GEP20186870B - Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination - Google Patents

Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination

Info

Publication number
GEP20186870B
GEP20186870B GEAP201414192A GEAP2014014192A GEP20186870B GE P20186870 B GEP20186870 B GE P20186870B GE AP201414192 A GEAP201414192 A GE AP201414192A GE AP2014014192 A GEAP2014014192 A GE AP2014014192A GE P20186870 B GEP20186870 B GE P20186870B
Authority
GE
Georgia
Prior art keywords
glycopyrronium bromide
solution composition
aerosol solution
pressurised aerosol
formoterol combination
Prior art date
Application number
GEAP201414192A
Other languages
English (en)
Inventor
Farmaceutici S P A Chiesi
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49886776&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GEP20186870(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of GEP20186870B publication Critical patent/GEP20186870B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/141—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant specially adapted for specific contents or propellants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
    • B65D83/52—Metering valves; Metering devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M2039/226—Spindles or actuating means

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Mechanical Engineering (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)
GEAP201414192A 2013-12-30 2014-12-23 Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination GEP20186870B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13199783 2013-12-30

Publications (1)

Publication Number Publication Date
GEP20186870B true GEP20186870B (en) 2018-06-25

Family

ID=49886776

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP201414192A GEP20186870B (en) 2013-12-30 2014-12-23 Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination

Country Status (36)

Country Link
US (3) US20150182459A1 (enEXAMPLES)
EP (1) EP3096737B1 (enEXAMPLES)
JP (2) JP6534397B2 (enEXAMPLES)
KR (1) KR101865131B1 (enEXAMPLES)
CN (2) CN113143894A (enEXAMPLES)
AR (2) AR098983A1 (enEXAMPLES)
AU (1) AU2014375300B2 (enEXAMPLES)
BR (1) BR112016014586A2 (enEXAMPLES)
CA (1) CA2935302C (enEXAMPLES)
CL (1) CL2016001652A1 (enEXAMPLES)
CY (1) CY1120205T1 (enEXAMPLES)
DK (1) DK3096737T3 (enEXAMPLES)
EA (1) EA033228B1 (enEXAMPLES)
ES (1) ES2666905T4 (enEXAMPLES)
GE (1) GEP20186870B (enEXAMPLES)
HR (1) HRP20180944T1 (enEXAMPLES)
HU (1) HUE039359T2 (enEXAMPLES)
IL (1) IL246502B (enEXAMPLES)
LT (1) LT3096737T (enEXAMPLES)
MA (1) MA39154A1 (enEXAMPLES)
ME (1) ME03076B (enEXAMPLES)
MX (1) MX368834B (enEXAMPLES)
MY (1) MY176191A (enEXAMPLES)
NO (1) NO3096737T3 (enEXAMPLES)
PE (1) PE20161132A1 (enEXAMPLES)
PH (1) PH12016501269B1 (enEXAMPLES)
PL (1) PL3096737T3 (enEXAMPLES)
PT (1) PT3096737T (enEXAMPLES)
RS (1) RS57269B1 (enEXAMPLES)
SA (1) SA516371428B1 (enEXAMPLES)
SG (1) SG11201605309UA (enEXAMPLES)
SI (1) SI3096737T1 (enEXAMPLES)
TN (1) TN2016000262A1 (enEXAMPLES)
TR (1) TR201809356T4 (enEXAMPLES)
UA (1) UA117846C2 (enEXAMPLES)
WO (1) WO2015101575A1 (enEXAMPLES)

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SI2515855T1 (sl) 2009-12-23 2014-08-29 Chiesi Farmaceutici S.P.A. KOMBINIRANA TERAPIJA ZA KOPB (v angl.: COPD)
EP2515853B1 (en) * 2009-12-23 2014-03-19 Chiesi Farmaceutici S.p.A. Combination therapy for COPD
CN102665680B (zh) 2009-12-23 2014-07-30 奇斯药制品公司 用于copd的气雾剂制剂
NO3096737T3 (enEXAMPLES) * 2013-12-30 2018-09-01
SG11201605311UA (en) * 2013-12-30 2016-07-28 Chiesi Farma Spa Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination
GB201520862D0 (en) * 2015-11-25 2016-01-13 Jagotec Ag Pharmaceutical composition
TW201735914A (zh) * 2015-12-22 2017-10-16 阿斯特捷利康公司 用於治療慢性阻塞性肺疾病之醫藥組成物
US10098837B2 (en) * 2016-07-28 2018-10-16 Chiesi Farmaceutici S.P.A. Combination therapy for COPD
WO2018051130A1 (en) 2016-09-19 2018-03-22 Mexichem Fluor S.A. De C.V. Pharmaceutical composition
WO2020070620A2 (en) * 2018-10-01 2020-04-09 3M Innovative Properties Company Formulation and aerosol canisters, inhalers, and the like containing the formulation
EP3996681A1 (en) * 2019-07-12 2022-05-18 Kindeva Drug Delivery L.P. Aerosol formulation, canister and inhaler containing the formulation, and method of use
WO2021033081A1 (en) * 2019-08-16 2021-02-25 Glenmark Pharmaceutical Limited Stable aerosol composition for inhalation comprising glycopyrronium, formoterol and corticosteroid
CN112438966B (zh) * 2019-08-30 2022-08-26 四川普锐特药业有限公司 一种医用定量吸入气雾剂
NZ786610A (en) 2019-12-02 2025-06-27 Chiesi Farm Spa Stainless steel can for pressurised metered dose inhalers
WO2021138386A1 (en) * 2020-01-04 2021-07-08 Cai Gu Huang Propellant-free formulation for inhalation
CN117599290A (zh) * 2020-01-28 2024-02-27 奇斯药制品公司 包含缓冲药物制剂的加压定量吸入器
JP2023513969A (ja) * 2020-02-20 2023-04-04 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 緩衝化医薬製剤を含む加圧定量吸入器
EP4188327B1 (en) 2020-07-31 2025-05-28 Chemo Research, S.L. Combination therapy for inhalation administration

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CN102665680B (zh) 2009-12-23 2014-07-30 奇斯药制品公司 用于copd的气雾剂制剂
SI2515855T1 (sl) * 2009-12-23 2014-08-29 Chiesi Farmaceutici S.P.A. KOMBINIRANA TERAPIJA ZA KOPB (v angl.: COPD)
KR101795348B1 (ko) 2009-12-23 2017-12-01 키에시 파르마슈티시 엣스. 피. 에이. Ｃｏｐｄ용 에어로졸 제제
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SG11201605311UA (en) * 2013-12-30 2016-07-28 Chiesi Farma Spa Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination
NO3096737T3 (enEXAMPLES) * 2013-12-30 2018-09-01

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MX368834B (es) 2019-10-18
JP2017507168A (ja) 2017-03-16
PL3096737T3 (pl) 2018-08-31
SI3096737T1 (en) 2018-07-31
IL246502B (en) 2020-05-31
KR20160104042A (ko) 2016-09-02
US10617669B2 (en) 2020-04-14
KR101865131B1 (ko) 2018-06-08
TN2016000262A1 (en) 2017-10-06
RS57269B1 (sr) 2018-08-31
JP6534397B2 (ja) 2019-06-26
ES2666905T3 (es) 2018-05-08
PT3096737T (pt) 2018-04-27
DK3096737T3 (en) 2018-06-25
LT3096737T (lt) 2018-06-11
NZ721640A (en) 2021-02-26
PH12016501269A1 (en) 2016-08-15
US20170095444A1 (en) 2017-04-06
US20160303044A1 (en) 2016-10-20
BR112016014586A2 (pt) 2017-08-08
JP6826145B2 (ja) 2021-02-03
UA117846C2 (uk) 2018-10-10
AR130238A2 (es) 2024-11-20
CL2016001652A1 (es) 2017-08-25
IL246502A0 (en) 2016-08-31
SA516371428B1 (ar) 2018-09-30
CN113143894A (zh) 2021-07-23
JP2019112458A (ja) 2019-07-11
EP3096737B1 (en) 2018-04-04
PH12016501269B1 (en) 2019-09-18
ME03076B (me) 2019-01-20
MX2016008591A (es) 2016-09-26
CA2935302C (en) 2022-06-21
ES2666905T4 (es) 2018-06-07
SG11201605309UA (en) 2016-07-28
AU2014375300A1 (en) 2016-07-14
US10596149B2 (en) 2020-03-24
CN105848642A (zh) 2016-08-10
MY176191A (en) 2020-07-24
WO2015101575A1 (en) 2015-07-09
EA201691127A1 (ru) 2016-12-30
AR098983A1 (es) 2016-06-22
AU2014375300B2 (en) 2019-10-24
HRP20180944T1 (hr) 2018-08-10
MA39154A1 (fr) 2017-08-31
HUE039359T2 (hu) 2018-12-28
PE20161132A1 (es) 2016-11-02
US20150182459A1 (en) 2015-07-02
EP3096737A1 (en) 2016-11-30
CY1120205T1 (el) 2018-12-12
CA2935302A1 (en) 2015-07-09
EA033228B1 (ru) 2019-09-30
NO3096737T3 (enEXAMPLES) 2018-09-01
TR201809356T4 (tr) 2018-07-23

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