PT2483242E - Novos inibidores de histona desacetilases baseados simultaneamente em 1h-pirrolos trissubstituídos e espaçadores aromáticos e heteroaromáticos - Google Patents
Novos inibidores de histona desacetilases baseados simultaneamente em 1h-pirrolos trissubstituídos e espaçadores aromáticos e heteroaromáticos Download PDFInfo
- Publication number
- PT2483242E PT2483242E PT107636763T PT10763676T PT2483242E PT 2483242 E PT2483242 E PT 2483242E PT 107636763 T PT107636763 T PT 107636763T PT 10763676 T PT10763676 T PT 10763676T PT 2483242 E PT2483242 E PT 2483242E
- Authority
- PT
- Portugal
- Prior art keywords
- trisubstituted
- pyrroles
- aromatic
- histone deacetylase
- deacetylase inhibitors
- Prior art date
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 title 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 title 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382193A EP2305643A1 (en) | 2009-10-02 | 2009-10-02 | New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2483242E true PT2483242E (pt) | 2014-03-17 |
Family
ID=41716282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT107636763T PT2483242E (pt) | 2009-10-02 | 2010-10-01 | Novos inibidores de histona desacetilases baseados simultaneamente em 1h-pirrolos trissubstituídos e espaçadores aromáticos e heteroaromáticos |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8685992B2 (forum.php) |
| EP (2) | EP2305643A1 (forum.php) |
| JP (1) | JP5746185B2 (forum.php) |
| KR (1) | KR101754940B1 (forum.php) |
| CN (1) | CN102648177B (forum.php) |
| AU (1) | AU2010302572B2 (forum.php) |
| BR (1) | BR112012007411B8 (forum.php) |
| CA (1) | CA2776351C (forum.php) |
| ES (1) | ES2452868T3 (forum.php) |
| IL (1) | IL218995A (forum.php) |
| IN (1) | IN2012DN03129A (forum.php) |
| MX (1) | MX2012003988A (forum.php) |
| PL (1) | PL2483242T3 (forum.php) |
| PT (1) | PT2483242E (forum.php) |
| RU (1) | RU2549885C2 (forum.php) |
| WO (1) | WO2011039353A1 (forum.php) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140027907A (ko) * | 2010-10-11 | 2014-03-07 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 치환된 벤즈아미드 및 그의 용도 |
| DK2991982T3 (en) | 2013-04-29 | 2018-12-10 | Chong Kun Dang Pharmaceutical Corp | PRESENT UNKNOWN RELATIONS TO SELECTIVE HISTONDEACETYLASE INHIBITORS AND PHARMACEUTICAL COMPOSITION, INCLUDING THESE |
| US10183934B2 (en) | 2015-02-02 | 2019-01-22 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
| SG10202100915RA (en) | 2015-02-02 | 2021-02-25 | Valo Early Discovery Inc | 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors |
| WO2017029684A1 (en) * | 2015-08-17 | 2017-02-23 | University Of Mysore | 2,3,5 trisubstituted pyrrole derivatives as topoisomerase inhibitors and therapeutic uses thereof |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| CN107793375A (zh) * | 2016-08-31 | 2018-03-13 | 中国科学院上海药物研究所 | 一类芳基2,2’‑串联双噻唑类化合物及其制备方法和用途 |
| EP3318256A1 (en) * | 2016-11-08 | 2018-05-09 | Quimatryx, S.L | Compounds for the treatment of autoimmune diseases |
| GB201708457D0 (en) | 2017-05-26 | 2017-07-12 | Univ Oxford Innovation Ltd | Inhibitors of metallo-beta-lactamases |
| CN110938055A (zh) * | 2018-09-21 | 2020-03-31 | 华东师范大学 | 六元环甲酰胺类化合物及其合成方法和应用 |
| CN114269739B (zh) | 2019-04-17 | 2025-04-22 | 奎马特里克斯公司 | 作为组蛋白脱乙酰酶抑制剂的1,3,4-𫫇二唑衍生物 |
| CN112225737B (zh) * | 2020-12-11 | 2021-04-09 | 北京鑫开元医药科技有限公司 | 具有hdac抑制活性的化合物、制备方法、组合物及用途 |
| CN112516142B (zh) * | 2020-12-11 | 2021-10-15 | 北京华氏精恒医药科技有限公司 | 一种具有hdac抑制活性的药物组合物、制备方法及其用途 |
| CN116813560A (zh) * | 2022-03-28 | 2023-09-29 | 上海科技大学 | 三唑酰胺类化合物及其制备方法和用途 |
| CN114558004B (zh) * | 2022-03-29 | 2023-08-11 | 奎马特里克斯有限公司 | Qtx125药物制剂 |
| CN114634489B (zh) * | 2022-04-19 | 2023-07-04 | 奎马特里克斯有限公司 | 结晶形式 |
| CN114652715B (zh) * | 2022-04-29 | 2023-04-25 | 奎马特里克斯有限公司 | 联合疗法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA76977C2 (en) * | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| BRPI0414581C1 (pt) | 2003-09-22 | 2021-05-25 | Mei Pharma Inc | composto, composição farmacêutica compreendendo o referido composto e uso do referido composto |
| MXPA06005915A (es) * | 2003-12-05 | 2006-06-27 | Warner Lambert Co | N-alquil pirroles como inhibidores de la hmg-coa reductasa. |
| WO2006108864A2 (en) * | 2005-04-15 | 2006-10-19 | Dominion Pharmakine S.L. | New nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof |
| US7754717B2 (en) * | 2005-08-15 | 2010-07-13 | Amgen Inc. | Bis-aryl amide compounds and methods of use |
| EP1975158B9 (en) * | 2005-12-27 | 2012-02-29 | Universidad Del Pais Vasco-Euskal Herriko Unibersitatea | Novel pyrrole derivatives with histone deacetylase inhibitor activity |
| JP2011502133A (ja) * | 2007-11-02 | 2011-01-20 | メシルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
-
2009
- 2009-10-02 EP EP09382193A patent/EP2305643A1/en not_active Withdrawn
-
2010
- 2010-10-01 CN CN201080052814.XA patent/CN102648177B/zh active Active
- 2010-10-01 EP EP10763676.3A patent/EP2483242B1/en active Active
- 2010-10-01 KR KR1020127011407A patent/KR101754940B1/ko active Active
- 2010-10-01 US US13/499,839 patent/US8685992B2/en active Active
- 2010-10-01 JP JP2012531445A patent/JP5746185B2/ja active Active
- 2010-10-01 PT PT107636763T patent/PT2483242E/pt unknown
- 2010-10-01 AU AU2010302572A patent/AU2010302572B2/en active Active
- 2010-10-01 BR BR112012007411A patent/BR112012007411B8/pt active IP Right Grant
- 2010-10-01 CA CA2776351A patent/CA2776351C/en active Active
- 2010-10-01 MX MX2012003988A patent/MX2012003988A/es active IP Right Grant
- 2010-10-01 WO PCT/EP2010/064653 patent/WO2011039353A1/en active Application Filing
- 2010-10-01 ES ES10763676.3T patent/ES2452868T3/es active Active
- 2010-10-01 PL PL10763676T patent/PL2483242T3/pl unknown
- 2010-10-01 IN IN3129DEN2012 patent/IN2012DN03129A/en unknown
- 2010-10-01 RU RU2012117885/04A patent/RU2549885C2/ru not_active IP Right Cessation
-
2012
- 2012-04-02 IL IL218995A patent/IL218995A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012007411A2 (pt) | 2016-12-06 |
| CN102648177B (zh) | 2015-01-07 |
| IL218995A0 (en) | 2012-06-28 |
| KR20120091176A (ko) | 2012-08-17 |
| MX2012003988A (es) | 2012-07-23 |
| BR112012007411B1 (pt) | 2020-12-15 |
| AU2010302572B2 (en) | 2016-10-20 |
| CA2776351A1 (en) | 2011-04-07 |
| PL2483242T3 (pl) | 2014-05-30 |
| EP2305643A1 (en) | 2011-04-06 |
| IN2012DN03129A (forum.php) | 2015-09-18 |
| EP2483242A1 (en) | 2012-08-08 |
| JP2013506637A (ja) | 2013-02-28 |
| KR101754940B1 (ko) | 2017-07-06 |
| RU2549885C2 (ru) | 2015-05-10 |
| JP5746185B2 (ja) | 2015-07-08 |
| AU2010302572A1 (en) | 2012-05-17 |
| BR112012007411B8 (pt) | 2021-05-25 |
| CN102648177A (zh) | 2012-08-22 |
| HK1173450A1 (en) | 2013-05-16 |
| RU2012117885A (ru) | 2013-11-10 |
| US20120196885A1 (en) | 2012-08-02 |
| CA2776351C (en) | 2017-10-31 |
| ES2452868T3 (es) | 2014-04-03 |
| AU2010302572A8 (en) | 2012-05-24 |
| US8685992B2 (en) | 2014-04-01 |
| EP2483242B1 (en) | 2013-12-11 |
| WO2011039353A1 (en) | 2011-04-07 |
| IL218995A (en) | 2016-11-30 |
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