BR112012014519A2 - antibióticos tricíclicos - Google Patents
antibióticos tricíclicosInfo
- Publication number
- BR112012014519A2 BR112012014519A2 BR112012014519A BR112012014519A BR112012014519A2 BR 112012014519 A2 BR112012014519 A2 BR 112012014519A2 BR 112012014519 A BR112012014519 A BR 112012014519A BR 112012014519 A BR112012014519 A BR 112012014519A BR 112012014519 A2 BR112012014519 A2 BR 112012014519A2
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- substituted
- unsubstituted
- nitrogen
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
antibiótico tricíclico. composto de fórmula (i): em que a1 representa -o-, -s- ou -n-r3; a2 represneta -ch~ 2~, -o-, -n-r4, -c(=o)-ou -ch(o-r4)-; a3 representa c~ 3~-c~ 8~cicloalquileno; heterociclodiíla saturada e insaturada de 4 a 8 elementos com 1, 2 ou 3 heteroátomos selecionados de nitrogênio, oxigênio e enxofre, grupo a3 o qual é não substituído ou substituído; a4 representa c~ 1~c~ 4~alquileno, c~ 2~c~ 4~alquileno, >c=o ou um grupo selecionado de -c~ 2~h~ 4~nh-, -c~2 ~h~ 4~s- sendo ligado ao grupo nr5- adjacente via átomo de carbono; e g representa arila ou heteroarila, as quais são não substituídas ou substituídas e r^ 1^ e r^2 ^representam, independentemente um do outro, hidrogênio ou um substituinte selecionadfo de hidróxi, halogênio, mercapto, cioano, nitro, c~ 1~-c~ 6~alquila, c~ 1~c~ 6~alcóxi, c~ 1~-c~ 6~alquiltio, c~ 1~-c~ 6~alquilcarbonilóxi, c~ 1~- c~ 6~alquil-sulfonilóxi, c~1 ~c~6 ~heteroalquilcarbonilóxi, c~ 5~-c~ 6~heterociclilcarbonilóxi, c~1 ~-c~ 6~heteroalcóxi, em que os grupos heteroalquila, heteroalcóxi ou heterociclila compreendem 1, 2 ou 3 heteroátomos selecionados de nitrogênio, oxigênio e enxofre, substituintes nos quais as porções alquila são não substituídas ou ainda substituídas; r3, r4 e r5 representam, independentemente um do outro, hidrogênio ou c~1 ~-c~ 6~alquila; x1 e x2 representam, independentemente um do outro, um átomo de nitrogênio ou cr2, contato que pelo menos um de x1 e x2 representa um átomo de nitrogênio; m é 1; e a porção (ch2)m é opcionalmente substituída por c~1 ~-c~ 4~alquila; hidrogênio, carbóxi, hidróxi, c~ 1~-c~4 ~alcóxi, c~1 ~-c~ 4~-alquilcarbonilóxi, amino, mono- ou di-_c~ 1~-c~4 ~alquil)amino ou acilamino n é 0, 1 ou 2 os sais farmaceuticamente aceitáveis dos mesmos são valiosos para uso como um medicamento para o tratamento de infecções bacterianas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179956 | 2009-12-18 | ||
| PCT/EP2010/070043 WO2011073378A1 (en) | 2009-12-18 | 2010-12-17 | Tricyclic antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012014519A2 true BR112012014519A2 (pt) | 2016-08-16 |
| BR112012014519A8 BR112012014519A8 (pt) | 2017-12-26 |
Family
ID=41716611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012014519A BR112012014519A8 (pt) | 2009-12-18 | 2010-12-17 | antibióticos tricíclicos |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8927541B2 (pt) |
| EP (1) | EP2513115B1 (pt) |
| JP (1) | JP5697685B2 (pt) |
| KR (1) | KR101891834B1 (pt) |
| CN (1) | CN102666548B (pt) |
| AU (1) | AU2010332767B2 (pt) |
| BR (1) | BR112012014519A8 (pt) |
| CA (1) | CA2780006A1 (pt) |
| CY (1) | CY1114802T1 (pt) |
| DK (1) | DK2513115T3 (pt) |
| ES (1) | ES2441348T3 (pt) |
| HK (1) | HK1174026A1 (pt) |
| HR (1) | HRP20140005T1 (pt) |
| MX (1) | MX2012006094A (pt) |
| PL (1) | PL2513115T3 (pt) |
| PT (1) | PT2513115E (pt) |
| SI (1) | SI2513115T1 (pt) |
| TW (1) | TWI487709B (pt) |
| WO (1) | WO2011073378A1 (pt) |
| ZA (1) | ZA201203540B (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9321788B2 (en) * | 2011-06-17 | 2016-04-26 | Basilea Pharmaceutica Ag | Tricyclic antibiotics |
| TWI598099B (zh) * | 2012-04-30 | 2017-09-11 | 健生科學愛爾蘭無限公司 | 新化合物及其新用途 |
| GB201406486D0 (en) | 2014-04-10 | 2014-05-28 | Redx Pharma Ltd | Antibacterial compounds |
| WO2016105468A1 (en) * | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
| EP3567044A4 (en) | 2017-01-06 | 2020-06-10 | Korea University Research and Business Foundation, Sejong Campus | INNOVATIVE CHINOLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF ALLERGIC DISEASES LIKE ASTHMA OR ATOPIA THEREFORE AS AN ACTIVE SUBSTANCE |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430148A (en) | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
| DE60127434T2 (de) | 2000-10-26 | 2007-11-29 | Smithkline Beecham P.L.C., Brentford | Benzoxazinonderivative, deren herstellung und verwendung |
| TW200406413A (en) | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
| AR042486A1 (es) | 2002-12-18 | 2005-06-22 | Glaxo Group Ltd | Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion . |
| US7037909B2 (en) | 2003-07-02 | 2006-05-02 | Sugen, Inc. | Tetracyclic compounds as c-Met inhibitors |
| US20050101644A1 (en) | 2003-11-10 | 2005-05-12 | Schering Aktiengesellschaft | Benzylether amine compounds useful as CCR-5 antagonists |
| GB0403038D0 (en) | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
| JP2008505920A (ja) * | 2004-07-08 | 2008-02-28 | グラクソ グループ リミテッド | 抗菌剤 |
| DE102004041163A1 (de) | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| WO2006038734A1 (en) | 2004-10-08 | 2006-04-13 | Astellas Pharma Inc. | Pyridazinone derivatives cytokines inhibitors |
| TW200615273A (en) * | 2004-11-10 | 2006-05-16 | Nicholas Piramal India Ltd | Fused tricyclic compounds as inhibitors of tumor necrosis factor-alpha |
| CA2603322C (en) | 2005-03-31 | 2014-12-16 | Janssen Pharmaceutica N.V. | Bicyclic pyrazole compounds as antibacterial agents |
| WO2007052843A1 (ja) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
| AU2007214594B2 (en) | 2006-02-13 | 2010-11-11 | F. Hoffmann-La Roche Ag | Heterobicyclic sulfonamide derivatives for the treatment of diabetes |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| GB0707708D0 (en) | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
| WO2009012647A1 (fr) | 2007-07-20 | 2009-01-29 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Procédés de préparation de dérivés de quinazoline et leurs utilisations pharmaceutiques |
| WO2009125808A1 (ja) * | 2008-04-11 | 2009-10-15 | 第一三共株式会社 | アミノシクロヘキシル誘導体 |
| WO2009125809A1 (ja) * | 2008-04-11 | 2009-10-15 | 第一三共株式会社 | ピペリジン誘導体 |
| EP2276766A1 (en) * | 2008-04-15 | 2011-01-26 | Actelion Pharmaceuticals Ltd. | Tricyclic antibiotics |
| DE102008028996B4 (de) | 2008-06-20 | 2011-06-09 | Technische Universität Braunschweig | Verfahren zur Nachbehandlung einer Schweißverbindung |
| JP2011529960A (ja) | 2008-08-04 | 2011-12-15 | アクテリオン ファーマシューティカルズ リミテッド | 三環式アルキルアミノメチルオキサゾリジノン誘導体 |
-
2010
- 2010-12-17 KR KR1020127018328A patent/KR101891834B1/ko active IP Right Grant
- 2010-12-17 AU AU2010332767A patent/AU2010332767B2/en not_active Ceased
- 2010-12-17 ES ES10793255.0T patent/ES2441348T3/es active Active
- 2010-12-17 DK DK10793255.0T patent/DK2513115T3/da active
- 2010-12-17 SI SI201030487T patent/SI2513115T1/sl unknown
- 2010-12-17 US US13/511,292 patent/US8927541B2/en active Active - Reinstated
- 2010-12-17 PL PL10793255T patent/PL2513115T3/pl unknown
- 2010-12-17 BR BR112012014519A patent/BR112012014519A8/pt not_active Application Discontinuation
- 2010-12-17 TW TW099144554A patent/TWI487709B/zh not_active IP Right Cessation
- 2010-12-17 PT PT107932550T patent/PT2513115E/pt unknown
- 2010-12-17 CN CN201080057649.7A patent/CN102666548B/zh active Active
- 2010-12-17 WO PCT/EP2010/070043 patent/WO2011073378A1/en active Application Filing
- 2010-12-17 JP JP2012543782A patent/JP5697685B2/ja not_active Expired - Fee Related
- 2010-12-17 MX MX2012006094A patent/MX2012006094A/es active IP Right Grant
- 2010-12-17 EP EP10793255.0A patent/EP2513115B1/en active Active
- 2010-12-17 CA CA2780006A patent/CA2780006A1/en not_active Abandoned
-
2012
- 2012-05-15 ZA ZA2012/03540A patent/ZA201203540B/en unknown
-
2013
- 2013-01-22 HK HK13100956.7A patent/HK1174026A1/xx not_active IP Right Cessation
- 2013-12-27 CY CY20131101172T patent/CY1114802T1/el unknown
-
2014
- 2014-01-03 HR HRP20140005AT patent/HRP20140005T1/hr unknown
- 2014-11-18 US US14/546,589 patent/US9120822B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010332767A1 (en) | 2012-05-24 |
| US8927541B2 (en) | 2015-01-06 |
| BR112012014519A8 (pt) | 2017-12-26 |
| ES2441348T3 (es) | 2014-02-04 |
| US20120245345A1 (en) | 2012-09-27 |
| JP2013514331A (ja) | 2013-04-25 |
| SI2513115T1 (sl) | 2014-02-28 |
| AU2010332767B2 (en) | 2014-04-24 |
| CN102666548A (zh) | 2012-09-12 |
| PL2513115T3 (pl) | 2014-04-30 |
| WO2011073378A1 (en) | 2011-06-23 |
| ZA201203540B (en) | 2013-01-30 |
| TW201132645A (en) | 2011-10-01 |
| HRP20140005T1 (hr) | 2014-01-31 |
| KR101891834B1 (ko) | 2018-09-28 |
| US20150072975A1 (en) | 2015-03-12 |
| EP2513115A1 (en) | 2012-10-24 |
| EP2513115B1 (en) | 2013-10-09 |
| MX2012006094A (es) | 2012-06-19 |
| PT2513115E (pt) | 2013-12-19 |
| CA2780006A1 (en) | 2011-06-23 |
| HK1174026A1 (en) | 2013-05-31 |
| CN102666548B (zh) | 2015-07-15 |
| US9120822B2 (en) | 2015-09-01 |
| TWI487709B (zh) | 2015-06-11 |
| KR20120101711A (ko) | 2012-09-14 |
| JP5697685B2 (ja) | 2015-04-08 |
| DK2513115T3 (da) | 2014-01-13 |
| CY1114802T1 (el) | 2016-12-14 |
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| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
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| B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
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| B06A | Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11N | Dismissal: publication cancelled |
Free format text: ANULADA A PUBLICACAO CODIGO 11.5 NA RPI NO 2534 DE 30/07/2019 POR TER SIDO INDEVIDA. |
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| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |