PT3082956T - Um inibidor de ponto de verificação e uma micobactéria de célula inteira para utilização em terapêutica do cancro - Google Patents

Um inibidor de ponto de verificação e uma micobactéria de célula inteira para utilização em terapêutica do cancro

Info

Publication number
PT3082956T
PT3082956T PT148275183T PT14827518T PT3082956T PT 3082956 T PT3082956 T PT 3082956T PT 148275183 T PT148275183 T PT 148275183T PT 14827518 T PT14827518 T PT 14827518T PT 3082956 T PT3082956 T PT 3082956T
Authority
PT
Portugal
Prior art keywords
cancer therapy
whole cell
checkpoint inhibitor
cell mycobacterium
mycobacterium
Prior art date
Application number
PT148275183T
Other languages
English (en)
Original Assignee
Immodulon Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immodulon Therapeutics Ltd filed Critical Immodulon Therapeutics Ltd
Publication of PT3082956T publication Critical patent/PT3082956T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
PT148275183T 2013-12-20 2014-12-16 Um inibidor de ponto de verificação e uma micobactéria de célula inteira para utilização em terapêutica do cancro PT3082956T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1322725.1A GB201322725D0 (en) 2013-12-20 2013-12-20 Cancer therapy

Publications (1)

Publication Number Publication Date
PT3082956T true PT3082956T (pt) 2022-07-29

Family

ID=50071260

Family Applications (1)

Application Number Title Priority Date Filing Date
PT148275183T PT3082956T (pt) 2013-12-20 2014-12-16 Um inibidor de ponto de verificação e uma micobactéria de célula inteira para utilização em terapêutica do cancro

Country Status (18)

Country Link
US (7) US10610577B2 (pt)
EP (1) EP3082956B1 (pt)
JP (2) JP6858558B2 (pt)
KR (1) KR101820393B1 (pt)
CN (2) CN105979964B (pt)
AU (2) AU2014369510B2 (pt)
BR (1) BR112016013887B1 (pt)
CA (1) CA2932659C (pt)
ES (1) ES2913460T3 (pt)
GB (1) GB201322725D0 (pt)
IL (1) IL246083B2 (pt)
MX (1) MX2016007709A (pt)
NZ (1) NZ721009A (pt)
PL (1) PL3082956T3 (pt)
PT (1) PT3082956T (pt)
RU (1) RU2719934C2 (pt)
SG (2) SG10202111098RA (pt)
WO (1) WO2015092382A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4169951A1 (en) 2008-12-09 2023-04-26 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
GB201120779D0 (en) 2011-12-02 2012-01-11 Immodulon Therapeutics Ltd Cancer therapy
GB201322725D0 (en) 2013-12-20 2014-02-05 Immodulon Therapeutics Ltd Cancer therapy
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
EP3868406A1 (en) * 2015-06-24 2021-08-25 Immodulon Therapeutics Limited A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy
SG11201802830QA (en) * 2015-10-05 2018-05-30 Calithera Biosciences Inc Combination therapy with glutaminase inhibitors and immuno-oncology agents
MX2018006243A (es) * 2015-11-18 2018-11-09 Merck Sharp & Dohme Proteinas de union a pd1/ctla4.
RU2018123481A (ru) 2015-12-16 2020-01-20 Мерк Шарп И Доум Корп. Анти-lag3 антитела и антигенсвязывающие фрагменты
SG11201805556QA (en) 2016-01-08 2018-07-30 Momotaro Gene Inc A combination therapy using REIC/Dkk-3 gene and a checkpoint inhibitor
GB201601248D0 (en) * 2016-01-22 2016-03-09 Immodulon Therapeutics Ltd Cancer therapy
EP3195878A1 (en) * 2016-01-22 2017-07-26 Werner Lubitz Bacterial ghosts for the treatment of cancer
SG10201912563XA (en) 2016-05-27 2020-02-27 Agenus Inc Anti-tim-3 antibodies and methods of use thereof
KR20190019121A (ko) * 2016-06-17 2019-02-26 오사카 유니버시티 종양 내 정맥 형성 촉진제
CN110475560B (zh) * 2016-12-15 2023-06-20 普罗基Pg500系列私人有限公司 组合物及其用途
US11077179B2 (en) 2017-08-10 2021-08-03 Epicgenetics, Inc. Method for treating fibromyalgia and chronic fatigue syndrome
WO2019088590A2 (ko) * 2017-11-06 2019-05-09 서울대학교 산학협력단 마이코박테리움 파라고르도네의 항암 면역치료법 용도
AU2019293157A1 (en) * 2018-06-25 2021-01-28 Immodulon Therapeutics Limited Cancer therapy
GB201820554D0 (en) * 2018-12-17 2019-01-30 Univ Oxford Innovation Ltd BTLA antibodies
GB201919428D0 (en) * 2019-12-30 2020-02-12 Immodulon Therapeutics Ltd Immunotherapeutic treatment of cancer
CN113358872B (zh) * 2021-06-03 2022-10-21 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 用于评估肿瘤免疫治疗疗效的标志物组及系统
US20240024449A1 (en) * 2022-07-20 2024-01-25 Immunology Diagnostics, LLC Methods and compositions for improving immune system function

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008488A1 (en) 1990-11-08 1992-05-29 University College London Mycobacterium as adjuvant for antigens
US5207223A (en) 1990-10-19 1993-05-04 Accuray, Inc. Apparatus for and method of performing stereotaxic surgery
US5458125A (en) 1994-01-28 1995-10-17 Board Of Directors Of The Leland Standford Jr. University Treatment planning method and apparatus for radiosurgery and radiation therapy
AU4281200A (en) 1999-04-23 2000-11-10 Qlt Inc. Immuno-adjuvant pdt treatment of metastatic tumors
US20020022032A1 (en) 1999-04-23 2002-02-21 Curry Patrick Mark Immuno-adjuvant PDT treatment of metastatic tumors
WO2003049751A1 (en) 2001-12-10 2003-06-19 Bakulesh Mafatlal Khamar The process of manufacturing a pharmaceutical composition useful for management of cancer
WO2004004771A1 (ja) 2002-07-03 2004-01-15 Ono Pharmaceutical Co., Ltd. 免疫賦活組成物
CN1859851A (zh) * 2002-07-12 2006-11-08 约翰斯霍普金斯大学 间皮素疫苗与模型系统
JP2006521090A (ja) * 2002-07-12 2006-09-21 ザ ジョンズ ホプキンス ユニバーシティー メゾテリンワクチンおよびモデルシステム
WO2007050405A2 (en) 2005-10-21 2007-05-03 Medical College Of Georgia Research Institute, Inc. The induction of indoleamine 2,3-dioxygenase in dendritic cells by tlr ligands and uses thereof
US20080318252A1 (en) 2007-04-23 2008-12-25 Scott Kachlany Rapid assay to test anti-cancer drugs under physiological conditions
GB0526033D0 (en) * 2005-12-21 2006-02-01 Bioeos Ltd Method
US8557257B2 (en) 2006-03-24 2013-10-15 Oncovac Inc. Mycobacterial immunotherapy for cancer treatment
WO2008110491A2 (en) 2007-03-09 2008-09-18 University Of Basel Chemotherapy of neoplastic diseases using combinations of rapamycin and compounds modulating mtor pathway alone or in combination with heat
RU2350338C2 (ru) * 2007-05-14 2009-03-27 ФГУ Ростовский научно-исследовательский онкологический институт Росздрава Способ лечения поверхностного рака мочевого пузыря
BRPI0812913B8 (pt) * 2007-06-18 2021-05-25 Merck Sharp & Dohme anticorpos monoclonais ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotideo, método para produzir os referidos anticorpos ou fragmentos de anticorpos, composição que os compreende e uso dos mesmos
WO2012122471A2 (en) 2011-03-09 2012-09-13 The Johns Hopkins University Compounds and methods of use in ablative radiotherapy
ES2536465T3 (es) 2008-10-01 2015-05-25 Immatics Biotechnologies Gmbh Composición de péptidos tumor-asociados y relacionados con la vacuna contra el cáncer para el tratamiento de glioblastoma (GBM) y otros cánceres
US8367075B2 (en) * 2010-07-02 2013-02-05 Indian Institute Of Science Synergistic combination and method thereof
AU2012273182A1 (en) * 2011-06-21 2014-01-16 The Johns Hopkins University Focused radiation for augmenting immune-based therapies against neoplasms
GB201120779D0 (en) * 2011-12-02 2012-01-11 Immodulon Therapeutics Ltd Cancer therapy
EP2620159A1 (en) * 2012-01-24 2013-07-31 Institut Pasteur Improved cancer treatment by immunotherapy with bcg or antigenically related non-pathogenic mycobacteria
JP2015512616A (ja) * 2012-02-01 2015-04-30 コンピュゲン エルティーディー． Ｃ１ｏｒｆ３２抗体およびがんの治療のためのその使用
US8617520B2 (en) * 2012-02-15 2013-12-31 Immodulon Therapeutics Limited Cancer therapy
AR090263A1 (es) * 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
CN104470949A (zh) * 2012-05-15 2015-03-25 百时美施贵宝公司 通过破坏pd-1/pd-l1信号传输的免疫治疗
WO2014064240A1 (en) * 2012-10-26 2014-05-01 Institut Gustave Roussy Methods for predicting the sensitivity of a subject to immunotherapy
WO2014181221A2 (en) 2013-05-08 2014-11-13 Ashwin Bharadwaj Heat sink
GB201308325D0 (en) 2013-05-09 2013-06-19 Immodulon Therapeutics Ltd Cancer Therapy
GB201322725D0 (en) * 2013-12-20 2014-02-05 Immodulon Therapeutics Ltd Cancer therapy
CA2935375C (en) 2014-01-06 2023-08-08 The Trustees Of The University Of Pennsylvania Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy
ES2931337T3 (es) 2014-07-31 2022-12-28 Univ Western Australia Un método para la identificación de combinaciones de inmunoterapia-fármacos usando un enfoque de red
US10975112B2 (en) 2015-06-16 2021-04-13 Hangzhou Dac Biotech Co., Ltd. Linkers for conjugation of cell-binding molecules
EP3868406A1 (en) 2015-06-24 2021-08-25 Immodulon Therapeutics Limited A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy
JP6786529B2 (ja) 2015-06-29 2020-11-18 バイオメッド バレー ディスカバリーズ，インコーポレイティド Ｌｐｔ−７２３と免疫チェックポイント阻害剤との組み合わせおよび処置の方法
AU2019293157A1 (en) 2018-06-25 2021-01-28 Immodulon Therapeutics Limited Cancer therapy

Also Published As

Publication number Publication date
US20200215175A1 (en) 2020-07-09
US20210213128A1 (en) 2021-07-15
US20210213127A1 (en) 2021-07-15
RU2719934C2 (ru) 2020-04-23
RU2016123370A (ru) 2018-01-25
KR20160093023A (ko) 2016-08-05
US11000584B2 (en) 2021-05-11
BR112016013887B1 (pt) 2023-02-14
IL246083B2 (en) 2023-03-01
PL3082956T3 (pl) 2022-05-23
EP3082956B1 (en) 2022-04-20
AU2020201754A1 (en) 2020-03-26
CA2932659A1 (en) 2015-06-25
US10994002B2 (en) 2021-05-04
US12042532B2 (en) 2024-07-23
US20200215174A1 (en) 2020-07-09
AU2014369510B2 (en) 2019-12-12
JP2019196394A (ja) 2019-11-14
AU2020201754B2 (en) 2021-04-01
AU2014369510A1 (en) 2016-06-30
EP3082956A1 (en) 2016-10-26
BR112016013887A2 (pt) 2017-08-08
GB201322725D0 (en) 2014-02-05
US10610578B2 (en) 2020-04-07
KR101820393B1 (ko) 2018-01-19
NZ721009A (en) 2022-08-26
IL246083A0 (en) 2016-07-31
JP2017500341A (ja) 2017-01-05
US20200215176A1 (en) 2020-07-09
CN111671908A (zh) 2020-09-18
US10925952B2 (en) 2021-02-23
JP6858558B2 (ja) 2021-04-14
WO2015092382A1 (en) 2015-06-25
SG11201604602TA (en) 2016-07-28
CA2932659C (en) 2022-10-18
CN105979964A (zh) 2016-09-28
ES2913460T3 (es) 2022-06-02
US20190008942A1 (en) 2019-01-10
SG10202111098RA (en) 2021-11-29
MX2016007709A (es) 2017-02-23
US20170028047A1 (en) 2017-02-02
US10610577B2 (en) 2020-04-07
CN105979964B (zh) 2020-07-14
IL246083B (en) 2022-11-01

Similar Documents

Publication Publication Date Title
IL246083A0 (en) A barrier inhibitor and a whole mycobacterium cell, for use in cancer treatment
IL256467B (en) A control block and a whole-cell microbacterium for the treatment of cancer
HK1257187B (zh) 包含非天然胰腺β細胞的裝置以及在治療疾病如糖尿病中的用途
IL272921A (en) Combined treatment including a B-Raf inhibitor and a second inhibitor
IL259479B (en) Cancer treatment using 2-deoxy-2-fluoro-l-fucose in combination with a checkpoint inhibitor
EP2953191A4 (en) ANION-CONDUCTIVE MATERIAL AND BATTERY
SG11201505858VA (en) A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
HK1209799A1 (en) A non-invasion cancer detection method and a kit for performing the same
PL3065759T3 (pl) Środki immunosupresyjne i ich zastosowanie w leczeniu
EP2830719A4 (en) MOVING METHOD IN A PHYSICALLY CONFIGURABLE SPACE AND DEVICE FOR USE WITH THE METHOD
EP2968345A4 (en) DOUBLE MEK / PI3K INHIBITORS AND THERAPEUTIC PROCESSES USING SAME
SG11201504638RA (en) Cancer cell isolation device and cancer cell isolation method
GB201305076D0 (en) A portable storage and activity device
EP2872973A4 (en) IMPROVEMENTS IN DEVICES FOR USE WITH COMPUTERS
IL238453A0 (en) Trans-clomiphene for use in cancer treatment
HK1208735A1 (en) Electrochromic cells and their use
GB201305940D0 (en) Methods and arrays for use in the same
EP3017440A4 (en) SYSTEMS AND METHOD FOR POWER MANAGEMENT IN A BEACOM
EP2978521A4 (en) INCLINED BASE PLATE FOR DEHYDROGENATION REACTOR
GB201308753D0 (en) Compounds and their use in therapy
GB201308217D0 (en) Compounds and their use in therapy
SG10201704704SA (en) Cancer cell isolation device and cancer cell isolation method