PT3096737T - Composição de solução de aerossol pressurizado estável de brometo de glicopirrónio e formoterol - Google Patents

Composição de solução de aerossol pressurizado estável de brometo de glicopirrónio e formoterol

Info

Publication number
PT3096737T
PT3096737T PT148274491T PT14827449T PT3096737T PT 3096737 T PT3096737 T PT 3096737T PT 148274491 T PT148274491 T PT 148274491T PT 14827449 T PT14827449 T PT 14827449T PT 3096737 T PT3096737 T PT 3096737T
Authority
PT
Portugal
Prior art keywords
glycopyronum
formoterol
bromide
stabilized
pressurized aerosol
Prior art date
Application number
PT148274491T
Other languages
English (en)
Portuguese (pt)
Inventor
Zambelli Enrico
Bonelli Sauro
Copelli Diego
Dagli Alberi Massimiliano
Usberti Francesca
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49886776&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3096737(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of PT3096737T publication Critical patent/PT3096737T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/141—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant specially adapted for specific contents or propellants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
    • B65D83/52—Metering valves; Metering devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M2039/226—Spindles or actuating means

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Mechanical Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
PT148274491T 2013-12-30 2014-12-23 Composição de solução de aerossol pressurizado estável de brometo de glicopirrónio e formoterol PT3096737T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13199783 2013-12-30

Publications (1)

Publication Number Publication Date
PT3096737T true PT3096737T (pt) 2018-04-27

Family

ID=49886776

Family Applications (1)

Application Number Title Priority Date Filing Date
PT148274491T PT3096737T (pt) 2013-12-30 2014-12-23 Composição de solução de aerossol pressurizado estável de brometo de glicopirrónio e formoterol

Country Status (36)

Country Link
US (3) US20150182459A1 (enEXAMPLES)
EP (1) EP3096737B1 (enEXAMPLES)
JP (2) JP6534397B2 (enEXAMPLES)
KR (1) KR101865131B1 (enEXAMPLES)
CN (2) CN105848642A (enEXAMPLES)
AR (2) AR098983A1 (enEXAMPLES)
AU (1) AU2014375300B2 (enEXAMPLES)
BR (1) BR112016014586A2 (enEXAMPLES)
CA (1) CA2935302C (enEXAMPLES)
CL (1) CL2016001652A1 (enEXAMPLES)
CY (1) CY1120205T1 (enEXAMPLES)
DK (1) DK3096737T3 (enEXAMPLES)
EA (1) EA033228B1 (enEXAMPLES)
ES (1) ES2666905T4 (enEXAMPLES)
GE (1) GEP20186870B (enEXAMPLES)
HR (1) HRP20180944T1 (enEXAMPLES)
HU (1) HUE039359T2 (enEXAMPLES)
IL (1) IL246502B (enEXAMPLES)
LT (1) LT3096737T (enEXAMPLES)
MA (1) MA39154A1 (enEXAMPLES)
ME (1) ME03076B (enEXAMPLES)
MX (1) MX368834B (enEXAMPLES)
MY (1) MY176191A (enEXAMPLES)
NO (1) NO3096737T3 (enEXAMPLES)
PE (1) PE20161132A1 (enEXAMPLES)
PH (1) PH12016501269B1 (enEXAMPLES)
PL (1) PL3096737T3 (enEXAMPLES)
PT (1) PT3096737T (enEXAMPLES)
RS (1) RS57269B1 (enEXAMPLES)
SA (1) SA516371428B1 (enEXAMPLES)
SG (1) SG11201605309UA (enEXAMPLES)
SI (1) SI3096737T1 (enEXAMPLES)
TN (1) TN2016000262A1 (enEXAMPLES)
TR (1) TR201809356T4 (enEXAMPLES)
UA (1) UA117846C2 (enEXAMPLES)
WO (1) WO2015101575A1 (enEXAMPLES)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG181868A1 (en) 2009-12-23 2012-07-30 Chiesi Farma Spa Combination therapy for copd
WO2011076841A2 (en) * 2009-12-23 2011-06-30 Chiesi Farmaceutici S.P.A. Combination therapy for copd
UA106098C2 (uk) 2009-12-23 2014-07-25 К'Єзі Фармачеутічі С.П.А. Аерозольна композиція для хозл
SG11201605311UA (en) * 2013-12-30 2016-07-28 Chiesi Farma Spa Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination
ME03076B (me) * 2013-12-30 2019-01-20 Chiesi Farm Spa Stabilna pod priтiskom kompozicija aerosolnog rastvora glikopironijum bromida i kombinacije formoterola
GB201520862D0 (en) * 2015-11-25 2016-01-13 Jagotec Ag Pharmaceutical composition
TW201735914A (zh) * 2015-12-22 2017-10-16 阿斯特捷利康公司 用於治療慢性阻塞性肺疾病之醫藥組成物
US10098837B2 (en) * 2016-07-28 2018-10-16 Chiesi Farmaceutici S.P.A. Combination therapy for COPD
ES2892673T3 (es) 2016-09-19 2022-02-04 Mexichem Fluor Sa De Cv Composición farmacéutica que comprende glicopirrolato
EP3860580A4 (en) * 2018-10-01 2022-07-20 Kindeva Drug Delivery L.P. FORMULATION AND AEROSOL CARTRIDGES, INHALATORS AND THE LIKE CONTAINING THE FORMULATION
CN114206317A (zh) * 2019-07-12 2022-03-18 金德瓦药物控释有限公司 气雾剂制剂、含有该制剂的罐和吸入器以及使用方法
WO2021033081A1 (en) * 2019-08-16 2021-02-25 Glenmark Pharmaceutical Limited Stable aerosol composition for inhalation comprising glycopyrronium, formoterol and corticosteroid
CN112438966B (zh) * 2019-08-30 2022-08-26 四川普锐特药业有限公司 一种医用定量吸入气雾剂
MX2022004781A (es) 2019-12-02 2022-05-16 Chiesi Farm Spa Lata de acero inoxidable para inhaladores dosificadores presurizados.
WO2021138386A1 (en) * 2020-01-04 2021-07-08 Cai Gu Huang Propellant-free formulation for inhalation
BR112022012361A2 (pt) * 2020-01-28 2022-09-06 Chiesi Farm Spa Inaladores pressurizados de dose calibrada compreendendo uma formulação farmacêutica tamponada
NZ790703A (en) * 2020-02-20 2025-06-27 Chiesi Farm Spa Pressurised metered dose inhalers comprising a buffered pharmaceutical formulation
JP2023540171A (ja) 2020-07-31 2023-09-22 ケモ リサーチ， エス．エル． 吸入投与のための併用療法

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WO2011076841A2 (en) 2009-12-23 2011-06-30 Chiesi Farmaceutici S.P.A. Combination therapy for copd
SG181868A1 (en) * 2009-12-23 2012-07-30 Chiesi Farma Spa Combination therapy for copd
EA201490991A1 (ru) * 2011-05-17 2014-09-30 Перл Терапьютикс, Инк. Композиции, способы и устройства для респираторной доставки двух или более активных средств
ME03076B (me) * 2013-12-30 2019-01-20 Chiesi Farm Spa Stabilna pod priтiskom kompozicija aerosolnog rastvora glikopironijum bromida i kombinacije formoterola
SG11201605311UA (en) * 2013-12-30 2016-07-28 Chiesi Farma Spa Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination

Also Published As

Publication number Publication date
HUE039359T2 (hu) 2018-12-28
PL3096737T3 (pl) 2018-08-31
ES2666905T3 (es) 2018-05-08
US10596149B2 (en) 2020-03-24
CN105848642A (zh) 2016-08-10
SG11201605309UA (en) 2016-07-28
AR098983A1 (es) 2016-06-22
PH12016501269B1 (en) 2019-09-18
CA2935302A1 (en) 2015-07-09
NO3096737T3 (enEXAMPLES) 2018-09-01
BR112016014586A2 (pt) 2017-08-08
LT3096737T (lt) 2018-06-11
HRP20180944T1 (hr) 2018-08-10
UA117846C2 (uk) 2018-10-10
MY176191A (en) 2020-07-24
AU2014375300A1 (en) 2016-07-14
KR20160104042A (ko) 2016-09-02
EP3096737A1 (en) 2016-11-30
CN113143894A (zh) 2021-07-23
CL2016001652A1 (es) 2017-08-25
CY1120205T1 (el) 2018-12-12
TN2016000262A1 (en) 2017-10-06
IL246502A0 (en) 2016-08-31
AU2014375300B2 (en) 2019-10-24
DK3096737T3 (en) 2018-06-25
IL246502B (en) 2020-05-31
JP6826145B2 (ja) 2021-02-03
MX2016008591A (es) 2016-09-26
WO2015101575A1 (en) 2015-07-09
GEP20186870B (en) 2018-06-25
AR130238A2 (es) 2024-11-20
US20170095444A1 (en) 2017-04-06
ME03076B (me) 2019-01-20
NZ721640A (en) 2021-02-26
PH12016501269A1 (en) 2016-08-15
TR201809356T4 (tr) 2018-07-23
SI3096737T1 (en) 2018-07-31
US20160303044A1 (en) 2016-10-20
KR101865131B1 (ko) 2018-06-08
MX368834B (es) 2019-10-18
EP3096737B1 (en) 2018-04-04
JP2019112458A (ja) 2019-07-11
SA516371428B1 (ar) 2018-09-30
ES2666905T4 (es) 2018-06-07
PE20161132A1 (es) 2016-11-02
US20150182459A1 (en) 2015-07-02
CA2935302C (en) 2022-06-21
JP6534397B2 (ja) 2019-06-26
US10617669B2 (en) 2020-04-14
RS57269B1 (sr) 2018-08-31
JP2017507168A (ja) 2017-03-16
EA033228B1 (ru) 2019-09-30
MA39154A1 (fr) 2017-08-31
EA201691127A1 (ru) 2016-12-30

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