PL3082956T3 - Inhibitor punktu kontrolnego i mycobacterium całokomórkowe do stosowania w terapii raka - Google Patents

Inhibitor punktu kontrolnego i mycobacterium całokomórkowe do stosowania w terapii raka

Info

Publication number
PL3082956T3
PL3082956T3 PL14827518T PL14827518T PL3082956T3 PL 3082956 T3 PL3082956 T3 PL 3082956T3 PL 14827518 T PL14827518 T PL 14827518T PL 14827518 T PL14827518 T PL 14827518T PL 3082956 T3 PL3082956 T3 PL 3082956T3
Authority
PL
Poland
Prior art keywords
cancer therapy
whole cell
checkpoint inhibitor
cell mycobacterium
mycobacterium
Prior art date
Application number
PL14827518T
Other languages
English (en)
Inventor
Charles AKLE
John Grange
Kevin Bilyard
Original Assignee
Immodulon Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immodulon Therapeutics Limited filed Critical Immodulon Therapeutics Limited
Publication of PL3082956T3 publication Critical patent/PL3082956T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/58Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
PL14827518T 2013-12-20 2014-12-16 Inhibitor punktu kontrolnego i mycobacterium całokomórkowe do stosowania w terapii raka PL3082956T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1322725.1A GB201322725D0 (en) 2013-12-20 2013-12-20 Cancer therapy
EP14827518.3A EP3082956B1 (en) 2013-12-20 2014-12-16 A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy
PCT/GB2014/053717 WO2015092382A1 (en) 2013-12-20 2014-12-16 A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy

Publications (1)

Publication Number Publication Date
PL3082956T3 true PL3082956T3 (pl) 2022-05-23

Family

ID=50071260

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14827518T PL3082956T3 (pl) 2013-12-20 2014-12-16 Inhibitor punktu kontrolnego i mycobacterium całokomórkowe do stosowania w terapii raka

Country Status (18)

Country Link
US (7) US10610577B2 (pl)
EP (1) EP3082956B1 (pl)
JP (2) JP6858558B2 (pl)
KR (1) KR101820393B1 (pl)
CN (2) CN111671908A (pl)
AU (2) AU2014369510B2 (pl)
BR (1) BR112016013887B1 (pl)
CA (1) CA2932659C (pl)
ES (1) ES2913460T3 (pl)
GB (1) GB201322725D0 (pl)
IL (1) IL246083B2 (pl)
MX (1) MX2016007709A (pl)
NZ (1) NZ721009A (pl)
PL (1) PL3082956T3 (pl)
PT (1) PT3082956T (pl)
RU (1) RU2719934C2 (pl)
SG (2) SG11201604602TA (pl)
WO (1) WO2015092382A1 (pl)

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GB201120779D0 (en) 2011-12-02 2012-01-11 Immodulon Therapeutics Ltd Cancer therapy
GB201322725D0 (en) 2013-12-20 2014-02-05 Immodulon Therapeutics Ltd Cancer therapy
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
EP3868406A1 (en) * 2015-06-24 2021-08-25 Immodulon Therapeutics Limited A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy
JP6971239B2 (ja) * 2015-10-05 2021-11-24 キャリセラ バイオサイエンシーズ, インコーポレイテッド グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法
EP3377526A1 (en) * 2015-11-18 2018-09-26 Merck Sharp & Dohme Corp. PD1/CTLA4 Binders
MA43576A (fr) 2015-12-16 2018-11-14 Merck Sharp & Dohme Anticorps anti-lag3 et fragments de fixation à l'antigène
KR20180102106A (ko) * 2016-01-08 2018-09-14 모모타로겐 가부시키가이샤 REIC/Dkk-3 유전자 및 체크포인트 저해제를 이용한 병용 요법
EP3195878A1 (en) * 2016-01-22 2017-07-26 Werner Lubitz Bacterial ghosts for the treatment of cancer
GB201601248D0 (en) * 2016-01-22 2016-03-09 Immodulon Therapeutics Ltd Cancer therapy
US10639368B2 (en) 2016-05-27 2020-05-05 Agenus Inc. Anti-TIM-3 antibodies and methods of use thereof
CA3027523A1 (en) * 2016-06-17 2017-12-21 Osaka University Intratumoral vein-formation promoting agent
CN110475560B (zh) * 2016-12-15 2023-06-20 普罗基Pg500系列私人有限公司 组合物及其用途
US11077179B2 (en) 2017-08-10 2021-08-03 Epicgenetics, Inc. Method for treating fibromyalgia and chronic fatigue syndrome
WO2019088590A2 (ko) * 2017-11-06 2019-05-09 서울대학교 산학협력단 마이코박테리움 파라고르도네의 항암 면역치료법 용도
AU2019293157A1 (en) * 2018-06-25 2021-01-28 Immodulon Therapeutics Limited Cancer therapy
GB201820554D0 (en) * 2018-12-17 2019-01-30 Univ Oxford Innovation Ltd BTLA antibodies
GB201919428D0 (en) * 2019-12-30 2020-02-12 Immodulon Therapeutics Ltd Immunotherapeutic treatment of cancer
CN113358872B (zh) * 2021-06-03 2022-10-21 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) 用于评估肿瘤免疫治疗疗效的标志物组及系统
WO2024020436A1 (en) * 2022-07-20 2024-01-25 Immunology Diagnostics, LLC Methods and compositions for improving immune system function

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GB201322725D0 (en) 2013-12-20 2014-02-05 Immodulon Therapeutics Ltd Cancer therapy
KR102395498B1 (ko) 2014-01-06 2022-05-09 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용
EP3868406A1 (en) 2015-06-24 2021-08-25 Immodulon Therapeutics Limited A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy

Also Published As

Publication number Publication date
WO2015092382A1 (en) 2015-06-25
JP2019196394A (ja) 2019-11-14
BR112016013887A2 (pt) 2017-08-08
SG10202111098RA (en) 2021-11-29
US20210213127A1 (en) 2021-07-15
US10994002B2 (en) 2021-05-04
JP6858558B2 (ja) 2021-04-14
US10610578B2 (en) 2020-04-07
PT3082956T (pt) 2022-07-29
EP3082956B1 (en) 2022-04-20
US11000584B2 (en) 2021-05-11
JP2017500341A (ja) 2017-01-05
AU2014369510B2 (en) 2019-12-12
US20190008942A1 (en) 2019-01-10
US20210213128A1 (en) 2021-07-15
US10925952B2 (en) 2021-02-23
NZ721009A (en) 2022-08-26
AU2020201754B2 (en) 2021-04-01
KR20160093023A (ko) 2016-08-05
US10610577B2 (en) 2020-04-07
US20200215174A1 (en) 2020-07-09
US20200215175A1 (en) 2020-07-09
CN105979964A (zh) 2016-09-28
BR112016013887B1 (pt) 2023-02-14
MX2016007709A (es) 2017-02-23
CA2932659C (en) 2022-10-18
AU2020201754A1 (en) 2020-03-26
US20170028047A1 (en) 2017-02-02
SG11201604602TA (en) 2016-07-28
IL246083B2 (en) 2023-03-01
EP3082956A1 (en) 2016-10-26
CN105979964B (zh) 2020-07-14
CN111671908A (zh) 2020-09-18
US20200215176A1 (en) 2020-07-09
KR101820393B1 (ko) 2018-01-19
RU2719934C2 (ru) 2020-04-23
IL246083A0 (en) 2016-07-31
RU2016123370A (ru) 2018-01-25
CA2932659A1 (en) 2015-06-25
AU2014369510A1 (en) 2016-06-30
IL246083B (en) 2022-11-01
GB201322725D0 (en) 2014-02-05
ES2913460T3 (es) 2022-06-02

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