PT2302063T - Minicélulas intactas, como vetores para a transferência de adn e terapêutica genética in vitro e in vivo - Google Patents

Minicélulas intactas, como vetores para a transferência de adn e terapêutica genética in vitro e in vivo

Info

Publication number
PT2302063T
PT2302063T PT101762094T PT10176209T PT2302063T PT 2302063 T PT2302063 T PT 2302063T PT 101762094 T PT101762094 T PT 101762094T PT 10176209 T PT10176209 T PT 10176209T PT 2302063 T PT2302063 T PT 2302063T
Authority
PT
Portugal
Prior art keywords
minicells
vectors
vitro
vivo
gene therapy
Prior art date
Application number
PT101762094T
Other languages
English (en)
Inventor
Himanshu Brahmbhatt
Macdiarmid Jennifer
Original Assignee
Engeneic Molecular Delivery Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engeneic Molecular Delivery Pty Ltd filed Critical Engeneic Molecular Delivery Pty Ltd
Publication of PT2302063T publication Critical patent/PT2302063T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
PT101762094T 2001-10-15 2002-10-15 Minicélulas intactas, como vetores para a transferência de adn e terapêutica genética in vitro e in vivo PT2302063T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32880101P 2001-10-15 2001-10-15

Publications (1)

Publication Number Publication Date
PT2302063T true PT2302063T (pt) 2016-07-28

Family

ID=23282498

Family Applications (2)

Application Number Title Priority Date Filing Date
PT02783361T PT1446489E (pt) 2001-10-15 2002-10-15 Minicélulas intactas, como vectores para a transferência de adn e terapia genética in vitro e in vivo
PT101762094T PT2302063T (pt) 2001-10-15 2002-10-15 Minicélulas intactas, como vetores para a transferência de adn e terapêutica genética in vitro e in vivo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT02783361T PT1446489E (pt) 2001-10-15 2002-10-15 Minicélulas intactas, como vectores para a transferência de adn e terapia genética in vitro e in vivo

Country Status (12)

Country Link
US (4) US20050222057A1 (pt)
EP (2) EP2302063B1 (pt)
JP (1) JP4458846B2 (pt)
CN (2) CN102172406B (pt)
AT (1) ATE541940T1 (pt)
AU (1) AU2002347426B2 (pt)
CA (2) CA2775218C (pt)
DK (1) DK1446489T3 (pt)
ES (2) ES2380612T3 (pt)
HK (1) HK1156069A1 (pt)
PT (2) PT1446489E (pt)
WO (1) WO2003033519A2 (pt)

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US20030194798A1 (en) 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
US7396822B2 (en) 2001-05-24 2008-07-08 Vaxiion Therapeutics, Inc. Immunogenic minicells and methods of use
EP2302063B1 (en) * 2001-10-15 2016-05-04 EnGeneIC Molecular Delivery Pty Ltd. Intact minicells as vectors for DNA transfer and gene therapy in vitro and in vivo
CA2517027A1 (en) 2002-02-25 2003-09-04 Vaxiion Therapeutics, Inc. Minicell compositions and methods
US7611885B2 (en) * 2003-06-24 2009-11-03 Engeneic Molecular Delivery Pty, Ltd. Pharmaceutically compatible method for purifying intact bacterial minicells
WO2005047504A1 (en) * 2003-11-07 2005-05-26 The Board Of Trustees Of The University Of Illinois Induction of cellular senescence by cdk4 disruption for tumor suppression and regression
CA2549840C (en) 2003-12-09 2012-03-20 Engeneic Molecular Delivery Pty Ltd. Targeted gene delivery to non-phagocytic mammalian cells via bacterially derived intact minicells
WO2005079854A1 (en) 2004-02-02 2005-09-01 Engeneic Molecular Delivery Pty Ltd. Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
US8772013B2 (en) 2004-02-02 2014-07-08 Engeneic Molecular Delivery Pty Ltd Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
GB0404209D0 (en) * 2004-02-25 2004-03-31 Uws Ventures Ltd Materials and methods for treatment of allergic disease
SI2386640T1 (sl) * 2004-08-26 2015-06-30 Engeneic Molecular Delivery Pty Ltd Dostava funkcionalnih nukleinskih kislin celicam sesalcev preko bakterijsko izvirajočih, intaktnih minicelic
US9878043B2 (en) * 2006-06-23 2018-01-30 Engeneic Molecular Delivery Pty Ltd Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells
DK2865755T3 (en) 2007-03-30 2017-05-15 Engeneic Molecular Delivery Pty Ltd BACTERIAL DERIVATIVE INTACT MINICELLS WITH REGULATORY RNA
WO2008133928A2 (en) * 2007-04-27 2008-11-06 The Gi Company, Inc. Mucin glycoproteins and their use for treatment of epithelial lesions and mucin dependent disorders
CA2729545C (en) 2008-06-25 2019-07-09 Vaxiion Therapeutics, Inc. Regulated genetic suicide mechanism compositions and methods
JP2010063404A (ja) * 2008-09-10 2010-03-25 Olympus Corp 幹細胞の分離方法
CN102648003B (zh) * 2009-10-09 2016-01-13 儿童医疗中心有限公司 选择性裂解的全细胞疫苗
DK2675474T3 (en) 2011-02-15 2019-04-23 Vaxiion Therapeutics Llc THERAPEUTIC COMPOSITIONS AND PROCEDURES FOR TARGETED ADMINISTRATION OF BIOACTIVE MOLECULES BY BACK-TERIAL MINICLES BASED ON ANTIBODY AND FC-CONTAINING TAR-GETING MOLECULES
US9844598B2 (en) 2011-12-13 2017-12-19 Engeneic Molecular Delivery Pty Ltd Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors
WO2013110120A1 (en) 2012-01-24 2013-08-01 Inter-K Pty Limited Peptide agents for cancer therapy
KR102433719B1 (ko) 2013-10-04 2022-08-17 엔진아이씨 몰레큘러 딜리버리 피티와이 리미티드 약물 로딩된, 이중특이성 리간드-표적화된 미니세포 및 인터페론 감마에 의한 복합 종양 치료
EP3200765A4 (en) 2014-10-03 2018-05-30 EnGeneIC Molecular Delivery Pty Ltd Enhanced loading of intact, bacterially derived vesicles with small molecule compounds
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
CN110022905B (zh) 2016-10-06 2024-02-06 安吉尼科分子传输公司 用于递送核酸佐剂的细菌小细胞和使用其的方法
WO2018201160A1 (en) * 2017-04-28 2018-11-01 Agrospheres, Inc. Compositions and methods for enzyme immobilization
CA3056801A1 (en) 2017-04-28 2018-11-01 Agrospheres, Inc. Compositions and methods for the encapsulation and scalable delivery of agrochemicals
WO2019060903A1 (en) 2017-09-25 2019-03-28 Agrospheres, Inc. COMPOSITIONS AND METHODS FOR PRODUCING AND EVOLVING ADMINISTRATION OF BIOLOGICAL PRODUCTS
EP3826654A4 (en) 2018-07-23 2022-07-06 EnGeneIC Molecular Delivery Pty Ltd BACTERIA-DERIVED MINICELL COMPOSITIONS AND METHODS OF USE THEREOF
CN109540890A (zh) * 2018-11-27 2019-03-29 湖南品胜生物技术有限公司 一种基于细胞显微镜图像的dna定量分析方法
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
WO2021257788A1 (en) * 2020-06-17 2021-12-23 Flagship Pioneering Innovations Vi, Llc Methods for manufacturing adas
WO2022256427A1 (en) * 2021-06-01 2022-12-08 University Of Virginia Patent Foundation Minicells from highly genome reduced escherichia coli: cytoplasmic and surface expression of recombinant proteins and incorporation in the minicells

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US4497796A (en) * 1980-03-26 1985-02-05 The Regents Of The University Of California Gene transfer in intact mammals
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
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WO1995021191A1 (en) 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
JP2001501834A (ja) 1997-03-19 2001-02-13 ザイモジェネティクス，インコーポレイティド 分泌される唾液ｚｓｉｇ３２ポリペプチド
WO2002072759A2 (en) * 2001-03-07 2002-09-19 Children's Medical Center Corporation Method to screen peptide display libraries using minicell display
US20030194798A1 (en) * 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
EP2302063B1 (en) * 2001-10-15 2016-05-04 EnGeneIC Molecular Delivery Pty Ltd. Intact minicells as vectors for DNA transfer and gene therapy in vitro and in vivo
CA2517027A1 (en) * 2002-02-25 2003-09-04 Vaxiion Therapeutics, Inc. Minicell compositions and methods
US7611885B2 (en) * 2003-06-24 2009-11-03 Engeneic Molecular Delivery Pty, Ltd. Pharmaceutically compatible method for purifying intact bacterial minicells
CA2549840C (en) * 2003-12-09 2012-03-20 Engeneic Molecular Delivery Pty Ltd. Targeted gene delivery to non-phagocytic mammalian cells via bacterially derived intact minicells
US8772013B2 (en) * 2004-02-02 2014-07-08 Engeneic Molecular Delivery Pty Ltd Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
US7124679B2 (en) * 2004-08-25 2006-10-24 L&P Property Management Company Lower guide track for down packing press apparatus and method
SI2386640T1 (sl) * 2004-08-26 2015-06-30 Engeneic Molecular Delivery Pty Ltd Dostava funkcionalnih nukleinskih kislin celicam sesalcev preko bakterijsko izvirajočih, intaktnih minicelic
US9878043B2 (en) * 2006-06-23 2018-01-30 Engeneic Molecular Delivery Pty Ltd Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells

Also Published As

Publication number Publication date
CA2775218C (en) 2016-04-26
CA2463631A1 (en) 2003-04-24
JP2005505296A (ja) 2005-02-24
CA2463631C (en) 2012-07-03
CN1599797A (zh) 2005-03-23
AU2002347426B2 (en) 2007-05-10
HK1156069A1 (zh) 2012-06-01
US20120208866A1 (en) 2012-08-16
DK1446489T3 (da) 2012-05-14
ES2380612T3 (es) 2012-05-16
CN102172406B (zh) 2013-03-13
JP4458846B2 (ja) 2010-04-28
EP2302063A2 (en) 2011-03-30
EP2302063B1 (en) 2016-05-04
CN102172406A (zh) 2011-09-07
WO2003033519A2 (en) 2003-04-24
PT1446489E (pt) 2012-04-24
EP1446489A2 (en) 2004-08-18
ES2584305T3 (es) 2016-09-27
WO2003033519A3 (en) 2003-09-25
EP1446489B1 (en) 2012-01-18
US20050222057A1 (en) 2005-10-06
US20080188436A1 (en) 2008-08-07
EP2302063A3 (en) 2011-05-25
EP1446489A4 (en) 2006-09-06
US20080020441A1 (en) 2008-01-24
CA2775218A1 (en) 2003-04-24
ATE541940T1 (de) 2012-02-15

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