PT3117837T - Formulações de anticorpo - Google Patents
Formulações de anticorpoInfo
- Publication number
- PT3117837T PT3117837T PT16180643T PT16180643T PT3117837T PT 3117837 T PT3117837 T PT 3117837T PT 16180643 T PT16180643 T PT 16180643T PT 16180643 T PT16180643 T PT 16180643T PT 3117837 T PT3117837 T PT 3117837T
- Authority
- PT
- Portugal
- Prior art keywords
- antibody formulations
- antibody
- formulations
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/601,598 US8613919B1 (en) | 2012-08-31 | 2012-08-31 | High concentration antibody and protein formulations |
US13/843,780 US9592297B2 (en) | 2012-08-31 | 2013-03-15 | Antibody and protein formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3117837T true PT3117837T (pt) | 2019-08-26 |
Family
ID=49162239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT16180643T PT3117837T (pt) | 2012-08-31 | 2013-08-28 | Formulações de anticorpo |
Country Status (26)
Country | Link |
---|---|
US (7) | US9592297B2 (pt) |
EP (3) | EP3117837B1 (pt) |
JP (3) | JP6462567B2 (pt) |
CN (2) | CN114392353A (pt) |
AR (2) | AR092388A1 (pt) |
AU (3) | AU2013308902B2 (pt) |
BR (1) | BR112015003838A2 (pt) |
CA (2) | CA2883095C (pt) |
CY (1) | CY1121989T1 (pt) |
DK (1) | DK3117837T3 (pt) |
ES (1) | ES2741575T3 (pt) |
HK (1) | HK1210794A1 (pt) |
HR (1) | HRP20191299T1 (pt) |
HU (1) | HUE045652T2 (pt) |
IL (6) | IL286784B (pt) |
LT (1) | LT3117837T (pt) |
MX (2) | MX369653B (pt) |
PL (1) | PL3117837T3 (pt) |
PT (1) | PT3117837T (pt) |
RS (1) | RS59221B1 (pt) |
RU (2) | RU2678097C2 (pt) |
SG (2) | SG11201501116RA (pt) |
SI (1) | SI3117837T1 (pt) |
TW (4) | TW201414496A (pt) |
UY (1) | UY34995A (pt) |
WO (1) | WO2014036071A1 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG183443A1 (en) | 2010-03-01 | 2012-09-27 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
AU2012236296A1 (en) * | 2011-04-01 | 2013-10-24 | Bayer Healthcare Llc | Monoclonal antibodies against tissue factor pathway inhibitor (TFPI) |
AT512589B1 (de) * | 2012-03-12 | 2014-06-15 | Zizala Lichtsysteme Gmbh | Lichtleitelement für einen Laser-Fahrzeugscheinwerfer sowie Fahrzeugscheinwerfer |
US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
EP3791862B1 (en) | 2013-09-11 | 2024-05-29 | Eagle Biologics, Inc. | Liquid protein formulations containing viscosity-lowering agents |
US10478498B2 (en) | 2014-06-20 | 2019-11-19 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
SG10201902915VA (en) | 2014-10-01 | 2019-04-29 | Eagle Biologics Inc | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
CN106715473B (zh) | 2014-10-01 | 2021-11-23 | 免疫医疗有限公司 | 替格瑞洛的抗体及其使用方法 |
EP3337827A2 (en) | 2015-08-19 | 2018-06-27 | Pfizer Inc | Tissue factor pathway inhibitor antibodies and uses thereof |
RU2731737C2 (ru) | 2015-08-19 | 2020-09-08 | Астразенека Аб | Стабильный состав на основе антитела к ifnar1 |
CA2999118C (en) * | 2015-09-22 | 2022-06-14 | Pfizer Inc. | Method of preparing a therapeutic protein formulation and antibody formulation produced by such a method |
EP3443346B1 (en) * | 2016-04-13 | 2023-08-30 | Medimmune, LLC | Use of amino acids as stabilizing compounds in pharmaceutical compositions containing high concentrations of protein-based therapeutic agents |
HUE066142T2 (hu) | 2016-06-30 | 2024-07-28 | Celltrion Inc | Stabil folyékony gyógyszerészeti készítmény |
WO2018013673A1 (en) * | 2016-07-13 | 2018-01-18 | Reform Biologics, Llc | Stabilizing excipients for therapeutic protein formulations |
US20190216925A1 (en) | 2016-09-16 | 2019-07-18 | Leukocare Ag | A Novel Method for Stabilization of a Biopharmaceutical Drug Product During Processing |
AU2017380842A1 (en) * | 2016-12-23 | 2019-07-11 | Serum Institute Of India Private Limited | Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof |
US11845798B2 (en) | 2017-05-02 | 2023-12-19 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
MA52570A (fr) | 2018-05-10 | 2021-03-17 | Regeneron Pharma | Formulations contenant des protéines de fusion du récepteur vegf à haute concentration |
AU2019297498A1 (en) * | 2018-07-05 | 2021-01-21 | Bayer Aktiengesellschaft | Method for the production of freeze-dried pellets comprising an anti-coagulation factor xia (FXIa) antibody |
KR102337683B1 (ko) * | 2018-09-21 | 2021-12-13 | 주식회사 녹십자 | 고효율 항-tfpi 항체 조성물 |
SG11202103907PA (en) * | 2018-10-18 | 2021-05-28 | Merck Sharp & Dohme | Formulations of anti-rsv antibodies and methods of use thereof |
CN111346225A (zh) * | 2018-12-21 | 2020-06-30 | 上海张江生物技术有限公司 | 含有蛋白质的药物制剂 |
WO2020172002A1 (en) * | 2019-02-18 | 2020-08-27 | Eli Lilly And Company | Therapeutic antibody formulation |
EP4058061A1 (en) * | 2019-11-13 | 2022-09-21 | Pfizer Inc. | Stable aqueous anti-tfpi antibody formulation |
WO2024026388A1 (en) * | 2022-07-27 | 2024-02-01 | Viela Bio, Inc. | Formulations comprising an immunoglobulin-like transcript 7 (ilt7)-binding protein |
Family Cites Families (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1064396A (en) | 1975-02-18 | 1979-10-16 | Myer L. Coval | Fractional precipitation of gamma globulin with polyethylene glycol |
US4075193A (en) | 1976-11-26 | 1978-02-21 | Parke, Davis & Company | Process for producing intravenous immune globulin |
US4374763A (en) | 1979-09-17 | 1983-02-22 | Morishita Pharmaceutical Co., Ltd. | Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof |
US4499073A (en) | 1981-08-24 | 1985-02-12 | Cutter Laboratories, Inc. | Intravenously injectable immune serum globulin |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4597966A (en) | 1985-01-09 | 1986-07-01 | Ortho Diagnostic Systems, Inc. | Histidine stabilized immunoglobulin and method of preparation |
ES2044941T5 (es) | 1987-08-21 | 1999-02-16 | Mallinckrodt Group Inc | Estabilizador de hormonas promotoras del crecimiento. |
US4877608A (en) | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
US4912861A (en) * | 1988-04-11 | 1990-04-03 | Huang Ing Chung | Removable pressure-adjustable shock-absorbing cushion device with an inflation pump for sports goods |
US5096885A (en) | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
DE68908175T2 (de) | 1988-05-27 | 1994-03-03 | Centocor Inc | Gefriergetrocknete formulierung für antikörperprodukte. |
WO1990011091A1 (en) | 1989-03-27 | 1990-10-04 | Centocor, Inc. | FORMULATIONS FOR STABILIZING OF IgM ANTIBODIES |
US5217954A (en) | 1990-04-04 | 1993-06-08 | Scios Nova Inc. | Formulations for stabilizing fibroblast growth factor |
JPH0565233A (ja) | 1991-03-08 | 1993-03-19 | Mitsui Toatsu Chem Inc | モノクローナル抗体含有凍結乾燥製剤 |
JP2966592B2 (ja) | 1991-07-20 | 1999-10-25 | 萩原 義秀 | 安定化されたヒトモノクローナル抗体製剤 |
US6165467A (en) | 1991-07-20 | 2000-12-26 | Yoshihide Hagiwara | Stabilized human monoclonal antibody preparation |
GB9122820D0 (en) | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
US5849700A (en) | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
PT686045E (pt) | 1993-02-23 | 2001-04-30 | Genentech Inc | Estabilizacao por excipientes de polipeptidos tratados com solventes organicos |
DE4344824C1 (de) | 1993-12-28 | 1995-08-31 | Immuno Ag | Hochkonzentriertes Immunglobulin-Präparat und Verfahren zu seiner Herstellung |
US5580856A (en) | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
GB9418092D0 (en) | 1994-09-08 | 1994-10-26 | Red Cross Found Cent Lab Blood | Organic compounds |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
BR9609743A (pt) | 1995-07-27 | 1999-03-02 | Genentech Inc | Formulação reconstituída estável método para a preparação de uma formulação artigo manufaturado e uso da formação |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US6686191B1 (en) | 1995-09-22 | 2004-02-03 | Bayer Healthcare Llc | Preparation of virally inactivated intravenously injectable immune serum globulin |
US5770700A (en) | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
PL328199A1 (en) | 1996-01-25 | 1999-01-18 | Schering Ag | Improved concentrated intravascular injection and infusion solutions |
KR100236393B1 (ko) | 1996-02-02 | 1999-12-15 | 나까니시 히로유끼 | 사람성장호르몬을 함유하는 의약제제 |
TWI240627B (en) | 1996-04-26 | 2005-10-01 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
GB9610992D0 (en) | 1996-05-24 | 1996-07-31 | Glaxo Group Ltd | Concentrated antibody preparation |
EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
US5994511A (en) | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
EP1005776B1 (de) | 1997-08-21 | 2003-01-08 | Siemens Aktiengesellschaft | Verfahren zum übertragen von nutzdaten, die unterschiedlichen anwendungen zuordenbar sind |
GB9820525D0 (en) | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
JP2000247903A (ja) | 1999-03-01 | 2000-09-12 | Chugai Pharmaceut Co Ltd | 長期安定化製剤 |
US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
US6525102B1 (en) | 1999-10-04 | 2003-02-25 | Chiron Corporation | Stabilized liquid polypeptide-containing pharmaceutical compositions |
US7163671B2 (en) | 2000-02-29 | 2007-01-16 | Chugai Seiyaku Kabushiki Kaisha | Long-term stabilized formulations |
AU5133601A (en) | 2000-04-07 | 2001-10-23 | Ellis L Kline | Methods and compositions for treating neoplasms |
EP1336410A4 (en) | 2000-08-04 | 2005-10-12 | Chugai Pharmaceutical Co Ltd | PROTEIN INJECTION PREPARATIONS |
EP2311492B1 (en) | 2000-08-11 | 2017-10-04 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing stabilized preparations |
NZ524482A (en) | 2000-09-01 | 2005-11-25 | Chugai Pharmaceutical Co Ltd | Solution formulations having long-term stability |
JP4340062B2 (ja) | 2000-10-12 | 2009-10-07 | ジェネンテック・インコーポレーテッド | 粘度の減少した濃縮タンパク質製剤 |
GB0113179D0 (en) | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
MXPA04000747A (es) * | 2001-07-25 | 2004-07-08 | Protein Desing Labs Inc | Formulacion farmaceutica liofilizada estable de anticuerpos igg. |
CN1604788B (zh) | 2001-10-16 | 2013-04-17 | 里克斯金蒂克斯公司 | 高浓度蛋白制剂及其制备方法 |
ES2392073T3 (es) | 2001-11-08 | 2012-12-04 | Abbott Biotherapeutics Corp. | Formulación farmacéutica líquida estable de anticuerpos IGG |
US20030138416A1 (en) | 2001-12-03 | 2003-07-24 | Jesper Lau | Use of glucokinase activator in combination with a glucagon antagonist for treating type 2 diabetes |
AU2002351353A1 (en) | 2001-12-19 | 2003-09-02 | Genentech, Inc. | Stabilizing polypeptides which have been exposed to urea |
AU2003211990A1 (en) | 2002-02-14 | 2003-09-04 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing solution pharmaceuticals |
DE60322513D1 (de) | 2002-02-27 | 2008-09-11 | Immunex Corp | Stabilisierte TNFR-Fc Formulierung mit Arginin |
US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
US20040022792A1 (en) | 2002-06-17 | 2004-02-05 | Ralph Klinke | Method of stabilizing proteins at low pH |
CA2490423A1 (en) | 2002-06-21 | 2003-12-31 | Biogen Idec Inc. | Buffered formulations for concentrating antibodies and methods of use thereof |
JP2006502116A (ja) | 2002-07-12 | 2006-01-19 | メダレックス, インク. | タンパク質の酸化分解を防ぐ方法及び組成物 |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
UA89610C2 (ru) | 2002-10-08 | 2010-02-25 | Ринат Ньюросайенс Корп. | Способы лечения послеоперационной боли путем применения антагониста фактора роста нервов и композиции, которые его содержат |
WO2004055164A2 (en) | 2002-12-13 | 2004-07-01 | Abgenix, Inc. | System and method for stabilizing antibodies with histidine |
PL215171B1 (pl) | 2002-12-24 | 2013-10-31 | Rinat Neuroscience Corp | Przeciwcialo przeciw czynnikowi wzrostu nerwów (NGF) lub jego fragment, kompozycja farmaceutyczna, zestaw, sposób wytwarzania przeciwciala lub jego fragmentu, zastosowanie skutecznej ilosci antagonistycznego przeciwciala anty-NGF lub jego fragmentu, zastosowanie antagonistycznego przeciwciala anty-NGF lub jego fragmentu, izolowany polinukleotyd zawierajacy sekwencje nukleotydowa kodujaca przeciwcialo lub jego fragment, wektor oraz komórka gospodarza zawierajaca polinukleotyd |
US7569364B2 (en) | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
US20050158303A1 (en) | 2003-04-04 | 2005-07-21 | Genentech, Inc. | Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations |
ES2609010T3 (es) | 2003-04-04 | 2017-04-18 | Genentech, Inc. | Formulaciones de anticuerpos y de proteínas a concentración elevada |
RS20100555A (en) | 2003-07-15 | 2011-08-31 | Amgen Inc. | HUMAN ANTI-NGF NEUTRAL ANTIBODIES AS SELECTIVE NGF SIGNAL ROUTE INHIBITORS |
HUE026793T2 (en) | 2003-10-01 | 2016-07-28 | Kyowa Hakko Kirin Co Ltd | A method for stabilizing an antibody and a stabilized solution-type antibody preparation |
EP1532983A1 (en) | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
WO2005063291A1 (ja) | 2003-12-25 | 2005-07-14 | Kirin Beer Kabushiki Kaisha | 抗体を含有する安定な水性医薬製剤 |
JP2008505192A (ja) | 2004-06-14 | 2008-02-21 | メッドイミューン バクシーンズ,インコーポレイティド | 生物活性材料の高圧噴霧乾燥 |
US20060051347A1 (en) | 2004-09-09 | 2006-03-09 | Winter Charles M | Process for concentration of antibodies and therapeutic products thereof |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
TW200638943A (en) | 2005-01-28 | 2006-11-16 | Wyeth Corp | Stabilized liquid polypeptide formulations |
JP2006249082A (ja) | 2005-03-08 | 2006-09-21 | Pharmacia & Upjohn Co Llc | 低減レベルの内毒素を有する抗m−csf抗体組成物 |
TWI365747B (en) | 2005-03-08 | 2012-06-11 | Pharmacia & Upjohn Co Llc | Anti-ctla-4 antibody compositions |
US7785595B2 (en) | 2005-04-18 | 2010-08-31 | Yeda Research And Development Company Limited | Stabilized anti-hepatitis B (HBV) antibody formulations |
EP1893647A2 (en) * | 2005-06-23 | 2008-03-05 | MedImmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
US20090148406A1 (en) | 2005-07-02 | 2009-06-11 | Arecor Limited | Stable Aqueous Systems Comprising Proteins |
KR101566393B1 (ko) | 2005-08-03 | 2015-11-05 | 이뮤노젠 아이엔씨 | 면역접합체 제형 |
CA2915270C (en) | 2005-08-05 | 2017-07-11 | Amgen Inc. | Stable aqueous protein or antibody pharmaceutical formulations and their preparation |
WO2007056847A1 (en) | 2005-11-21 | 2007-05-24 | Sanofi Pasteur Limited | Stabilizing formulations for recombinant viruses |
EP1977763A4 (en) | 2005-12-28 | 2010-06-02 | Chugai Pharmaceutical Co Ltd | STABILIZER PREPARATION CONTAINING ANTIBODIES |
JP2009525986A (ja) | 2006-02-03 | 2009-07-16 | メディミューン,エルエルシー | タンパク質製剤 |
DE102006005094A1 (de) | 2006-02-04 | 2007-08-09 | Degussa Gmbh | Titandioxid und Polycarboxylatether enthaltende Dispersion |
CA2654794A1 (en) | 2006-06-14 | 2007-12-21 | Imclone Systems Incorporated | Lyophilized formulations of anti-egfr antibodies |
ES2531933T3 (es) | 2006-06-30 | 2015-03-20 | Novo Nordisk A/S | Anticuerpos anti-NKG2A y usos de los mismos |
US7744890B2 (en) | 2006-10-12 | 2010-06-29 | Wyeth Llc | Methods and compositions with reduced opalescence |
KR20090104017A (ko) | 2006-12-11 | 2009-10-05 | 에프. 호프만-라 로슈 아게 | A베타 항체 비경구 제제 |
US9127064B2 (en) | 2006-12-21 | 2015-09-08 | Novo Nordisk A/S | Antibodies against human NKG2D and uses thereof |
EP2077859A4 (en) | 2007-03-30 | 2010-11-24 | Medimmune Llc | ANTIBODY FORMULATION |
GB0707938D0 (en) | 2007-04-25 | 2007-05-30 | Univ Strathclyde | Precipitation stabilising compositions |
ES2707815T3 (es) | 2007-06-14 | 2019-04-05 | Biogen Ma Inc | Formulaciones de anticuerpo natalizumab |
JP5513380B2 (ja) * | 2007-06-25 | 2014-06-04 | アムジエン・インコーポレーテツド | 肝細胞増殖因子に対する特異的結合剤の組成物 |
UA107557C2 (xx) | 2007-07-06 | 2015-01-26 | Композиція антитіла офатумумабу | |
JP5490714B2 (ja) | 2007-11-28 | 2014-05-14 | メディミューン,エルエルシー | タンパク質製剤 |
MX2010006395A (es) | 2007-12-21 | 2010-07-01 | Hoffmann La Roche | Formulacion de anticuerpos. |
NZ586303A (en) | 2007-12-28 | 2012-03-30 | Bioinvent Int Ab | Antibody-containing formulation for the use for treating cardiovascular diseases associated with atherosclerosis |
RU2010138612A (ru) | 2008-02-20 | 2012-03-27 | Джи2 ИНФЛЕММЕЙШН ПТИ ЛТД (AU) | ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ C5аR |
WO2009120684A1 (en) | 2008-03-25 | 2009-10-01 | Medimmune, Llc | Antibody formulation |
CN102137871A (zh) | 2008-06-30 | 2011-07-27 | 诺沃—诺迪斯克有限公司 | 抗-人白介素-20抗体 |
UA112050C2 (uk) | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
WO2010032220A1 (en) | 2008-09-19 | 2010-03-25 | Pfizer Inc. | Stable liquid antibody formulation |
KR20110096553A (ko) * | 2008-11-28 | 2011-08-30 | 아보트 러보러터리즈 | 안정한 항체 조성물 및 이의 안정화 방법 |
EP2196476A1 (en) | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
CN102325795B (zh) | 2008-12-22 | 2015-03-25 | 诺沃—诺迪斯克有限公司 | 针对组织因子途径抑制剂的抗体 |
EP2403874A1 (en) | 2009-03-06 | 2012-01-11 | Genentech, Inc. | Antibody formulation |
MX2011013722A (es) | 2009-06-18 | 2012-05-08 | Wyeth Llc | Formulaciones liofilizadas para inmunofarmaceuticos modulares pequeños. |
PT3438126T (pt) | 2009-09-03 | 2020-11-09 | Ablynx Nv | Formulações estáveis de polipéptidos e seus usos |
EP2332995A1 (en) * | 2009-12-10 | 2011-06-15 | Bayer Schering Pharma Aktiengesellschaft | Neutralizing prolactin receptor antibodies and their therapeutic use |
CN107496917B (zh) | 2010-02-26 | 2021-06-11 | 诺沃—诺迪斯克有限公司 | 包含稳定抗体的组合物 |
SG183443A1 (en) | 2010-03-01 | 2012-09-27 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
WO2011108452A1 (ja) * | 2010-03-02 | 2011-09-09 | Jnc株式会社 | 還元反応器 |
KR101948463B1 (ko) * | 2010-03-19 | 2019-02-14 | 박스알타 인코퍼레이티드 | Tfpi 저해제 및 사용 방법 |
CN105055306B (zh) | 2010-05-28 | 2019-10-01 | 诺沃—诺迪斯克有限公司 | 包含抗体和防腐剂的稳定的多剂量组合物 |
EP2624865B1 (en) * | 2010-10-06 | 2018-08-01 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies |
AU2012236296A1 (en) | 2011-04-01 | 2013-10-24 | Bayer Healthcare Llc | Monoclonal antibodies against tissue factor pathway inhibitor (TFPI) |
US8613919B1 (en) * | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
-
2013
- 2013-03-15 US US13/843,780 patent/US9592297B2/en active Active
- 2013-08-28 BR BR112015003838A patent/BR112015003838A2/pt not_active Application Discontinuation
- 2013-08-28 CN CN202111330122.3A patent/CN114392353A/zh active Pending
- 2013-08-28 PT PT16180643T patent/PT3117837T/pt unknown
- 2013-08-28 ES ES16180643T patent/ES2741575T3/es active Active
- 2013-08-28 PL PL16180643T patent/PL3117837T3/pl unknown
- 2013-08-28 EP EP16180643.5A patent/EP3117837B1/en active Active
- 2013-08-28 EP EP19175217.9A patent/EP3590536A1/en not_active Ceased
- 2013-08-28 IL IL286784A patent/IL286784B/en unknown
- 2013-08-28 CN CN201380051319.0A patent/CN104684933B/zh not_active Expired - Fee Related
- 2013-08-28 SG SG11201501116RA patent/SG11201501116RA/en unknown
- 2013-08-28 LT LTEP16180643.5T patent/LT3117837T/lt unknown
- 2013-08-28 RS RSP20190976 patent/RS59221B1/sr unknown
- 2013-08-28 SI SI201331538T patent/SI3117837T1/sl unknown
- 2013-08-28 IL IL294567A patent/IL294567A/en unknown
- 2013-08-28 DK DK16180643.5T patent/DK3117837T3/da active
- 2013-08-28 MX MX2015002411A patent/MX369653B/es active IP Right Grant
- 2013-08-28 AU AU2013308902A patent/AU2013308902B2/en not_active Ceased
- 2013-08-28 WO PCT/US2013/056970 patent/WO2014036071A1/en active Application Filing
- 2013-08-28 EP EP13760179.5A patent/EP2890718A1/en not_active Withdrawn
- 2013-08-28 RU RU2015111341A patent/RU2678097C2/ru not_active IP Right Cessation
- 2013-08-28 US US14/421,607 patent/US20150209431A1/en not_active Abandoned
- 2013-08-28 CA CA2883095A patent/CA2883095C/en active Active
- 2013-08-28 RU RU2019100887A patent/RU2019100887A/ru not_active Application Discontinuation
- 2013-08-28 CA CA3129277A patent/CA3129277A1/en active Pending
- 2013-08-28 HU HUE16180643A patent/HUE045652T2/hu unknown
- 2013-08-28 JP JP2015529977A patent/JP6462567B2/ja active Active
- 2013-08-28 SG SG10201708215YA patent/SG10201708215YA/en unknown
- 2013-08-29 AR ARP130103085A patent/AR092388A1/es unknown
- 2013-08-29 UY UY0001034995A patent/UY34995A/es not_active Application Discontinuation
- 2013-08-30 TW TW102131326A patent/TW201414496A/zh unknown
- 2013-08-30 TW TW102131180A patent/TWI609697B/zh not_active IP Right Cessation
- 2013-08-30 AR ARP130103099A patent/AR092400A1/es unknown
- 2013-08-30 TW TW106131685A patent/TW201825116A/zh unknown
- 2013-08-30 TW TW108113538A patent/TW201927338A/zh unknown
- 2013-12-16 US US14/107,658 patent/US20140105892A1/en not_active Abandoned
-
2014
- 2014-08-12 US US14/457,408 patent/US9849181B2/en active Active
-
2015
- 2015-02-11 IL IL237188A patent/IL237188A0/en unknown
- 2015-02-24 MX MX2019013670A patent/MX2019013670A/es unknown
- 2015-11-27 HK HK15111675.2A patent/HK1210794A1/xx unknown
-
2017
- 2017-08-16 US US15/679,053 patent/US20180055940A1/en not_active Abandoned
- 2017-10-18 US US15/787,610 patent/US20180028669A1/en not_active Abandoned
-
2018
- 2018-05-11 AU AU2018203320A patent/AU2018203320B2/en not_active Expired - Fee Related
- 2018-12-17 JP JP2018235273A patent/JP2019048886A/ja active Pending
-
2019
- 2019-04-07 IL IL265865A patent/IL265865A/en unknown
- 2019-04-07 IL IL265864A patent/IL265864B/en active IP Right Grant
- 2019-07-18 HR HRP20191299TT patent/HRP20191299T1/hr unknown
- 2019-08-16 CY CY20191100881T patent/CY1121989T1/el unknown
-
2020
- 2020-01-08 AU AU2020200134A patent/AU2020200134A1/en not_active Abandoned
- 2020-11-11 US US17/095,102 patent/US20230190637A9/en not_active Abandoned
- 2020-12-06 IL IL279237A patent/IL279237A/en unknown
-
2021
- 2021-01-13 JP JP2021003390A patent/JP2021059602A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL276234B (en) | Antibody compositions | |
HK1203146A1 (en) | Antibody formulation | |
SI3117837T1 (sl) | Formulacije protiteles | |
IL235807A0 (en) | Immunoprecipitates containing anti–cd79b antibodies | |
IL235989A0 (en) | Immunoprecipitates containing anti–cd79b antibodies | |
HK1204571A1 (en) | Protease-regulated antibodies | |
HK1210192A1 (en) | Anti-siglec-15 antibodies siglec-15 | |
AP2014008102A0 (en) | Anti-FcRn antibodies | |
EP2930240A4 (en) | ANTI-FOLR1 ANTIBODY | |
ZA201407316B (en) | Anti-fgfr2 antibody | |
EP2832855A4 (en) | NEW ANTI-SIGLEC ANTIBODY-15 | |
EP2826790A4 (en) | GREMLIN-1 ANTIBODY | |
ZA201407079B (en) | Cdr-modified anti-siglec-15 antibody | |
HK1210186A1 (en) | Anti-h7cr antibodies h7cr | |
GB201220242D0 (en) | Antibody | |
EP2848633A4 (en) | ANTI-CXADR ANTIBODY | |
EP2811018A4 (en) | ANTI-BODY ANTI-sAPPß | |
GB201206178D0 (en) | Formulations | |
GB201216749D0 (en) | Antigen combinations | |
GB201200568D0 (en) | Antigen combinations |