PT2218452E - Combinação que compreende ácido pirrolidona-5-carboxilico e pelo menos um composto entre citrulina, arginina e asparagina, e utilização deste no tratamento de dermatite atópica - Google Patents
Combinação que compreende ácido pirrolidona-5-carboxilico e pelo menos um composto entre citrulina, arginina e asparagina, e utilização deste no tratamento de dermatite atópica Download PDFInfo
- Publication number
- PT2218452E PT2218452E PT101652501T PT10165250T PT2218452E PT 2218452 E PT2218452 E PT 2218452E PT 101652501 T PT101652501 T PT 101652501T PT 10165250 T PT10165250 T PT 10165250T PT 2218452 E PT2218452 E PT 2218452E
- Authority
- PT
- Portugal
- Prior art keywords
- citrulline
- asparagine
- arginine
- pyrrolidone
- compound
- Prior art date
Links
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 title 1
- 239000004475 Arginine Substances 0.000 title 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 title 1
- 206010012438 Dermatitis atopic Diseases 0.000 title 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 title 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 title 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 title 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 title 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title 1
- 229960003121 arginine Drugs 0.000 title 1
- 235000009697 arginine Nutrition 0.000 title 1
- 235000009582 asparagine Nutrition 0.000 title 1
- 229960001230 asparagine Drugs 0.000 title 1
- 201000008937 atopic dermatitis Diseases 0.000 title 1
- 235000013477 citrulline Nutrition 0.000 title 1
- 229960002173 citrulline Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0755186A FR2916351B1 (fr) | 2007-05-22 | 2007-05-22 | Composition pharmaceutique comprenant au moins deux composes choisis parmi l'acide pyrrolidone-5-carboxylique, la citrulline, l'arginine et l'asparagine et leur utilisation dans le traitement de la dermatite atopique |
| US92471207P | 2007-05-29 | 2007-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2218452E true PT2218452E (pt) | 2016-01-27 |
Family
ID=38606551
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT101652501T PT2218452E (pt) | 2007-05-22 | 2008-05-22 | Combinação que compreende ácido pirrolidona-5-carboxilico e pelo menos um composto entre citrulina, arginina e asparagina, e utilização deste no tratamento de dermatite atópica |
| PT87599346T PT2164482E (pt) | 2007-05-22 | 2008-05-22 | Combinação que compreende ácido pirrolidona-5-carboxilico e pelo menos um composto entre citrulina, arginina e asparagina, e utilização deste no tratamento de dermatite atópica |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87599346T PT2164482E (pt) | 2007-05-22 | 2008-05-22 | Combinação que compreende ácido pirrolidona-5-carboxilico e pelo menos um composto entre citrulina, arginina e asparagina, e utilização deste no tratamento de dermatite atópica |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8795705B2 (pt) |
| EP (2) | EP2218452B1 (pt) |
| JP (2) | JP2010527970A (pt) |
| KR (1) | KR20100017202A (pt) |
| CN (1) | CN101686957A (pt) |
| BR (1) | BRPI0810323A2 (pt) |
| CA (1) | CA2687324A1 (pt) |
| ES (2) | ES2554776T3 (pt) |
| FR (1) | FR2916351B1 (pt) |
| HU (2) | HUE026388T2 (pt) |
| MX (1) | MX2009012472A (pt) |
| PL (2) | PL2164482T3 (pt) |
| PT (2) | PT2218452E (pt) |
| RU (1) | RU2476214C2 (pt) |
| WO (1) | WO2008142147A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5689026B2 (ja) * | 2010-06-17 | 2015-03-25 | 株式会社 資生堂 | 水中油型乳化皮膚化粧料 |
| KR101066859B1 (ko) * | 2010-12-10 | 2011-09-26 | 전명자 | 패드 및 이를 포함하는 깔창 |
| JP6009147B2 (ja) * | 2011-03-15 | 2016-10-19 | 株式会社 資生堂 | ブレオマイシン水解酵素産生促進剤 |
| RU2538084C1 (ru) * | 2013-07-25 | 2015-01-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Министерства здравоохранения и социального развития Российской Федерации" (ГБОУ ВПО УГМА Минздрава России) | Средство для лечения и профилактики атопического дерматита |
| KR101732428B1 (ko) | 2015-06-25 | 2017-05-24 | 이정재 | 탄성 리포좀 조성물 및 이를 포함하는 화장료 조성물 |
| KR102396603B1 (ko) | 2015-09-16 | 2022-05-11 | 원광대학교산학협력단 | 시트룰린을 유효성분으로 함유하는 간 기능 개선용 조성물 |
| US9909427B2 (en) | 2015-12-22 | 2018-03-06 | General Electric Company | Turbine airfoil with trailing edge cooling circuit |
| AU2017283511B2 (en) * | 2016-06-17 | 2020-02-06 | Drug Delivery Solutions Aps | Formulation for use in the treatment of uremic pruritus |
| CN112137995A (zh) | 2019-06-28 | 2020-12-29 | 默克专利股份有限公司 | 增加皮肤细胞中钙的细胞利用率的方法和混合物 |
| CN112569162B (zh) * | 2019-09-27 | 2024-04-12 | 默克专利股份有限公司 | 麦冬提取物、氨基酸、氨基酸衍生物和乳酸钙水合物的协同作用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61215307A (ja) | 1985-03-20 | 1986-09-25 | Shiseido Co Ltd | 皮膚外用剤 |
| JPS61215308A (ja) | 1985-03-20 | 1986-09-25 | Shiseido Co Ltd | 皮膚外用剤 |
| JPH0729911B2 (ja) | 1986-05-15 | 1995-04-05 | 株式会社資生堂 | 皮膚外用剤 |
| US4837019A (en) * | 1986-08-11 | 1989-06-06 | Charles Of The Ritz Group Ltd. | Skin treatment composition and method for treating burned skin |
| DE4341000A1 (de) * | 1993-12-02 | 1995-06-08 | Beiersdorf Ag | Verwendung von L-Arginin, L-Ornithin oder L-Citrullin und topischen Zubereitungen mit diesen Stoffen |
| JPH0820525A (ja) | 1994-07-06 | 1996-01-23 | Nendo Kagaku Kenkyusho:Kk | ボディシャンプ |
| DE69601765T2 (de) | 1995-09-07 | 1999-07-08 | Oreal | Extrakt von Iridaceen und Zusammensetzungen, die ihn enthalten |
| PL186017B1 (pl) * | 1995-09-07 | 2003-09-30 | Oreal | Zastosowanie ekstraktu z niefotosyntetyzującej bakterii nitkowatej oraz kompozycja zawierająca takiekstrakt |
| JP3525233B2 (ja) | 1995-09-20 | 2004-05-10 | 味の素株式会社 | 化粧料 |
| FR2768622B1 (fr) | 1997-09-22 | 1999-11-26 | Oreal | Extrait de rosacees en tant qu'antagoniste de bradykinine |
| FR2778562B1 (fr) * | 1998-05-14 | 2000-08-04 | Sephra | Composition pharmaceutique, hygienique et/ou cosmetique contenant de l'eau de mer et de l'arginine |
| DE19831798A1 (de) * | 1998-07-15 | 2000-01-27 | Mandorlo Investment Gmbh Luxem | Mittel zur Pflege und/oder Behandlung von Haut und Gewebe |
| JP2002053428A (ja) | 2000-08-12 | 2002-02-19 | Tadashi Fukiya | 皮膚外用剤 |
| JP4681132B2 (ja) * | 2001-01-29 | 2011-05-11 | 味の素株式会社 | 一酸化窒素合成酵素産生促進剤および化粧料若しくは医薬組成物 |
| DE10111049A1 (de) * | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen, zur Prophylaxe und Behandlung von entzündlichen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter trockener Haut |
| JP4851046B2 (ja) * | 2002-06-19 | 2012-01-11 | 味の素株式会社 | 細胞への塩基性アミノ酸取り込み促進剤および医薬組成物 |
| JP2004168763A (ja) * | 2002-10-30 | 2004-06-17 | Dsr Corp | 皮膚化粧料 |
| US20060063827A1 (en) * | 2004-09-23 | 2006-03-23 | Yu Ruey J | Systemic administration of therapeutic amino acids and N-acetylamino acids |
| JPWO2005077349A1 (ja) | 2004-02-17 | 2007-10-18 | 大塚製薬株式会社 | ヒトβディフェンシン産生促進剤 |
-
2007
- 2007-05-22 FR FR0755186A patent/FR2916351B1/fr not_active Expired - Fee Related
-
2008
- 2008-05-22 KR KR1020097024242A patent/KR20100017202A/ko not_active Application Discontinuation
- 2008-05-22 JP JP2010508859A patent/JP2010527970A/ja active Pending
- 2008-05-22 HU HUE10165250A patent/HUE026388T2/en unknown
- 2008-05-22 HU HUE08759934A patent/HUE025824T2/en unknown
- 2008-05-22 ES ES08759934.6T patent/ES2554776T3/es active Active
- 2008-05-22 CN CN200880016754A patent/CN101686957A/zh active Pending
- 2008-05-22 EP EP10165250.1A patent/EP2218452B1/en active Active
- 2008-05-22 WO PCT/EP2008/056333 patent/WO2008142147A1/en active Application Filing
- 2008-05-22 US US12/601,113 patent/US8795705B2/en active Active
- 2008-05-22 MX MX2009012472A patent/MX2009012472A/es active IP Right Grant
- 2008-05-22 PT PT101652501T patent/PT2218452E/pt unknown
- 2008-05-22 PL PL08759934T patent/PL2164482T3/pl unknown
- 2008-05-22 BR BRPI0810323-2A2A patent/BRPI0810323A2/pt not_active Application Discontinuation
- 2008-05-22 CA CA002687324A patent/CA2687324A1/en not_active Abandoned
- 2008-05-22 PT PT87599346T patent/PT2164482E/pt unknown
- 2008-05-22 ES ES10165250.1T patent/ES2554834T3/es active Active
- 2008-05-22 PL PL10165250T patent/PL2218452T3/pl unknown
- 2008-05-22 RU RU2009147465/15A patent/RU2476214C2/ru active
- 2008-05-22 EP EP08759934.6A patent/EP2164482B1/en active Active
-
2014
- 2014-01-10 JP JP2014003184A patent/JP2014065742A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008252925A1 (en) | 2008-11-27 |
| KR20100017202A (ko) | 2010-02-16 |
| FR2916351B1 (fr) | 2012-12-07 |
| WO2008142147A1 (en) | 2008-11-27 |
| PT2164482E (pt) | 2016-02-03 |
| EP2164482A1 (en) | 2010-03-24 |
| US20100291002A1 (en) | 2010-11-18 |
| RU2009147465A (ru) | 2011-06-27 |
| BRPI0810323A2 (pt) | 2014-10-14 |
| US8795705B2 (en) | 2014-08-05 |
| CN101686957A (zh) | 2010-03-31 |
| EP2218452A1 (en) | 2010-08-18 |
| PL2218452T3 (pl) | 2016-04-29 |
| EP2218452B1 (en) | 2015-09-30 |
| PL2164482T3 (pl) | 2016-05-31 |
| JP2014065742A (ja) | 2014-04-17 |
| MX2009012472A (es) | 2009-12-01 |
| HUE026388T2 (en) | 2016-06-28 |
| HUE025824T2 (en) | 2016-05-30 |
| JP2010527970A (ja) | 2010-08-19 |
| RU2476214C2 (ru) | 2013-02-27 |
| ES2554776T3 (es) | 2015-12-23 |
| CA2687324A1 (en) | 2008-11-27 |
| FR2916351A1 (fr) | 2008-11-28 |
| ES2554834T3 (es) | 2015-12-23 |
| EP2164482B1 (en) | 2015-10-07 |
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