PT2016414E - Vacina de células t - Google Patents

Info

Publication number

PT2016414E

PT2016414E PT77973477T PT07797347T PT2016414E PT 2016414 E PT2016414 E PT 2016414E PT 77973477 T PT77973477 T PT 77973477T PT 07797347 T PT07797347 T PT 07797347T PT 2016414 E PT2016414 E PT 2016414E

Authority

PT

Portugal

Prior art keywords

gly

leu

cells

peptides

ala

Prior art date

2006-05-05

Links

• Espacenet
• Global Dossier
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• 210000001744 T-lymphocyte Anatomy 0.000 title claims description 164
• 229940030156 cell vaccine Drugs 0.000 title claims description 23
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 257
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 183
• 239000000203 mixture Substances 0.000 claims description 52
• 239000000427 antigen Substances 0.000 claims description 44
• 108091007433 antigens Proteins 0.000 claims description 44
• 102000036639 antigens Human genes 0.000 claims description 44
• 238000000034 method Methods 0.000 claims description 43
• 210000004027 cell Anatomy 0.000 claims description 40
• 230000000638 stimulation Effects 0.000 claims description 34
• 229920001184 polypeptide Polymers 0.000 claims description 31
• 150000001413 amino acids Chemical class 0.000 claims description 26
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims description 4
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims description 4
• 230000010076 replication Effects 0.000 claims description 3
• 238000010348 incorporation Methods 0.000 claims description 2
• NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 claims 1
• 241000282414 Homo sapiens Species 0.000 description 162
• KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 53
• 102000047918 Myelin Basic Human genes 0.000 description 51
• 101710107068 Myelin basic protein Proteins 0.000 description 51
• 108010000123 Myelin-Oligodendrocyte Glycoprotein Proteins 0.000 description 51
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• 230000009257 reactivity Effects 0.000 description 46
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• 102000006386 Myelin Proteins Human genes 0.000 description 30
• 108010083674 Myelin Proteins Proteins 0.000 description 30
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 27
• 210000005012 myelin Anatomy 0.000 description 25
• 238000004458 analytical method Methods 0.000 description 21
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 18
• 230000008859 change Effects 0.000 description 18
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 18
• 108090000623 proteins and genes Proteins 0.000 description 17
• 238000003556 assay Methods 0.000 description 16
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• 201000010099 disease Diseases 0.000 description 14
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
• 238000004519 manufacturing process Methods 0.000 description 14
• 102000055324 Myelin Proteolipid Human genes 0.000 description 13
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• 230000012010 growth Effects 0.000 description 11
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• 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 description 10
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• 102000000588 Interleukin-2 Human genes 0.000 description 9
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• 238000009171 T-cell vaccination Methods 0.000 description 9
• 230000002238 attenuated effect Effects 0.000 description 9
• 210000004369 blood Anatomy 0.000 description 9
• 239000008280 blood Substances 0.000 description 9
• 238000002255 vaccination Methods 0.000 description 9
• 108010050848 glycylleucine Proteins 0.000 description 8
• 108010015792 glycyllysine Proteins 0.000 description 8
• 230000000890 antigenic effect Effects 0.000 description 7
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• 108010061238 threonyl-glycine Proteins 0.000 description 7
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• 108010092114 histidylphenylalanine Proteins 0.000 description 6
• 230000028993 immune response Effects 0.000 description 6
• 238000011282 treatment Methods 0.000 description 6
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• 230000004913 activation Effects 0.000 description 5
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• 230000004936 stimulating effect Effects 0.000 description 5
• 102100038222 60 kDa heat shock protein, mitochondrial Human genes 0.000 description 4
• OSRZOHXQCUFIQG-FPMFFAJLSA-N Ala-Phe-Pro Chemical compound C([C@H](NC(=O)[C@@H]([NH3+])C)C(=O)N1[C@H](CCC1)C([O-])=O)C1=CC=CC=C1 OSRZOHXQCUFIQG-FPMFFAJLSA-N 0.000 description 4
• HGKHPCFTRQDHCU-IUCAKERBSA-N Arg-Pro-Gly Chemical compound NC(N)=NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O HGKHPCFTRQDHCU-IUCAKERBSA-N 0.000 description 4
• XJQRWGXKUSDEFI-ACZMJKKPSA-N Asp-Glu-Asn Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O XJQRWGXKUSDEFI-ACZMJKKPSA-N 0.000 description 4
• WBDWQKRLTVCDSY-WHFBIAKZSA-N Asp-Gly-Asp Chemical compound OC(=O)C[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O WBDWQKRLTVCDSY-WHFBIAKZSA-N 0.000 description 4
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• SQJSYLDKQBZQTG-FXQIFTODSA-N Cys-Asn-Met Chemical compound CSCC[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CS)N SQJSYLDKQBZQTG-FXQIFTODSA-N 0.000 description 4
• OQQKUTVULYLCDG-ONGXEEELSA-N Gly-Lys-Val Chemical compound CC(C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)CN)C(O)=O OQQKUTVULYLCDG-ONGXEEELSA-N 0.000 description 4
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• WNGHUXFWEWTKAO-YUMQZZPRSA-N Gly-Ser-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)CN WNGHUXFWEWTKAO-YUMQZZPRSA-N 0.000 description 4
• JBCLFWXMTIKCCB-UHFFFAOYSA-N H-Gly-Phe-OH Natural products NCC(=O)NC(C(O)=O)CC1=CC=CC=C1 JBCLFWXMTIKCCB-UHFFFAOYSA-N 0.000 description 4
• WNGVUZWBXZKQES-YUMQZZPRSA-N Leu-Ala-Gly Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O WNGVUZWBXZKQES-YUMQZZPRSA-N 0.000 description 4
• AAKRWBIIGKPOKQ-ONGXEEELSA-N Leu-Val-Gly Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)NCC(O)=O AAKRWBIIGKPOKQ-ONGXEEELSA-N 0.000 description 4
• GQZMPWBZQALKJO-UWVGGRQHSA-N Lys-Gly-Arg Chemical compound [H]N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O GQZMPWBZQALKJO-UWVGGRQHSA-N 0.000 description 4
• 241001465754 Metazoa Species 0.000 description 4
• 101500027988 Mus musculus ADGRV1 subunit beta Proteins 0.000 description 4
• PESQCPHRXOFIPX-UHFFFAOYSA-N N-L-methionyl-L-tyrosine Natural products CSCCC(N)C(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 PESQCPHRXOFIPX-UHFFFAOYSA-N 0.000 description 4
• 108010079364 N-glycylalanine Proteins 0.000 description 4
• DOXQMJCSSYZSNM-BZSNNMDCSA-N Phe-Lys-Leu Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O DOXQMJCSSYZSNM-BZSNNMDCSA-N 0.000 description 4
• 108010047620 Phytohemagglutinins Proteins 0.000 description 4
• FKLSMYYLJHYPHH-UWVGGRQHSA-N Pro-Gly-Leu Chemical compound [H]N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(O)=O FKLSMYYLJHYPHH-UWVGGRQHSA-N 0.000 description 4
• QAYSODICXVZUIA-WLTAIBSBSA-N Tyr-Gly-Thr Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(O)=O QAYSODICXVZUIA-WLTAIBSBSA-N 0.000 description 4
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• 108010029539 arginyl-prolyl-proline Proteins 0.000 description 4
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• 108010065135 phenylalanyl-phenylalanyl-phenylalanine Proteins 0.000 description 4
• 230000001885 phytohemagglutinin Effects 0.000 description 4
• 238000002360 preparation method Methods 0.000 description 4
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• IQFYYKKMVGJFEH-OFKYTIFKSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(tritiooxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO[3H])O[C@H]1N1C(=O)NC(=O)C(C)=C1 IQFYYKKMVGJFEH-OFKYTIFKSA-N 0.000 description 3
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