PT2513115E - Antibióticos tricíclicos - Google Patents

Antibióticos tricíclicos

Info

Publication number
PT2513115E
PT2513115E PT107932550T PT10793255T PT2513115E PT 2513115 E PT2513115 E PT 2513115E PT 107932550 T PT107932550 T PT 107932550T PT 10793255 T PT10793255 T PT 10793255T PT 2513115 E PT2513115 E PT 2513115E
Authority
PT
Portugal
Prior art keywords
mdash
substituted
independently
nitrogen
another
Prior art date
Application number
PT107932550T
Other languages
English (en)
Inventor
Lin Xu
Berangere Gaucher
Franck Hubert Danel
Xiaohu Tang
Tong Xie
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of PT2513115E publication Critical patent/PT2513115E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems
    • C07D491/147Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PT107932550T 2009-12-18 2010-12-17 Antibióticos tricíclicos PT2513115E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09179956 2009-12-18

Publications (1)

Publication Number Publication Date
PT2513115E true PT2513115E (pt) 2013-12-19

Family

ID=41716611

Family Applications (1)

Application Number Title Priority Date Filing Date
PT107932550T PT2513115E (pt) 2009-12-18 2010-12-17 Antibióticos tricíclicos

Country Status (20)

Country Link
US (2) US8927541B2 (pt)
EP (1) EP2513115B1 (pt)
JP (1) JP5697685B2 (pt)
KR (1) KR101891834B1 (pt)
CN (1) CN102666548B (pt)
AU (1) AU2010332767B2 (pt)
BR (1) BR112012014519A8 (pt)
CA (1) CA2780006A1 (pt)
CY (1) CY1114802T1 (pt)
DK (1) DK2513115T3 (pt)
ES (1) ES2441348T3 (pt)
HK (1) HK1174026A1 (pt)
HR (1) HRP20140005T1 (pt)
MX (1) MX2012006094A (pt)
PL (1) PL2513115T3 (pt)
PT (1) PT2513115E (pt)
SI (1) SI2513115T1 (pt)
TW (1) TWI487709B (pt)
WO (1) WO2011073378A1 (pt)
ZA (1) ZA201203540B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103635474B (zh) * 2011-06-17 2016-04-27 巴斯利尔药物股份公司 三环抗生素
TWI598099B (zh) * 2012-04-30 2017-09-11 健生科學愛爾蘭無限公司 新化合物及其新用途
GB201406486D0 (en) 2014-04-10 2014-05-28 Redx Pharma Ltd Antibacterial compounds
US10344023B2 (en) * 2014-12-23 2019-07-09 Proteostasis Therapeutics, Inc. Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis
EP3567044A4 (en) * 2017-01-06 2020-06-10 Korea University Research and Business Foundation, Sejong Campus INNOVATIVE CHINOLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF ALLERGIC DISEASES LIKE ASTHMA OR ATOPIA THEREFORE AS AN ACTIVE SUBSTANCE

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430148A (en) 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
AU2002224791A1 (en) 2000-10-26 2002-05-06 Smithkline Beecham P.L.C. Benzoxazinone derivatives, their preparation and use
AR040335A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
TW200427688A (en) 2002-12-18 2004-12-16 Glaxo Group Ltd Antibacterial agents
US7037909B2 (en) 2003-07-02 2006-05-02 Sugen, Inc. Tetracyclic compounds as c-Met inhibitors
BRPI0415874A (pt) 2003-11-10 2007-01-09 Schering Ag compostos de amina de éter benzìlico como antagonistas de ccr-5
GB0403038D0 (en) 2004-02-11 2004-03-17 Novartis Ag Organic compounds
JP2008505920A (ja) * 2004-07-08 2008-02-28 グラクソ グループ リミテッド 抗菌剤
DE102004041163A1 (de) 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
WO2006038734A1 (en) 2004-10-08 2006-04-13 Astellas Pharma Inc. Pyridazinone derivatives cytokines inhibitors
TW200615273A (en) * 2004-11-10 2006-05-16 Nicholas Piramal India Ltd Fused tricyclic compounds as inhibitors of tumor necrosis factor-alpha
MX2007012234A (es) 2005-03-31 2008-03-18 Johnson & Johnson Compuestos de pirazol biciclico como agentes antibacterianos.
WO2007052843A1 (ja) 2005-11-04 2007-05-10 Takeda Pharmaceutical Company Limited 複素環アミド化合物およびその用途
WO2007093507A1 (en) 2006-02-13 2007-08-23 F. Hoffmann-La Roche Ag Heterobicyclic sulfonamide derivatives for the treatment of diabetes
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
GB0707708D0 (en) 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds
WO2009012647A1 (fr) 2007-07-20 2009-01-29 Shanghai Hengrui Pharmaceutical Co., Ltd. Procédés de préparation de dérivés de quinazoline et leurs utilisations pharmaceutiques
WO2009125809A1 (ja) 2008-04-11 2009-10-15 第一三共株式会社 ピペリジン誘導体
WO2009125808A1 (ja) * 2008-04-11 2009-10-15 第一三共株式会社 アミノシクロヘキシル誘導体
US8012961B2 (en) 2008-04-15 2011-09-06 Actelion Pharmaceutical Ltd. Tricyclic antibiotics
DE102008028996B4 (de) 2008-06-20 2011-06-09 Technische Universität Braunschweig Verfahren zur Nachbehandlung einer Schweißverbindung
BRPI0916571A2 (pt) 2008-08-04 2015-11-10 Actelion Pharmaceuticals Ltd composto derivado de alquilaminometiloxazolidinona tricíclo, medicamento e composição farmacêutica que o contém e uso do composto

Also Published As

Publication number Publication date
TWI487709B (zh) 2015-06-11
US9120822B2 (en) 2015-09-01
AU2010332767B2 (en) 2014-04-24
KR101891834B1 (ko) 2018-09-28
HRP20140005T1 (hr) 2014-01-31
CY1114802T1 (el) 2016-12-14
SI2513115T1 (sl) 2014-02-28
HK1174026A1 (en) 2013-05-31
KR20120101711A (ko) 2012-09-14
EP2513115A1 (en) 2012-10-24
BR112012014519A8 (pt) 2017-12-26
TW201132645A (en) 2011-10-01
PL2513115T3 (pl) 2014-04-30
DK2513115T3 (da) 2014-01-13
ZA201203540B (en) 2013-01-30
JP5697685B2 (ja) 2015-04-08
US20150072975A1 (en) 2015-03-12
JP2013514331A (ja) 2013-04-25
US8927541B2 (en) 2015-01-06
EP2513115B1 (en) 2013-10-09
ES2441348T3 (es) 2014-02-04
CA2780006A1 (en) 2011-06-23
WO2011073378A1 (en) 2011-06-23
AU2010332767A1 (en) 2012-05-24
CN102666548B (zh) 2015-07-15
US20120245345A1 (en) 2012-09-27
CN102666548A (zh) 2012-09-12
BR112012014519A2 (pt) 2016-08-16
MX2012006094A (es) 2012-06-19

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