JP2009536036A - T細胞ワクチン - Google Patents

T細胞ワクチン Download PDF

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Publication number
JP2009536036A
JP2009536036A JP2009510114A JP2009510114A JP2009536036A JP 2009536036 A JP2009536036 A JP 2009536036A JP 2009510114 A JP2009510114 A JP 2009510114A JP 2009510114 A JP2009510114 A JP 2009510114A JP 2009536036 A JP2009536036 A JP 2009536036A
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JP
Japan
Prior art keywords
cells
epitope
cell
autoreactive
peptide
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JP2009510114A
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English (en)
Japanese (ja)
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JP2009536036A5 (enExample
Inventor
ジム シー. ウィリアムス,
ミツィー エム. モンゴメリー,
ブライアン エス. ニューサム,
Original Assignee
オペクサ セラピューティクス
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Publication of JP2009536036A publication Critical patent/JP2009536036A/ja
Publication of JP2009536036A5 publication Critical patent/JP2009536036A5/ja
Withdrawn legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047Cells of the immune system
    • G01N33/505Cells of the immune system involving T-cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0008Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22Immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/414Nervous system antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/416Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
JP2009510114A 2006-05-05 2007-05-04 T細胞ワクチン Withdrawn JP2009536036A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74661106P 2006-05-05 2006-05-05
US74790306P 2006-05-22 2006-05-22
PCT/US2007/068304 WO2007131210A2 (en) 2006-05-05 2007-05-04 T-cell vaccine

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2013163134A Division JP6000205B2 (ja) 2006-05-05 2013-08-06 T細胞ワクチン
JP2016003678A Division JP2016053090A (ja) 2006-05-05 2016-01-12 T細胞ワクチン

Publications (2)

Publication Number Publication Date
JP2009536036A true JP2009536036A (ja) 2009-10-08
JP2009536036A5 JP2009536036A5 (enExample) 2013-09-19

Family

ID=38668612

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009510114A Withdrawn JP2009536036A (ja) 2006-05-05 2007-05-04 T細胞ワクチン
JP2013163134A Expired - Fee Related JP6000205B2 (ja) 2006-05-05 2013-08-06 T細胞ワクチン
JP2016003678A Withdrawn JP2016053090A (ja) 2006-05-05 2016-01-12 T細胞ワクチン

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013163134A Expired - Fee Related JP6000205B2 (ja) 2006-05-05 2013-08-06 T細胞ワクチン
JP2016003678A Withdrawn JP2016053090A (ja) 2006-05-05 2016-01-12 T細胞ワクチン

Country Status (12)

Country Link
US (1) US20100003228A1 (enExample)
EP (3) EP2016414B1 (enExample)
JP (3) JP2009536036A (enExample)
AU (1) AU2007247869B2 (enExample)
CA (1) CA2651328A1 (enExample)
DK (2) DK2016414T3 (enExample)
ES (2) ES2552667T3 (enExample)
IL (1) IL195115A (enExample)
NZ (1) NZ572644A (enExample)
PL (2) PL2016414T3 (enExample)
PT (2) PT2016414E (enExample)
WO (1) WO2007131210A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017508480A (ja) * 2014-03-12 2017-03-30 ナショナル キャンサー センター 自己癌抗原特異的cd8+t細胞の分離及び増殖方法
US10919972B2 (en) 2017-01-06 2021-02-16 Eutilex Co., Ltd. Anti-human 4-1BB antibodies and uses thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL398077A1 (pl) * 2012-02-10 2012-08-27 Krzysztof Selmaj Kompozycja farmaceutyczna oraz zastosowanie kompozycji do wytwarzania leku, do podawania naskórnego, do leczenia stwardnienia rozsianego
GB201300684D0 (en) * 2013-01-15 2013-02-27 Apitope Int Nv Peptide
CN105992950A (zh) * 2013-12-19 2016-10-05 欧普萨治疗股份有限公司 T 细胞表位表达谱分析、制备 t 细胞组合物以及治疗疾病的方法
WO2016037123A2 (en) 2014-09-05 2016-03-10 Opexa Therapeutics, Inc. Compositions and methods for treating b cell mediated autoimmune disorders
US10231033B1 (en) 2014-09-30 2019-03-12 Apple Inc. Synchronizing out-of-band content with a media stream

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077232A2 (en) * 2000-11-22 2002-10-03 Diadexus, Inc. Compositions and methods relating to breast specific genes and proteins
WO2005042746A1 (en) * 2003-10-31 2005-05-12 The University Of British Columbia Bacterial virulence factors and uses thereof

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5852225A (ja) * 1981-09-22 1983-03-28 Mitsui Pharmaceut Inc 脱髄疾患治療剤
US5766920A (en) * 1982-08-11 1998-06-16 Cellcor, Inc. Ex vivo activation of immune cells
US4550086A (en) * 1983-02-16 1985-10-29 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that recognize human T cells
IL69686A (en) * 1983-09-11 1988-03-31 Yeda Res & Dev Compositions containing cell membrane proteins and process for their preparation
US4608365A (en) * 1984-03-30 1986-08-26 University Of Southern California Treatment of neurologic functions
US4677061A (en) * 1984-10-19 1987-06-30 Genetic Systems Corporation T-cell lymphocyte subset monitoring of immunologic disease
US4902680A (en) * 1984-10-29 1990-02-20 Chaovanee Aroonsakul Treating central nervous system diseases
US4898857A (en) * 1984-10-29 1990-02-06 Chaovanee Aroonsakul Treating control nervous system diseases
US4898856A (en) * 1984-10-29 1990-02-06 Chaovanee Aroonsakul Method for treating central nervous system diseases
US4897389A (en) * 1984-10-29 1990-01-30 Chaovanee Aroonsakul Treating central nervous system diseases
CA1296622C (en) * 1986-08-12 1992-03-03 Jeffrey E. Anderson Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system
US5849298A (en) * 1987-06-24 1998-12-15 Autoimmune Inc. Treatment of multiple sclerosis by oral administration of bovine myelin
US5039660A (en) * 1988-03-02 1991-08-13 Endocon, Inc. Partially fused peptide pellet
US5242687A (en) * 1989-03-15 1993-09-07 Tkb Associates Limited Partnership Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells
US5861164A (en) * 1989-03-21 1999-01-19 The Immune Response Corporation Vaccination against diseases resulting from pathogenic responses by specific T cell populations
US6007815A (en) * 1989-03-21 1999-12-28 The Immune Response Corporation Anti-idiotype vaccination against diseases resulting from pathogenic responses by specific T cell populations
US6221352B1 (en) * 1989-03-21 2001-04-24 The Immune Response Corporation Method of preventing the proliferation of Vβ14 or Vβ17-Expressing T cells
US6207645B1 (en) * 1989-03-21 2001-03-27 The Immune Response Corporation Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations
US5837246A (en) * 1989-03-21 1998-11-17 The Immune Response Corporation Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations
US5612035A (en) * 1989-03-21 1997-03-18 The Immune Response Corporation Vaccination against diseases resulting from pathogenic responses by specific T cell populations
US5776459A (en) * 1989-07-19 1998-07-07 Connetics Corporation TCR V beta 5 peptides
US5614192A (en) * 1989-07-19 1997-03-25 Connective Therapeutics, Inc. T cell receptor peptides as therapeutics for immune-related disease
US5298396A (en) * 1989-11-15 1994-03-29 National Jewish Center For Immunology And Respiratory Medicine Method for identifying T cells disease involved in autoimmune disease
WO1992001044A1 (en) * 1990-07-06 1992-01-23 Allergene, Inc. Mouse/human heterohybrid cell line el41 and methods for the production of human monoclonal antibodies
US5668117A (en) * 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
US5211952A (en) * 1991-04-12 1993-05-18 University Of Southern California Contraceptive methods and formulations for use therein
US6083503A (en) * 1991-08-28 2000-07-04 The United States Of America As Represented By The Department Of Health And Human Services Interleukin-2 stimulated T lymphocyte cell death for the treatment of autoimmune diseases, allergic responses, and graft rejection
US5480895A (en) * 1991-09-27 1996-01-02 New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery Method of producing antibodies to a restricted population of T lymphocytes, antibodies produced therefrom and methods of use thereof
US5545716A (en) * 1992-09-08 1996-08-13 University Of Florida Superantigen agonist and antagonist peptides
WO1994020120A1 (en) * 1993-03-12 1994-09-15 Cellcor, Inc. In vitro assay measuring degree of activation of immune cells
US5494899A (en) * 1993-04-07 1996-02-27 Oklahoma Medical Research Foundation Selective regulation of B lymphocyte precursors by hormones
IL110787A0 (en) * 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
JPH09510437A (ja) * 1993-12-28 1997-10-21 カイロン ミモトープス プロプライエトリー リミテッド T細胞エピトープ
US5552300A (en) * 1994-01-13 1996-09-03 T Cell Sciences, Inc. T cell antigen receptor V region proteins and methods of preparation thereof
US6410518B1 (en) * 1994-05-31 2002-06-25 Isis Pharmaceuticals, Inc. Antisense oligonucleotide inhibition of raf gene expression
US5723503A (en) * 1994-09-28 1998-03-03 Thomas Jefferson University Biological treatment for rheumatoid arthritis
US5674487A (en) * 1994-09-28 1997-10-07 Univ Jefferson Method for treating autoimmune diseases
US6033661A (en) * 1995-06-07 2000-03-07 Thomas Jefferson University Composition and method for allogenetic mononuclear cell immunotherapy
US6096314A (en) * 1994-10-07 2000-08-01 Yeda Research And Development Co. Ltd. Peptides and pharmaceutical compositions comprising them
EP1172376A1 (en) * 1994-11-18 2002-01-16 Neurocrine Biosciences, Inc. Peptide analogues at position 91 of human myelin basic protein for treatment of multiple sclerosis
FR2727117A1 (fr) * 1994-11-18 1996-05-24 Geffard Michel Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun
US6218166B1 (en) * 1994-12-09 2001-04-17 John Wayne Cancer Institute Adjuvant incorporation into antigen carrying cells: compositions and methods
US5874531A (en) * 1995-03-07 1999-02-23 President And Fellows Of Harvard College Identification of self and non-self antigens implicated autoimmune disease
US5869057A (en) * 1995-06-07 1999-02-09 Rock; Edwin P. Recombinant vaccines to break self-tolerance
SE9502921D0 (sv) * 1995-08-23 1995-08-23 Astra Ab New compounds
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
US5750356A (en) * 1996-05-31 1998-05-12 Anergen, Inc. Method for monitoring T cell reactivity
US5849886A (en) * 1996-07-10 1998-12-15 Oy Aboatech Ab Extraction of myelin basic protein
US20010031253A1 (en) * 1996-07-24 2001-10-18 Gruenberg Micheal L. Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
US6130087A (en) * 1996-10-07 2000-10-10 Fordham University Methods for generating cytotoxic T cells in vitro
KR20000049096A (ko) * 1996-10-11 2000-07-25 린다 에스. 스티븐슨 혼합 림프구와 조합된 종양세포를 사용하는 암 면역요법
US6054292A (en) * 1997-07-18 2000-04-25 Incyte Pharmaceuticals, Inc. T-cell receptor protein
US20020009448A1 (en) * 1997-09-19 2002-01-24 Leslie P. Weiner T-cell vaccination for the treatment of multiple sclerosis
US20020072493A1 (en) * 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
US20020001841A1 (en) * 1998-06-26 2002-01-03 Keld Kaltoft Continuous t-cell lines
AU774952B2 (en) * 1999-02-23 2004-07-15 Baylor College Of Medicine T cell receptor Vbeta-Dbeta-Jbeta sequence and methods for its detection
US6187750B1 (en) * 1999-08-25 2001-02-13 Everyoung Technologies, Inc. Method of hormone treatment for patients with symptoms consistent with multiple sclerosis
US6746670B2 (en) * 2000-08-15 2004-06-08 Schering Corporation Regulatory T cells; methods
SI1311542T1 (sl) * 2000-08-21 2009-02-28 Apitope Technology Bristol Ltd Tolerogenski peptidi
US20030078347A1 (en) * 2001-08-28 2003-04-24 General Electric Company Triazine compounds, polymers comprising triazine structural units, and method
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
EP1444330A1 (en) * 2001-11-07 2004-08-11 Kirin Beer Kabushiki Kaisha Expansion of t cells in vitro and expanded t cell populations
US20050181459A1 (en) * 2002-06-11 2005-08-18 Matthew Baker Method for mapping and eliminating T cell epitopes
CA2542668C (en) * 2003-10-17 2014-04-29 Baylor College Of Medicine A method for increasing cd8+ cytotoxic t cell reponses and for treating multiple sclerosis
WO2005074579A2 (en) * 2004-02-02 2005-08-18 Mixture Sciences, Inc. Peptide mixtures with immunomodulatory activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077232A2 (en) * 2000-11-22 2002-10-03 Diadexus, Inc. Compositions and methods relating to breast specific genes and proteins
WO2005042746A1 (en) * 2003-10-31 2005-05-12 The University Of British Columbia Bacterial virulence factors and uses thereof

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
JPN5009008673; ZHANG.J.: SCIENCE V261, 19930910, P1451-1454 *
JPN5009008674; VERGELLI.M.: J.NEUROSCI.RES V66, 2001, P517-524 *
JPN6014000198; International immunology. 2003, Vol.15, No.4, p.535-546 *
JPN6014000200; Lancet. 1995, Vol.346, No.8978, p.807-808 *
JPN7012004166; Clinical immunology Vol.113, 2004, p.155-160 *
JPN7012004167; Clin Exp Immunol Vol.131, 2003, p.155-168 *
JPN7012004168; J Neurol Vol.249, 2002, p.212-218 *
JPN7012004169; J. Clin. Invest. Vol.92, 1993, p.2633-2643 *
JPN7012004170; LANCET Vol.346, 1995, p.807-808 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017508480A (ja) * 2014-03-12 2017-03-30 ナショナル キャンサー センター 自己癌抗原特異的cd8+t細胞の分離及び増殖方法
JP2019050826A (ja) * 2014-03-12 2019-04-04 ナショナル キャンサー センター 自己癌抗原特異的cd8+t細胞の分離及び増殖方法
US10570371B2 (en) 2014-03-12 2020-02-25 Eutilex Co., Ltd. Methods for isolating and proliferating autologous cancer antigen-specific CD8+T cells
JP2020124214A (ja) * 2014-03-12 2020-08-20 ナショナル キャンサー センター 自己癌抗原特異的cd8+t細胞の分離及び増殖方法
US10801011B2 (en) 2014-03-12 2020-10-13 National Cancer Center Methods for isolating and proliferating autologous cancer antigen-specific CD8+ T cells
JP7122336B2 (ja) 2014-03-12 2022-08-19 ナショナル キャンサー センター 自己癌抗原特異的cd8+t細胞の分離及び増殖方法
US10919972B2 (en) 2017-01-06 2021-02-16 Eutilex Co., Ltd. Anti-human 4-1BB antibodies and uses thereof
US11859004B2 (en) 2017-01-06 2024-01-02 Eutilex Co., Ltd. Anti-human 4-1BB antibodies and uses thereof

Also Published As

Publication number Publication date
NZ572644A (en) 2012-06-29
EP2420833B1 (en) 2015-09-02
EP2712623A1 (en) 2014-04-02
US20100003228A1 (en) 2010-01-07
AU2007247869B2 (en) 2013-11-21
IL195115A (en) 2012-12-31
EP2016414B1 (en) 2015-09-02
JP6000205B2 (ja) 2016-09-28
PT2016414E (pt) 2015-11-24
DK2420833T3 (en) 2015-12-07
JP2013252142A (ja) 2013-12-19
CA2651328A1 (en) 2007-11-15
PL2420833T3 (pl) 2016-03-31
PL2016414T3 (pl) 2016-01-29
JP2016053090A (ja) 2016-04-14
WO2007131210A2 (en) 2007-11-15
EP2420833A1 (en) 2012-02-22
ES2552667T3 (es) 2015-12-01
PT2420833E (pt) 2015-11-24
DK2016414T3 (en) 2015-12-07
IL195115A0 (en) 2009-09-22
EP2016414A2 (en) 2009-01-21
ES2553192T3 (es) 2015-12-04
WO2007131210A3 (en) 2008-10-30
AU2007247869A1 (en) 2007-11-15
EP2016414A4 (en) 2009-08-12

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