NZ572644A - T-cell vaccine - Google Patents
T-cell vaccineInfo
- Publication number
- NZ572644A NZ572644A NZ572644A NZ57264407A NZ572644A NZ 572644 A NZ572644 A NZ 572644A NZ 572644 A NZ572644 A NZ 572644A NZ 57264407 A NZ57264407 A NZ 57264407A NZ 572644 A NZ572644 A NZ 572644A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cells
- plp
- mog
- epitopes
- mbp
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title claims abstract description 186
- 229940030156 cell vaccine Drugs 0.000 title claims abstract description 31
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 269
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 184
- 238000000034 method Methods 0.000 claims abstract description 55
- 229920001184 polypeptide Polymers 0.000 claims abstract description 42
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- 150000001413 amino acids Chemical class 0.000 claims description 30
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
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- 108010058432 Chaperonin 60 Proteins 0.000 claims description 5
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 3
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- 230000001404 mediated effect Effects 0.000 claims description 3
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 claims 3
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- 108010000123 Myelin-Oligodendrocyte Glycoprotein Proteins 0.000 description 144
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- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 2
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- 101100084046 Caenorhabditis elegans cyn-4 gene Proteins 0.000 description 2
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- 102000006354 HLA-DR Antigens Human genes 0.000 description 2
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- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 2
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 2
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- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
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- 230000007503 antigenic stimulation Effects 0.000 description 2
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
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- VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 description 1
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
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- 101100001672 Emericella variicolor andG gene Proteins 0.000 description 1
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- 101000931921 Homo sapiens Short-chain dehydrogenase/reductase family 9C member 7 Proteins 0.000 description 1
- 101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 description 1
- 101710094913 Myelin proteolipid protein Proteins 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/414—Nervous system antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74661106P | 2006-05-05 | 2006-05-05 | |
| US74790306P | 2006-05-22 | 2006-05-22 | |
| PCT/US2007/068304 WO2007131210A2 (en) | 2006-05-05 | 2007-05-04 | T-cell vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ572644A true NZ572644A (en) | 2012-06-29 |
Family
ID=38668612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ572644A NZ572644A (en) | 2006-05-05 | 2007-05-04 | T-cell vaccine |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100003228A1 (enExample) |
| EP (3) | EP2016414B1 (enExample) |
| JP (3) | JP2009536036A (enExample) |
| AU (1) | AU2007247869B2 (enExample) |
| CA (1) | CA2651328A1 (enExample) |
| DK (2) | DK2016414T3 (enExample) |
| ES (2) | ES2552667T3 (enExample) |
| IL (1) | IL195115A (enExample) |
| NZ (1) | NZ572644A (enExample) |
| PL (2) | PL2016414T3 (enExample) |
| PT (2) | PT2016414E (enExample) |
| WO (1) | WO2007131210A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9862751B2 (en) | 2013-01-15 | 2018-01-09 | Apitope Technology (Bristol) Limited | Myelin oligodendrocyte glycoprotein peptides |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL398077A1 (pl) * | 2012-02-10 | 2012-08-27 | Krzysztof Selmaj | Kompozycja farmaceutyczna oraz zastosowanie kompozycji do wytwarzania leku, do podawania naskórnego, do leczenia stwardnienia rozsianego |
| CN105992950A (zh) * | 2013-12-19 | 2016-10-05 | 欧普萨治疗股份有限公司 | T 细胞表位表达谱分析、制备 t 细胞组合物以及治疗疾病的方法 |
| KR101503341B1 (ko) * | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
| WO2016037123A2 (en) | 2014-09-05 | 2016-03-10 | Opexa Therapeutics, Inc. | Compositions and methods for treating b cell mediated autoimmune disorders |
| US10231033B1 (en) | 2014-09-30 | 2019-03-12 | Apple Inc. | Synchronizing out-of-band content with a media stream |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9862751B2 (en) | 2013-01-15 | 2018-01-09 | Apitope Technology (Bristol) Limited | Myelin oligodendrocyte glycoprotein peptides |
| US10377800B2 (en) | 2013-01-15 | 2019-08-13 | Apitope Technology (Bristol) Limited | Myelin oligodendrocyte glycoprotein (MOG) peptide |
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| EP2712623A1 (en) | 2014-04-02 |
| US20100003228A1 (en) | 2010-01-07 |
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| IL195115A (en) | 2012-12-31 |
| EP2016414B1 (en) | 2015-09-02 |
| JP6000205B2 (ja) | 2016-09-28 |
| PT2016414E (pt) | 2015-11-24 |
| DK2420833T3 (en) | 2015-12-07 |
| JP2013252142A (ja) | 2013-12-19 |
| CA2651328A1 (en) | 2007-11-15 |
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| PL2016414T3 (pl) | 2016-01-29 |
| JP2016053090A (ja) | 2016-04-14 |
| JP2009536036A (ja) | 2009-10-08 |
| WO2007131210A2 (en) | 2007-11-15 |
| EP2420833A1 (en) | 2012-02-22 |
| ES2552667T3 (es) | 2015-12-01 |
| PT2420833E (pt) | 2015-11-24 |
| DK2016414T3 (en) | 2015-12-07 |
| IL195115A0 (en) | 2009-09-22 |
| EP2016414A2 (en) | 2009-01-21 |
| ES2553192T3 (es) | 2015-12-04 |
| WO2007131210A3 (en) | 2008-10-30 |
| AU2007247869A1 (en) | 2007-11-15 |
| EP2016414A4 (en) | 2009-08-12 |
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