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
TW332201B (en) * | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
US6268373B1 (en) | 1995-06-07 | 2001-07-31 | Euro-Celtique S.A. | Trisubstituted thioxanthines |
EP0827495A4 (en) * | 1995-07-14 | 1998-11-04 | Smithkline Beecham Corp | SUBSTITUTED PENT-4-IN ACIDS |
AT405286B (de) * | 1995-10-16 | 1999-06-25 | Danubia Petrochem Polymere | Polypropylene mit reduzierter weissbruchneigung |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
US5710170A (en) * | 1995-12-15 | 1998-01-20 | Merck Frosst Canada, Inc. | Tri-aryl ethane derivatives as PDE IV inhibitors |
GB9603723D0 (en) * | 1996-02-22 | 1996-04-24 | Merck & Co Inc | Diphenyl pyridyl derivatives as pde iv inhibitors |
EP0873311A1 (en) * | 1995-12-15 | 1998-10-28 | Merck Frosst Canada Inc. | Tri-aryl ethane derivatives as pde iv inhibitors |
GB9526243D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
GB9526246D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
GB9526245D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
US6294541B1 (en) | 1996-06-06 | 2001-09-25 | Euro-Celtique S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
WO1997048697A1 (en) | 1996-06-19 | 1997-12-24 | Rhone-Poulenc Rorer Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
DE19628622A1 (de) * | 1996-07-16 | 1998-01-22 | Byk Gulden Lomberg Chem Fab | Neue 5-substituierte [2H] Chromene |
DE19628621A1 (de) * | 1996-07-16 | 1998-01-22 | Byk Gulden Lomberg Chem Fab | Neue 4-substituierte Benzofurane |
US5744473A (en) * | 1996-09-16 | 1998-04-28 | Euro-Celtique, S.A. | PDE IV inhibitors: "bis-compounds" |
GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
WO1998012178A1 (en) * | 1996-09-17 | 1998-03-26 | Merck & Co., Inc. | Method of preparing phosphodiesterase iv inhibitors |
TW508353B (en) * | 1996-09-17 | 2002-11-01 | Merck & Co Inc | Method of preparing phosphodiesterase IV inhibitors |
GB9622363D0 (en) | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
GB9625184D0 (en) * | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
US6057329A (en) * | 1996-12-23 | 2000-05-02 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives |
GB9705361D0 (en) | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
ID24224A (id) * | 1997-07-10 | 2000-07-13 | Janssen Pharmaceutica Nv | Turunan-turunan 6-azaurasil sebagai inhibitor il-5 |
BR9815170A (pt) | 1997-12-12 | 2000-10-10 | Euro Celtique S A Luxembourg | "método de obter composto aplicável no tratamento de asma em mamìferos" |
KR100484599B1 (ko) * | 1998-05-22 | 2005-08-31 | 씨제이 주식회사 | 캐테콜아세토니트릴유도체,이의제조방법및그를함유한약제학적조성물 |
US6319928B1 (en) | 1998-11-30 | 2001-11-20 | Euro-Celtique, S.A. | Purine derivatives having phosphodiesterase IV inhibition activity |
EA004806B1 (ru) | 1998-12-18 | 2004-08-26 | Янссен Фармацевтика Н.В. | Производные 6-азаурацила, ингибирующие il-5 |
JP2002541078A (ja) | 1999-04-02 | 2002-12-03 | ユーロ−セルティーク,エス.エー. | ホスホジエステラーゼiv阻害活性を有するプリン誘導体 |
GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
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EP1392662B1 (de) | 2001-05-29 | 2009-01-07 | Bayer Schering Pharma Aktiengesellschaft | Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel |
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EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
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-
1993
- 1993-03-10 GB GB939304920A patent/GB9304920D0/en active Pending
-
1994
- 1994-03-09 ES ES94908454T patent/ES2162623T3/es not_active Expired - Lifetime
- 1994-03-09 PT PT94908454T patent/PT640065E/pt unknown
- 1994-03-09 DK DK94908454T patent/DK0640065T3/da active
- 1994-03-09 SI SI9430400T patent/SI0640065T1/xx unknown
- 1994-03-09 AU AU61489/94A patent/AU675511B2/en not_active Ceased
- 1994-03-09 JP JP6519748A patent/JPH08505158A/ja active Pending
- 1994-03-09 CA CA002135480A patent/CA2135480C/en not_active Expired - Fee Related
- 1994-03-09 DE DE69428650T patent/DE69428650T2/de not_active Expired - Fee Related
- 1994-03-09 EP EP94908454A patent/EP0640065B1/en not_active Expired - Lifetime
- 1994-03-09 AT AT94908454T patent/ATE207051T1/de not_active IP Right Cessation
- 1994-03-09 NZ NZ262170A patent/NZ262170A/en unknown
- 1994-03-09 WO PCT/GB1994/000453 patent/WO1994020446A1/en active IP Right Grant
-
1995
- 1995-10-17 US US08/543,962 patent/US5739144A/en not_active Expired - Fee Related
-
1998
- 1998-01-16 US US09/008,173 patent/US5962483A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0640065A1 (en) | 1995-03-01 |
ES2162623T3 (es) | 2002-01-01 |
US5962483A (en) | 1999-10-05 |
CA2135480A1 (en) | 1994-09-15 |
NZ262170A (en) | 1997-02-24 |
CA2135480C (en) | 2006-06-20 |
DE69428650T2 (de) | 2002-08-01 |
US5739144A (en) | 1998-04-14 |
JPH08505158A (ja) | 1996-06-04 |
DK0640065T3 (da) | 2001-11-12 |
ATE207051T1 (de) | 2001-11-15 |
GB9304920D0 (en) | 1993-04-28 |
SI0640065T1 (en) | 2002-06-30 |
AU675511B2 (en) | 1997-02-06 |
WO1994020446A1 (en) | 1994-09-15 |
DE69428650D1 (de) | 2001-11-22 |
EP0640065B1 (en) | 2001-10-17 |
AU6148994A (en) | 1994-09-26 |
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