HK1156069A1 - 用作體外和體內 轉染與基因治療載體的完整微細胞 - Google Patents

用作體外和體內 轉染與基因治療載體的完整微細胞

Info

Publication number
HK1156069A1
HK1156069A1 HK11110232.4A HK11110232A HK1156069A1 HK 1156069 A1 HK1156069 A1 HK 1156069A1 HK 11110232 A HK11110232 A HK 11110232A HK 1156069 A1 HK1156069 A1 HK 1156069A1
Authority
HK
Hong Kong
Prior art keywords
minicells
dna
vectors
vitro
gene therapy
Prior art date
Application number
HK11110232.4A
Other languages
English (en)
Inventor
Himanshu Brahmbhatt
Jennifer Macdiarmid
Original Assignee
Engeneic Molecular Delivery Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engeneic Molecular Delivery Pty Ltd filed Critical Engeneic Molecular Delivery Pty Ltd
Publication of HK1156069A1 publication Critical patent/HK1156069A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
HK11110232.4A 2001-10-15 2011-09-28 用作體外和體內 轉染與基因治療載體的完整微細胞 HK1156069A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32880101P 2001-10-15 2001-10-15

Publications (1)

Publication Number Publication Date
HK1156069A1 true HK1156069A1 (zh) 2012-06-01

Family

ID=23282498

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11110232.4A HK1156069A1 (zh) 2001-10-15 2011-09-28 用作體外和體內 轉染與基因治療載體的完整微細胞

Country Status (12)

Country Link
US (4) US20050222057A1 (zh)
EP (2) EP2302063B1 (zh)
JP (1) JP4458846B2 (zh)
CN (2) CN1599797A (zh)
AT (1) ATE541940T1 (zh)
AU (1) AU2002347426B2 (zh)
CA (2) CA2463631C (zh)
DK (1) DK1446489T3 (zh)
ES (2) ES2380612T3 (zh)
HK (1) HK1156069A1 (zh)
PT (2) PT2302063T (zh)
WO (1) WO2003033519A2 (zh)

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US7396822B2 (en) 2001-05-24 2008-07-08 Vaxiion Therapeutics, Inc. Immunogenic minicells and methods of use
CA2463631C (en) * 2001-10-15 2012-07-03 Engeneic Gene Therapy Pty Limited Intact minicells as vectors for dna transfer and gene therapy in vitro and in vivo
WO2003072014A2 (en) * 2002-02-25 2003-09-04 Mpex Bioscience, Inc. Minicell compositions and methods
US7611885B2 (en) 2003-06-24 2009-11-03 Engeneic Molecular Delivery Pty, Ltd. Pharmaceutically compatible method for purifying intact bacterial minicells
US20070275918A1 (en) * 2003-11-07 2007-11-29 The Board Of Trustees Of The University Of Illinois Induction of Cellular Senescence by Cdk4 Disruption for Tumor Suppression and Regression
PL1694361T3 (pl) 2003-12-09 2011-08-31 Engeneic Molecular Delivery Pty Ltd Ukierunkowane dostarczanie genów do niefagocytujących komórek ssaczych z zastosowaniem nienaruszonych minikomórek pochodzących od bakterii
CN102028953B (zh) * 2004-02-02 2013-10-30 恩杰内克分子递送有限公司 经细菌来源的完整微细胞在体外和体内将药物靶向递送至哺乳动物细胞的组合物和方法
US8772013B2 (en) 2004-02-02 2014-07-08 Engeneic Molecular Delivery Pty Ltd Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
GB0404209D0 (en) * 2004-02-25 2004-03-31 Uws Ventures Ltd Materials and methods for treatment of allergic disease
ES2535235T3 (es) 2004-08-26 2015-05-07 Engeneic Molecular Delivery Pty Ltd Administración de ácidos nucleicos funcionales a células de mamífero a través de minicélulas intactas obtenidas a partir de bacterias
PL2712618T3 (pl) * 2006-06-23 2017-07-31 Engeneic Molecular Delivery Pty Ltd. Ukierunkowane dostarczanie leków, terapeutycznych kwasów nukleinowych i funkcjonalnych kwasów nukleinowych do komórek ssaczych przez nienaruszone, uśmiercone komórki bakteryjne
CA2933978C (en) 2007-03-30 2018-08-21 Engeneic Molecular Delivery Pty. Ltd. Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells
US20080286211A1 (en) * 2007-04-27 2008-11-20 Barker Nicholas P Using mucin glycoproteins in combination with therapeutic agents to treat epithelial lesions and disorders of impaired mucin function
KR101813824B1 (ko) * 2008-06-25 2017-12-29 벡션 테라퓨틱스 엘엘씨 조절된 유전자 자살 메커니즘 조성물 및 방법
JP2010063404A (ja) * 2008-09-10 2010-03-25 Olympus Corp 幹細胞の分離方法
EP2485764A4 (en) * 2009-10-09 2014-01-29 Childrens Medical Center WHOLE CELL VACCINE WITH SELECTIVE DISSOCIATION
DK2675474T3 (en) 2011-02-15 2019-04-23 Vaxiion Therapeutics Llc THERAPEUTIC COMPOSITIONS AND PROCEDURES FOR TARGETED ADMINISTRATION OF BIOACTIVE MOLECULES BY BACK-TERIAL MINICLES BASED ON ANTIBODY AND FC-CONTAINING TAR-GETING MOLECULES
SG11201403062YA (en) * 2011-12-13 2014-07-30 Engeneic Molecular Delivery Pty Ltd Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors
EP2807180B1 (en) 2012-01-24 2018-03-28 InterK Peptide Therapeutics Limited Peptide agents for cancer therapy
MX2016004285A (es) 2013-10-04 2016-07-08 Engeneic Molecular Delivery Pty Ltd Tratamiento de tumor por combinacion con minicelulas dirigidas a ligando, biespecificas, cargadas con farmacos e interferon-gamma.
EP3200765A4 (en) 2014-10-03 2018-05-30 EnGeneIC Molecular Delivery Pty Ltd Enhanced loading of intact, bacterially derived vesicles with small molecule compounds
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
EP3522935A4 (en) 2016-10-06 2020-05-13 EnGeneIC Molecular Delivery Pty Ltd. BACTERIAL MINICELLS FOR THE DELIVERY OF NUCLEIC ACID ADJUVANTS AND METHODS OF USE THEREOF
CA3056801A1 (en) 2017-04-28 2018-11-01 Agrospheres, Inc. Compositions and methods for the encapsulation and scalable delivery of agrochemicals
US11624061B2 (en) 2017-04-28 2023-04-11 Agrospheres, Inc. Compositions and methods for enzyme immobilization
US11812743B2 (en) 2017-09-25 2023-11-14 Agrospheres, Inc. Compositions and methods for scalable production and delivery of biologicals
JP2021532106A (ja) 2018-07-23 2021-11-25 エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド 細菌由来ミニ細胞を含む組成物およびそれを使用する方法
CN109540890A (zh) * 2018-11-27 2019-03-29 湖南品胜生物技术有限公司 一种基于细胞显微镜图像的dna定量分析方法
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
EP4168025A1 (en) * 2020-06-17 2023-04-26 Flagship Pioneering Innovations VI, LLC Methods for manufacturing adas
WO2022256427A1 (en) * 2021-06-01 2022-12-08 University Of Virginia Patent Foundation Minicells from highly genome reduced escherichia coli: cytoplasmic and surface expression of recombinant proteins and incorporation in the minicells

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AU6762498A (en) 1997-03-19 1998-10-12 Zymogenetics Inc. Secreted salivary zsig32 polypeptides
WO2002072759A2 (en) * 2001-03-07 2002-09-19 Children's Medical Center Corporation Method to screen peptide display libraries using minicell display
US20030194798A1 (en) * 2001-05-24 2003-10-16 Surber Mark W. Minicell compositions and methods
CA2463631C (en) * 2001-10-15 2012-07-03 Engeneic Gene Therapy Pty Limited Intact minicells as vectors for dna transfer and gene therapy in vitro and in vivo
WO2003072014A2 (en) * 2002-02-25 2003-09-04 Mpex Bioscience, Inc. Minicell compositions and methods
US7611885B2 (en) * 2003-06-24 2009-11-03 Engeneic Molecular Delivery Pty, Ltd. Pharmaceutically compatible method for purifying intact bacterial minicells
PL1694361T3 (pl) * 2003-12-09 2011-08-31 Engeneic Molecular Delivery Pty Ltd Ukierunkowane dostarczanie genów do niefagocytujących komórek ssaczych z zastosowaniem nienaruszonych minikomórek pochodzących od bakterii
US8772013B2 (en) * 2004-02-02 2014-07-08 Engeneic Molecular Delivery Pty Ltd Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
US7124679B2 (en) * 2004-08-25 2006-10-24 L&P Property Management Company Lower guide track for down packing press apparatus and method
ES2535235T3 (es) * 2004-08-26 2015-05-07 Engeneic Molecular Delivery Pty Ltd Administración de ácidos nucleicos funcionales a células de mamífero a través de minicélulas intactas obtenidas a partir de bacterias
PL2712618T3 (pl) * 2006-06-23 2017-07-31 Engeneic Molecular Delivery Pty Ltd. Ukierunkowane dostarczanie leków, terapeutycznych kwasów nukleinowych i funkcjonalnych kwasów nukleinowych do komórek ssaczych przez nienaruszone, uśmiercone komórki bakteryjne

Also Published As

Publication number Publication date
CN102172406B (zh) 2013-03-13
PT1446489E (pt) 2012-04-24
CN102172406A (zh) 2011-09-07
EP2302063B1 (en) 2016-05-04
US20080020441A1 (en) 2008-01-24
EP1446489B1 (en) 2012-01-18
US20120208866A1 (en) 2012-08-16
JP4458846B2 (ja) 2010-04-28
ES2584305T3 (es) 2016-09-27
CA2775218C (en) 2016-04-26
CN1599797A (zh) 2005-03-23
EP2302063A3 (en) 2011-05-25
AU2002347426B2 (en) 2007-05-10
WO2003033519A2 (en) 2003-04-24
EP2302063A2 (en) 2011-03-30
ES2380612T3 (es) 2012-05-16
US20080188436A1 (en) 2008-08-07
CA2463631C (en) 2012-07-03
CA2463631A1 (en) 2003-04-24
WO2003033519A3 (en) 2003-09-25
US20050222057A1 (en) 2005-10-06
DK1446489T3 (da) 2012-05-14
PT2302063T (pt) 2016-07-28
JP2005505296A (ja) 2005-02-24
CA2775218A1 (en) 2003-04-24
ATE541940T1 (de) 2012-02-15
EP1446489A2 (en) 2004-08-18
EP1446489A4 (en) 2006-09-06

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20201011