JP2009536036A5 - - Google Patents
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- JP2009536036A5 JP2009536036A5 JP2009510114A JP2009510114A JP2009536036A5 JP 2009536036 A5 JP2009536036 A5 JP 2009536036A5 JP 2009510114 A JP2009510114 A JP 2009510114A JP 2009510114 A JP2009510114 A JP 2009510114A JP 2009536036 A5 JP2009536036 A5 JP 2009536036A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- epitope
- autoreactive
- acid sequence
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 29
- 210000001744 T-lymphocyte Anatomy 0.000 claims 32
- 238000000034 method Methods 0.000 claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims 22
- 229920001184 polypeptide Polymers 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 230000000890 antigenic effect Effects 0.000 claims 7
- 229940030156 cell vaccine Drugs 0.000 claims 7
- 230000000638 stimulation Effects 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 3
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 125000001151 peptidyl group Chemical group 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 102000006303 Chaperonin 60 Human genes 0.000 claims 1
- 108010058432 Chaperonin 60 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000002771 cell marker Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74661106P | 2006-05-05 | 2006-05-05 | |
| US74790306P | 2006-05-22 | 2006-05-22 | |
| PCT/US2007/068304 WO2007131210A2 (en) | 2006-05-05 | 2007-05-04 | T-cell vaccine |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013163134A Division JP6000205B2 (ja) | 2006-05-05 | 2013-08-06 | T細胞ワクチン |
| JP2016003678A Division JP2016053090A (ja) | 2006-05-05 | 2016-01-12 | T細胞ワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536036A JP2009536036A (ja) | 2009-10-08 |
| JP2009536036A5 true JP2009536036A5 (enExample) | 2013-09-19 |
Family
ID=38668612
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510114A Withdrawn JP2009536036A (ja) | 2006-05-05 | 2007-05-04 | T細胞ワクチン |
| JP2013163134A Expired - Fee Related JP6000205B2 (ja) | 2006-05-05 | 2013-08-06 | T細胞ワクチン |
| JP2016003678A Withdrawn JP2016053090A (ja) | 2006-05-05 | 2016-01-12 | T細胞ワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013163134A Expired - Fee Related JP6000205B2 (ja) | 2006-05-05 | 2013-08-06 | T細胞ワクチン |
| JP2016003678A Withdrawn JP2016053090A (ja) | 2006-05-05 | 2016-01-12 | T細胞ワクチン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100003228A1 (enExample) |
| EP (3) | EP2016414B1 (enExample) |
| JP (3) | JP2009536036A (enExample) |
| AU (1) | AU2007247869B2 (enExample) |
| CA (1) | CA2651328A1 (enExample) |
| DK (2) | DK2016414T3 (enExample) |
| ES (2) | ES2552667T3 (enExample) |
| IL (1) | IL195115A (enExample) |
| NZ (1) | NZ572644A (enExample) |
| PL (2) | PL2016414T3 (enExample) |
| PT (2) | PT2016414E (enExample) |
| WO (1) | WO2007131210A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL398077A1 (pl) * | 2012-02-10 | 2012-08-27 | Krzysztof Selmaj | Kompozycja farmaceutyczna oraz zastosowanie kompozycji do wytwarzania leku, do podawania naskórnego, do leczenia stwardnienia rozsianego |
| GB201300684D0 (en) * | 2013-01-15 | 2013-02-27 | Apitope Int Nv | Peptide |
| CN105992950A (zh) * | 2013-12-19 | 2016-10-05 | 欧普萨治疗股份有限公司 | T 细胞表位表达谱分析、制备 t 细胞组合物以及治疗疾病的方法 |
| KR101503341B1 (ko) * | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
| WO2016037123A2 (en) | 2014-09-05 | 2016-03-10 | Opexa Therapeutics, Inc. | Compositions and methods for treating b cell mediated autoimmune disorders |
| US10231033B1 (en) | 2014-09-30 | 2019-03-12 | Apple Inc. | Synchronizing out-of-band content with a media stream |
| AU2018206015B2 (en) | 2017-01-06 | 2019-05-30 | Eutilex Co., Ltd. | Anti-human 4-1 BB antibodies and use thereof |
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| US4902680A (en) * | 1984-10-29 | 1990-02-20 | Chaovanee Aroonsakul | Treating central nervous system diseases |
| US4898857A (en) * | 1984-10-29 | 1990-02-06 | Chaovanee Aroonsakul | Treating control nervous system diseases |
| US4898856A (en) * | 1984-10-29 | 1990-02-06 | Chaovanee Aroonsakul | Method for treating central nervous system diseases |
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| CA1296622C (en) * | 1986-08-12 | 1992-03-03 | Jeffrey E. Anderson | Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system |
| US5849298A (en) * | 1987-06-24 | 1998-12-15 | Autoimmune Inc. | Treatment of multiple sclerosis by oral administration of bovine myelin |
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| US5242687A (en) * | 1989-03-15 | 1993-09-07 | Tkb Associates Limited Partnership | Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells |
| US5861164A (en) * | 1989-03-21 | 1999-01-19 | The Immune Response Corporation | Vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| US6007815A (en) * | 1989-03-21 | 1999-12-28 | The Immune Response Corporation | Anti-idiotype vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| US6221352B1 (en) * | 1989-03-21 | 2001-04-24 | The Immune Response Corporation | Method of preventing the proliferation of Vβ14 or Vβ17-Expressing T cells |
| US6207645B1 (en) * | 1989-03-21 | 2001-03-27 | The Immune Response Corporation | Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations |
| US5837246A (en) * | 1989-03-21 | 1998-11-17 | The Immune Response Corporation | Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations |
| US5612035A (en) * | 1989-03-21 | 1997-03-18 | The Immune Response Corporation | Vaccination against diseases resulting from pathogenic responses by specific T cell populations |
| US5776459A (en) * | 1989-07-19 | 1998-07-07 | Connetics Corporation | TCR V beta 5 peptides |
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| US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
| US5211952A (en) * | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
| US6083503A (en) * | 1991-08-28 | 2000-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Interleukin-2 stimulated T lymphocyte cell death for the treatment of autoimmune diseases, allergic responses, and graft rejection |
| US5480895A (en) * | 1991-09-27 | 1996-01-02 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Method of producing antibodies to a restricted population of T lymphocytes, antibodies produced therefrom and methods of use thereof |
| US5545716A (en) * | 1992-09-08 | 1996-08-13 | University Of Florida | Superantigen agonist and antagonist peptides |
| WO1994020120A1 (en) * | 1993-03-12 | 1994-09-15 | Cellcor, Inc. | In vitro assay measuring degree of activation of immune cells |
| US5494899A (en) * | 1993-04-07 | 1996-02-27 | Oklahoma Medical Research Foundation | Selective regulation of B lymphocyte precursors by hormones |
| IL110787A0 (en) * | 1993-08-27 | 1994-11-11 | Sandoz Ag | Biodegradable polymer, its preparation and pharmaceutical composition containing it |
| JPH09510437A (ja) * | 1993-12-28 | 1997-10-21 | カイロン ミモトープス プロプライエトリー リミテッド | T細胞エピトープ |
| US5552300A (en) * | 1994-01-13 | 1996-09-03 | T Cell Sciences, Inc. | T cell antigen receptor V region proteins and methods of preparation thereof |
| US6410518B1 (en) * | 1994-05-31 | 2002-06-25 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide inhibition of raf gene expression |
| US5723503A (en) * | 1994-09-28 | 1998-03-03 | Thomas Jefferson University | Biological treatment for rheumatoid arthritis |
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| US6033661A (en) * | 1995-06-07 | 2000-03-07 | Thomas Jefferson University | Composition and method for allogenetic mononuclear cell immunotherapy |
| US6096314A (en) * | 1994-10-07 | 2000-08-01 | Yeda Research And Development Co. Ltd. | Peptides and pharmaceutical compositions comprising them |
| EP1172376A1 (en) * | 1994-11-18 | 2002-01-16 | Neurocrine Biosciences, Inc. | Peptide analogues at position 91 of human myelin basic protein for treatment of multiple sclerosis |
| FR2727117A1 (fr) * | 1994-11-18 | 1996-05-24 | Geffard Michel | Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun |
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| US5874531A (en) * | 1995-03-07 | 1999-02-23 | President And Fellows Of Harvard College | Identification of self and non-self antigens implicated autoimmune disease |
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| US6130087A (en) * | 1996-10-07 | 2000-10-10 | Fordham University | Methods for generating cytotoxic T cells in vitro |
| KR20000049096A (ko) * | 1996-10-11 | 2000-07-25 | 린다 에스. 스티븐슨 | 혼합 림프구와 조합된 종양세포를 사용하는 암 면역요법 |
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| US20020001841A1 (en) * | 1998-06-26 | 2002-01-03 | Keld Kaltoft | Continuous t-cell lines |
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| US20050181459A1 (en) * | 2002-06-11 | 2005-08-18 | Matthew Baker | Method for mapping and eliminating T cell epitopes |
| CA2542668C (en) * | 2003-10-17 | 2014-04-29 | Baylor College Of Medicine | A method for increasing cd8+ cytotoxic t cell reponses and for treating multiple sclerosis |
| CN101711861A (zh) * | 2003-10-31 | 2010-05-26 | 不列颠哥伦比亚大学 | 细菌毒力因子及其用途 |
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-
2007
- 2007-05-04 PT PT77973477T patent/PT2016414E/pt unknown
- 2007-05-04 AU AU2007247869A patent/AU2007247869B2/en not_active Ceased
- 2007-05-04 JP JP2009510114A patent/JP2009536036A/ja not_active Withdrawn
- 2007-05-04 EP EP07797347.7A patent/EP2016414B1/en not_active Not-in-force
- 2007-05-04 PT PT111886768T patent/PT2420833E/pt unknown
- 2007-05-04 ES ES11188676.8T patent/ES2552667T3/es active Active
- 2007-05-04 NZ NZ572644A patent/NZ572644A/en not_active IP Right Cessation
- 2007-05-04 CA CA002651328A patent/CA2651328A1/en not_active Abandoned
- 2007-05-04 EP EP13187264.0A patent/EP2712623A1/en not_active Withdrawn
- 2007-05-04 ES ES07797347T patent/ES2553192T3/es active Active
- 2007-05-04 EP EP11188676.8A patent/EP2420833B1/en not_active Not-in-force
- 2007-05-04 PL PL07797347T patent/PL2016414T3/pl unknown
- 2007-05-04 DK DK07797347.7T patent/DK2016414T3/en active
- 2007-05-04 US US12/299,585 patent/US20100003228A1/en not_active Abandoned
- 2007-05-04 WO PCT/US2007/068304 patent/WO2007131210A2/en not_active Ceased
- 2007-05-04 PL PL11188676T patent/PL2420833T3/pl unknown
- 2007-05-04 DK DK11188676.8T patent/DK2420833T3/en active
-
2008
- 2008-11-04 IL IL195115A patent/IL195115A/en not_active IP Right Cessation
-
2013
- 2013-08-06 JP JP2013163134A patent/JP6000205B2/ja not_active Expired - Fee Related
-
2016
- 2016-01-12 JP JP2016003678A patent/JP2016053090A/ja not_active Withdrawn
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