AR098983A1 - Composición combinada de bromuro de glicopirronio y formoterol en solución estable presurizada para aerosol - Google Patents
Composición combinada de bromuro de glicopirronio y formoterol en solución estable presurizada para aerosolInfo
- Publication number
- AR098983A1 AR098983A1 ARP140104939A ARP140104939A AR098983A1 AR 098983 A1 AR098983 A1 AR 098983A1 AR P140104939 A ARP140104939 A AR P140104939A AR P140104939 A ARP140104939 A AR P140104939A AR 098983 A1 AR098983 A1 AR 098983A1
- Authority
- AR
- Argentina
- Prior art keywords
- range
- dosage
- salt
- pharmaceutical composition
- aerosol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/44—Valves specially adapted therefor; Regulating devices
- B65D83/52—Valves specially adapted therefor; Regulating devices for metering
- B65D83/54—Metering valves ; Metering valve assemblies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/75—Aerosol containers not provided for in groups B65D83/16 - B65D83/74
- B65D83/752—Aerosol containers not provided for in groups B65D83/16 - B65D83/74 characterised by the use of specific products or propellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M2039/226—Spindles or actuating means
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Mechanical Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Cosmetics (AREA)
Abstract
Reivindicación 1: Una composición farmacéutica en solución para aerosol para utilizar en un inhalador presurizado de dosis medida caracterizada porque comprende: (a) bromuro de glicopirronio con una dosificación dentro del rango entre 5 y 26 mg por accionamiento; (b) formoterol, o una sal del mismo o un solvato de dicha sal, con una dosificación dentro del rango entre 1 y 25 mg por accionamiento; (c) un propelente que consiste en un HFA; (d) un co-solvente; (e) una cantidad útil como estabilizante de un ácido mineral, donde dicha composición está contenida en un envase de aerosol provisto de una válvula dosificadora que tiene por lo menos una junta de caucho butílico. Reivindicación 2: Una composición farmacéutica en solución para aerosol de acuerdo con la reivindicación 1 caracterizada porque la cantidad del producto de degradación N-(3-bromo)-[2-hidroxi-5-[1-hidroxi-2-[1-(4-metoxifenil)propan-2-ilamino]etil]fenil]formamida es menor al 0,10% peso en peso con respecto al contenido teórico de fumarato de formoterol de 6 mg/accionamiento, cuando se almacena en condiciones de envejecimiento acelerado a 25ºC y 60% de humedad relativa (RH) durante por lo menos 6 meses. Reivindicación 3: Una composición farmacéutica en solución para aerosol de acuerdo con la reivindicación 1 ó 2 caracterizada porque la cantidad de ácido mineral útil como estabilizante es una cantidad de ácido equivalente a ácido clorhídrico 1M dentro del rango entre 0,15 y 0,28 mg/ml. Reivindicación 9: Una composición farmacéutica en solución para aerosol de acuerdo con la reivindicación 8 caracterizada porque el corticoesteroide para inhalación se selecciona entre el grupo de: dipropionato de beclometasona, budesonida o su epímero 22R-, ciclesonida, flunisolida, propionato de fluticasona, furoato de fluticasona, furoato de mometasona, butixooort, triamcinolona acetonida, triamcinolona, metilprednisolona, prednisona, loteprednol y rofleponida. Reivindicación 14: Un envase de aerosol provisto de una válvula dosificadora que tiene por lo menos una junta de caucho butílico para utilizar con una composición farmacéutica en solución para aerosol para utilizar en un inhalador presurizado de dosis medida caracterizada porque comprende: (a) bromuro de glicopirronio con una dosificación dentro del rango entre 5 y 26 mg por accionamiento; (b) formoterol, o una sal del mismo o un solvato de dicha sal, con una dosificación dentro del rango entre 1 y 25 mg por accionamiento; (c) un propelente que consiste en un HFA, (d) un co-solvente; (e) una cantidad útil como estabilizante de un ácido mineral, y, opcionalmente, (f) un corticoesteroide para inhalación. Reivindicación 15: Un método para reducir la cantidad del producto de degradación N-(3-bromo)-[2-hidroxi-5-[1-hidroxi-2-[1-(4-metoxifenil)propan-2-ilamino]etil]fenil]formamida (DP3) durante la vida de estante de una composición farmacéutica en solución para aerosol para utilizar en un inhalador presurizado de dosis medida que comprende: (a) bromuro de glicopirronio con una dosificación dentro del rango entre 5 y 26 mg por accionamiento; (b) formoterol, o una sal del mismo o un solvato de dicha sal, con una dosificación dentro del rango entre 1 y 25 mg por accionamiento; (c) un propelente que consiste en un HFA,(d) un co-solvente; (e) una cantidad útil como estabilizante de un ácido mineral, y, opcionalmente, (f) un corticoesteroide para inhalación caracterizado porque dicho método comprende envasar la anterior composición en un envase de aerosol provisto de una válvula dosificadora que tiene por lo menos una junta de caucho butílico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13199783 | 2013-12-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR098983A1 true AR098983A1 (es) | 2016-06-22 |
Family
ID=49886776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140104939A AR098983A1 (es) | 2013-12-30 | 2014-12-29 | Composición combinada de bromuro de glicopirronio y formoterol en solución estable presurizada para aerosol |
Country Status (36)
Country | Link |
---|---|
US (3) | US20150182459A1 (es) |
EP (1) | EP3096737B1 (es) |
JP (2) | JP6534397B2 (es) |
KR (1) | KR101865131B1 (es) |
CN (2) | CN105848642A (es) |
AR (1) | AR098983A1 (es) |
AU (1) | AU2014375300B2 (es) |
BR (1) | BR112016014586A2 (es) |
CA (1) | CA2935302C (es) |
CL (1) | CL2016001652A1 (es) |
CY (1) | CY1120205T1 (es) |
DK (1) | DK3096737T3 (es) |
EA (1) | EA033228B1 (es) |
ES (1) | ES2666905T4 (es) |
GE (1) | GEP20186870B (es) |
HR (1) | HRP20180944T1 (es) |
HU (1) | HUE039359T2 (es) |
IL (1) | IL246502B (es) |
LT (1) | LT3096737T (es) |
MA (1) | MA39154A1 (es) |
ME (1) | ME03076B (es) |
MX (1) | MX368834B (es) |
MY (1) | MY176191A (es) |
NO (1) | NO3096737T3 (es) |
PE (1) | PE20161132A1 (es) |
PH (1) | PH12016501269A1 (es) |
PL (1) | PL3096737T3 (es) |
PT (1) | PT3096737T (es) |
RS (1) | RS57269B1 (es) |
SA (1) | SA516371428B1 (es) |
SG (1) | SG11201605309UA (es) |
SI (1) | SI3096737T1 (es) |
TN (1) | TN2016000262A1 (es) |
TR (1) | TR201809356T4 (es) |
UA (1) | UA117846C2 (es) |
WO (1) | WO2015101575A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA113832C2 (xx) | 2009-12-23 | 2017-03-27 | Комбінаційна терапія для хозл | |
EP2515853B1 (en) * | 2009-12-23 | 2014-03-19 | Chiesi Farmaceutici S.p.A. | Combination therapy for COPD |
PE20121467A1 (es) | 2009-12-23 | 2012-11-07 | Chiesi Farma Spa | Formulacion de aerosol para la enfermedad pulmonar obstructiva cronica |
CN111150728B (zh) * | 2013-12-30 | 2024-02-06 | 奇斯药制品公司 | 格隆溴铵和福莫特罗组合的稳定的加压气雾剂溶液组合物 |
NO3096737T3 (es) * | 2013-12-30 | 2018-09-01 | ||
GB201520862D0 (en) * | 2015-11-25 | 2016-01-13 | Jagotec Ag | Pharmaceutical composition |
WO2017108917A1 (en) * | 2015-12-22 | 2017-06-29 | Astrazeneca Ab | Pharmaceutical compositions for use in the treatment of chronic obstructive pulmonary disease |
US10098837B2 (en) | 2016-07-28 | 2018-10-16 | Chiesi Farmaceutici S.P.A. | Combination therapy for COPD |
ES2957459T3 (es) | 2016-09-19 | 2024-01-19 | Mexichem Fluor Sa De Cv | Composición farmacéutica que comprende glicopirrolato |
WO2021009573A1 (en) * | 2019-07-12 | 2021-01-21 | Kindeva Drug Delivery L.P. | Aerosol formulation, canister and inhaler containing the formulation, and method of use |
WO2021033081A1 (en) * | 2019-08-16 | 2021-02-25 | Glenmark Pharmaceutical Limited | Stable aerosol composition for inhalation comprising glycopyrronium, formoterol and corticosteroid |
CN112438966B (zh) * | 2019-08-30 | 2022-08-26 | 四川普锐特药业有限公司 | 一种医用定量吸入气雾剂 |
AU2019477296A1 (en) | 2019-12-02 | 2022-04-14 | Chiesi Farmaceutici S.P.A. | Stainles steel can for pressurised metered dose inhalers |
WO2021138386A1 (en) * | 2020-01-04 | 2021-07-08 | Cai Gu Huang | Propellant-free formulation for inhalation |
WO2021151857A1 (en) * | 2020-01-28 | 2021-08-05 | Chiesi Farmaceutici S.P.A. | Pressurised metered dose inhalers comprising a buffered pharmaceutical formulation |
EP4106722A1 (en) * | 2020-02-20 | 2022-12-28 | Chiesi Farmaceutici S.p.A. | Pressurised metered dose inhalers comprising a buffered pharmaceutical formulation |
JP2023540171A (ja) | 2020-07-31 | 2023-09-22 | ケモ リサーチ, エス.エル. | 吸入投与のための併用療法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
ME00220B (me) * | 2000-05-22 | 2010-10-10 | Chiesi Farm Spa | Stabilne farmaceutske formulacije rastvora za inhalatore odmjerene doze pod pritiskom |
US6750210B2 (en) * | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
US20040126325A1 (en) * | 2002-03-12 | 2004-07-01 | David Lewis | Medicinal aerosol solution formulation products with improved chemical stability |
GB0315791D0 (en) * | 2003-07-07 | 2003-08-13 | 3M Innovative Properties Co | Two component molded valve stems |
CA2550841C (en) * | 2004-02-06 | 2012-10-02 | Meda Pharma Gmbh & Co. Kg | Novel combination of anticholinergic and .beta. mimetics for the treatment of respiratory diseases |
EP1595531A1 (en) * | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
WO2005112902A2 (en) * | 2004-05-13 | 2005-12-01 | Chiesi Farmaceutici S.P.A. | Medicinal aerosol formulation products with improved chemical stability |
GB0613161D0 (en) * | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
EP2201934A1 (en) * | 2008-12-23 | 2010-06-30 | CHIESI FARMACEUTICI S.p.A. | Tiotropium aerosol formulation products with improved chemical stability |
CA2764867C (en) * | 2009-06-09 | 2016-05-17 | Elevation Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease with nebulized beta 2-agonist or combined nebulized beta 2-agonist and anticholinergic administration |
PE20121467A1 (es) * | 2009-12-23 | 2012-11-07 | Chiesi Farma Spa | Formulacion de aerosol para la enfermedad pulmonar obstructiva cronica |
EP2515853B1 (en) | 2009-12-23 | 2014-03-19 | Chiesi Farmaceutici S.p.A. | Combination therapy for COPD |
KR20120106753A (ko) | 2009-12-23 | 2012-09-26 | 키에시 파르마슈티시 엣스. 피. 에이. | Copd용 에어로졸 제제 |
UA113832C2 (xx) * | 2009-12-23 | 2017-03-27 | Комбінаційна терапія для хозл | |
AU2011368334A1 (en) * | 2011-05-17 | 2013-11-21 | Pearl Therapeutics, Inc. | Compositions, methods & systems for respiratory delivery of two or more active agents |
NO3096737T3 (es) * | 2013-12-30 | 2018-09-01 | ||
CN111150728B (zh) * | 2013-12-30 | 2024-02-06 | 奇斯药制品公司 | 格隆溴铵和福莫特罗组合的稳定的加压气雾剂溶液组合物 |
-
2014
- 2014-12-23 NO NO14827449A patent/NO3096737T3/no unknown
- 2014-12-23 JP JP2016561078A patent/JP6534397B2/ja active Active
- 2014-12-23 EP EP14827449.1A patent/EP3096737B1/en active Active
- 2014-12-23 LT LTEP14827449.1T patent/LT3096737T/lt unknown
- 2014-12-23 CA CA2935302A patent/CA2935302C/en active Active
- 2014-12-23 CN CN201480071531.8A patent/CN105848642A/zh active Pending
- 2014-12-23 MA MA39154A patent/MA39154A1/fr unknown
- 2014-12-23 PT PT148274491T patent/PT3096737T/pt unknown
- 2014-12-23 ME MEP-2018-149A patent/ME03076B/me unknown
- 2014-12-23 PL PL14827449T patent/PL3096737T3/pl unknown
- 2014-12-23 SI SI201430734T patent/SI3096737T1/en unknown
- 2014-12-23 GE GEAP201414192A patent/GEP20186870B/en unknown
- 2014-12-23 DK DK14827449.1T patent/DK3096737T3/en active
- 2014-12-23 RS RS20180635A patent/RS57269B1/sr unknown
- 2014-12-23 MY MYPI2016001208A patent/MY176191A/en unknown
- 2014-12-23 WO PCT/EP2014/079258 patent/WO2015101575A1/en active Application Filing
- 2014-12-23 PE PE2016000969A patent/PE20161132A1/es unknown
- 2014-12-23 BR BR112016014586A patent/BR112016014586A2/pt not_active Application Discontinuation
- 2014-12-23 KR KR1020167020696A patent/KR101865131B1/ko active IP Right Grant
- 2014-12-23 HU HUE14827449A patent/HUE039359T2/hu unknown
- 2014-12-23 TN TN2016000262A patent/TN2016000262A1/en unknown
- 2014-12-23 AU AU2014375300A patent/AU2014375300B2/en active Active
- 2014-12-23 EA EA201691127A patent/EA033228B1/ru unknown
- 2014-12-23 MX MX2016008591A patent/MX368834B/es active IP Right Grant
- 2014-12-23 SG SG11201605309UA patent/SG11201605309UA/en unknown
- 2014-12-23 CN CN202110424305.5A patent/CN113143894A/zh active Pending
- 2014-12-23 TR TR2018/09356T patent/TR201809356T4/tr unknown
- 2014-12-23 ES ES14827449.1T patent/ES2666905T4/es active Active
- 2014-12-23 UA UAA201606911A patent/UA117846C2/uk unknown
- 2014-12-29 AR ARP140104939A patent/AR098983A1/es not_active Application Discontinuation
- 2014-12-30 US US14/585,366 patent/US20150182459A1/en not_active Abandoned
-
2016
- 2016-06-28 SA SA516371428A patent/SA516371428B1/ar unknown
- 2016-06-28 IL IL246502A patent/IL246502B/en active IP Right Grant
- 2016-06-28 PH PH12016501269A patent/PH12016501269A1/en unknown
- 2016-06-28 CL CL2016001652A patent/CL2016001652A1/es unknown
- 2016-06-29 US US15/196,253 patent/US10617669B2/en active Active
- 2016-12-15 US US15/379,924 patent/US10596149B2/en active Active
-
2018
- 2018-05-15 CY CY20181100498T patent/CY1120205T1/el unknown
- 2018-06-19 HR HRP20180944TT patent/HRP20180944T1/hr unknown
-
2019
- 2019-03-20 JP JP2019053624A patent/JP6826145B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR098983A1 (es) | Composición combinada de bromuro de glicopirronio y formoterol en solución estable presurizada para aerosol | |
AR098982A1 (es) | Composición combinada de bromuro de glicopirronio y formoterol en solución estable presurizada para aerosol | |
AR079726A1 (es) | Terapia combinada para enfermedad pulmonar obstructiva cronica (epoc) . composicion farmaceutica.frasco de aerosol. metodo.conjunto de componentes | |
MX340924B (es) | Composiciones farmaceuticas. | |
AR081540A1 (es) | Proceso para proveer particulas con cargas electroestaticas reducidas | |
NZ600789A (en) | Aerosol formulation for copd | |
BR112022014228A2 (pt) | Inaladores pressurizados de dose calibrada compreendendo uma formulação farmacêutica tamponada | |
AR123674A2 (es) | Composición farmacéutica en aerosol de formoterol y dipropionato de beclometasona | |
ES2247959T1 (es) | Formulacion medica en aerosol estabilizada en agua. | |
PE20221867A1 (es) | Inhaladores de dosis medida presurizada que comprenden una formulacion farmaceutica amortiguada | |
TH171993A (th) | องค์ประกอบสารละลายชนิดละอองลอยแบบอัดความดันที่เสถียรของการรวมกันของ ไกลโคไพร์โรเนียมโบรไมด์ และฟอร์โมเทอรอล | |
TH171992A (th) | องค์ประกอบสารละลายชนิดละอองลอยแบบอัดความดันที่เสถียรของการรวมกันของ ไกลโคไพร์โรเนียมโบรไมด์ และฟอร์โมเทอรอล | |
AR085443A1 (es) | Formulaciones medicinales en aerosol que no dañan la capa de ozono y con bajo efecto invernadero | |
BR112022010188A2 (pt) | Formulação farmacêutica de solução de aerossol, lata de aerossol, inaladores pressurizados de dose calibrada e uso da referida formulação | |
TH171993B (th) | องค์ประกอบสารละลายชนิดละอองลอยแบบอัดความดันที่เสถียรของการรวมกันของ ไกลโคไพร์โรเนียมโบรไมด์ และฟอร์โมเทอรอล |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |